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2004 StandoutNobel
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2000
100 Years of peroxynitrite chemistry and 11 years of peroxynitrite biochemistry
2001
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Relative reactivity of lysine and other peptide-bound amino acids to oxidation by hypochlorite
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Modification of tryptophan and tryptophan residues in proteins by reactive nitrogen species
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[39] Immunohistochemical methods to detect nitrotyrosine
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The Human Microbiome Project
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2000
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1999
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The Role of Oxidative Stress in the Pathogenesis??of COPD
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Biological selectivity and functional aspects of protein tyrosine nitration
2003
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1999
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2005
Biochemistry and molecular cell biology of diabetic complications
2001 StandoutNature
Reactive oxygen species, antioxidants, and the mammalian thioredoxin system1 1This review is based on the licentiate thesis “Thioredoxin reductase—interactions with the redox active compounds 1-chloro-2,4-dinitrobenzene and lipoic acid” by Jonas Nordberg, 2001, Karolinska Institute, Stockholm, ISBN 91-631-1064-4.
2001 Standout
The Oxidation of Lipoproteins by Monocytes-Macrophages
1999
Protective effects of Mn(III)tetrakis (4-benzoic acid) porphyrin (MnTBAP), a superoxide dismutase mimetic, in paw oedema induced by carrageenan in the rat
1999
Peroxynitrite and drug-dependent toxicity
2004
Antimicrobial reactive oxygen and nitrogen species: concepts and controversies
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Progress and challenges in translating the biology of atherosclerosis
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Role of Peroxynitrite Anion in Renal Hypothermic Preservation Injury
2005
Redox signaling in macrophages
2001
Tyrosine Nitration of c-SRC Tyrosine Kinase in Human Pancreatic Ductal Adenocarcinoma
2000
Contributions of Myeloperoxidase to Proinflammatory Events: More Than an Antimicrobial System
2001
The protective role of endogenous glutathione in carrageenan-induced pleurisy in the rat
1999
TP53 and liver carcinogenesis
2003
Intra-coronary administration of ?-arginine aggravates myocardial stunning through production of peroxynitrite in dogs
1998
Nitrogen dioxide and carbonate radical anion: two emerging radicals in biology
2002
Points of control in inflammation
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Atherosclerosis
2000 StandoutNature
Aβ-Induced Vascular Oxidative Stress and Attenuation of Functional Hyperemia in Mouse Somatosensory Cortex
2004
The ubiquitous role of nitric oxide in cardioprotection
2005
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
The Pathobiochemistry of Nitrogen Dioxide
2002
C-Reactive Protein and Other Emerging Blood Biomarkers to Optimize Risk Stratification of Vulnerable Patients
2006
Factors Determining the Selectivity of Protein Tyrosine Nitration
1999
Peroxynitrite and myeloperoxidase leave the same footprint in protein nitration
1997
Protein carbonyl formation and tyrosine nitration as markers of oxidative damage during ischaemia-reperfusion injury to rat sciatic nerve
1999
Activation of src tyrosine kinases by peroxynitrite
1999
ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC)
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2002
Immunohistochemical evidence for the myeloperoxidase/H2O2/halide system in human atherosclerotic lesions
2000
Peroxynitrite Irreversibly Inactivates the Human Xenobioticmetabolizing Enzyme Arylamine N-Acetyltransferase 1 (NAT1) in Human Breast Cancer Cells
2004
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1999
Peroxynitrite-dependent activation of src tyrosine kinases lyn and hck in erythrocytes is under mechanistically different pathways of redox control
2001
Is nitric oxide overproduction the target of choice for the management of septic shock?
2001
Nitrotyrosine mimics phosphotyrosine binding to the SH2 domain of the src family tyrosine kinase lyn
2001
Peroxynitrite: biochemistry, pathophysiology and development of therapeutics
2007 Standout
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
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Cytochrome c Nitration by Peroxynitrite
2000
Oxidants and antioxidants in alcohol-induced liver disease
2003
Role of oxidants/antioxidants in smoking-induced lung diseases
1996
A Newly Identified Role for Superoxide in Inflammatory Pain
2004
Biochemical Evidence of Atherosclerosis Progression Mediated by Increased Oxidative Stress in Apolipoprotein E–Deficient Spontaneously Hyperlipidemic Mice Exposed to Chronic Cigarette Smoke
2009
Nitration of Profilin Effects Its Interaction with Poly (L-Proline) and Actin
2005
Myeloperoxidase and Horseradish Peroxidase Catalyze Tyrosine Nitration in Proteins from Nitrite and Hydrogen Peroxide
1998
Radical causes of cancer
2003
Reactions of manganese porphyrins and manganese-superoxide dismutase with peroxynitrite
2002
Selective Nitration of Histone Tyrosine Residues in Vivo in Mutatect Tumors
2002
Peroxynitrite decomposition catalyst ameliorates renal damage and protein nitration in cisplatin-induced nephrotoxicity in rats
2004
Potential of Sanguiin H-6 against Oxidative Damage in Renal Mitochondria and Apoptosis Mediated by Peroxynitrite in vivo
2002
Chronic obstructive pulmonary disease: molecular and cellularmechanisms
2003
Prognostic Value of Myeloperoxidase in Patients with Chest Pain
2003
Association of Nitrotyrosine Levels With Cardiovascular Disease and Modulation by Statin Therapy
2003
Protein Tyrosine Nitration in Cytokine-activated Murine Macrophages
2001
Dynamics of Nitrotyrosine Formation and Decay in Rat Brain during Focal Ischemia-Reperfusion
1999
Concurrent evaluation of novel cardiac biomarkers in acute coronary syndrome: myeloperoxidase and soluble CD40 ligand and the risk of recurrent ischaemic events in TACTICS-TIMI 18
2008
Deleterious poly(ADP-ribose)polymerase-1 pathway activation in traumatic brain injury in rat
2003
Protective Mechanisms of a Metalloporphyrinic Peroxynitrite Decomposition Catalyst, WW85, in Rat Cardiac Transplants
2005
4-Hydroxy-2-Nonenal, a Specific Lipid Peroxidation Product, Is Elevated in Lungs of Patients with Chronic Obstructive Pulmonary Disease
2002
Reactive Nitrogen Species and Cell Signaling
2002
Oxidative Stress in Severe Pulmonary Hypertension
2004
Role of Peroxynitrite in Airway Microvascular Hyperpermeability during Late Allergic Phase in Guinea Pigs
1999
Astroglial Nitration after Postnatal Excitotoxic Damage: Correlation with Nitric Oxide Sources, Cytoskeletal, Apoptotic and Antioxidant Proteins
2005
Peroxynitrite Induces an Alternative NF-κB Activation Pathway in L8 Rat Myoblasts
2006
Oxidative Stress and Endothelial Nitric Oxide Bioactivity
2003
Effect of Nitric Oxide Donors on Oxygen-Dependent Cytotoxic Responses Mediated by Neutrophils
1999
Inactivation of wild-type p53 protein function by reactive oxygen and nitrogen species in malignant glioma cells.
2003
Activation of TLR-9 Induces IL-8 Secretion through Peroxynitrite Signaling in Human Neutrophils
2006
The Central Role of CD4+ T Cells in the Antitumor Immune Response
1998
Intraphagosomal Chlorination Dynamics and Yields Determined Using Unique Fluorescent Bacterial Mimics
1997
Inactivation of the Inducible Nitric Oxide Synthase by Peroxynitrite
1997
Kinetic Analysis of the Role of Histidine Chloramines in Hypochlorous Acid Mediated Protein Oxidation
2005
Peroxynitrite Decomposition Activity of Iron Porphyrin Complexes
2002
Biological significance of nitric oxide-mediated protein modifications
2004
An activity in rat tissues that modifies nitrotyrosine-containing proteins
1998 StandoutNobel
Mass spectrometric quantification of amino acid oxidation products in proteins: insights into pathways that promote LDL oxidation in the human artery wall
1999
Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation
2001
Inhibition of poly(ADP-ribose) polymerase attenuates inflammation in a model of chronic colitis
2000
Peroxynitrite Is a Major Contributor to Cytokine-Induced Myocardial Contractile Failure
2000
Loss of Pentameric Symmetry in C-Reactive Protein Induces Interleukin-8 Secretion Through Peroxynitrite Signaling in Human Neutrophils
2005
Biological Tyrosine Nitration: A Pathophysiological Function of Nitric Oxide and Reactive Oxygen Species
1998
Protein modification during biological aging: selective tyrosine nitration of the SERCA2a isoform of the sarcoplasmic reticulum Ca2+-ATPase in skeletal muscle
1999
Proteomic method identifies proteins nitrated in vivo during inflammatory challenge
2001
Activated antigen-presenting cells select and present chemically modified peptides recognized by unique CD4 T cells
2005
CD40 Ligand–Dependent Tyrosine Nitration of Prostacyclin Synthase In Vivo
2005
Nitric oxide and the immune response
2001 Standout
Role of Nitrosative Stress and Poly(ADP-ribose) Polymerase Activation in Diabetic Vascular Dysfunction
2005
Beneficial effects of Mn(III)tetrakis (4‐benzoic acid) porphyrin (MnTBAP), a superoxide dismutase mimetic, in zymosan‐induced shock
1999
Genetic Disruption of Poly (ADP-Ribose) Synthetase Inhibits the Expression of P-Selectin and Intercellular Adhesion Molecule-1 in Myocardial Ischemia/Reperfusion Injury
1998
Biochemistry and pathology of radical-mediated protein oxidation
1997
Bacteria-Induced Intestinal Cancer in Mice with DisruptedGpx1andGpx2Genes
2004
The Role of Poly(ADP-Ribose) Polymerase Activation in the Development of Myocardial and Endothelial Dysfunction in Diabetes
2002
2001
Bicarbonate enhances alpha-synuclein oligomerization and nitration: intermediacy of carbonate radical anion and nitrogen dioxide radical
2004
Effects of oxidant stress on inflammation and survival of iNOS knockout mice after marrow transplantation
2001
Eosinophils Are a Major Source of Nitric Oxide-Derived Oxidants in Severe Asthma: Characterization of Pathways Available to Eosinophils for Generating Reactive Nitrogen Species
2001
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
Enhanced NO and superoxide generation in dysfunctional hearts from endotoxemic rats
2002
Fatty acid transduction of nitric oxide signaling: Nitrolinoleic acid potently activates endothelial heme oxygenase 1 expression
2006
Accumulation of 8-nitroguanine in human gastric epithelium induced by Helicobacter pylori infection
2004
Activation of poly(ADP-ribose) polymerase contributes to the endothelial dysfunction associated with hypertension and aging
2002
Inflammation and Atherothrombosis
2006
Nitrate Tolerance
2002
Carbon dioxide enhances nitration of surfactant protein A by activated alveolar macrophages
2000
Peroxynitrite-Mediated Inactivation of Manganese Superoxide Dismutase Involves Nitration and Oxidation of Critical Tyrosine Residues
1998
Ce-Duox1/BLI-3 Generates Reactive Oxygen Species as a Protective Innate Immune Mechanism in Caenorhabditis elegans
2009
Increased Inducible Nitric Oxide Synthase Expression Contributes to Myocardial Dysfunction and Higher Mortality After Myocardial Infarction in Mice
2001
The adenine nucleotide translocator: a target of nitric oxide, peroxynitrite, and 4-hydroxynonenal
2001
Vitamin E Oxidation in Human Atherosclerotic Lesions
2002
Enhanced Activity of Human IL-10 After Nitration in Reducing Human IL-1 Production by Stimulated Peripheral Blood Mononuclear Cells
2002
Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly(ADP-ribose) synthase
1998
Reactive Nitrogen Species-Induced Cell Death Requires Fas-Dependent Activation of c-Jun N-Terminal Kinase
2004
Oxidation of LDL by Myeloperoxidase and Reactive Nitrogen Species
2000
Double-knockout mice for α- and β-synucleins: Effect on synaptic functions
2004 StandoutNobel
Novel transcripts of Nox1 are regulated by alternative promoters and expressed under phenotypic modulation of vascular smooth muscle cells
2006
Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients
2003 StandoutNobel
Nitration of succinyl-CoA:3-oxoacid CoA-transferase in rats after endotoxin administration
2001 Nobel
Regulation of apoptosis by the circadian clock through NF-κB signaling
2011 StandoutNobel
Poly(ADP-Ribose) Polymerase Is Activated in Subjects at Risk of Developing Type 2 Diabetes and Is Associated With Impaired Vascular Reactivity
2002
Myoglobin Catalyzes Its Own Nitration
2001
Potent Metalloporphyrin Peroxynitrite Decomposition Catalyst Protects Against the Development of Doxorubicin-Induced Cardiac Dysfunction
2003
Alpha-synuclein: between synaptic function and dysfunction.
2003
The relationship between oxidative/nitrative stress and pathological inclusions in Alzheimer’s and Parkinson’s diseases1,2 11Guest Editors: Mark A. Smith and George Perry 22This article is part of a series of reviews on “Causes and Consequences of Oxidative Stress in Alzheimer’s Disease.” The full list of papers may be found on the homepage of the journal.
2002
Nitric oxide, oxidants, and protein tyrosine nitration
2004
Peroxynitrite Inactivation of Tyrosine Hydroxylase: Mediation by Sulfhydryl Oxidation, not Tyrosine Nitration
1999
Nitration and Functional Loss of Voltage-Gated K+ Channels in Rat Coronary Microvessels Exposed to High Glucose
2004
Science and technology for water purification in the coming decades
2008 StandoutNature
Peroxynitrite-derived carbonate and nitrogen dioxide radicals readily react with lipoic and dihydrolipoic acid
2005
Delayed K + clearance associated with aquaporin-4 mislocalization: Phenotypic defects in brains of α-syntrophin-null mice
2003 StandoutNobel
2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation
2015 Standout
Superoxide, peroxynitrite and oxidative/nitrative stress in inflammation
2006
Time Course and Site(s) of Cytochrome c Tyrosine Nitration by Peroxynitrite
2005
Peroxynitrite activates the phosphoinositide 3-kinase/Akt pathway in human skin primary fibroblasts
2000
Analysis of peptides and proteins containing nitrotyrosine by matrix-assisted laser desorption/ionization mass spectrometry
2001
Mechanisms of cardioprotection by peroxynitrite in myocardial ischemia and reperfusion injury
1998
Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury
2007 StandoutNobel
Beneficial effects of tempol, a membrane-permeable radical scavenger, on the multiple organ failure induced by zymosan in the rat
2001
Colon Epithelial Cell Death in 2,4,6-Trinitrobenzenesulfonic Acid-Induced Colitis Is Associated with Increased Inducible Nitric-Oxide Synthase Expression and Peroxynitrite Production
2001
Mechanisms of Activation of NADPH Oxidases
2004
Oxidation and Antioxidation of Human Low-Density Lipoprotein and Plasma Exposed to 3-Morpholinosydnonimine and Reagent Peroxynitrite
1998
Myeloperoxidase produces nitrating oxidants in vivo
2002
Mercaptoethylguanidine, a Combined Inhibitor of Nitric Oxide Synthase and Peroxynitrite Scavenger, Reduces Trinitrobenzene Sulfonic Acid-Induced Colonic Damage in Rats
1998
Role of calcium and superoxide dismutase in sensitizing mitochondria to peroxynitrite-induced permeability transition
2004
Nitric oxide partitioning into mitochondrial membranes and the control of respiration at cytochrome c oxidase
2001
Mitogen-activated protein kinases mediate peroxynitrite-induced cell death in human bronchial epithelial cells
2003
Enzymatic aminoacylation of tRNA with unnatural amino acids
2006 StandoutNobel
Attenuation of vascular relaxation after development of tachyphylaxis to peroxynitrite in vivo
1998
Superoxide: a key player in hypertension
2004
THE REGULATION AND PHARMACOLOGY OF ENDOTHELIAL NITRIC OXIDE SYNTHASE
2005
Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps
2010 Standout
Interactions of Oxidants With Vascular Signaling Systems
2000
Stent-induced neutrophil activation is associated with an oxidative burst in the inflammatory process, leading to neointimal thickening
2005
Protection against peroxynitrite dependent tyrosine nitration and alpha 1-antiproteinase inactivation by some anti-inflammatory drugs and by the antibiotic tetracycline.
1996
Nitric Oxide Synthase Plays a Signaling Role in TCR-Triggered Apoptotic Death
1998
Cutting Edge: MHC Class II-Restricted Peptides Containing the Inflammation-Associated Marker 3-Nitrotyrosine Evade Central Tolerance and Elicit a Robust Cell-Mediated Immune Response
2003
Endothelial dysfunction and peroxynitrite formation are early events in angiotensin‐induced cardiovascular disorders
2000
Generation of Intramolecular and Intermolecular Sulfenamides, Sulfinamides, and Sulfonamides by Hypochlorous Acid: A Potential Pathway for Oxidative Cross-Linking of Low-Density Lipoprotein by Myeloperoxidase
2001
Does vitamin C act as a pro‐oxidant under physiological conditions?
1999
Formation of Nitric Oxide–Derived Oxidants by Myeloperoxidase in Monocytes
1999
Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism
2003 StandoutScience
Inducible nitric oxide synthase (NOS2) expressed in septic patients is nitrated on selected tyrosine residues: implications for enzymic activity
2002
Electrochemical Analysis of Protein Nitrotyrosine and Dityrosine in the Alzheimer Brain Indicates Region-Specific Accumulation
1998
Defenses against peroxynitrite: selenocompounds and flavonoids
2003
Beneficial effects of peroxynitrite decomposition catalyst in a rat model of splanchnic artery occlusion and reperfusion
2000
Serum Myeloperoxidase Levels Independently Predict Endothelial Dysfunction in Humans
2004
NOVEL NEURAL MODULATORS
2003
Lipoxin A4and aspirin-triggered 15-epi-lipoxin A4inhibit peroxynitrite formation, NF-κB and AP-1 activation, and IL-8 gene expression in human leukocytes
2002
Myeloperoxidase: friend and foe
2005 Standout
Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer
1996 Standout
Chemical Glycoproteomics
2016 StandoutNobel
Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry
2005
Deficiency of Myeloperoxidase Increases Infarct Volume and Nitrotyrosine Formation in Mouse Brain
2002
High Glucose via Peroxynitrite Causes Tyrosine Nitration and Inactivation of Prostacyclin Synthase That Is Associated With Thromboxane/Prostaglandin H2 Receptor–Mediated Apoptosis and Adhesion Molecule Expression in Cultured Human Aortic Endothelial Cells
2002
Works of Jason P. Eiserich being referenced
[47] Nitration of unsaturated fatty acids by nitric oxide-derived reactive species
1999
Endothelial transcytosis of myeloperoxidase confers specificity to vascular ECM proteins as targets of tyrosine nitration
2001
Alteration of the C-terminal Amino Acid of Tubulin Specifically Inhibits Myogenic Differentiation
2002
Concentration-dependent Effects of Nitric Oxide on Mitochondrial Permeability Transition and Cytochrome cRelease
2000
Peroxynitrite Induces Covalent Dimerization of Epidermal Growth Factor Receptors in A431 Epidermoid Carcinoma Cells
1998
Nitrolinoleate Inhibits Platelet Activation by Attenuating Calcium Mobilization and Inducing Phosphorylation of Vasodilator-stimulated Phosphoprotein through Elevation of cAMP
2002
Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium
2005
Pathophysiology of nitric oxide and related species: free radical reactions and modification of biomolecules
1998
[48] Analysis of aromatic nitration, chlorination, and hydroxylation by gas chromatography-mass spectrometry
1999
Nitric Oxide Reaction with Lipid Peroxyl Radicals Spares α-Tocopherol during Lipid Peroxidation
2000
[16] Nitrotyrosine as biomarker for reactive nitrogen species
1996
Induction of motor neuron apoptosis by free 3‐nitro‐l ‐tyrosine
2004
Myeloperoxidase enhances nitric oxide catabolism during myocardial ischemia and reperfusion
2004
Inactivation of Glutathione S-Transferases by Nitric Oxide-Derived Oxidants: Exploring a Role for Tyrosine Nitration
2001
A reappraisal of the genomic organization of human Nox1 and its splice variants
2005
Cytochrome c: a catalyst and target of nitrite-hydrogen peroxide-dependent protein nitration
2003
l-Arginine Chlorination Products Inhibit Endothelial Nitric Oxide Production
2001
Formation of Nitrating and Chlorinating Species by Reaction of Nitrite with Hypochlorous Acid
1996
Formation of Reactive Nitrogen Species during Peroxidase-catalyzed Oxidation of Nitrite
1997
Spatial mapping of pulmonary and vascular nitrotyrosine reveals the pivotal role of myeloperoxidase as a catalyst for tyrosine nitration in inflammatory diseases
2002
Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils
1998 Nature
Duox2 exhibits potent heme peroxidase activity in human respiratory tract epithelium
2006
Reactive Nitrogen Species and Tyrosine Nitration in the Respiratory Tract
1999
Molecular mechanisms of damage by excess nitrogen oxides: Nitration of tyrosine by gas‐phase cigarette smoke
1994
Microtubule dysfunction by posttranslational nitrotyrosination of α-tubulin: A nitric oxide-dependent mechanism of cellular injury
1999
Myeloperoxidase Serum Levels Predict Risk in Patients With Acute Coronary Syndromes
2003
Endothelial dysfunction is induced by proinflammatory oxidant hypochlorous acid
2001
Myeloperoxidase and protein oxidation in cystic fibrosis
2000
Nitrolinoleate, a nitric oxide-derived mediator of cell function: Synthesis, characterization, and vasomotor activity
2002
Nitration of Unsaturated Fatty Acids by Nitric Oxide-Derived Reactive Nitrogen Species Peroxynitrite, Nitrous Acid, Nitrogen Dioxide, and Nitronium Ion
1998
Endothelial transcytosis of myeloperoxidase confers specificity to vascular ECM proteins as targets of tyrosine nitration
2001
Myeloperoxidase, a Leukocyte-Derived Vascular NO Oxidase
2002 Science
Hypercapnia induces injury to alveolar epithelial cells via a nitric oxide-dependent pathway
2000