Standout Papers
Citation Impact
Citing Papers
Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling
2009 StandoutScience
TFEB Links Autophagy to Lysosomal Biogenesis
2011 StandoutScience
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
2010 StandoutScience
Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation
2009 StandoutScience
Caenorhabditis elegans ADAR editing and the ERI-6/7/MOV10 RNAi pathway silence endogenous viral elements and LTR retrotransposons
2020 StandoutNobel
Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis
2011 Science
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses
2017
The DNA-damage response in human biology and disease
2009 StandoutNature
Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k
1997
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
2001 StandoutNature
Mechanisms, regulation and functions of the unfolded protein response
2020 Standout
mTOR Signaling in Growth Control and Disease
2012 Standout
Oncogenic potential of TAR RNA binding protein TRBP and its regulatory interaction with RNA-dependent protein kinase PKR
1997
Inflammation and metabolic disorders
2006 StandoutNature
Autophagy and Viruses: Adversaries or Allies?
2013 Standout
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
2002 StandoutNature
The tor pathway: a target for cancer therapy
2004 Standout
Solution Structure of Human Initiation Factor eIF2α Reveals Homology to the Elongation Factor eEF1B
2004
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
GCN2 Kinase in T Cells Mediates Proliferative Arrest and Anergy Induction in Response to Indoleamine 2,3-Dioxygenase
2005
Metazoan stress granule assembly is mediated by P-eIF2α-dependent and -independent mechanisms
2009
Iron Metabolism: Interactions with Normal and Disordered Erythropoiesis
2012
The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth
2003
Mammalian Stress Granules and Processing Bodies
2007
Regulation of translation initiation by FRAP/mTOR
2001
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
2005 StandoutNature
Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency
2001
Overexpression of the eukaryotic translation initiation factor 4G (eIF4G‐1) in squamous cell lung carcinoma
2001
Clinical development of mammalian target of rapamycin inhibitors
2002
Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress
2001
Functional characterization of Drosophila melanogaster PERK eukaryotic initiation factor 2α (eIF2α) kinase
2003
Characterization of Transgenic Mice with Targeted Disruption of the Catalytic Domain of the Double-stranded RNA-dependent Protein Kinase, PKR
1999
ER stress, autophagy, and RNA viruses
2014
Gene-Specific Regulation by General Translation Factors
2002
Translational control in cancer
2010
Human nutrition, the gut microbiome and the immune system
2011 StandoutNature
Eukaryotic translation initiation machinery can operate in a bacterial-like mode without eIF2
2008
Telomeres shorten during ageing of human fibroblasts
1990 StandoutNatureNobel
Stress-Regulated Translational Attenuation Adapts Mitochondrial Protein Import through Tim17A Degradation
2013
Antiviral effect of the mammalian translation initiation factor 2α kinase GCN2 against RNA viruses
2006
A role of PIEZO1 in iron metabolism in mice and humans
2021 StandoutNobel
Stress Granules and Processing Bodies in Translational Control
2018
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
1999 StandoutNature
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
1999 StandoutNobel
From endoplasmic-reticulum stress to the inflammatory response
2008 StandoutNature
Antisense RNA to eIF4E Suppresses Oncogenic Properties of a Head and Neck Squamous Cell Carcinoma Cell Line
2000
Insulin signalling and the regulation of glucose and lipid metabolism
2001 StandoutNature
Predominant Nuclear Localization of Mammalian Target of Rapamycin in Normal and Malignant Cells in Culture
2002
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
2000 StandoutNature
Activation of GCN2 in UV-Irradiated Cells Inhibits Translation
2002
Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival
2017
Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells
2000 Standout
c-Myc Can Induce DNA Damage, Increase Reactive Oxygen Species, and Mitigate p53 Function
2002
Cryo-EM Visualization of a Viral Internal Ribosome Entry Site Bound to Human Ribosomes
2004 StandoutNobel
TBL2 Is a Novel PERK-Binding Protein that Modulates Stress-Signaling and Cell Survival during Endoplasmic Reticulum Stress
2014
N6-methyladenosine-dependent regulation of messenger RNA stability
2013 StandoutNature
Crystal Structure of the Intact Archaeal Translation Initiation Factor 2 Demonstrates Very High Conformational Flexibility in the α- and β-Subunits
2008
The role of the DNA double-strand break response network in meiosis
2004
Upregulated expression of the genes encoding translation initiation factors eIF-4E and eIF-2α in transformed cells
1996
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
Positional cloning of the zebrafish sauternes gene: a model for congenital sideroblastic anaemia
1998
Expression of eukaryotic translation initiation factors 4E and 2? is increased frequently in bronchioloalveolar but not in squamous cell carcinomas of the lung
2001
Rapamycin Inhibition of the G1 to S Transition Is Mediated by Effects on Cyclin D1 mRNA and Protein Stability
1998
Structure of the Mammalian Ribosomal 43S Preinitiation Complex Bound to the Scanning Factor DHX29
2013 StandoutNobel
Translational Control and the Unfolded Protein Response
2007
The Heme-Bach1 Pathway in the Regulation of Oxidative Stress Response and Erythroid Differentiation
2006
Expression of Eukaryotic Translation Initiation Factors 4E and 2 α Correlates with the Progression of Thyroid Carcinoma
2001
A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans
2015 StandoutNobel
Pharmacodynamic Evaluation of CCI-779, an Inhibitor of mTOR, in Cancer Patients.
2003
Coping with Protein Quality Control Failure
2017
Telomere length predicts replicative capacity of human fibroblasts.
1992 StandoutNobel
The Transcriptional Landscape of the Yeast Genome Defined by RNA Sequencing
2008 StandoutScience
Advances in engineering hydrogels
2017 StandoutScience
Stress granules and processing bodies are dynamically linked sites of mRNP remodeling
2005
Tight Binding of the Phosphorylated α Subunit of Initiation Factor 2 (eIF2α) to the Regulatory Subunits of Guanine Nucleotide Exchange Factor eIF2B Is Required for Inhibition of Translation Initiation
2001
Expression of the translation initiation factor eIF4E in the polyp-cancer sequence in the colon.
2001
Mouse Norovirus Infection Arrests Host Cell Translation Uncoupled from the Stress Granule-PKR-eIF2α Axis
2019
ATP-independent diffusion of double-stranded RNA binding proteins
2012 StandoutNobel
OGFOD1, a Novel Modulator of Eukaryotic Translation Initiation Factor 2α Phosphorylation and the Cellular Response to Stress
2010
The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
2011 StandoutScience
Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1
2000 StandoutScience
Global Gene Expression Profiling Reveals Widespread yet Distinctive Translational Responses to Different Eukaryotic Translation Initiation Factor 2B-Targeting Stress Pathways
2005
Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems
2001 StandoutNobel
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability
2009 StandoutNobel
Resistance to Vesicular Stomatitis Virus Infection Requires a Functional Cross Talk between the Eukaryotic Translation Initiation Factor 2α Kinases PERK and PKR
2004
Translational Repression Mediates Activation of Nuclear Factor Kappa B by Phosphorylated Translation Initiation Factor 2
2004
The Ubiquitin-Proteasome System Plays an Important Role during Various Stages of the Coronavirus Infection Cycle
2010
Disease Tolerance as a Defense Strategy
2012 StandoutScience
Integrin Signaling
1999 StandoutScience
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR
2001
Specific Inhibition of the PKR-Mediated Antiviral Response by the Murine Cytomegalovirus Proteins m142 and m143
2008
BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1α, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin
2002
GCN2 phosphorylation of eIF2α activates NF-κB in response to UV irradiation
2005
Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy
2014 StandoutNobel
Cellular Senescence revisited: a review
1987
TRANSLATIONAL REGULATION OFGCN4AND THE GENERAL AMINO ACID CONTROL OF YEAST
2005
Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
2004 StandoutScience
Increased Susceptibility to DNA Virus Infection in Mice with a GCN2 Mutation
2011 StandoutNobel
Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth
2014 StandoutNobel
RNA granules
2006
Identification and Characterization of Pancreatic Eukaryotic Initiation Factor 2 α-Subunit Kinase, PEK, Involved in Translational Control
1998
Stress Granule Assembly Is Mediated by Prion-like Aggregation of TIA-1
2004
Injectable Graphene Oxide/Hydrogel-Based Angiogenic Gene Delivery System for Vasculogenesis and Cardiac Repair
2014
Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3)
2011 StandoutNobel
Stimulation of Protein Synthesis, Eukaryotic Translation Initiation Factor 4E Phosphorylation, and PHAS-I Phosphorylation by Insulin Requires Insulin Receptor Substrate 1 and Phosphatidylinositol 3-Kinase
1996
OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation
2014 StandoutNobel
The Insulin-Induced Signalling Pathway Leading to S6 and Initiation Factor 4E Binding Protein 1 Phosphorylation Bifurcates at a Rapamycin-Sensitive Point Immediately Upstream of p70s6k
1997
E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes
2020 StandoutNobel
Liquid phase condensation in cell physiology and disease
2017 StandoutScience
Coping with stress: eIF2 kinases and translational control
2006
Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells
2018 Science
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
1998 StandoutScience
Expression of eukaryotic initiation factor 4E in atypical adenomatous hyperplasia and adenocarcinoma of the human peripheral lung.
2002
Works of Jane-Jane Chen being referenced
14 Heme-regulated eIF2α Kinase
2000
Regulation of protein synthesis by heme-regulated eIF-2α kinase
1995
Translational control by heme-regulated eIF2α kinase during erythropoiesis
2014
Upregulation of protein synthesis initiation factor eIF-4E is an early event during colon carcinogenesis
1999
Expression of the Eukaryotic Translation Initiation Factors 4E and 2α in Non-Hodgkin's Lymphomas
1999
Expression of the translation initiation factors eIF-4E and eIF-2α is frequently increased in neoplastic cells of Hodgkin lymphoma
2008
Heme-regulated Inhibitor Kinase-mediated Phosphorylation of Eukaryotic Translation Initiation Factor 2 Inhibits Translation, Induces Stress Granule Formation, and Mediates Survival upon Arsenite Exposure
2005
Eukaryotic Translation Initiation Factor 4E Regulates Expression of Cyclin D1 at Transcriptional and Post-transcriptional Levels
1995
Graphene Oxide Induces Toll-like Receptor 4 (TLR4)-Dependent Necrosis in Macrophages
2013
RNA and protein synthesis in cultured human fibroblasts derived from donors of various ages
1980
Expression of Mutant Eukaryotic Initiation Factor 2 α Subunit (eIF-2α) Reduces Inhibition of Guanine Nucleotide Exchange Activity of eIF-2B Mediated by eIF-2α Phosphorylation
1994
Erythroid Expression of the Heme-Regulated eIF-2α Kinase
1994
Regulation of hemoglobin synthesis and proliferation of differentiating erythroid cells by heme-regulated eIF-2α kinase
2000
Regulation of protein synthesis by the heme-regulated eIF2α kinase: relevance to anemias
2006
Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2α) dephosphorylation in mammalian development
2009
BRCA1, BRCA2, and Rad51 operate in a common DNA damage response pathway.
1999
Translation Initiation Control by Heme-Regulated Eukaryotic Initiation Factor 2α Kinase in Erythroid Cells under Cytoplasmic Stresses
2001
Phosphorylation of Eukaryotic Initiation Factor 2 by Heme-Regulated Inhibitor Kinase-Related Protein Kinases in Schizosaccharomyces pombe Is Important for Resistance to Environmental Stresses
2002
Regulation of hemoglobin synthesis and proliferation of differentiating erythroid cells by heme-regulated eIF-2α kinase
2000