Citation Impact
Citing Papers
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4
2015 Science
Origin of myofibroblasts in the fibrotic liver in mice
2014
High burden and pervasive positive selection of somatic mutations in normal human skin
2015 StandoutScience
BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance
2016
Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis
2023 StandoutNobel
Recurrent turnover of senescent cells during regeneration of a complex structure
2015
p53 in Bronchial Club Cells Facilitates Chronic Lung Inflammation by Promoting Senescence
2018
Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3
2019
Mutational landscape and significance across 12 major cancer types
2013 StandoutNature
Impaired immune surveillance accelerates accumulation of senescent cells and aging
2018
Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells
2018
Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL
2016
Pan-cancer patterns of somatic copy number alteration
2013
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
2021 Standout
Contributions of metabolic dysregulation and inflammation to nonalcoholic steatohepatitis, hepatic fibrosis, and cancer
2013
Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation
2015
Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity
2020 StandoutNobel
A view on drug resistance in cancer
2019 StandoutNature
p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer
2016
Cancer nanomedicine: progress, challenges and opportunities
2016 Standout
Mechanisms of hepatic stellate cell activation
2017 Standout
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
2011 StandoutNature
Hepatic Stellate Cells and Liver Fibrosis
2013
Wnt signaling in cancer
2016 Standout
Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future
2017 Standout
Hallmarks of aging: An expanding universe
2023 Standout
Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies
2019 Standout
Understanding the tumor immune microenvironment (TIME) for effective therapy
2018 Standout
Optimized base editors enable efficient editing in cells, organoids and mice
2018
Autophagy and senescence, converging roles in pathophysiology as seen through mouse models
2021
The biology and function of fibroblasts in cancer
2016 Standout
Pancreatic cancer
2016 Standout
The mini-driver model of polygenic cancer evolution
2015 StandoutNobel
Immunosurveillance of senescent cells: the bright side of the senescence program
2013
Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis
2016
Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation
2014 Standout
Senescent cells: an emerging target for diseases of ageing
2017
New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer
2018 Standout
The Cancer Genome Atlas Pan-Cancer analysis project
2013 Standout
Cancer stem cells revisited
2017 Standout
Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape
2013
Tumor-Associated Macrophages: From Mechanisms to Therapy
2014 Standout
Cumulative Haploinsufficiency and Triplosensitivity Drive Aneuploidy Patterns and Shape the Cancer Genome
2013
Super-Enhancers in the Control of Cell Identity and Disease
2013 Standout
CRISPR-Barcoding for Intratumor Genetic Heterogeneity Modeling and Functional Analysis of Oncogenic Driver Mutations
2016
Cellular senescence in ageing: from mechanisms to therapeutic opportunities
2020 Standout
Mechanisms of NAFLD development and therapeutic strategies
2018 Standout
Molecular and cellular mechanisms of liver fibrosis and its regression
2020
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
2020 Standout
Forging a signature of in vivo senescence
2015
Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression
2016
Physiological and pathological consequences of cellular senescence
2014
Stable RNA interference rules for silencing
2013
Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks
2012 StandoutNobel
Emerging Biological Principles of Metastasis
2017 Standout
Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains
2015
Programmed Cell Senescence during Mammalian Embryonic Development
2013 Standout
EMT: 2016
2016 Standout
The causes and consequences of genetic heterogeneity in cancer evolution
2013 StandoutNature
Implications of Cellular Senescence in Tissue Damage Response, Tumor Suppression, and Stem Cell Biology
2008
The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration
2017
TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis
2018 Nature
Senolytic CAR T cells reverse senescence-associated pathologies
2020 Nature
From discoveries in ageing research to therapeutics for healthy ageing
2019 Nature
Senescent cells communicate via intercellular protein transfer
2015
Applications of CRISPR technologies in research and beyond
2016 StandoutNobel
Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function
2015 Nature
Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology
2013
The role of senescent cells in ageing
2014 StandoutNature
Ferroptosis: mechanisms, biology and role in disease
2021 Standout
Senescence and the SASP: many therapeutic avenues
2020
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
2016 Standout
Cornerstones of CRISPR–Cas in drug discovery and therapy
2016 StandoutNobel
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
2016 StandoutNature
Metastatic colonization by circulating tumour cells
2016 StandoutNature
β-PDGF receptor expressed by hepatic stellate cells regulates fibrosis in murine liver injury, but not carcinogenesis
2015
The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy
2014
Discovery and saturation analysis of cancer genes across 21 tumour types
2014 StandoutNature
Microenvironmental regulation of tumor progression and metastasis
2013 Standout
Cell fusion induced by ERVWE1 or measles virus causes cellular senescence
2013
Unmasking senescence: context-dependent effects of SASP in cancer
2019
MLL3 Is a Haploinsufficient 7q Tumor Suppressor in Acute Myeloid Leukemia
2014
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
2017 Standout
An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance
2011
Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response
2018 Standout
Cellular senescence controls fibrosis in wound healing
2010
Molecular links between cellular senescence, longevity and age-related diseases – a systems biology perspective
2011
Metabolic control of cell death
2014 Science
Strategies targeting cellular senescence
2018
Molecular pathways of senescence regulate placental structure and function
2019
Lysosome-mediated processing of chromatin in senescence
2013
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Uncoupling the Senescence-Associated Secretory Phenotype from Cell Cycle Exit via Interleukin-1 Inactivation Unveils Its Protumorigenic Role
2019
Adult-onset, short-term dietary restriction reduces cell senescence in mice
2010
Quantitative identification of senescent cells in aging and disease
2017
NKG2D ligands mediate immunosurveillance of senescent cells
2016
Targeting Wnt signaling in colorectal cancer. A Review in the Theme: Cell Signaling: Proteins, Pathways and Mechanisms
2015
Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells
2016
Cancer Genome Landscapes
2013 StandoutScience
Senescent cells expose and secrete an oxidized form of membrane-bound vimentin as revealed by a natural polyreactive antibody
2017
T cell exclusion, immune privilege, and the tumor microenvironment
2015 StandoutScience
Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy
2016 Standout
Cellular senescence in development, regeneration and disease
2019
Caenorhabditis elegans responses to bacteria from its natural habitats
2016 StandoutNobel
Fast detection of liver fibrosis with collagen-binding single-nanometer iron oxide nanoparticles via T 1 -weighted MRI
2023 StandoutNobel
Works of Janelle Simon being referenced
Granule exocytosis mediates immune surveillance of senescent cells
2012
Non-Cell-Autonomous Tumor Suppression by p53
2013
Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer
2020
Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer
2015
Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer
2017
Senescence of Activated Stellate Cells Limits Liver Fibrosis
2008
Reversible suppression of an essential gene in adult mice using transgenic RNA interference
2011
A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions
2012