Standout Papers
Citation Impact
Citing Papers
Preferential Generation of Follicular B Helper T Cells from Foxp3 + T Cells in Gut Peyer's Patches
2009 StandoutScienceNobel
CTLA-4 Control over Foxp3 + Regulatory T Cell Function
2008 StandoutScienceNobel
Number of T Reg Cells That Differentiate Does Not Increase upon Encounter of Agonist Ligand on Thymic Epithelial Cells
2004
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
2003 StandoutScienceNobel
Induction of FOXP3 expression in naive human CD4+FOXP3− T cells by T-cell receptor stimulation is transforming growth factor-β–dependent but does not confer a regulatory phenotype
2007
Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development
2006 Standout
Mouse models of acute and chronic hepacivirus infection
2017 StandoutScienceNobel
Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter
2005
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
Nonredundant roles for Stat5a/b in directly regulating Foxp3
2007
PD-1 + regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer
2019 StandoutNobel
Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells
2013 StandoutScienceNobel
Regulatory T Cells Dynamically Control the Primary Immune Response to Foreign Antigen
2007
Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells
2010
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells
2007
Treg and CTLA-4: Two intertwining pathways to immune tolerance
2013
Regulatory T Cells
2000 StandoutNobel
Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome
2002
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
2007 StandoutNatureNobel
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
FOXP3 acts as a rheostat of the immune response
2005
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
2003 Standout
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
2001 StandoutNobel
Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self
2005 StandoutNobel
Foxp3+CD25+CD4+ natural regulatory T cells in dominant self‐tolerance and autoimmune disease
2006 StandoutNobel
The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
2009
FOXP3 and scurfy: how it all began
2014 StandoutNobel
A forkhead-domain gene is mutated in a severe speech and language disorder
2001 Nature
An essential role for Scurfin in CD4+CD25+ T regulatory cells
2003 StandoutNobel
Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression
2007 Nature
Foxp3: a genetic foundation for regulatory T cell differentiation and function
2020 StandoutNobel
Regulatory T Cells Control Antigen-Specific Expansion of Tfh Cell Number and Humoral Immune Responses via the Coreceptor CTLA-4
2014 StandoutNobel
Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells
2004 StandoutNobel
How regulatory T cells work
2008 Standout
Foxp3 occupancy and regulation of key target genes during T-cell stimulation
2007 Nature
Distinct Foxp3 enhancer elements coordinate development, maintenance, and function of regulatory T cells
2021 StandoutNobel
Th17 and Regulatory T Cells in Mediating and Restraining Inflammation
2010
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
2011 StandoutNobel
Foxp3 and Natural Regulatory T Cells
2003 StandoutNobel
CD25+CD4+ regulatory T cells exert in vitro suppressive activity independent of CTLA-4
2005
FOXP3+ regulatory T cells in the human immune system
2010 StandoutNobel
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
Regulatory T cell development in the absence of functional Foxp3
2007
Regulatory T Cell-Specific Epigenomic Region Variants Are a Key Determinant of Susceptibility to Common Autoimmune Diseases
2020 StandoutNobel
TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function
2008 StandoutNature
Molecular evolution of FOXP2, a gene involved in speech and language
2002 StandoutNatureNobel
The Human Condition—A Molecular Approach
2014 StandoutNobel
FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT
2006
Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis
2006 StandoutNobel
Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer
2019 StandoutNobel
Scurfin (FOXP3) Acts as a Repressor of Transcription and Regulates T Cell Activation
2001 StandoutNobel
Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
2006
Hepatitis C Virus RNA Functionally Sequesters miR-122
2015 StandoutNobel
TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells
2005
Naturally Arising CD4+Regulatory T Cells for Immunologic Self -Tolerance and Negative Control of Immune Responses
2003 StandoutNobel
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
FOXP3: Of Mice and Men
2005
Regulatory T Cells: Mechanisms of Differentiation and Function
2007 Standout
Roles of regulatory T cells in cancer immunity
2016
Dendritic cells with TGF-β1 differentiate naïve CD4+CD25−T cells into islet-protective Foxp3+regulatory T cells
2007 StandoutNobel
The origin of FOXP3-expressing CD4+ regulatory T cells: thymus or periphery
2003 StandoutNobel
Expansion of FOXP3high regulatory T cells by human dendritic cells (DCs) in vitro and after injection of cytokine-matured DCs in myeloma patients
2006 StandoutNobel
Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells
2012
Analysis of the Cellular Mechanism of Antitumor Responses and Autoimmunity in Patients Treated with CTLA-4 Blockade
2005
Blockade of CTLA-4 on CD4+CD25+ Regulatory T Cells Abrogates Their Function In Vivo
2006
The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease
2008
In Vivo Instruction of Suppressor Commitment in Naive T Cells
2004
Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients
2008 StandoutNobel
IL-10-Secreting Regulatory T Cells Do Not Express Foxp3 but Have Comparable Regulatory Function to Naturally Occurring CD4+CD25+ Regulatory T Cells
2004
Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood
2016 StandoutNobel
Foxp3+natural regulatory T cells preferentially form aggregates on dendritic cellsin vitroand actively inhibit their maturation
2008 StandoutNobel
The Amount of Scurfin Protein Determines Peripheral T Cell Number and Responsiveness
2001 StandoutNobel
The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer
2017 Standout
Emerging Challenges in Regulatory T Cell Function and Biology
2007 StandoutScienceNobel
Conditional stability of T cells
2010 StandoutNatureNobel
Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3
2003 Standout
Induced CD4+Foxp3+Regulatory T Cells in Immune Tolerance
2012
Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+regulatory T cells, evoking antitumor immune responses in humans
2013 StandoutNobel
CD25+ CD4+ T Cells, Expanded with Dendritic Cells Presenting a Single Autoantigenic Peptide, Suppress Autoimmune Diabetes
2004 StandoutNobel
Regulatory T Cells: Differentiation and Function
2016
Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells
2021 StandoutNobel
CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit
2008 StandoutNobel
Differentiation of Effector CD4 T Cell Populations
2010 Standout
Characterization of Foxp3+CD4+CD25+ and IL-10-Secreting CD4+CD25+ T Cells during Cure of Colitis
2006 StandoutNobel
Works of Jane Peake being referenced
X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy
2001 StandoutNobel
X-linked immune dysregulation, neonatal insulin dependent diabetes, and intractable diarrhoea.
1996