Citation Impact
Citing Papers
Guidelines for the welfare and use of animals in cancer research
2010 Standout
Volume-sensitive chloride currents in four epithelial cell lines are not directly correlated to the expression of the MDR-1 gene.
1994
Multidrug resistance in cancer: role of ATP–dependent transporters
2002 Standout
cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3)1
1998
Increased Lipophilicity and Subsequent Cell Partitioning Decrease Passive Transcellular Diffusion of Novel, Highly Lipophilic Antioxidants
1999 StandoutNobel
Inhibition of P-Glycoprotein by D-α-Tocopheryl Polyethylene Glycol 1000 Succinate (TPGS)
1999
Positively Cooperative Sites for Drug Transport by P‐Glycoprotein with Distinct Drug Specificities
1997
Role of transport proteins in drug absorption, distribution and excretion
2001
Nutraceuticals: Facts and fiction
2007 Standout
Interactions of Herbs with Cytochrome P450
2003
Caco‐2 versus Caco‐2/HT29‐MTX Co‐cultured Cell Lines: Permeabilities Via Diffusion, Inside‐ and Outside‐Directed Carrier‐Mediated Transport
2000
The metabolism of antihistamines and drug interactions: the role of cytochrome P450 enzymes
1999
Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota
2005
P‐glycoprotein is not a swelling‐activated Cl− channel; possible role as a Cl− channel regulator
1997
Virtual screening of intestinal drug permeability
2000
Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs
2004 Standout
Induction of UDP-Glucuronosyl-Transferase by the Flavonoids Chrysin and Quercetin in Caco-2 Cells
2000
Unravelling the pathogenesis of inflammatory bowel disease
2007 StandoutNature
Structure and function of the blood–brain barrier
2009 Standout
A comparison of commonly used polyethoxylated pharmaceutical excipients on their ability to inhibit P‐glycoprotein activity in vitro
2002
Volume-sensitive Chloride Channel Activity Does Not Depend on Endogenous P-glycoprotein
1995
Microemulsion-based media as novel drug delivery systems
2000 Standout
Oral Anticoagulant Therapy
2012 Standout
Cytochrome P450-mediated metabolism in the human gut wall
2009
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1
2001 Standout
Pharmacokinetic interactions between herbal remedies and medicinal drugs
2002
Intestinal epithelial cell accumulation of the cancer preventive polyphenol ellagic acid—extensive binding to protein and DNA
2003
Carrier-Mediated Intestinal Transport of Drugs
1996
Properties and regulation of ion channels in MDCK cells
1995
Transport of the flavonoid chrysin and its conjugated metabolites by the human intestinal cell line Caco-2
1999
Cremophor EL
2001 Standout
Effect of Solar Particle Event Radiation and Hindlimb Suspension on Gastrointestinal Tract Bacterial Translocation and Immune Activation
2012 StandoutNobel
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
2009 Standout
Natural lignans from Arctium lappa modulate P-glycoprotein efflux function in multidrug resistant cancer cells
2015
Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine*
1997 Standout
In vitro systems for studying intestinal drug absorption
1995
Cell volume regulated transporters of compatible osmolytes
1995
Inflammatory Bowel Disease
2009 Standout
Impact of Cremophor-EL and Polysorbate-80 on Digoxin Permeability across Rat Jejunum: Delineation of Thermodynamic and Transporter Related Events Using the Reciprocal Permeability Approach
2006
Role of P-Glycoprotein and Cytochrome P450 3A in Limiting Oral Absorption of Peptides and Peptidomimetics†
1998
Modulation of Intestinal P-Glycoprotein Function by Cremophor EL and Other Surfactants by an In Vitro Diffusion Chamber Method Using the Isolated Rat Intestinal Membranes
2004
Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs
2007 Standout
Role of P-Glycoprotein in Pharmacokinetics
2003
pH-sensitive vesicles, polymeric micelles, and nanospheres prepared with polycarboxylates
2011
Targeting multidrug resistance in cancer
2006 Standout
Allergic Rhinitis and Its Impact on Asthma
2001 Standout
The biochemistry and medical significance of the flavonoids
2002 Standout
Clinical Relevance of P-Glycoprotein in Drug Therapy
2003
Enhanced cellular accumulation of a P-glycoprotein substrate, rhodamine-123, by caco-2 cells using low molecular weight methoxypolyethylene glycol-block-polycaprolactone diblock copolymers
2002
Transport characteristics of peptides and peptidomimetics: I. N‐methylated peptides as substrates for the oligopeptide transporter and P‐glycoprotein in the intestinal mucosa
2001
The biology of the P-glycoproteins
1995
Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine
2008 Standout
Gut microbiota modulation of chemotherapy efficacy and toxicity
2017 Standout
Hepatobiliary and intestinal clearance of amphiphilic cationic drugs in mice in which both mdr1a and mdr1b genes have been disrupted
1998
Applicability of an in vitro digestion model in assessing the bioaccessibility of mycotoxins from food
2004 Standout
Clinical Pharmacokinetics and Pharmacodynamics of Tacrolimus in Solid Organ Transplantation
2004 Standout
ATP-DEPENDENT TRANSPORT SYSTEMS IN BACTERIA AND HUMANS: Relevance to Cystic Fibrosis and Multidrug Resistance
1993
Regions involved in the opening of CIC-2 chloride channel by voltage and cell volume
1992 Nature
Polyphenols: food sources and bioavailability
2004 Standout
Structured emulsion-based delivery systems: Controlling the digestion and release of lipophilic food components
2010 Standout
Influence of Dietary Components on the Gastrointestinal Metabolism and Transport of Drugs
2000
Polymeric micelles for oral drug delivery
2010
HIGH ABSORPTION BUT VERY LOW BIOAVAILABILITY OF ORAL RESVERATROL IN HUMANS
2004 Standout
Antisense oligonucleotides suppress cell-volume-induced activation of chloride channels
1995
Caco-2 monolayers in experimental and theoretical predictions of drug transport1PII of original article: S0169-409X(96)00415-2. The article was originally published in Advanced Drug Delivery Reviews 22 (1996) 67–84.1
2001
The Effects of Pluronic® Block Copolymers and Cremophor® EL on Intestinal Lipoprotein Processing and the Potential Link with P-Glycoprotein in Caco-2 Cells
2003
Inhibitory effect of a bitter melon extract on the P‐glycoprotein activity in intestinal Caco‐2 cells
2004
Lipid Formulation Strategies for Enhancing Intestinal Transport and Absorption of P-Glycoprotein (P-gp) Substrate Drugs: In vitro/In vivo Case Studies
2006
P-glycoprotein and surfactants: Effect on intestinal talinolol absorption
2005
Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview
2003 Standout
The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability
2003
HMG‐CoA reductase inhibitors and P‐glycoprotein modulation
2001
Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.
1996 Standout
Pharmacokinetic and Pharmacodynamic Implications of P‐glycoprotein Modulation
2001
Possible Involvement of Multiple P-Glycoprotein-Mediated Efflux Systems in the Transport of Verapamil and Other Organic Cations Across Rat Intestine
1995
The human intestinal epithelial cell line Caco-2; pharmacological and pharmacokinetic applications
1995
Review of theoretical passive drug absorption models: Historical background, recent developments and limitations
1996
Competitive and Non‐Competitive Inhibition of the Multidrug‐Resistance‐Associated P‐glycoprotein ATPase
1997
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial
2010 Standout
Molecular physiology of anion channels
1994
Herb-Drug Interactions
2005 Standout
Influence of vitamin E TPGS poly(ethylene glycol) chain length on apical efflux transporters in Caco-2 cell monolayers
2006
Relevance of Multidrug Resistance Proteins for Intestinal Drug Absorption in vitro and in vivo
2002
Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation
2013 Standout
Drug Transport and Targeting
2002
Pharmacokinetics of Erythromycin in Rabbit Corneas after Single-Dose Infusion: Role of P-Glycoprotein as a Barrier to in Vivo Ocular Drug Absorption
2004
Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions
2021 Standout
MDCK (Madin-Darby Canine Kidney) Cells: A Tool for Membrane Permeability Screening
1999
Relationships between the hydrophilic–lipophilic balance values of pharmaceutical excipients and their multidrug resistance modulating effect in Caco-2 cells and rat intestines
2003
Monolayers of IEC-18 cells as an in vitro model for screening the passive transcellular and paracellular transport across the intestinal barrier: comparison of active and passive transport with the human colon carcinoma Caco-2 cell line
2002
Engineered Nanoparticles for Drug Delivery in Cancer Therapy
2014 Standout
The transport of organic cations in the small intestine: Current knowledge and emerging concepts
2006
Swelling-activated organic osmolyte efflux: A new role for anion channels
1995
Developmental Pharmacology — Drug Disposition, Action, and Therapy in Infants and Children
2003 Standout
Saquinavir, an HIV Protease Inhibitor, Is Transported by P-Glycoprotein
1998
Concise Review: Clinical Relevance of Drug–Drug and Herb–Drug Interactions Mediated by the ABC Transporter ABCB1 (MDR1, P-glycoprotein)
2007
Absorption prediction from physicochemical parameters
1999
Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview
2012 Standout
Intestinal absorption of the quaternary trospium chloride: permeability-lowering factors and bioavailabilities for oral dosage forms
1997
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
1997 Standout
Volume-activated chloride currents are not correlated with P-glycoprotein expression
1995
Molecular Properties That Influence the Oral Bioavailability of Drug Candidates
2002 Standout
Prediction of Drug Absorption Using Multivariate Statistics
2000 Standout
BIOCHEMICAL, CELLULAR, AND PHARMACOLOGICAL ASPECTS OF THE MULTIDRUG TRANSPORTER
1999 Standout
Nuclear Receptors and Lipid Physiology: Opening the X-Files
2001 StandoutScience
Phase I and Pharmacokinetic Study of XRP6258 (RPR 116258A), a Novel Taxane, Administered as a 1-Hour Infusion Every 3 Weeks in Patients with Advanced Solid Tumors
2009
IN VITRO AND IN VIVO DRUG INTERACTIONS INVOLVING HUMAN CYP3A
1998
Doxorubicin selection for MDR1/P-glycoprotein reduces swelling-activated K+ and Cl- currents in MES-SA cells
1996
Grapefruit Juice Activates P-Glycoprotein-Mediated Drug Transport
1999
Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore
2010 Standout
Bright Side of Lignin Depolymerization: Toward New Platform Chemicals
2018 Standout
Caco-2 monolayers in experimental and theoretical predictions of drug transport
1996
Spinal and Supraspinal Factors in Human Muscle Fatigue
2001 Standout
Involvement of P-glycoprotein in the transmembrane transport of interleukin-2 (IL-2), IL-4, and interferon-gamma in normal human T lymphocytes
1996
Mechanisms of Cancer Drug Resistance
2002 Standout
Estimation of Caco‐2 Cell Permeability using Calculated Molecular Descriptors
1996
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
2012 Standout
Cytochrome P450-mediated metabolism in the human gut wall
2009
Is the Role of the Small Intestine in First-Pass Metabolism Overemphasized?
1999
Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties
2000 Standout
Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine
1997
Penetration of Drugs through the Blood-Cerebrospinal Fluid/Blood-Brain Barrier for Treatment of Central Nervous System Infections
2010 Standout
Pharmaceuticals and personal care products in the environment: agents of subtle change?
1999 Standout
Hepatic Expression of Multidrug Resistance-Associated Protein-Like Proteins Maintained in Eisai Hyperbilirubinemic Rats
1998
A physiologic function for p-glycoprotein (MDR-1) during the migration of dendritic cells from skin via afferent lymphatic vessels
1998 StandoutNobel
Design, Synthesis, and in Vitro Activity of Catamphiphilic Reverters of Multidrug Resistance: Discovery of a Selective, Highly Efficacious Chemosensitizer with Potency in the Nanomolar Range
1999
Physicochemical and drug-delivery considerations for oral drug bioavailability
1996
Volume‐activated chloride currents associated with the multidrug resistance P‐glycoprotein.
1995
Functional Significance of Cell Volume Regulatory Mechanisms
1998 Standout
Applications of the Caco-2 model in the design and development of orally active drugs: elucidation of biochemical and physical barriers posed by the intestinal epithelium
1997
In vitro permeability of peptidomimetic drugs: The role of polarized efflux pathways as additional barriers to absorption
1997
TLR Signaling Modulates Side Effects of Anticancer Therapy in the Small Intestine
2015
Works of Janice Hunter being referenced
Volume‐activated Cl− secretion and transepithelial vinblastine secretion mediated by P‐glycoprotein are not correlated in cultured human T84 intestinal epithelial layers
1992
Epithelial secretion of vinblastine by human intestinal adenocarcinoma cell (HCT-8 and T84) layers expressing P-glycoprotein
1991
Drug Absorption Limited by P-Glycoprotein-Mediated Secretory Drug Transport in Human Intestinal Epithelial Caco-2 Cell Layers
1993
Polarized efflux of 2′,7′-bis(2-carboxyethyl)-5(6)-carboxyfluorescein from cultured epithelial cell monolayers
1992
Transepithelial secretion, cellular accumulation and cytotoxicity of vinblastine in defined MDCK cell strains
1993
Renal secretion of xenobiotics mediated by P-glycoprotein: Importance to renal function in health and exploitation for targeted drug delivery to epithelial cysts in polycystic kidney disease
1997
Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators
1993
Intestinal secretion of drugs. The role of P-glycoprotein and related drug efflux systems in limiting oral drug absorption
1997