Standout Papers
- Alpha2 adrenergic receptors are located prejunctionally in the Auerbach's plexus of the guinea pig small intestine: Direct demonstration by radioligand binding (1982)
- Solubilization of rat liver alpha1-adrenergic receptors (1983)
- Photoaffinity labeling of mammalian alpha 1-adrenergic receptors. Identification of the ligand binding subunit with a high affinity radioiodinated probe. (1984)
- Covalent labeling of the cerebral cortex α1-adrenergic receptor with a new high affinity radioiodinated photoaffinity probe (1983)
Citation Impact
Citing Papers
Limits of long-term selection against Neandertal introgression
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Expansive discovery of chemically diverse structured macrocyclic oligoamides
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International Union of Pharmacology nomenclature of adrenoceptors.
1994 StandoutNobel
Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function
1993
Molecular biology of α-adrenergic receptors: implications for receptor classification and for structure-function relationships
1991 StandoutNobel
Guanfacine, But Not Clonidine, Improves Planning and Working Memory Performance in Humans
1999
Structure of the E. coli signal recognition particle bound to a translating ribosome
2006 Nature
Characterisation of ACTH Peptides in Human Skin and Their Activation of the Melanocortin‐1 Receptor
1997
The Asp84Glu variant of the melanocortin 1 receptor (MC1R) is associated with melanoma
1996
Medetomidine, atipamezole, and guanfacine in delayed response performance of aged monkeys
1996
SRP-mediated protein targeting: structure and function revisited
2004
cGMP Signaling through cAMP- and cGMP-Dependent Protein Kinases
1995
Distributions of mRNAs for alpha‐2 adrenergic receptor subtypes in rat brain: An in situ hybridization study
1993
The Alpha-2A-Adrenoceptor Agonist, Guanfacine, Increases Regional Cerebral Blood Flow in Dorsolateral Prefrontal Cortex of Monkeys Performing a Spatial Working Memory Task
2000
Induction of Neuropeptide Y Gene Expression in the Dorsal Medial Hypothalamic Nucleus in Two Models of theAgoutiObesity Syndrome
1997
The α2‐adrenoceptors of the human retinoblastoma cell line (Y79) may represent an additional example of the α2C‐adrenoceptor
1992
Melanin Pigmentation in Mammalian Skin and Its Hormonal Regulation
2004 Standout
Melanocortin Signalling Mechanisms
2010
Receptor systems: Will mining the receptorome yield novel targets for pharmacotherapy?
2005
The α-2A noradrenergic receptor agonist guanfacine improves visual object discrimination reversal performance in aged rhesus monkeys.
1997
A predictive pharmacophore model of human melanocortin-4 receptor as derived from the solution structures of cyclic peptides
2004
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
Rationalizing membrane protein overexpression
2006
Strategies for development of dengue virus inhibitors
2010
α-Melanotropin hormone inhibits the binding of []SCH 23390 to the dopamine D1 receptor in vitro
1998
Structure-function studies on the cyclic peptide MT-II, lactam derivative of α-melanotropin
1999
Functional Characterization of cis and trans Activity of the Flavivirus NS2B-NS3 Protease
2007
The role of imidazoline receptors in blood pressure regulation
1992
Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice
1997 Standout
Melanocortins and their implication in melanoma
1995
Binding of cyclic and linear MSH core peptides to the melanocortin receptor subtypes
1997
A cradle for new proteins: trigger factor at the ribosome
2005
Perikaryal and synaptic localization ofα2A-adrenergic receptor-like immunoreactivity
1994
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
2012 StandoutNatureNobel
Class-1 release factor eRF1 promotes GTP binding by class-2 release factor eRF3
2006
Gene targeting — homing in on α2-adrenoceptor-subtype function
1997 StandoutNobel
β-Alanine dipeptides as MC4R agonists
2003
Further characterization of human α2-adrenoceptor subtypes: [3H]RX821002 binding and definition of additional selective drugs
1994
Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor
1994 Nature
The Contribution of α2-Noradrenergic Mechanisms to Prefrontal Cortical Cognitive Function
1996
Contribution of Melanocortin Receptor Exoloops to Agouti-related Protein Binding
1999
Two functionally distinct α2-adrenergic receptors regulate sympathetic neurotransmission
1999 StandoutNatureNobel
The Melanocortin-1 Receptor
2001
Extensive structure–activity studies of lactam derivatives of MT‐II and SHU‐9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5
2003
Subtype determination of presynaptic ?2-autoreceptors in the rabbit pulmonary artery and human saphenous vein
1995
Presynaptic ?2-autoreceptors in mouse heart atria: evidence for the ?2D subtype
1996
Structure–Activity relationship of linear peptide Bu-His6-DPhe7-Arg8-Trp9-Gly10-NH2 at the human melanocortin-1 and -4 receptors: DPhe7 and Trp9 substitution
2003
Design of a new peptidomimetic agonist for the melanocortin receptors based on the solution structure of the peptide ligand, Ac-Nle-cyclo[Asp-Pro-dPhe-Arg-Trp-Lys]-NH2
2003
Melanocortin control of energy balance: evidence from rodent models
2011
Presynaptic ?2-autoreceptors in brain cortex: ?2D in the rat and ?2A in the rabbit
1993
Design of new small cyclic melanocortin receptor-binding peptides using molecular modelling: Role of the His residue in the melanocortin peptide core
2001
“The role of melanocortins in body weight regulation: opportunities for the treatment of obesity”
2002
L 1 ‐ IMIDAZOLINE RECEPTORS: HISTORICAL PERSPECTIVE
1992
The role of norepinephrine in the pathophysiology of cognitive disorders: potential applications to the treatment of cognitive dysfunction in schizophrenia and Alzheimer's disease
1999
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
End-capping of the modified melanocortin tetrapeptide (p-Cl)Phe-D-Phe-Arg-Trp-NH2 as a route to hMC4R agonists
2004
Synthesis and biological evaluation of α-MSH analogues substituted with alanine
1994
An Open Trial of Guanfacine in the Treatment of Attention-Deficit Hyperactivity Disorder
1995
Nitric Oxide as a Mediator of Relaxation of the Corpus Cavernosum in Response to Nonadrenergic, Noncholinergic Neurotransmission
1992 StandoutNobel
A re-investigation of questionable subclassifications of presynaptic α2-autoreceptors: rat vena cava, rat atria, human kidney and guinea-pig urethra
1997
Characterization of melanocortin receptor ligands on cloned brain melanocortin receptors and on grooming behavior in the rat
1999
Structure-Activity Relationships (SAR) of Melanocortin and Agouti-Related (AGRP) Peptides
2010
Exocrine Gland Dysfunction in MC5-R-Deficient Mice: Evidence for Coordinated Regulation of Exocrine Gland Function by Melanocortin Peptides
1997
Structure, function and regulation of the melanocortin receptors
2011
UV Light and MSH Receptors
1999
Effects of medetomidine, an α-2 adrenoceptor agonist, and atipamezole, an α-2 antagonist, on spatial memory performance in adult and aged rats
1992
Potent and Selective Peptide Agonists of α-Melanotropin Action at Human Melanocortin Receptor 4: Their Synthesis and Biological Evaluation in Vitro
2001
Analogs of Lactam Derivatives of α-Melanotropin with Basic and Acidic Residues
2000
Cultured Human Melanocytes Respond to MSH Peptides and ACTH
1994
PREDICT modeling and in‐silico screening for G‐protein coupled receptors
2004
Conformation of the Core Sequence in Melanocortin Peptides Directs Selectivity for the Melanocortin MC3 and MC4 Receptors
1999
Synthesis of novel melanocortin 4 receptor agonists and antagonists containing a succinamide core
2003
Toward high-resolution prediction and design of transmembrane helical protein structures
2007 StandoutNobel
Effects of ring substitution on the pre- and postjunctional alpha-adrenergic activity of aryliminoimidazolidines
1979
Beta-agonist- and prostaglandin E1-induced translocation of the beta-adrenergic receptor kinase: evidence that the kinase may act on multiple adenylate cyclase-coupled receptors.
1986 StandoutNobel
Scanning Mutagenesis Studies of the M 1 Muscarinic Acetylcholine Receptor
2003
Atrial natriuretic factor elicits an endothelium-independent relaxation and activates particulate guanylate cyclase in vascular smooth muscle.
1984 StandoutNobel
Mitogenic and melanogenic stimulation of normal human melanocytes by melanotropic peptides.
1995
Requirement of thiols for activation of coronary arterial guanylate cyclase by glyceryl trinitrate and sodium nitrite possible involvement of S-nitrosothiols
1980 StandoutNobel
The 1,4-Benzodiazepine-2,5-dione Small Molecule Template Results in Melanocortin Receptor Agonists with Nanomolar Potencies
2008
SARS-CoV 3CL protease cleaves its C-terminal autoprocessing site by novel subsite cooperativity
2016
Tolerance towards nitroglycerin, induced in vivo, is correlated to a reduced cGMP response and an alteration in cGMP turnover
1983
Guanylate cyclase from bovine lung. Evidence that enzyme activation by phenylhydrazine is mediated by iron-phenyl hemoprotein complexes.
1984 StandoutNobel
Systematic Backbone Conformational Constraints on a Cyclic Melanotropin Ligand Leads to Highly Selective Ligands for Multiple Melanocortin Receptors
2015
Dengue reporter viruses reveal viral dynamics in interferon receptor-deficient mice and sensitivity to interferon effectors in vitro
2012 StandoutNobel
Regulation of transmembrane signaling by receptor phosphorylation
1987 StandoutNobel
Agonist versus antagonist binding to alpha-adrenergic receptors.
1980 StandoutNobel
Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain.
1994
Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism.
1985 StandoutNobel
Phorbol ester effects on α1-adrenoceptor binding and phosphatidylinositol metabolism in cultured vascular smooth muscle cells
1985 StandoutNobel
Activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside, and nitrosoguanidine—Inhibition by calcium, lanthanum, and other cations, enhancement by thiols
1980 StandoutNobel
Regulation of adrenergic receptor function by phosphorylation. I. Agonist-promoted desensitization and phosphorylation of alpha 1-adrenergic receptors coupled to inositol phospholipid metabolism in DDT1 MF-2 smooth muscle cells.
1987 StandoutNobel
Arylazide photoaffinity probe for α2-adrenoceptors
1985 Nobel
Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype.
1988 StandoutNobel
β-Adrenergic Receptor Kinase: Primary Structure Delineates a Multigene Family
1989 StandoutScienceNobel
Identification of the subunit-binding site of alpha 2-adrenergic receptors using [3H]phenoxybenzamine.
1984 StandoutNobel
A Family of AMPA-Selective Glutamate Receptors
1990 StandoutScienceNobel
Solubilization of Kainic Acid Binding Sites from Rat Brain
1987
Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein.
1989 StandoutNobel
Prevention and Reversal of Nitrate Tolerance in Patients with Congestive Heart Failure
1987
Heterozygous α 2A -adrenergic receptor mice unveil unique therapeutic benefits of partial agonists
2002 StandoutNobel
Functional mapping of disease susceptibility loci using cell biology
2006 StandoutNobel
A Gene Conferring Susceptibility to Type 2 Diabetes in Conjunction With Obesity Is Located on Chromosome 18p11
2001
Cardiovascular Regulation in Mice Lacking α 2 -Adrenergic Receptor Subtypes b and c
1996 StandoutScienceNobel
Mammalian alpha 1-adrenergic receptor. Purification and characterization of the native receptor ligand binding subunit.
1986 StandoutNobel
Activation of purified soluble guanylate cyclase by protoporphyrin IX.
1982 StandoutNobel
Development of Tolerance to Glyceryl Trinitrate in an Isolated Human Peripheral Vein and Its Relation to Cyclic GMP Metabolism
1986
Heterogeneity of mammalian α2-adrenoceptors delineated by [3H]yohimbine binding
1986
Mutation of the α2A-Adrenoceptor Impairs Working Memory Performance and Annuls Cognitive Enhancement by Guanfacine
2002 StandoutNobel
Selective, High Affinity Peptide Antagonists of α-Melanotropin Action at Human Melanocortin Receptor 4: Their Synthesis and Biological Evaluation in Vitro
2001
Structure−Activity Studies of the Melanocortin Peptides: Discovery of Potent and Selective Affinity Antagonists for thehMC3 andhMC4 Receptors
2002
A Macrocyclic Agouti-Related Protein/[Nle4,DPhe7]α-Melanocyte Stimulating Hormone Chimeric Scaffold Produces Subnanomolar Melanocortin Receptor Ligands
2017
Molecular cloning, expression, and gene localization of a fourth melanocortin receptor
1993
Structure-based discovery of β 2 -adrenergic receptor ligands
2009 StandoutNobel
[3H]‐rauwolscine binding to α2‐adrenoceptors in the mammalian kidney: apparent receptor heterogeneity between species
1985
Prolactin: Structure, Function, and Regulation of Secretion
2000 Standout
Computational Modeling Approaches to Structure−Function Analysis of G Protein-Coupled Receptors
2005
Click-Chemistry-Mediated Synthesis of Selective Melanocortin Receptor 4 Agonists
2017 StandoutNobel
Spatiotemporal dynamics of guanosine 3′,5′-cyclic monophosphate revealed by a genetically encoded, fluorescent indicator
2001 StandoutNobel
Guanylate cyclase from bovine lung. A kinetic analysis of the regulation of the purified soluble enzyme by protoporphyrin IX, heme, and nitrosyl-heme.
1982
Adrenergic receptor of the alpha1-subtype mediates the activation of the glycogen phosphorylase in normal rat liver
1980
Quantitative Analysis of the Purkinje Cell and the Granule Cell Populations in the Cerebellum ofNudeMice
1995
Endothelin-1 is a paracrine growth factor that modulates melanogenesis of human melanocytes and participates in their responses to ultraviolet radiation.
1998
Overexpression of Alpha2C-adrenoceptors impairs water maze navigation
1999
Light-dependent phosphorylation of rhodopsin by β-adrenergic receptor kinase
1986 StandoutNatureNobel
Mechanisms of Membrane-Receptor Regulation
1984 StandoutNobel
Cryo-EM structure of the mammalian eukaryotic release factor eRF1–eRF3-associated termination complex
2012 StandoutNobel
Molecular cloning of a novel melanocortin receptor.
1993
Hepatic cyclic GMP formation is regulated by similar factors that modulate activation of purified hepatic soluble guanylate cyclase.
1987 StandoutNobel
Cloning, Sequencing, and Expression of the Gene Coding for the Human Platelet α 2 -Adrenergic Receptor
1987 StandoutScienceNobel
Structure–Activity Relationships of Peptides Incorporating a Bioactive Reverse-Turn Heterocycle at the Melanocortin Receptors: Identification of a 5800-fold Mouse Melanocortin-3 Receptor (mMC3R) Selective Antagonist/Partial Agonist versus the Mouse Melanocortin-4 Receptor (mMC4R)
2013
Antagonism of Catecholamine Receptor Signaling by Expression of Cytoplasmic Domains of the Receptors
1993 StandoutScienceNobel
Synthesis and Pharmacology of α/β3-Peptides Based on the Melanocortin Agonist Ac-His-d Phe-Arg-Trp-NH2 Sequence
2015
Synthesis, Biophysical, and Pharmacological Evaluation of the Melanocortin Agonist AST3-88: Modifications of Peptide Backbone at Trp 7 Position Lead to a Potent, Selective, and Stable Ligand of the Melanocortin 4 Receptor (MC4R)
2014
Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system.
1993
Modulation of melanocyte-stimulating hormone receptor expression on normal human melanocytes: evidence for a regulatory role of ultraviolet B, interleukin-1α, interleukin-1β, endothelin-1 and tumour necrosis factor-α
1998
The Crystal Structure of the Signal Recognition Particle in Complex with Its Receptor
2011 StandoutScienceNobel
Update 1 of: Computational Modeling Approaches to Structure–Function Analysis of G Protein-Coupled Receptors
2011
The Mating of a Fly
1994 StandoutScienceNobel
Evidence for cyclic GMP-mediated relaxant effects of nitro-compounds in coronary smooth muscle
1979
Pre- and postsynaptic effects of yohimbine stereoisomers on noradrenergic transmission in the pulmonary artery of the rabbit
1979
1,4-Disubstituted-[1,2,3]triazolyl-Containing Analogues of MT-II: Design, Synthesis, Conformational Analysis, and Biological Activity
2014
SLiM 2: Flexible, Interactive Forward Genetic Simulations
2016
Structure activity studies of the melanocortin antagonist SHU9119 modified at the 6, 7, 8, and 9 positions☆
2000
Interactions of Human Melanocortin 4 Receptor with Nonpeptide and Peptide Agonists,
2005
Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor.
1988 StandoutNobel
The α2aAdrenergic Receptor Subtype Mediates Spinal Analgesia Evoked by α2Agonists and Is Necessary for Spinal Adrenergic–Opioid Synergy
1997
Melanin-concentrating hormone: a functional melanocortin antagonist in the hypothalamus
1998
Structure of trigger factor binding domain in biologically homologous complex with eubacterial ribosome reveals its chaperone action
2005 StandoutNobel
α-melanocyte stimulating hormone and its analogue nle4dphe7α-MSH affect morphology, tyrosinase activity and melanogenesis in cultured human melanocytes
1994
Synthesis and Structure–Activity Relationships of Substituted Urea Derivatives on Mouse Melanocortin Receptors
2015
Protein Translocation Across Biological Membranes
2005 StandoutScienceNobel
Relaxation of hormonally stimulated smooth muscular tissues by the 8-bromo derivative of cyclic GMP
1979
Structure-guided SCHEMA recombination generates diverse chimeric channelrhodopsins
2017 StandoutNobel
Corticotropin Releasing Hormone and Proopiomelanocortin Involvement in the Cutaneous Response to Stress
2000
Affinity chromatography of human platelet α 2 -adrenergic receptors
1982 StandoutNobel
Discovery of a β-MSH-Derived MC-4R Selective Agonist
2005
NG-methyl-L-arginine causes endothelium-dependent contraction and inhibition of cyclic GMP formation in artery and vein.
1990 StandoutNobel
Works of Jarl E. S. Wikberg being referenced
Unbiased descriptor and parameter selection confirms the potential of proteochemometric modelling
2005
Discovery of novel melanocortin4 receptor selective MSH analogues
1998
Targeting melanocortin receptors: an approach to treat weight disorders and sexual dysfunction
2008
Polyclonal antibodies against human melanocortin MC1 receptor: preliminary immunohistochemical localisation of melanocortin MC1 receptor to malignant melanoma cells
1995
A Three-Dimensional Model for the Interaction of MSH with the Melanocortin-1 Receptor
1995
Evidence That Orexigenic Effects of Melanocortin 4 Receptor Antagonist HS014 Are Mediated by Neuropeptide Y
1998
[3H]‐MK 912 binding delineates two α2‐adrenoceptor subtypes in rat CNS one of which is identical with the cloned pA2d α2‐adrenoceptor
1992
Classification of G‐protein coupled receptors by alignment‐independent extraction of principal chemical properties of primary amino acid sequences
2002
Characterisation of D117A and H260A mutations in the melanocortin 1 receptor
1997
New aspects on the melanocortins and their receptors
2000
Evidence for the existence of two forms of α2A-adrenoceptors in the rat
1993
Proteochemometrics analysis of substrate interactions with dengue virus NS3 proteases
2008
Localization of ACTH receptor mRNA by in situ hybridization in mouse adrenal gland
1996
Pharmacological comparison of rat and human melanocortin 3 and 4 receptors in vitro
2002
Medetomidine stereoisomers delineate two closely related subtypes of idazoxan (imidazoline) I-receptors in the guinea pig
1991
Evidence Indicating That the TM4, EL2, and TM5 of the Melanocortin 3 Receptor Do Not Participate in Ligand Binding
1996
Selectivity of [Phe-I 7 ], [Ala 6 ], and [ d -Ala 4 ,Gln 5 ,Tyr 6 ] Substituted ACTH(4-10) Analogues for the Melanocortin Receptors
1997
The Melanocortin 4 Receptor Mediates Leptin Stimulation of Luteinizing Hormone and Prolactin Surges in Steroid-Primed Ovariectomized Rats
1999
Identification of an additional gene belonging to the α2adrenergic receptor family in the human genome by PCR
1991
Expression of Functional Melanocortin 1 Receptors in Insect Cells
1996
Quantification of α2A and α2C adrenoceptors in the rat striatum and in different regions of the spinal cord
1997
Further pharmacological characterization of the selective melanocortin 4 receptor antagonist HS014: comparison with SHU9119
1999
Evidence for Alternate Points of Attachment for α-MSH and Its Stereoisomer (Nle4,D-Phe7)-α-MSH at the Melanocortin-1 Receptor
1994
Receptor subtypes Y1 and Y5 mediate neuropeptide Y induced feeding in the guinea‐pig
2002
Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA
1992
PLS modeling of chimeric MS04/MSH-peptide and MC1/MC3-receptor interactions reveals a novel method for the analysis of ligand–receptor interactions
2001
Proteochemometrics mapping of the interaction space for retroviral proteases and their substrates
2009
Evidence That Physiological Levels of Circulating Leptin Exert a Stimulatory Effect on Luteinizing Hormone and Prolactin Surges in Rats
1999
Selective Antagonist for the Melanocortin 4 Receptor (HS014) Increases Food Intake in Free-Feeding Rats
1998
Delineation of three pharmacological subtypes of α2‐adrenoceptor in the rat kidney
1991
Localization of the human melanocortin-5 receptor gene (MC5R) to chromosome band 18p11.2 by fluorescence in situ hybridization
1995
Differential influence of a selective melanocortin MC4 receptor antagonist (HS014) on melanocortin-induced behavioral effects in rats
1998
Long term orexigenic effect of a novel melanocortin 4 receptor selective antagonist
1999
Bioclipse 2: A scriptable integration platform for the life sciences
2009
Expression of melanocortin 1 receptor in periaqueductal gray matter
1995
Comparison of the Binding Activities of Some Drugs on α2A, α2Band α2C‐Adrenoceptors and Non‐Adrenergic Imidazoline Sites in the Guinea Pig
1995
Delineation of rat kidney α2A- and α2B-adrenoeeptors with [3H]RX821002 radiollgand binding: computer modelling reveals that guanfacine is an α2A-selective compound
1991
Further Evidence for the Existence of Two Forms of α2B‐Adrenoceptors in Rat
1993
The MC4 receptor mediates α-MSH induced release of nucleus accumbens dopamine
2001
Melanocortin receptors form constitutive homo- and heterodimers
2004
Modeling of the three-dimensional structure of the human melanocortin 1 receptor, using an automated method and docking of a rigid cyclic melanocyte-stimulating hormone core peptide
1997
Antinociceptive Actions of α2‐Adrenoceptor Agonists in the Rat Spinal Cord: Evidence for Antinociceptive α2‐Adrenoceptor Subtypes and Dissociation of Antinociceptive α2‐Adrenoceptors from Cyclic AMP
1990
Phage Display Selection on Whole Cells Yields a Peptide Specific for Melanocortin Receptor 1
1997
Rat Spinal Cord α2‐Adrenoceptors are of the α2A‐Subtype: Comparison with α2A‐ and α2B‐Adrenoceptors in Rat Spleen, Cerebral Cortex and Kidney Using3H‐RX821002 Ligand Binding
1991
Melanocortin receptors: perspectives for novel drugs
1999
High Affinity Binding of Idazoxan to a Non‐Catecholaminergic Binding Site in the Central Nervous System: Description of a Putative Idazoxan‐Receptor
1989
Simultaneous binding of trigger factor and signal recognition particle to the E. coli ribosome
2004
Further Characterization of the Guinea Pig Cerebral Cortex Idazoxan Receptor: Solubilization, Distinction from the Imidazole Site, and Demonstration of Cirazoline as an Idazoxan Receptor‐Selective Drug
1990
Targeting and insertion of heterologous membrane proteins in E. coli
2003
A promoting action of cyclic GMP on contractions of guinea-pig vas deferens
1978
Discovery of a Novel Superpotent and Selective Melanocortin-4 Receptor Antagonist (HS024): Evaluation in Vitro and in Vivo**This work was supported by grants from the Swedish Medical Research Council (04X-05957), the Swedish Society for Medical Research, and the Estonian Science Foundation (Grant 3267); the Ants ja Maria Silvere ning Sigfried Panti Malestusstipendium Foundation (to A.K.); and the Swedish Institute (to I.M.).
1998
Photoaffinity cross-linking of a radioiodinated probe, 125I-A55453, into alpha 1-adrenergic receptors.
1984
Proteochemometrics Modeling of the Interaction of Amine G-Protein Coupled Receptors with a Diverse Set of Ligands
2002
Photoaffinity labeling of mammalian alpha 1-adrenergic receptors. Identification of the ligand binding subunit with a high affinity radioiodinated probe.
1984 StandoutNobel
Inhibitory Effects of Different Retinoids (Vitamin A Analogues) on the Stimulated Rat Liver Guanylate Cyclase Activity
1982
Selectivity of Cyclic [d-Nal7] and [d-Phe7] Substituted MSH Analogues for the Melanocortin Receptor Subtypes
1997
Selective properties of C- and N-terminals and core residues of the melanocyte-stimulating hormone on binding to the human melanocortin receptor subtypes
1998
Covalent labeling of the cerebral cortex α1-adrenergic receptor with a new high affinity radioiodinated photoaffinity probe
1983 StandoutNobel
Pharmacological Characterization of the Autonomous Innervation of the Guinea Pig Tracheobronchial Smooth Muscle
1981
Norepinephrine-induced down regulation of alpha1 adrenergic receptors in cultured rabbit aorta smooth muscle cells
1983
Correlation between Vascular Smooth Muscle Relaxation and Increase in Cyclic GMP Induced by some Organic Nitro Esters
1981
Differentiation between pre‐ and postjunctional α‐receptors in guinea pig ileum and rabbit aorta
1978
New Substituted Piperazines as Ligands for Melanocortin Receptors. Correlation to the X-ray Structure of “THIQ”
2004
Relationship between nitroglycerin, cyclic GMP and relaxation of vascular smooth muscle
1979
Probing the substrate specificity of the dengue virus type 2 NS3 serine protease by using internally quenched fluorescent peptides
2006
Pharmacological classification of adrenergic α receptors in the guinea pig
1978 Nature
Vascular Smooth Muscle Relaxation by Nitro Compounds: Reduced Relaxation and cGMP Elevation in Tolerant Vessels and Reversal of Tolerance by Dithiothreitol
1982
Cyclic nucleotides and the contraction of smooth muscle.
1975
Melanocortin receptors: new opportunities in drug discovery
2001
Solubilization of rat liver alpha1-adrenergic receptors
1983 StandoutNobel