Citation Impact
Citing Papers
Pathophysiology of Migraine: A Disorder of Sensory Processing
2017 Standout
The endocannabinoid nervous system
2001
Analysis of humanCYP1A1andCYP1A2genes and their shared bidirectional promoter in eight world populations
2009
N-Acylethanolamines and precursor phospholipids — relation to cell injury
2000
The general anesthetic propofol increases brain N‐arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase
2003
New perspectives on enigmatic vanilloid receptors
2000
International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors
2002 Standout
Understanding Synapses: Past, Present, and Future
2008 StandoutNobel
Role of Aryl Hydrocarbon Receptor-mediated Induction of the CYP1 Enzymes in Environmental Toxicity and Cancer
2004
Stimulation of voluntary ethanol intake by cannabinoid receptor agonists in ethanol-preferring sP rats
2001
Modulation of anxiety through blockade of anandamide hydrolysis
2002 Standout
Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications
2011 Standout
In vivo drug metabolism model for human cytochrome P450 enzyme using chimeric mice with humanized liver
2006
Endocannabinoid system and alcohol addiction: Pharmacological studies
2005
Fatal Autoimmune Hepatitis Induced by Concurrent Loss of Naturally Arising Regulatory T Cells and PD-1-Mediated Signaling
2008 StandoutNobel
Adverse Health Effects of Marijuana Use
2014 Standout
Leptin-regulated endocannabinoids are involved in maintaining food intake
2001 Nature
Adverse health effects of non-medical cannabis use
2009
Cannabinoid signalling
2005
Central nervous system control of food intake and body weight
2006 StandoutNature
Descending control of pain
2002 Standout
Vascularized and functional human liver from an iPSC-derived organ bud transplant
2013 StandoutNature
Endocannabinoid-Mediated Long-Term Plasticity Requires cAMP/PKA Signaling and RIM1α
2007 StandoutNobel
Preparation of human metabolites of propranolol using laboratory‐evolved bacterial cytochromes P450
2005 StandoutNobel
Assessment of Chimeric Mice with Humanized Liver as a Tool for Predicting Circulating Human Metabolites
2010
Dynorphin B and spinal analgesia: induction of antinociception by the cannabinoids CP55,940, Δ9-THC and anandamide1Published on the World Wide Web on 18 January 2000.1
2000
Cocaine, but not morphine, induces conditioned place preference and sensitization to locomotor responses in CB1 knockout mice
2000
Time course of the enhancement and restoration of the analgesic efficacy of codeine and morphine by Δ9-tetrahydrocannabinol
2006
An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
2011 StandoutNature
Cushing's syndrome
2015 Standout
Molecular Characterization of a Phospholipase D Generating Anandamide and Its Congeners
2004 Standout
Modulation of transmitter release via presynaptic cannabinoid receptors
2001
μ opioid and CB1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesis
2006
Mechanical, thermal and formalin-induced nociception is differentially altered in 5-HT1A−/−, 5-HT1B−/−, 5-HT2A−/−, 5-HT3A−/− and 5-HTT−/− knock-out male mice
2007 StandoutNobel
agriGO v2.0: a GO analysis toolkit for the agricultural community, 2017 update
2017 Standout
Potential role of the cannabinoid receptor cb1 in rapid eye movement sleep rebound
2003
Adolescent exposure to cannabinoids induces long-Lasting changes in the response to drugs of abuse of rat midbrain dopamine neurons
2004
The endocannabinoid system in the basal ganglia and in the mesolimbic reward system: implications for neurological and psychiatric disorders
2003
Neuroendocrine regulation of eating behavior
2002
Epoxygenase Pathways of Arachidonic Acid Metabolism
2001
Balancing Acts
2004 Standout
Locomotor networks are targets of modulation by sensory transient receptor potential vanilloid 1 and transient receptor potential melastatin 8 channels
2009 StandoutNobel
Adenosine A2A receptors are involved in physical dependence and place conditioning induced by THC
2004
Sex differences in antinociceptive and motoric effects of cannabinoids
2001
Context‐dependent effects of CB1 cannabinoid gene disruption on anxiety‐like and social behaviour in mice
2004
Intracerebral self-administration of the cannabinoid receptor agonist CP 55,940 in the rat: interaction with the opioid system
2001
The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept
2007 Standout
Molecular biology of cannabinoid receptors
2002
Synergistic effects of cannabinoid inverse agonist AM251 and opioid antagonist nalmefene on food intake in mice
2004
Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
2002 Standout
Activation of spinal cannabinoid 1 receptors inhibits C‐fibre driven hyperexcitable neuronal responses and increases [35S]GTPγS binding in the dorsal horn of the spinal cord of noninflamed and inflamed rats
2000
Synergistic Interactions between Cannabinoids and Environmental Stress in the Activation of the Central Amygdala
2004
The cannabinoid agonist WIN 55, 212-2 increases nociception threshold in cholestatic rats: implications for the treatment of the pruritus of cholestasis
2003
Biosynthesis and degradation of anandamide and 2-arachidonoylglycerol and their possible physiological significance
2002
Motivational Effects of Cannabinoids and Opioids on Food Reinforcement Depend on Simultaneous Activation of Cannabinoid and Opioid Systems
2005
Antidepressant-like and anorectic effects of the cannabinoid CB1 receptor inverse agonist AM251 in mice
2003
Changes in endocannabinoid contents in the brain of rats chronically exposed to nicotine, ethanol or cocaine
2002
Involvement of CB1 cannabinoid receptors in emotional behaviour
2002
Therapeutic potential of β-arrestin- and G protein-biased agonists
2010 StandoutNobel
The Endocannabinoid System as an Emerging Target of Pharmacotherapy
2006 Standout
Autism-Associated Neuroligin-3 Mutations Commonly Disrupt Tonic Endocannabinoid Signaling
2013 StandoutNobel
Unilateral 6-hydroxydopamine lesions of nigrostriatal dopaminergic neurons increased CB1 receptor mRNA levels in the caudate-putamen
2000
Anandamide activates peripheral nociceptors in normal and arthritic rat knee joints
2001
Cannabinoid receptor antagonist reduces heroin self-administration only in dependent rats
2004
A Common Regulatory Region Functions Bidirectionally in Transcriptional Activation of the Human CYP1A1 and CYP1A2 Genes
2006
Genetic polymorphism of hepatocyte nuclear factor‐4α influences human cytochrome P450 2D6 activity†
2008
Impaired action of anxiolytic drugs in mice deficient in cannabinoid CB1 receptors
2004
Cannabinoid receptors and pain
2001
Effects of delta-9-tetrahydrocannabinol on human immune function and host defense
2002
Mechanisms of drug combinations: interaction and network perspectives
2009 Standout
Clinical importance of the cytochromes P450
2002
The pharmacology of the endocannabinoid system: functional and structural interactions with other neurotransmitter systems and their repercussions in behavioral addiction
2008
Cannabinoids: potential anticancer agents
2003
Synergistic efects of opioid and cannabinoid antagonists on food intake
2001
The Central Cannabinoid Receptor Inactivation Suppresses Endocrine Reproductive Functions
2001
Physiology and Pathophysiology of Purinergic Neurotransmission
2007 Standout
Cannabis and the brain
2003
Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2
2009
Differential Regulation of Synaptic Inputs by Constitutively Released Endocannabinoids and Exogenous Cannabinoids
2005
Role of receptor internalization in the agonist‐induced desensitization of cannabinoid type 1 receptors
2007
Maximizing mouse cancer models
2007
Organization, structure and evolution of the CYP2 gene cluster on human chromosome 19
2001
C/EBPα Regulates Hepatic Transcription of Hepcidin, an Antimicrobial Peptide and Regulator of Iron Metabolism
2002
Reduction of opioid dependence by the CB1 antagonist SR141716A in mice: evaluation of the interest in pharmacotherapy of opioid addiction
2001
Coexpression of the cannabinoid receptor type 1 with the corticotropin-releasing hormone receptor type 1 in distinct regions of the adult mouse forebrain
2004
THE ENDOCANNABINOID SYSTEM: PHYSIOLOGY AND PHARMACOLOGY
2004
LTP and LTD
2004 Standout
The molecular logic of endocannabinoid signalling
2003 Standout
Cannabinoid CB1 receptor blockade enhances the protective effect of melanocortins in hemorrhagic shock in the rat
2002
Differential Distribution of β-Adrenergic Receptor Subtypes in Blood Vessels of Knockout Mice Lacking β1-or β2-Adrenergic Receptors
2001 StandoutNobel
Presence of Ghrelin in Normal and Adenomatous Human Pituitary
2001
Molecular Basis for Species-Specific Sensitivity to “Hot” Chili Peppers
2002 StandoutNobel
Endocannabinoid Signaling Negatively Modulates Stress-Induced Activation of the Hypothalamic-Pituitary-Adrenal Axis
2004
Antinociceptive, behavioural and neuroendocrine effects of CP 55,940 in young rats
2002
Animal models for autoimmune hepatitis
2006
Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review
2007 Standout
Paul Ehrlich's magic bullet concept: 100 years of progress
2008 Standout
Polymorphic Cytochrome P450 2D6: Humanized Mouse Model and Endogenous Substrates
2004
Cannabis-Associated Psychosis
2004
Cannabinoid CB1 Receptor Antagonists as Promising New Medications for Drug Dependence
2005
Molecular mechanisms involved in the asymmetric interaction between cannabinoid and opioid systems
2005
Role of endocannabinoid system in mental diseases
2004
Phosphorus acquisition and use: critical adaptations by plants for securing a nonrenewable resource
2003 Standout
Reversal of Δ9-THC hyperphagia by SR141716 and naloxone but not dexfenfluramine
2002
Cytochromes P450, Drugs, and Diseases
2003
The effects of cannabinoids on the brain
1999
Transient Receptor Potential Cation Channels in Disease
2007 Standout
Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation
2013 Standout
Endocannabinoid system and opioid addiction: Behavioural aspects
2005
Ghrelin: Structure and Function
2005 Standout
Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic
2007 Standout
Molecular Mechanisms of Polymorphic CYP3A7 Expression in Adult Human Liver and Intestine
2002
Molecular and cellular basis of cannabinoid and opioid interactions
2005
Functional responses to the cannabinoid agonist WIN 55,212-2 in neonatal rats of both genders: influence of weaning
2004
Synergistic and additive interactions of the cannabinoid agonist CP55,940 with μ opioid receptor and α2‐adrenoceptor agonists in acute pain models in mice
2005
Approaching the shared biology of obesity and depression: the stress axis as the locus of gene–environment interactions
2006
The endogenous cannabinoid system protects against colonic inflammation
2004
Endocannabinoid system and stress and anxiety responses
2005
Involvement of the opioid system in the anxiolytic-like effects induced by Δ9-tetrahydrocannabinol
2002
Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver
2008 Standout
Cannabis, cannabinoids and reproduction
2003
Xenobiotic metabolizing enzymes in the central nervous system: Contribution of cytochrome P450 enzymes in normal and pathological human brain
2007
Reduction of stress‐induced analgesia but not of exogenous opioid effects in mice lacking CB1 receptors
2000
Distinct Risk Factor Profiles for Human Papillomavirus Type 16–Positive and Human Papillomavirus Type 16–Negative Head and Neck Cancers
2008 Standout
Aryl hydrocarbon receptor inhibition downregulates the TGF-β/Smad pathway in human glioblastoma cells
2009
Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): multicentre randomised placebo-controlled trial
2003 Standout
Involvement of the κ-opioid receptor in the anxiogenic-like effect of CP 55,940 in male rats
2003
Endogenous cannabinoids and appetite.
2001
The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance
2005
Therapeutic potential of cannabinoid receptor agonists as analgesic agents
2005
The neurobiology and evolution of cannabinoid signalling
2001
Toward the evaluation of function in genetic variability: Characterizing human SNP frequencies and establishing BAC‐transgenic mice carrying the humanCYP1A1_CYP1A2locus
2005
Motivational Effects of Cannabinoids Are Mediated by μ-Opioid and κ-Opioid Receptors
2002
2003
Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection
2008
The Expression of the Growth Hormone Secretagogue Receptor Ligand Ghrelin in Normal and Abnormal Human Pituitary and Other Neuroendocrine Tumors1
2001
Suppression of Nerve Growth Factor Trk Receptors and Prolactin Receptors by Endocannabinoids Leads to Inhibition of Human Breast and Prostate Cancer Cell Proliferation1
2000
Ultrastructural Localization of the CB1 Cannabinoid Receptor in μ-Opioid Receptor Patches of the Rat Caudate Putamen Nucleus
2001
Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation
2003 Standout
Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology
2001 StandoutScience
Effect of the cannabinoid CB1 receptor antagonist SR-141716A on ethanol self-administration and ethanol-seeking behaviour in rats
2005
Functional Tolerance and Blockade of Long-Term Depression at Synapses in the Nucleus Accumbens after Chronic Cannabinoid Exposure
2003
Enhanced Rewarding Properties of Morphine, but not Cocaine, in βarrestin-2 Knock-Out Mice
2003 StandoutNobel
Sleep modulates cannabinoid receptor 1 expression in the pons of rats
2003
The endogenous cannabinoid system protects against colonic inflammation
2004
Functional Interaction between Opioid and Cannabinoid Receptors in Drug Self-Administration
2001
Intercellular signaling of reproductive development by theC. elegansDAF-9 cytochrome P450
2004 StandoutNobel
Protein−Surfactant Film Voltammetry of Wild-Type and Mutant Cytochrome P450 BM3
2005 StandoutNobel
Anti-obesity effect of SR141716, a CB1 receptor antagonist, in diet-induced obese mice
2003
Endocannabinoid Signaling in the Brain
2002 Science
Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning
2011 StandoutNobel
Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor.
2001
Clinical endocannabinoid deficiency (CECD): can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?
2004
Phylogenetic Relationships within Cation Transporter Families of Arabidopsis
2001
Pituitary Control of BK Potassium Channel Function and Intrinsic Firing Properties of Adrenal Chromaffin Cells
2001
Evidence for an Interaction between CB1 Cannabinoid and Melanocortin MCR-4 Receptors in Regulating Food Intake
2004
Cutting Edge: Chronic Inflammatory Liver Disease in Mice Expressing a CD28-Specific Ligand
2012 StandoutNobel
Absence of Δ-9-Tetrahydrocannabinol Dysphoric Effects in Dynorphin-Deficient Mice
2001
Adenosine A2a blockade prevents synergy between μ-opiate and cannabinoid CB1 receptors and eliminates heroin-seeking behavior in addicted rats
2006
Neural Systems Underlying Opiate Addiction
2002
Endogenous cannabinoids and appetite
2001
NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory
2006 Standout
Variation in CYP1A2 Activity and its Clinical Implications: Influence of Environmental Factors and Genetic Polymorphisms
2008
Works of Javier Corchero being referenced
Perinatal Δ9-tetrahydrocannabinol exposure reduces proenkephalin gene expression in the caudate-putamen of adult female rats
1998
Chronic administration of cannabinoids regulates proenkephalin mRNA levels in selected regions of the rat brain
1998
Feedback Inhibition of the Retinaldehyde Dehydrogenase GeneALDH1 by Retinoic Acid through Retinoic Acid Receptor α and CCAAT/Enhancer-binding Protein β
2000
Identification of Endocannabinoids and Cannabinoid CB<sub>1</sub> Receptor mRNA in the Pituitary Gland
1999
Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation
2001
Pharmacological and biochemical interactions between opioids and cannabinoids
1999
Repeated administration of Δ9-tetrahydrocannabinol produces a differential time related responsiveness on proenkephalin, proopiomelanocortin and corticotropin releasing factor gene expression in the hypothalamus and pituitary gland of the rat
1999
Δ-9-Tetrahydrocannabinol increases prodynorphin and proenkephalin gene expression in the spinal cord of the rat
1997
Opioid and cannabinoid receptor-mediated regulation of the increase in adrenocorticotropin hormone and corticosterone plasma concentrations induced by central administration of Δ9-tetrahydrocannabinol in rats
1999
Time-course of the cannabinoid receptor down-regulation in the adult rat brain caused by repeated exposure to ?9-tetrahydrocannabinol
1998
Time-dependent differences of repeated administration with Δ9-tetrahydrocannabinol in proenkephalin and cannabinoid receptor gene expression and G-protein activation by μ-opioid and CB1-cannabinoid receptors in the caudate–putamen
1999
Liver portal fibrosis in dioxin receptor‐null mice that overexpress the latent transforming growth factor‐β‐binding protein‐1
2004
Chronic treatment with CP-55,940 regulates corticotropin releasing factor and proopiomelanocortin gene expression in the hypothalamus and pituitary gland of the rat
1999
The CYP2D6 Humanized Mouse: Effect of the Human CYP2D6 Transgene and HNF4 on the Disposition of Debrisoquine in the Mouse
2001
Δ9-Tetrahydrocannabinol increases proopiomelanocortin gene expression in the arcuate nucleus of the rat hypothalamus
1997
The Relative Contribution of Monoamine Oxidase and Cytochrome P450 Isozymes to the Metabolic Deamination of the Trace Amine Tryptamine
2003
Repeated administration with δ9- tetrahydrocannabinol regulates µ-opioid receptor density in the rat brain
2004
Gender differences in proenkephalin gene expression response to ∆9-tetrahydrocannabinol in the hypothalamus of the rat
2002
Cannabinoids as potential new analgesics
1999
A single nucleotide change in theMNR1 (VCX1/HUM1) gene determines resistance to manganese inSaccharomyces cerevisiae
1999