Standout Papers
Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
TRP channel activation by reversible covalent modification
2006 StandoutNobel
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
RIP140-Targeted Repression of Gene Expression in Adipocytes
2005
Structure of the human TRPM4 ion channel in a lipid nanodisc
2017 StandoutScienceNobel
Intrinsic Differences in Adipocyte Precursor Cells From Different White Fat Depots
2012
Cold-Activated Brown Adipose Tissue in Healthy Men
2009 Standout
High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans
2009 Standout
VEGF 189 Expression Is Highly Related to Adaptation of the Plateau Pika ( Ochotona curzoniae ) Inhabiting High Altitudes
2013
Human Multipotent Adipose-Derived Stem Cells Differentiate into Functional Brown Adipocytes
2009
Adipose Tissue Overexpression of Vascular Endothelial Growth Factor Protects Against Diet-Induced Obesity and Insulin Resistance
2012
The stoichiometry of the exchange catalysed by the mitochondrial calcium/sodium antiporter
1985
Adipose tissue stem cells meet preadipocyte commitment: going back to the future
2011
Brown fat in a protoendothermic mammal fuels eutherian evolution
2013
EBF2 Determines and Maintains Brown Adipocyte Identity
2013
Hallmarks of Cancer: The Next Generation
2011 Standout
SRC-1 and TIF2 Control Energy Balance between White and Brown Adipose Tissues
2002
The TGR5 gene is expressed in human subcutaneous adipose tissue and is associated with obesity, weight loss and resting metabolic rate
2013
Three Classes of Inhibitors Share a Common Binding Domain in Mitochondrial Complex I (NADH:Ubiquinone Oxidoreductase)
1999
Regulation of vascular tone by adipocytes
2011
Quantitative assessment of brown adipose tissue metabolic activity and volume using 18F-FDG PET/CT and β3-adrenergic receptor activation
2011
The adipose organ of obesity-prone C57BL/6J mice is composed of mixed white and brown adipocytes
2012
Mice lacking Pctp /StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue
2009
Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs
2002
The adipose organ
2005
Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1α
2005
Adipose Subtype-Selective Recruitment of TLE3 or Prdm16 by PPARγ Specifies Lipid Storage versus Thermogenic Gene Programs
2013
Mitochondrial uncoupling and lifespan
2010
Skin-specific Deletion of Stearoyl-CoA Desaturase-1 Alters Skin Lipid Composition and Protects Mice from High Fat Diet-induced Obesity
2009
Recruited brown adipose tissue as an antiobesity agent in humans
2013
Energy balance regulation by thyroid hormones at central level
2013
Endocrine and signalling role of adipose tissue: new perspectives on fat
2005
Seasonal changes in metabolic and temperature responses to cold air in humans
2004
Beyond the Sympathetic Tone: The New Brown Fat Activators
2013
Orexin Is Required for Brown Adipose Tissue Development, Differentiation, and Function
2011
Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice
2010
Transcriptional control of brown adipocyte development and physiological function—of mice and men
2009
Adipocyte differentiation and transdifferentiation: Plasticity of the adipose organ
2002
Adipose tissue browning and metabolic health
2013
Human Skeletal Muscle Mitochondrial Uncoupling Is Associated with Cold Induced Adaptive Thermogenesis
2008
Cold-Inducible Zfp516 Activates UCP1 Transcription to Promote Browning of White Fat and Development of Brown Fat
2015
MicroRNA networks regulate development of brown adipocytes
2013
Proteome Differences between Brown and White Fat Mitochondria Reveal Specialized Metabolic Functions
2009
C/EBPβ Reprograms White 3T3-L1 Preadipocytes to a Brown Adipocyte Pattern of Gene Expression
2007
Comparison of Uptake of Multiple Clinical Radiotracers into Brown Adipose Tissue Under Cold-Stimulated and Nonstimulated Conditions
2007
Brown and beige fat: development, function and therapeutic potential
2013 Standout
Identification and Importance of Brown Adipose Tissue in Adult Humans
2009 Standout
PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein
2012
Pten Positively Regulates Brown Adipose Function, Energy Expenditure, and Longevity
2012
Analysis of knockout mice suggests a role for VGF in the control of fat storage and energy expenditure
2009
Role for ELOVL3 and Fatty Acid Chain Length in Development of Hair and Skin Function
2004 StandoutNobel
Mice with a Targeted Deletion of the Type 2 Deiodinase Are Insulin Resistant and Susceptible to Diet Induced Obesity
2011
Pharmacological and nutritional agents promoting browning of white adipose tissue
2012
Developmental Origins of the Adipocyte Lineage: New Insights from Genetics and Genomics Studies
2011
Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the β2-adrenoceptor
1995 StandoutNatureNobel
Brown Adipose Tissue Responds to Cold and Adrenergic Stimulation by Induction of FGF21
2011
Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone
2004
Peroxisome Proliferator-Activated Receptor γ Agonism Increases the Capacity for Sympathetically Mediated Thermogenesis in Lean andob/obMice
2004
Thematic review series: Adipocyte Biology. Sympathetic and sensory innervation of white adipose tissue
2007
Identification of a Mammalian Long Chain Fatty Acyl Elongase Regulated by Sterol Regulatory Element-binding Proteins
2001
Zfp423 Expression Identifies Committed Preadipocytes and Localizes to Adipose Endothelial and Perivascular Cells
2012
Hedgehog signaling plays a conserved role in inhibiting fat formation
2006
Orexin neurons are indispensable for stress-induced thermogenesis in mice
2010
Evidence for two types of brown adipose tissue in humans
2013
Peroxisome Proliferator-activated Receptor α (PPARα) Induces PPARγ Coactivator 1α (PGC-1α) Gene Expression and Contributes to Thermogenic Activation of Brown Fat
2011
Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat
2013 Nature
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
2008 Standout
Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes
2012
β3 and Atypical β‐Adrenoceptors
1993
Importance of TNFα and neutral lipases in human adipose tissue lipolysis
2006
The physiological regulation of uncoupling proteins
2006
Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue
2011
Thermal biology of the laboratory rat
1990
Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation
2000
β-adrenoceptor signaling networks in adipocytes for recruiting stored fat and energy expenditure
2011
Noradrenergic parenchymal nerve fiber branching after cold acclimatisation correlates with brown adipocyte density in mouse adipose organ
2008
ELOVL3 Is an Important Component for Early Onset of Lipid Recruitment in Brown Adipose Tissue
2005 StandoutNobel
Essential Role for miR-196a in Brown Adipogenesis of White Fat Progenitor Cells
2012
Adipocytes as regulators of energy balance and glucose homeostasis
2006 StandoutNature
Central Control of Brown Adipose Tissue Thermogenesis
2012
Subcutaneous fat in normal and diseased states
2005
The Vascular Endothelium of the Adipose Tissue Gives Rise to Both White and Brown Fat Cells
2012
Inactivation of the Mitochondrial Carrier SLC25A25 (ATP-Mg2+/Pi Transporter) Reduces Physical Endurance and Metabolic Efficiency in Mice
2011
Uncoupling protein-3 as a molecular determinant of the action of 3,5,3′-triiodothyronine on energy metabolism
2009
Tissue-specific regulation of metabolic pathways through the transcriptional coactivator PGC1-α
2005
Effects of neonatal sympathectomy on brown fat development and susceptibility to high fat diet induced obesity in mice
1991
Subcutaneous fat in normal and diseased states
2007
ATF4 regulates lipid metabolism and thermogenesis
2010
β-Adrenergic Activation of p38 MAP Kinase in Adipocytes
2001
Central Role of Brown Adipose Tissue Thyroxine 5′-Deiodinase on Thyroid Hormone-Dependent Thermogenic Response to Cold*
1991
A Novel Regulatory Pathway of Brown Fat Thermogenesis
1995
PTEN Loss in the Myf5 Lineage Redistributes Body Fat and Reveals Subsets of White Adipocytes that Arise from Myf5 Precursors
2012
In Vivo Identification of Bipotential Adipocyte Progenitors Recruited by β3-Adrenoceptor Activation and High-Fat Feeding
2012
Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity.
1995
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
Metabolism of lipids in human white adipocyte
2004
Decavanadate modulates gating of TRPM4 cation channels
2004
Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues
2011
Transcriptional coregulators in the control of energy homeostasis
2007
A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
1998 Standout
PRDM16 controls a brown fat/skeletal muscle switch
2008 StandoutNature
Thermogenic Mechanisms and Their Hormonal Regulation
2006
Functional Brown Adipose Tissue in Healthy Adults
2009 Standout
Brown adipose tissue activity controls triglyceride clearance
2011
The mitochondrial uncoupling-protein homologues
2005
A Central Thermogenic-like Mechanism in Feeding Regulation: An Interplay between Arcuate Nucleus T3 and UCP2
2007
Brown adipose tissue clinical impact of a re-discovered thermogenic organ
2013
Different Metabolic Responses of Human Brown Adipose Tissue to Activation by Cold and Insulin
2011
Adipose-derived circulating miRNAs regulate gene expression in other tissues
2017 Nature
Uncoupling Protein 1 of Brown Adipocytes, the Only Uncoupler: A Historical Perspective
2011
Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals
2012
Ultra-Deep Sequencing of Mouse Mitochondrial DNA: Mutational Patterns and Their Origins
2011
Regulation of β-Adrenergic Receptor Signaling by S-Nitrosylation of G-Protein-Coupled Receptor Kinase 2
2007 StandoutNobel
Gramicidin S identified as a potent inhibitor for cytochrome bd‐type quinol oxidase
2008 StandoutNobel
Twist-1 Is a PPARδ-Inducible, Negative-Feedback Regulator of PGC-1α in Brown Fat Metabolism
2009
TSC2 regulates VEGF through mTOR-dependent and -independent pathways
2003 StandoutNobel
Transcriptional Control of Brown Fat Determination by PRDM16
2007
Functional Evolution of Leptin of Ochotona curzoniae in Adaptive Thermogenesis Driven by Cold Environmental Stress
2011
Control of brown and beige fat development
2016
Differential sympathetic drive to adipose tissues after food deprivation, cold exposure or glucoprivation
2008
Identification of Two Mammalian Reductases Involved in the Two-carbon Fatty Acyl Elongation Cascade
2003
The different shades of fat
2014 Nature
TRPV4 Is a Regulator of Adipose Oxidative Metabolism, Inflammation, and Energy Homeostasis
2012
Mitochondrial DNA Mutations Induce Mitochondrial Dysfunction, Apoptosis and Sarcopenia in Skeletal Muscle of Mitochondrial DNA Mutator Mice
2010
Brown adipose tissue regulates glucose homeostasis and insulin sensitivity
2012
Towards a molecular understanding of adaptive thermogenesis
2000 Nature
Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity.
1998
MyomiR-133 regulates brown fat differentiation through Prdm16
2012
Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
2012 Standout
The nuclear receptor co-repressor RIP140 controls the expression of metabolic gene networks
2006
Chronic cold exposure results in subcutaneous adipose tissue browning and altered global metabolism in Qinghai-Tibetan plateau pika (Ochotona curzoniae)
2018 StandoutNobel
Transcriptional control of adipocyte formation
2006 Standout
Up-Regulation of Mitochondrial Activity and Acquirement of Brown Adipose Tissue-Like Property in the White Adipose Tissue of Fsp27 Deficient Mice
2008
Evidence for a Compensated Thermogenic Defect in Transgenic Mice Lacking the Mitochondrial Glycerol-3-Phosphate Dehydrogenase Gene
2003
Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity
2018 StandoutNobel
Reduced Expression of FOXC2 and Brown Adipogenic Genes in Human Subjects with Insulin Resistance
2003
Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans
2012
The influence of bio-behavioural factors on tumour biology: pathways and mechanisms
2006
Autophagy regulates adipose mass and differentiation in mice
2009
Increased mitochondrial function downstream from KDM5A histone demethylase rescues differentiation in pRB-deficient cells
2015
Does Brown Adipose Tissue (BAT) Have a Role in the Physiology or Treatment of Human Obesity?
2001
Mitochondrial Membrane Permeabilization in Cell Death
2007 Standout
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
Angiogenesis and Vascular Functions in Modulation of Obesity, Adipose Metabolism, and Insulin Sensitivity
2013
PPARγ signaling and metabolism: the good, the bad and the future
2013 Standout
Comparative studies of the role of hormone-sensitive lipase and adipose triglyceride lipase in human fat cell lipolysis
2007
Understanding the brown adipocyte as a contributor to energy homeostasis
2013
RNAi screens reveal novel metabolic regulators: RIP140, MAP4k4 and the lipid droplet associated fat specific protein (FSP) 27
2007
Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat
2006
Adaptive thermogenesis in adipocytes: Is beige the new brown?
2013
Initiation of myoblast to brown fat switch by a PRDM16–C/EBP-β transcriptional complex
2009 Nature
Inhibition of myostatin protects against diet-induced obesity by enhancing fatty acid oxidation and promoting a brown adipose phenotype in mice
2011
Cold adaptive thermogenesis in small mammals from different geographical zones of China
2001
New insights into adipose tissue VEGF-A actions in the control of obesity and insulin resistance
2013
Functional characterization of UCP1 in mammalian HEK293 cells excludes mitochondrial uncoupling artefacts and reveals no contribution to basal proton leak
2012
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
2012
What We Talk About When We Talk About Fat
2014 Standout
Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation
2006
UCP1 deficiency increases susceptibility to diet‐induced obesity with age
2005
Desnutrin/ATGL Is Regulated by AMPK and Is Required for a Brown Adipose Phenotype
2011
High Prevalence of Brown Adipose Tissue in Adult Humans
2011
Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells
2012
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis
2011 Nature
Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure
2013
BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions
2012
Attainment of Brown Adipocyte Features in White Adipocytes of Hormone-Sensitive Lipase Null Mice
2008
The Δ337T mutation on the TRβ causes alterations in growth, adiposity, and hepatic glucose homeostasis in mice
2011
Adipocyte differentiation from the inside out
2006 Standout
Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases
2010
Expression of beta adrenergic receptors in mouse oocytes and preimplantation embryos
2005
Acquirement of Brown Fat Cell Features by Human White Adipocytes
2003
The Hallmarks of Aging
2013 Standout
A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy
2001
MicroRNA-133 Controls Brown Adipose Determination in Skeletal Muscle Satellite Cells by Targeting Prdm16
2013
Tumour necrosis factor‐α in human adipose tissue – from signalling mechanisms to clinical implications
2007
Role of adipose specific lipid droplet proteins in maintaining whole body energy homeostasis
2013
Expression of Uncoupling Protein 1 in Mouse Brown Adipose Tissue Is Thyroid Hormone Receptor-β Isoform Specific and Required for Adaptive Thermogenesis
2009
Transplantation of adipose tissue and stem cells: role in metabolism and disease
2010
(S)NO Signals: Translocation, Regulation, and a Consensus Motif
1997
Brown Fat and Skeletal Muscle: Unlikely Cousins?
2008
EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection
2016 StandoutNobel
Targeted Disruption of the β3-Adrenergic Receptor Gene
1995
Mitochondrial uncoupling as a target for drug development for the treatment of obesity
2001
Using brown adipose tissue to treat obesity – the central issue
2011
Role of sympathetic activity in controlling the expression of vascular endothelial growth factor in brown fat cells of lean and genetically obese rats
1999
Protection from Obesity and Diabetes by Blockade of TGF-β/Smad3 Signaling
2011
Adipokines and the Endocrine Role of Adipose Tissues
2015
Low-Dose Oral Propranolol Could Reduce Brown Adipose Tissue F-18 FDG Uptake in Patients Undergoing PET Scans
2007
Adipose Tissue as an Endocrine Organ
2004 Standout
The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue
2001
Forming functional fat: a growing understanding of adipocyte differentiation
2011
Developmental Origin of Fat: Tracking Obesity to Its Source
2007
The Tumor Necrosis Factor Ligand and Receptor Families
1996 StandoutNobel
Sympathetic and sensory innervation of brown adipose tissue
2010
Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue
2012
Bi-directional interconversion of brite and white adipocytes
2013
miR-133a Regulates Adipocyte Browning In Vivo
2013
Thyroid Hormone Effects on Mitochondrial Energetics
2008
Thyroid Hormone as a Determinant of Metabolic and Contractile Phenotype of Skeletal Muscle
2008
Thyroid Hormone and Adipocyte Differentiation
2008
Thyroid–Adrenergic Interactions: Physiological and Clinical Implications
2008
Resistance to Obesity by Repression of VEGF Gene Expression through Induction of Brown-Like Adipocyte Differentiation
2012
BROWN ADIPOSE TISSUE, β3-ADRENERGIC RECEPTORS, AND OBESITY
1997
Effect of noradrenaline on triacylglycerol synthesis in rat brown adipocytes
1989
Dichotomous effects of VEGF-A on adipose tissue dysfunction
2012
Mechanism of Thyroid-Hormone Regulated Expression of the SERCA Genes in Skeletal Muscle: Implications for Thermogenesis
2001
Glutathione ester prevents buthionine sulfoximine-induced cataracts and lens epithelial cell damage.
1989
Functional assessment of white and brown adipocyte development and energy metabolism in cell culture Dissociation of terminal differentiation and thermogenesis in brown adipocytes
1995
The Nuclear Receptor Corepressor (NCoR) Controls Thyroid Hormone Sensitivity and the Set Point of the Hypothalamic-Pituitary-Thyroid Axis
2011
Modulation of age-related insulin sensitivity by VEGF-dependent vascular plasticity in adipose tissues
2014
C/EBPα and the Corepressors CtBP1 and CtBP2 Regulate Repression of Select Visceral White Adipose Genes during Induction of the Brown Phenotype in White Adipocytes by Peroxisome Proliferator-Activated Receptor γ Agonists
2009
Adipose Tissue-Derived Factors: Impact on Health and Disease
2006
βAR Signaling Required for Diet-Induced Thermogenesis and Obesity Resistance
2002 StandoutScienceNobel
Control of white and brown adipose tissues by the autonomic nervous system
1987
A new form of cerebellar long-term potentiation is postsynaptic and depends on nitric oxide but not cAMP
2002 StandoutNobel
Paracrine and Endocrine Effects of Adipose Tissue on Cancer Development and Progression
2011
Long noncoding RNAs regulate adipogenesis
2013
Regulatory circuits controlling white versus brown adipocyte differentiation
2006
Loss of Perivascular Adipose Tissue on Peroxisome Proliferator–Activated Receptor-γ Deletion in Smooth Muscle Cells Impairs Intravascular Thermoregulation and Enhances Atherosclerosis
2012
Brown Adipose Tissue Growth and Development
2013
Individual Thermogenic Responses to Mild Cold and Overfeeding Are Closely Related
2007
Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex
2008
Modulation of mitochondrial respiration by nitric oxide: investigation by single cell fluorescence microscopy
1999
GRK2 contribution to the regulation of energy expenditure and brown fat function
2012
Cold acclimation recruits human brown fat and increases nonshivering thermogenesis
2013
Angiogenesis Inhibitor, TNP-470, Prevents Diet-Induced and Genetic Obesity in Mice
2004
Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria
2012
Emerging Roles for the Transforming Growth Factor-β Superfamily in Regulating Adiposity and Energy Expenditure
2010
Cholesterol increases kinetic, energetic, and mechanical stability of the human β2-adrenergic receptor
2012 StandoutNobel
The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation
2010
Method for Decreasing Uptake of 18F-FDG by Hypermetabolic Brown Adipose Tissue on PET
2008
Transcriptional Synergy and the Regulation of Ucp1 during Brown Adipocyte Induction in White Fat Depots
2005
SUMO-1 Regulates Body Weight and Adipogenesis via PPARγ in Male and Female Mice
2012
Transcriptional Control of Energy Homeostasis by the Estrogen-Related Receptors
2008
Brown and Beige Fat: Molecular Parts of a Thermogenic Machine
2015
Thiazolidinediones inhibit the expression of beta3-adrenergic receptors at a transcriptional level.
2000
FOXC2 controls Ang-2 expression and modulates angiogenesis, vascular patterning, remodeling, and functions in adipose tissue
2008
Triiodothyronine amplifies norepinephrine stimulation of uncoupling protein gene transcription by a mechanism not requiring protein synthesis.
1988
Peroxisome Proliferator-Activated Receptor-γ Coactivator 1α (PGC-1α): Transcriptional Coactivator and Metabolic Regulator
2003 Standout
An anthelmintic compound, nafuredin, shows selective inhibition of complex I in helminth mitochondria
2000 StandoutNobel
Emergence during development of the white-adipocyte cell phenotype is independent of the brown-adipocyte cell phenotype
2001
In uncontrolled diabetes, thyroid hormone and sympathetic activators induce thermogenesis without increasing glucose uptake in brown adipose tissue
2013
Calcium transport mechanisms in basolateral plasma membrane-enriched vesicles from rat parotid gland
1985
Peroxisome Proliferator-Activated Receptor-γ-Mediated Positive Energy Balance in the Rat Is Associated with Reduced Sympathetic Drive to Adipose Tissues and Thyroid Status
2008
A Functional Interaction between RIP140 and PGC-1α Regulates the Expression of the Lipid Droplet Protein CIDEA
2008
Forkhead Transcription Factor FoxO1 in Adipose Tissue Regulates Energy Storage and Expenditure
2007
The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue
2001
Agonist-induced conformational changes in the G-protein-coupling domain of the β 2 adrenergic receptor
2001 StandoutNobel
Anatomical Locations of Human Brown Adipose Tissue
2013
Beige differentiation of adipose depots in mice lacking prolactin receptor protects against high‐fat‐diet‐induced obesity
2012
Triiodothyronine induces UCP-1 expression and mitochondrial biogenesis in human adipocytes
2011
Vascular endothelial growth factor is important for brown adipose tissue development and maintenance
2013
A new thiazolidinedione, NC-2100, which is a weak PPAR-gamma activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice.
2000
Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice
2011
Thyroid Hormone Regulation of Metabolism
2014 Standout
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
Brown fat is essential for cold-induced thermogenesis but not for obesity resistance in aP2-Ucp mice
1998
Increased Oxygen Consumption in Human Adipose Tissue From the “Brown Adipose Tissue” Region
2013
SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging
2012
Structure-based discovery of β 2 -adrenergic receptor ligands
2009 StandoutNobel
Cellular cross-talk between epicardial adipose tissue and myocardium in relation to the pathogenesis of cardiovascular disease
2012
A Novel Therapeutic Approach to Treating Obesity through Modulation of TGFβ Signaling
2012
Uncoupling protein 1 expression and high-fat diets
2010
Cyclooxygenase-2 Controls Energy Homeostasis in Mice by de Novo Recruitment of Brown Adipocytes
2010 Science
Health Care–Associated Bloodstream Infections
2003
Thyroid Hormone Induced Brown Adipose Tissue and Amelioration of Diabetes in a Patient with Extreme Insulin Resistance
2009
Brown Fat Activation Mediates Cold-Induced Thermogenesis in Adult Humans in Response to a Mild Decrease in Ambient Temperature
2013
Mitochondrial uncoupling protein from mouse brown fat. Molecular cloning, genetic mapping, and mRNA expression.
1985
Restricting the Mobility of Gsα: Impact on Receptor and Effector Coupling
1999 StandoutNobel
Role of a New Mammalian Gene Family in the Biosynthesis of Very Long Chain Fatty Acids and Sphingolipids
2000
Defective thermoregulation, impaired lipid metabolism, but preserved adrenergic induction of gene expression in brown fat of mice lacking C/EBPβ
2005
Absence of increased oxygen consumption in brown adipose tissue of rats exhibiting "cafeteria" diet-induced thermogenesis
1988
Disruption of Thyroid Hormone Activation in Type 2 Deiodinase Knockout Mice Causes Obesity With Glucose Intolerance and Liver Steatosis Only at Thermoneutrality
2011
Hypoxia and Adipose Tissue Function and Dysfunction in Obesity
2013
Learning New Tricks from Old Dogs: β-Adrenergic Receptors Teach New Lessons on Firing Up Adipose Tissue Metabolism
2004
An endocrine role for brown adipose tissue?
2013
Development of insulin resistance in mice lacking PGC-1α in adipose tissues
2012
The sequence of the major protein stored in ovine ceroid lipofuscinosis is identical with that of the dicyclohexylcarbodiimide-reactive proteolipid of mitochondrial ATP synthase
1990 StandoutNobel
Intense (18)F-FDG uptake in brown fat can be reduced pharmacologically.
2004
Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury
2007 StandoutNobel
Implications of nonshivering thermogenesis for energy balance regulation in humans
2011
Pref-1 in brown adipose tissue: specific involvement in brown adipocyte differentiation and regulatory role of C/EBPδ
2012
Targeted deletion of thioesterase superfamily member 1 promotes energy expenditure and protects against obesity and insulin resistance
2012
Mitochondrial DNA mutations in disease and aging
2011
Liver X Receptor α Is a Transcriptional Repressor of the Uncoupling Protein 1 Gene and the Brown Fat Phenotype
2008
Kinetics of mitochondrial calcium transport. II. A kinetic description of the sodium-dependent calcium efflux mechanism of liver mitochondria and inhibition by ruthenium red and by tetraphenylphosphonium.
1986
Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes.
1993
Lipocalin-2 Deficiency Impairs Thermogenesis and Potentiates Diet-Induced Insulin Resistance in Mice
2010
p38 Mitogen-Activated Protein Kinase Is the Central Regulator of Cyclic AMP-Dependent Transcription of the Brown Fat Uncoupling Protein 1 Gene
2004
Reconstitution, identification, purification, and immunological characterization of the 110-kDa Na+/Ca2+ antiporter from beef heart mitochondria.
1992
Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat
2010
Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa
2015 StandoutNobel
Multilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes
2000
Blockade of the Activin Receptor IIB Activates Functional Brown Adipogenesis and Thermogenesis by Inducing Mitochondrial Oxidative Metabolism
2012
The Adipocyte-Expressed Forkhead Transcription Factor Foxc2 Regulates Metabolism Through Altered Mitochondrial Function
2011
Relating tissue/organ energy expenditure to metabolic fluxes in mouse and human: experimental data integrated with mathematical modeling
2014
PPARγ activation attenuates cold-induced upregulation of thyroid status and brown adipose tissue PGC-1α and D2
2012
Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization
1992
Sodium/Calcium Exchange: Its Physiological Implications
1999 Standout
Brown fat in breast cancer patients: analysis of serial 18F-FDG PET/CT scans
2006
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Thyroid Hormone and the Energetic Cost of Keeping Body Temperature
2005
Why are there so many adrenoceptor subtypes?
1994
Follistatin Targets Distinct Pathways To Promote Brown Adipocyte Characteristics in Brown and White Adipose Tissues
2017
Fat cells directly sense temperature to activate thermogenesis
2013
Extracellular microRNAs in human circulation are associated with miRISC complexes that are accessible to anti-AGO2 antibody and can bind target mimic oligonucleotides
2020 StandoutNobel
How Now, Brown Fat?
2008 Science
Association Between Brain Temperature and Dentate Field Potentials in Exploring and Swimming Rats
1993 StandoutScienceNobel
Works of Jan Nedergaard being referenced
Nonshivering thermogenesis and its adequate measurement in metabolic studies
2010
Norepinephrine as a morphogen?: its unique interaction with brown adipose tissue
1995
Gene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity
2011
Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages
2007
Recruited vs. nonrecruited molecular signatures of brown, “brite,” and white adipose tissues
2011
Thermogenesis challenges the adipostat hypothesis for body-weight control
2009
UCP1 and Defense against Oxidative Stress
2006
A Classical Brown Adipose Tissue mRNA Signature Partly Overlaps with Brite in the Supraclavicular Region of Adult Humans
2013
The Browning of White Adipose Tissue: Some Burning Issues
2014
UCP1: The Original Uncoupling Protein—and Perhaps the Only One? New Perspectives on UCP1, UCP2, and UCP3 in the Light of the Bioenergetics of the UCP1-Ablated Mice
1999
Life without UCP1: mitochondrial, cellular and organismal characteristics of the UCP1-ablated mice
2001
Within brown-fat cells, UCP1-mediated fatty acid-induced uncoupling is independent of fatty acid metabolism
2008
Euthyroid status is essential for the perinatal increase in thermogenin mRNA in brown adipose tissue of rat pups
1987
β3- and α1-Adrenergic Erk1/2 Activation Is Src- but Not Gi-mediated in Brown Adipocytes
2000
The Changed Metabolic World with Human Brown Adipose Tissue: Therapeutic Visions
2010
Thermogenically competent nonadrenergic recruitment in brown preadipocytes by a PPARγ agonist
2008
UCP1 in Brite/Beige Adipose Tissue Mitochondria Is Functionally Thermogenic
2013
Three years with adult human brown adipose tissue
2010
UCP1 is essential for adaptive adrenergic nonshivering thermogenesis
2006
Uncoupling protein-1 is not leaky
2010
Norepinephrine‐induced synthesis of the uncoupling protein thermogenin (UCP) and its mitochondrial targeting in brown adipocytes differentiated in culture
1990
Contrasting adrenergic effects on lipoprotein lipase gene expression in the brown adipose tissue of intact mice and in cultured brown adipocytes from mice
1997
Random Point Mutations with Major Effects on Protein-Coding Genes Are the Driving Force behind Premature Aging in mtDNA Mutator Mice
2009
Metabolic consequences of the presence or absence of the thermogenic capacity of brown adipose tissue in mice (and probably in humans)
2010
Unexpected evidence for active brown adipose tissue in adult humans
2007 Standout
Cold‐induced expression of the VEGF gene in brown adipose tissue is independent of thermogenic oxygen consumption
2005
UCP1: the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency
2001
Brown adipocytes differentiated in vitro can express the gene for the uncoupling protein thermogenin: Effects of hypothyroidism and norepinephrine
1989
Cig30 and Pitx3 Genes Are Arranged in a Partially Overlapping Tail-to-Tail Array Resulting in Complementary Transcripts
1999
Adenosine 5?-Monophosphate Is a Selective Inhibitor of the Brown Adipocyte Nonselective Cation Channel
2002
UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality
2009
UCP1 mRNA does not produce heat
2013
Depressed Thermogenesis but Competent Brown Adipose Tissue Recruitment in Mice Devoid of All Hormone-Binding Thyroid Hormone Receptors
2003
Norepinephrine Induces Vascular Endothelial Growth Factor Gene Expression in Brown Adipocytes through a β-Adrenoreceptor/cAMP/Protein Kinase A Pathway Involving Src but Independently of Erk1/2
2000
The ‘Novel’‘Uncoupling’ Proteins UCP2 and UCP3: What Do They Really do? Pros and Cons for Suggested Functions
2003
PPARγ in the control of brown adipocyte differentiation
2005
Genetic and functional characterization of clonally derived adult human brown adipocytes
2015
Kinetics of the inhibition of mitochondrial respiration by NO
1997
Distinct expression of muscle‐specific MicroRNAs (myomirs) in brown adipocytes
2008
Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes
2009
Brown Adipose Tissue: More Than an Effector of Thermogenesis?a
1998
Native UCP1 Displays Simple Competitive Kinetics between the Regulators Purine Nucleotides and Fatty Acids
2004
Physiological activation of brown adipose tissue destabilizes thermogenin mRNA
1987
The Interaction between Thyroid and Brown‐Fat Thermogenesis
1997
DNA synthesis in mouse brown adipose tissue is under β-adrenergic control
1989
Uncoupled respiration, ROS production, acute lipotoxicity and oxidative damage in isolated skeletal muscle mitochondria from UCP3-ablated mice
2011
SOD2 overexpression: enhanced mitochondrial tolerance but absence of effect on UCP activity
2005
Adipose tissue pathways involved in weight loss of cancer cachexia
2010
The effect of intermittent cold treatment on the adipose tissue of the cat
1986
A Dual Component Analysis Explains the Distinctive Kinetics of cAMP Accumulation in Brown Adipocytes
1999
Hypoxia-Independent Angiogenesis in Adipose Tissues during Cold Acclimation
2009
Adrenergic receptor density in brown adipose tissue of active and hibernating hamsters and ground squirrels
2006
Cultures of Adipose Precursor Cells from Brown Adipose Tissue and of Clonal Brown-Adipocyte- Like Cell Lines
2003
Induction of uncoupling protein in brown adipose tissue
1996
The Expression of Subunit c Correlates with and Thus May Limit the Biosynthesis of the Mitochondrial F0F1-ATPase in Brown Adipose Tissue
1995
Uncoupling proteins: A role in protection against reactive oxygen species—or not?
2006
Thermogenic Responses in Brown Fat Cells Are Fully UCP1-dependent
2000
Respiratory and Thermogenic Capacities of Cells and Mitochondria from Brown and White Adipose Tissue
2003
Studies of Thermogenesis and Mitochondrial Function in Adipose Tissues
2008
Norepinephrine-induced proliferation of brown fat cell precursors.
1994
Exclusive occurrence of thermogenin antigen in brown adipose tissue
1982
Parallel increases in amount of (3H)GDP binding and thermogenin antigen in brown-adipose-tissue mitochondria of cafeteria-fed rats
1984
Adrenergic regulation of brown adipocyte differentiation
1996
Alpha- and beta-adrenergic induction of the expression of the uncoupling protein thermogenin in brown adipocytes differentiated in culture.
1990
Regulation of expression of the lipoprotein lipase gene in brown adipose tissue
1992
Na+‐dependent, α‐adrenergic mobilization of intracellular (mitochondrial) Ca2+ in brown adipocytes
1984
Brown adipose tissue and non-shivering thermogenesis
1978
Beta-adrenergic, cAMP-mediated stimulation of proliferation of brown fat cells in primary culture. Mediation via beta 1 but not via beta 3 adrenoceptors.
1992
α- and β-adrenergic control of thermogenin mRNA expression in brown adipose tissue
1986
Norepinephrine-induced sustained inward current in brown fat cells: α1-mediated by nonselective cation channels
2000
Differential adrenergic regulation of the gene expression of the β-adrenoceptor subtypes β1, β2 and β3 in brown adipocytes
2000
Development of brown fat cells in monolayer culture
1983
Life without UCPI: mitochondrial, cellular and organismal characteristics of the UCPI-ablated mice
2001
The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue
2009
Genome-Wide Profiling of Peroxisome Proliferator-Activated Receptor γ in Primary Epididymal, Inguinal, and Brown Adipocytes Reveals Depot-Selective Binding Correlated with Gene Expression
2012
Increased alpha 1-adrenoceptor density in brown adipose tissue indicates recruitment drive in hypothyroid rats
1992
Hormone-induced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure
2014
Mitochondrial ATP synthase levels in brown adipose tissue are governed by the c‐Fo subunit P1 isoform
2007
The Brown Fat Cell
1982
Cig30, a Mouse Member of a Novel Membrane Protein Gene Family, Is Involved in the Recruitment of Brown Adipose Tissue
1997
Beta-adrenergic stimulation of lipoprotein lipase in rat brown adipose tissue during acclimation to cold
1984
A possible physiological role of the Na+/Ca2+ exchange mechanism of brown-fat mitochondria in the mediation of α1-adrenergic signals
1984
The uncoupling protein thermogenin during acclimation: indications for pretranslational control
1994
An essential role for Tbx15 in the differentiation of brown and “brite” but not white adipocytes
2012
[1] Overview—Preparation and properties of mitochondria from different sources
1979
Brown Adipose Tissue: Function and Physiological Significance
2004 Standout
Attenuation of Gs α coupling efficiency in brown-adipose-tissue plasma membranes from cold-acclimated hamsters
1993
Noradrenaline represses PPAR (peroxisome-proliferator-activated receptor) γ2 gene expression in brown adipocytes: intracellular signalling and effects on PPARγ2 and PPARγ1 protein levels
2004
Polyunsaturated fatty acids recruit brown adipose tissue: increased UCP content and NST capacity
1995
Only UCP1 can mediate adaptive nonshivering thermogenesis in the cold
2001
β1 to β3 Switch in Control of Cyclic Adenosine Monophosphate during Brown Adipocyte Development Explains Distinct β-Adrenoceptor Subtype Mediation of Proliferation and Differentiation1
1999
Neither brown nor white
2012 Nature
Stabilization of the mRNA for the uncoupling protein thermogenin by transcriptional/translational blockade and by noradrenaline in brown adipocytes differentiated in culture: a degradation factor induced by cessation of stimulation?
1994
Effects of Cations on Brown Adipose Tissue in Relation to Possible Metabolic Consequences of Membrane Depolarisation
1981
‘Neuropeptide tyrosine’ (NPY) is co-stored with noradrenaline in vascular but not in parenchymal sympathetic nerves of brown adipose tissue
1986
Signal transduction in brown adipose tissue recruitment: noradrenaline and beyond.
1996
Cold-induced beta-adrenergic recruitment of lipoprotein lipase in brown fat is due to increased transcription
1988
Modulation of calcium‐activated non‐selective cation channel activity by nitric oxide in rat brown adipose tissue.
1995
Microcalorimetry of isolated mammalian cells
1977 Nature
Na+‐dependent regulation of extramitochondrial Ca2+ by rat‐liver mitochondria
1984
Uncoupling proteins: current status and therapeutic prospects
2005
Norepinephrine‐Stimulated Fatty‐Acid Release and Oxygen Consumption in Isolated Hamster Brown‐Fat Cells
1979
The Bioenergetics of Brown Fat Mitochondria from UCP1-ablated Mice
1999
Postnatal recruitment of brown adipose tissue is induced by the cold stress experienced by the pups. An analysis of mRNA levels for thermogenin and lipoprotein lipase
1989
A Human-Specific Role of Cell Death-Inducing DFFA (DNA Fragmentation Factor-α)-Like Effector A (CIDEA) in Adipocyte Lipolysis and Obesity
2005
The Physiological Role of Pyruvate Carboxylation in Hamster Brown Adipose Tissue
1979
The biochemistry of an inefficient tissue: brown adipose tissue.
1985
Coexisting beta-adrenoceptor subtypes: significance for thermogenic process in brown fat cells
1994
Thermogenin amount and activity in hamster brown fat mitochondria: effect of cold acclimation
1987
Quantitative differentiation of α- and β-adrenergic respiratory responses in isolated hamster brown fat cells: Evidence for the presence of an α1-adrenergic component
1983
Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation
2004
Cold acclimation-recruited nonshivering thermogenesis: the Syrian hamster is not an exception
1995
β3-adremergic regulation of hamster brown adipocyte thermogenesis
1990
Brown adipose tissue thermogenesis in neonatal and cold-adapted animals
1986
Effects of Monovalent Cations on Ca(2+) Transport in Mitochondria; A Comparison between Brown Fat and Liver Mitochondria from Rat.
1980
A stringent validation of mouse adipose tissue identity markers
2015
A novel type of short- and medium-chain acyl-CoA hydrolases in brown adipose tissue mitochondria.
1988
Induction and degradation of the uncoupling protein thermogenin in brown adipocytes in vitro and in vivo. Evidence for a rapidly degradable pool
1992
Apparent thermogenic effect of injected glucagon is not due to a direct effect on brown fat cells
1998