Jason Rupp

Structural Basis for Gating and Activation of RyR1

A human ether-á-go-go-related (hERG) ion channel atomistic model generated by long supercomputer molecular dynamics simulations and its use in predicting drug cardiotoxicity

Changing the research criteria for the diagnosis of Parkinson's disease: obstacles and opportunities

A comprehensive map of molecular drug targets

A structure-based computational workflow to predict liability and binding modes of small molecules to hERG

Identifying prodromal Parkinson's disease: Pre‐Motor disorders in Parkinson's disease

Parkinson's disease

Non-motor features of Parkinson disease

Size Matters: Erythromelalgia Mutation S241T in Nav1.7 Alters Channel Gating

Allosteric regulation and catalysis emerge via a common route

Preclinical Biomarkers of Parkinson Disease

COVID-19 prevention and treatment: A critical analysis of chloroquine and hydroxychloroquine clinical pharmacology

Class III antiarrhythmic drug dronedarone inhibits cardiac inwardly rectifying Kir2.1 channels through binding at residue E224

Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results

Gating Motions in Voltage-Gated Potassium Channels Revealed by Coarse-Grained Molecular Dynamics Simulations

Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications

The MARTINI Coarse-Grained Force Field: Extension to Proteins

Kv Channel Gating Requires a Compatible S4-S5 Linker and Bottom Part of S6, Constrained by Non-interacting Residues

MDS clinical diagnostic criteria for Parkinson's disease

Redox-Controlled Selective Docking in a [2]Catenane Host

Gut microbiota are related to Parkinson's disease and clinical phenotype

Modeling of Open, Closed, and Open-Inactivated States of the hERG1 Channel: Structural Mechanisms of the State-Dependent Drug Binding

Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype

Redox Control of the Binding Modes of an Organic Receptor

Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19

The S4-S5 Linker Directly Couples Voltage Sensor Movement to the Activation Gate in the Human Ether-á-go-go-related Gene (hERG) K+ Channel

Multiple step pattern as a biomarker in Parkinson disease

Cooperative Interactions Between R531 and Acidic Residues in the Voltage Sensing Module of hERG1 Channels

The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel