Standout Papers
Citation Impact
Citing Papers
Protein molecules as computational elements in living cells
1995 Nature
Sustained Loss of a Neoplastic Phenotype by Brief Inactivation of MYC
2002 ScienceNobel
MYC Can Induce DNA Breaks In vivo and In vitro Independent of Reactive Oxygen Species
2006
Genomic and Proteomic Analysis Reveals a Threshold Level of MYC Required for Tumor Maintenance
2008
Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch
2006
The A- and B-type cyclin associated cdc2 kinases in Xenopus turn on and off at different times in the cell cycle.
1990 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Synaptotagmin I: A major Ca2+ sensor for transmitter release at a central synapse
1994 StandoutNobel
MYC Inactivation Elicits Oncogene Addiction through Both Tumor Cell-Intrinsic and Host-Dependent Mechanisms
2010
From molecular to modular cell biology
1999 StandoutNatureNobel
Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice
1991 Standout
Control of M-phase by maturation-promoting factor
1990
Regulation of progression through the Gl phase of the cell cycle by the rum1+ gene
1994 StandoutNatureNobel
MYC on the Path to Cancer
2012 Standout
Oncogene addiction: setting the stage for molecularly targeted cancer therapy
2007
Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model
2009
In vitro disassembly of the nuclear lamina and M phase-specific phosphorylation of lamins by cdc2 kinase
1990
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
2011 StandoutNature
Transcription-independent functions of MYC: regulation of translation and DNA replication
2008
Lack of sustained regression of c-MYC-induced mammary adenocarcinomas following brief or prolonged MYC inactivation
2004
c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression
2002
Oncogene addiction
2004
Epidermal growth factor receptor mutations in lung cancer
2007 Standout
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Commitment to Division in Ciliate Cell Cycles
1996
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
1994 StandoutNature
The interaction between Myc and Miz1 is required to antagonize TGFβ-dependent autocrine signaling during lymphoma formation and maintenance
2010
Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice
1995 StandoutNatureNobel
Developmental Context Determines Latency of MYC-Induced Tumorigenesis
2004
Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis
1990
The cyclin B2 component of MPF is a substrate for the c-mosxe proto-oncogene product
1990
Proliferation, cell cycle and apoptosis in cancer
2001 StandoutNature
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties
1992 StandoutNobel
c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations
2001
AID Is Required for c-myc/IgH Chromosome Translocations In Vivo
2004 StandoutNobel
Involvement of p34cdc2 in establishing the dependency of S phase on mitosis
1991 StandoutNatureNobel
Angiogenesis: an organizing principle for drug discovery?
2007 Standout
A Long Twentieth Century of the Cell Cycle and Beyond
2000 StandoutNobel
Visualizing the mechanical activation of Src
2005 StandoutNatureNobel
Models, mechanisms and clinical evidence for cancer dormancy
2007
The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein
1991 StandoutNobel
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
Cooperation between oncogenes
1991
Triggering of cyclin degradation in interphase extracts of amphibian eggs by cdc2 kinase
1990 StandoutNatureNobel
Conditional transgenic models define how MYC initiates and maintains tumorigenesis
2006
The c-Myc target gene network
2006
Tissue-specific and reversible RNA interference in transgenic mice
2007
A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia
2006
Intrinsic tumour suppression
2004 Nature
Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase.
1991
MYC as a regulator of ribosome biogenesis and protein synthesis
2010
Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product
1991 StandoutNobel
Oncogenes and signal transduction
1991 Standout
MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer
2004 NatureNobel
Molecular themes in oncogenesis
1991 StandoutNobel
c-Myc depletion inhibits proliferation of human tumor cells at various stages of the cell cycle
2007
Substrates for p34cdc2: In vivo veritas?
1990 StandoutNobel
Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva
1991 StandoutNatureNobel
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma
2006
Modelling Myc inhibition as a cancer therapy
2008 Nature
The fission yeast cdc18+ gene product couples S phase to START and mitosis
1993 StandoutNobel
Identification of a Gl-type cyclin puc1+ in the fission yeast Schizosaccharomyces pombe
1991 StandoutNatureNobel
Therapeutic Targeting of Myc
2010
Xenopus oocytes and the biochemistry of cell division
1990
Identification of major nucleolar proteins as candidate mitotic substrates of cdc2 kinase
1990
Transcriptional regulation and transformation by Myc proteins
2005
The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element
1989
Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma
1990 Nature
Regulation of mitosis by cyclic accumulation of p80cdc25 mitotic inducer in fission yeast
1990 StandoutNatureNobel
Identification of cell cycle-regulated phosphorylation sites on nuclear lamin C
1990
Essential functions of synapsins I and II in synaptic vesicle regulation
1995 StandoutNatureNobel
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
1997 Standout
Cyclin A and the retinoblastoma gene product complex with a common transcription factor
1991 StandoutNatureNobel
Independent inactivation of MPF and cytostatic factor (Mos) upon fertilization of Xenopus eggs
1991 StandoutNatureNobel
The role of Rab3A in neurotransmitter release
1994 StandoutNatureNobel
Neoplastic development in plasma cells
2003
In Vitro Cytotoxicity and In Vivo Efficacy, Pharmacokinetics, and Metabolism of 10074-G5, a Novel Small-Molecule Inhibitor of c-Myc/Max Dimerization
2010
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Universal control mechanism regulating onset of M-phase
1990 StandoutNatureNobel
An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance
2011
Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
2009 Standout
Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex
1994 StandoutNobel
Activation of the proto-oncogene p60c-src by point mutations in the SH2 domain.
1990
Oncogene Addiction
2008
Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation
2007
Defective double-strand DNA break repair and chromosomal translocations by MYC overexpression
2003
ras Oncogenes in Chemical Carcinogenesis
1989
Therapeutic potential of a synthetic lethal interaction between the MYC proto-oncogene and inhibition of aurora-B kinase
2010 Nobel
Effect of Microinjection of a Low-Mr Human Placenta Protein Tyrosine Phosphatase on Induction of Meiotic Cell Division in Xenopus Oocytes
1990 StandoutNobel
Checkpoints and spindles
1991 StandoutNatureNobel
Targeting MYC-Regulated miRNAs to Combat Cancer
2010
Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice
1992 StandoutScienceNobel
Differential Phosphorylation of c-Abl in Cell Cycle Determined by cdc 2 Kinase and Phosphatase Activity
1990 Science
Memory Suppressor Genes: Inhibitory Constraints on the Storage of Long-Term Memory
1998 StandoutScienceNobel
Complementation of the Mitotic Activator, p80 cdc25 , by a Human Protein-tyrosine Phosphatase
1990 StandoutScienceNobel
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Cell cycle controls: potential targets for chemical carcinogens?
1993
Correction: Identification of a Gl-type cyclin puc+ in the fission yeast Schizosaccharomyces pombe
1991 StandoutNatureNobel
A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells
2003
The Incredible Life and Times of Biological Cells
2000 StandoutScienceNobel
CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES
1997 Standout
Induction of ribosomal genes and hepatocyte hypertrophy by adenovirus-mediated expression of c-Myc in vivo
2000
Tumor Rejection After Direct Costimulation of CD8 + T Cells by B7-Transfected Melanoma Cells
1993 StandoutScienceNobel
c-Myc induces chromosomal rearrangements through telomere and chromosome remodeling in the interphase nucleus
2005
Angiogenesis
2006
C-Myc Is a Critical Mediator of the Phenotypes of Apc Loss in the Intestine
2008
Cell cycle arrest and c-mos
1992 StandoutNatureNobel
Kinetic evidence of a rapid activation of phosphatidylcholine hydrolysis by Ki-ras oncogene. Possible involvement in late steps of the mitogenic cascade.
1990
Platelet-Derived Growth Factor (PDGF)-Dependent Association of Phospholipase C-γ with the PDGF Receptor Signaling Complex
1990
Block in Anaphase Chromosome Separation Caused by a Telomerase Template Mutation
1997 StandoutScienceNobel
Regulation of the Ets-Related Transcription Factor Elf-1 by Binding to the Retinoblastoma Protein
1993 StandoutScienceNobel
Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model
2010
Cell cycle tyrosine phosphorylation of p34cdc2 and a microtubule-associated protein kinase homolog in Xenopus oocytes and eggs.
1991
mos gene transforming efficiencies correlate with oocyte maturation and cytostatic factor activities.
1991
Works of Jamie Bishop being referenced
Mitosis-specific phosphorylation of p60c-src by p34cdc2-associated protein kinase
1989 StandoutNobel
Reversible Tumorigenesis by MYC in Hematopoietic Lineages
1999
Transforming genes in chronic myelogenous leukemia.
1988
The severe combined immunodeficient (SCID) mouse as a model for human myeloid leukemias.
1992