Standout Papers
Citation Impact
Citing Papers
Multiplex Genome Engineering Using CRISPR/Cas Systems
2013 StandoutScience
Trans-splicing of the C. elegans let-7 primary transcript developmentally regulates let-7 microRNA biogenesis and let-7 family microRNA activity
2019 StandoutNobel
Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility
2021 StandoutNobel
The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics
2015
RNA-Guided Human Genome Engineering via Cas9
2013 StandoutScience
Melting dsDNA Donor Molecules Greatly Improves Precision Genome Editing in Caenorhabditis elegans
2020 Nobel
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
2012 StandoutScienceNobel
ZSP‐1 is a Z granule surface protein required for Z granule fluidity and germline immortality in Caenorhabditis elegans
2021
Phosphorylation of the FUS low‐complexity domain disrupts phase separation, aggregation, and toxicity
2017
Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism
2024 StandoutNobel
In Vivo Formation of Vacuolated Multi-phase Compartments Lacking Membranes
2016
The DNA-damage response in human biology and disease
2009 StandoutNature
Autonomous zinc-finger nuclease pairs for targeted chromosomal deletion
2010
Biomolecular condensates: organizers of cellular biochemistry
2017 Standout
Connecting the Dots: Linking Caenorhabditis elegans Small RNA Pathways and Germ Granules
2021
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
2016 StandoutNature
Coexisting Liquid Phases Underlie Nucleolar Subcompartments
2016
Methods for Physical Characterization of Phase-Separated Bodies and Membrane-less Organelles
2018
Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments
2018
Assessment of the optimization of affinity and specificity at protein–DNA interfaces
2009 StandoutNobel
Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3
2015 StandoutNobel
Polar Positioning of Phase-Separated Liquid Compartments in Cells Regulated by an mRNA Competition Mechanism
2016
Combinatorial and computational challenges for biocatalyst design
2001 StandoutNatureNobel
P Granules Protect RNA Interference Genes from Silencing by piRNAs
2019
In vivo selection of engineered homing endonucleases using double-strand break induced homologous recombination
2005
Genome-Editing Technologies: Principles and Applications
2016
TAL nucleases (TALNs): hybrid proteins composed of TAL effectors and FokI DNA-cleavage domain
2010
Computational Enzyme Design
2013 StandoutNobel
Phase behaviour of disordered proteins underlying low density and high permeability of liquid organelles
2017
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
Tailoring new enzyme functions by rational redesign
2000
Spatiotemporal regulation of liquid-like condensates in epigenetic inheritance
2018 Nature
RNA Controls PolyQ Protein Phase Transitions
2015
Cas9-assisted recombineering in C. elegans : genome editing using in vivo assembly of linear DNAs
2016
Decoding ALS: from genes to mechanism
2016 StandoutNature
Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates
2019 Standout
Therapeutic genome editing: prospects and challenges
2015
High Efficiency, Homology-Directed Genome Editing in Caenorhabditis elegans Using CRISPR-Cas9 Ribonucleoprotein Complexes
2015
Transport Selectivity of Nuclear Pores, Phase Separation, and Membraneless Organelles
2015
Comprehensive computational design of mCreI homing endonuclease cleavage specificity for genome engineering
2011 StandoutNobel
Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases
2008
Homing endonuclease structure and function
2005
Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins
2015 Standout
Zinc-finger nuclease-driven targeted integration into mammalian genomes using donors with limited chromosomal homology
2010
Meganucleases and DNA Double-Strand Break-Induced Recombination: Perspectives for Gene Therapy
2007
Engineering of Large Numbers of Highly Specific Homing Endonucleases that Induce Recombination on Novel DNA Targets
2005
Intrinsically disordered sequences enable modulation of protein phase separation through distributed tyrosine motifs
2017
A User’s Guide for Phase Separation Assays with Purified Proteins
2018
Isolation and Characterization of New Homing Endonuclease Specificities at Individual Target Site Positions
2004
Independent active and thermodynamic processes govern the nucleolus assembly in vivo
2017 Nobel
Therapeutic modulation of endogenous gene function by agents with designed DNA-sequence specificities
2003
Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein
2016
Design, Activity, and Structure of a Highly Specific Artificial Endonuclease
2002 StandoutNobel
Search-and-replace genome editing without double-strand breaks or donor DNA
2019 StandoutNature
Principles and Properties of Stress Granules
2016
Phosphorylation-mediated RNA/peptide complex coacervation as a model for intracellular liquid organelles
2015
Computational redesign of endonuclease DNA binding and cleavage specificity
2006 StandoutNatureNobel
Homing endonuclease genes: the rise and fall and rise again of a selfish element
2004
Germ Granules Govern Small RNA Inheritance
2019
Biophysical characterization of organelle-based RNA/protein liquid phases using microfluidics
2016
Efficient in toto targeted recombination in mouse liver by meganuclease‐induced double‐strand break
2006
Kinase-controlled phase transition of membraneless organelles in mitosis
2018 Nature
Streamlined Genome Engineering with a Self-Excising Drug Selection Cassette
2015
A synthetic homing endonuclease-based gene drive system in the human malaria mosquito
2011 StandoutNatureNobel
Targeted genome editing in pluripotent stem cells using zinc-finger nucleases
2010
Compositional Control of Phase-Separated Cellular Bodies
2016
A novel engineered meganuclease induces homologous recombination in yeast and mammalian cells
2003
Sequence determinants of protein phase behavior from a coarse-grained model
2018
From catalytic asymmetric synthesis to the transcriptional regulation of genes: In vivo and in vitro evolution of proteins
2001 StandoutNobel
Targeted manipulation of mammalian genomes using designed zinc finger nucleases
2009
Mapping Local and Global Liquid Phase Behavior in Living Cells Using Photo-Oligomerizable Seeds
2018
Highly efficient endogenous human gene correction using designed zinc-finger nucleases
2005 Nature
An improved zinc-finger nuclease architecture for highly specific genome editing
2007
DNA-binding Specificity Is a Major Determinant of the Activity and Toxicity of Zinc-finger Nucleases
2007
Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases
2012 StandoutNobel
Cornerstones of CRISPR–Cas in drug discovery and therapy
2016 StandoutNobel
Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs
2010 StandoutNobel
Meganucleases and Other Tools for Targeted Genome Engineering: Perspectives and Challenges for Gene Therapy
2011
Using Zinc Finger Nucleases for Efficient and Heritable Gene Disruption in Zebrafish
2010
Phase Separation: Linking Cellular Compartmentalization to Disease
2016
Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder
2016
An unbiased genome-wide analysis of zinc-finger nuclease specificity
2011
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
Rapid Protein Depletion in Human Cells by Auxin-Inducible Degron Tagging with Short Homology Donors
2016
Evolution of protein function by Domain swapping
2001
Genome-editing Technologies for Gene and Cell Therapy
2016
Genome Engineering with Targetable Nucleases
2014
Targeted Chromosomal Cleavage and Mutagenesis in Drosophila Using Zinc-Finger Nucleases
2002
Stimulation of Homologous Recombination through Targeted Cleavage by Chimeric Nucleases
2001
Relationship of Sequence and Phase Separation in Protein Low-Complexity Regions
2018
Extreme stability in de novo-designed repeat arrays is determined by unusually stable short-range interactions
2018 StandoutNobel
Peptidic degron for IMiD-induced degradation of heterologous proteins
2019 StandoutNobel
Systematic discovery of natural CRISPR-Cas12a inhibitors
2018 StandoutScienceNobel
Genomes in Focus: Development and Applications of CRISPR‐Cas9 Imaging Technologies
2017 StandoutNobel
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Functional Implications of Intracellular Phase Transitions
2018
Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases
2007
MIB-1 Is Required for Spermatogenesis and Facilitates LIN-12 and GLP-1 Activity inCaenorhabditis elegans
2018
Genome Engineering With Zinc-Finger Nucleases
2011
Reprogramming homing endonuclease specificity through computational design and directed evolution
2013 StandoutNobel
Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1
2016 StandoutNobel
Regulation of Caenorhabditis elegans neuronal polarity by heterochronic genes
2019 StandoutNobel
The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways
2022 StandoutNobel
Progressive engineering of a homing endonuclease genome editing reagent for the murine X-linked immunodeficiency locus
2014 StandoutNobel
The synaptonemal complex has liquid crystalline properties and spatially regulates meiotic recombination factors
2017
The NMR–Rosetta capsid model of M13 bacteriophage reveals a quadrupled hydrophobic packing epitope
2015 StandoutNobel
The TRIM-NHL protein NHL-2 is a co-factor in the nuclear and somatic RNAi pathways in C. elegans
2018
Rapid and Precise Engineering of theCaenorhabditis elegansGenome with Lethal Mutation Co-Conversion and Inactivation of NHEJ Repair
2014
megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering
2013 StandoutNobel
Progress in Modeling of Protein Structures and Interactions
2005 StandoutScienceNobel
Enhancing Gene Targeting with Designed Zinc Finger Nucleases
2003 Science
Site-specific selfish genes as tools for the control and genetic engineering of natural populations
2003
A New Lens for RNA Localization: Liquid-Liquid Phase Separation
2018
Chimeric Nucleases Stimulate Gene Targeting in Human Cells
2003 ScienceNobel
Networks of electrostatic and hydrophobic interactions modulate the complex folding free energy surface of a designed βα protein
2019 StandoutNobel
Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling
2020 StandoutNobel
Homing endonucleases: DNA scissors on a mission
2012
Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery
2017 StandoutNobel
Throughput-scalable manufacturing of SARS-CoV-2 mRNA lipid nanoparticle vaccines
2023 StandoutNobel
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Modulating charge patterning and ionic strength as a strategy to induce conformational changes in intrinsically disordered proteins
2018
E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes
2020 StandoutNobel
Filamentous Phage Display in the New Millennium
2005
Polymer physics of intracellular phase transitions
2015
Liquid phase condensation in cell physiology and disease
2017 StandoutScience
A simple physical model for binding energy hot spots in protein–protein complexes
2002 StandoutNobel
Works of Jarrett Smith being referenced
Requirements for double-strand cleavage by chimeric restriction enzymes with zinc finger DNA-recognition domains
2000
A gel phase promotes condensation of liquid P granules in Caenorhabditis elegans embryos
2019
Chimeric Restriction Enzymes: What Is Next?
1999
A detailed study of the substrate specificity of a chimeric restriction enzyme
1999
Spatial patterning of P granules by RNA-induced phase separation of the intrinsically-disordered protein MEG-3
2016
Scalable and Versatile Genome Editing Using Linear DNAs with Microhomology to Cas9 Sites inCaenorhabditis elegans
2014
Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically disordered proteins in C. elegans
2014 StandoutNobel