Citation Impact
Citing Papers
A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles
2002 Standout
Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoei
2004 Standout
Origins of coevolution between residues distant in protein 3D structures
2017 StandoutNobel
Cracking the Polyketide Code
2004
The re-emergence of natural products for drug discovery in the genomics era
2015 Standout
Incorporation of Nonmethyl Branches by Isoprenoid-like Logic: Multiple β-Alkylation Events in the Biosynthesis of Myxovirescin A1
2007
An antibiotic factory caught in action
2004
Organocatalytic cascade reactions as a new tool in total synthesis
2010 Standout
Novel Intermolecular Iterative Mechanism for Biosynthesis of Mycoketide Catalyzed by a Bimodular Polyketide Synthase
2008
A Type II Polyketide Synthase from the Gram‐Negative Bacterium Stigmatella aurantiaca Is Involved in Aurachin Alkaloid Biosynthesis
2007
Natural products: A continuing source of novel drug leads
2013 Standout
The Leptomycin Gene Cluster and Its Heterologous Expression in Streptomyces lividans
2005
Virgaricin produced by Virgaria sp. FKI-4860
2012 StandoutNobel
Biosynthesis of novel carotenoid families based on unnatural carbon backbones: A model for diversification of natural product pathways
2006 StandoutNobel
Natural products: An evolving role in future drug discovery
2011 Standout
Type I polyketide biosynthesis in bacteria (Part A — erythromycin biosynthesis) (1994 to 2000)
2001
Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes
2001
Isolation and characterization of the epothilone biosynthetic gene cluster from Sorangium cellulosum
2000
Identification and analysis of the chivosazol biosynthetic gene cluster from the myxobacterial model strain Sorangium cellulosum So ce56
2005
A Complete Gene Cluster from Streptomyces nanchangensis NS3226 Encoding Biosynthesis of the Polyether Ionophore Nanchangmycin
2003
The ClusPro web server for protein–protein docking
2017 Standout
antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters
2015 Standout
The Enzymology of Combinatorial Biosynthesis
2003
Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase
2003
Cytochrome P450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2)
2003 StandoutNobel
Asymmetric spiroacetalization catalysed by confined Brønsted acids
2012 StandoutNatureNobel
The Hedamycin Locus Implicates a Novel Aromatic PKS Priming Mechanism
2004
Natural products for cancer chemotherapy
2010 Standout
A brief tour of myxobacterial secondary metabolism
2008
Organocatalytic Enantioselective Decarboxylative Aldol Reaction of Malonic Acid Half Thioesters with Aldehydes
2013 StandoutNobel
Alternative modular polyketide synthase expression controls macrolactone structure
2000 Nature
Natural products to drugs: natural product-derived compounds in clinical trials
2008 Standout
Skipping in a Hybrid Polyketide Synthase
2002
Biosynthesis of the red antibiotic, prodigiosin, in Serratia: identification of a novel 2‐methyl‐3‐n‐amyl‐pyrrole (MAP) assembly pathway, definition of the terminal condensing enzyme, and implications for undecylprodigiosin biosynthesis in Streptomyces
2005
A Type II Polyketide Synthase is Responsible for Anthraquinone Biosynthesis in Photorhabdus luminescens
2007
Asymmetric Organocatalytic Domino Reactions
2007 Standout
Analysis of Specific Mutants in the Lasalocid Gene Cluster: Evidence for Enzymatic Catalysis of a Disfavoured Polyether Ring Closure
2008
Metabolic engineering and directed evolution for the production of pharmaceuticals
2000
Structural control of polyketide formation in plant-specific polyketide synthases
2000
Natural Product Hybrids as New Leads for Drug Discovery
2003 Standout
Biosynthesis and attachment of novel bacterial polyketide synthase starter units
2001
Polyketide biosynthesis: a millennium review
2001 Standout
The Impact of Bacterial Genomics on Natural Product Research
2005
Polyketides, proteins and genes in fungi: programmed nano-machines begin to reveal their secrets
2007
Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization
2003
Isolation and Identification of Three New 5-Alkenyl-3,3(2H)-furanones from Two Streptomyces species using a Genomic Screening Approach
2006 StandoutNobel
CD1c Presentation of Synthetic Glycolipid Antigens with Foreign Alkyl Branching Motifs
2007 StandoutNobel
Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways
2008
Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork
2006
Engineering specificity of starter unit selection by the erythromycin‐producing polyketide synthase
2002
The contentious nature of soil organic matter
2015 StandoutNature
DNA‐Templated Organic Synthesis: Nature's Strategy for Controlling Chemical Reactivity Applied to Synthetic Molecules
2004 Standout
The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90
2000
Natural products in drug discovery
2008 Standout
Exploring the potential of endophytes from medicinal plants as sources of antimycobacterial compounds
2014
Combinatorial biosynthesis of polyketides and nonribosomal peptides
2001
Context-Dependent Behavior of the Enterocin Iterative Polyketide Synthase
2004
Analysis of the prodiginine biosynthesis gene cluster of Streptomyces coelicolor A3(2): new mechanisms for chain initiation and termination in modular multienzymes
2001
Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway
2000
The type I fatty acid and polyketide synthases: a tale of two megasynthases
2007
Myxovirescin A Biosynthesis is Directed by Hybrid Polyketide Synthases/Nonribosomal Peptide Synthetase, 3‐Hydroxy‐3‐Methylglutaryl–CoA Synthases, and trans‐Acting Acyltransferases
2006
Reveromycin A biosynthesis uses RevG and RevJ for stereospecific spiroacetal formation
2011
How antibiotics kill bacteria: from targets to networks
2010 Standout
Chain initiation on the soraphen-producing modular polyketide synthase from Sorangium cellulosum
2001
Multicomponent reactions for the synthesis of pyrroles
2010 Standout
The Biosynthetic Logic of Polyketide Diversity
2009 Standout
The biosynthesis of pramanicin in Stagonospora sp. ATCC 74235: a modified acyltetramic acid†
2000
Ribosomal Crystallography: Peptide Bond Formation, Chaperone Assistance, and Antibiotics Inactivation
2007 StandoutNobel
Structure and Malonyl CoA-ACP Transacylase Binding of Streptomyces coelicolor Fatty Acid Synthase Acyl Carrier Protein
2009
Prospects for Generating New Antibiotics
2002
Mechanisms of Antibiotic Resistance
2016 Standout
Ribosomal Synthesis of N-Methyl Peptides
2008 StandoutNobel
Total Synthesis of Borrelidin
2007 StandoutNobel
Priming Type II Polyketide Synthases via a Type II Nonribosomal Peptide Synthetase Mechanism
2006
Assembly-Line Enzymology for Polyketide and Nonribosomal Peptide Antibiotics: Logic, Machinery, and Mechanisms
2006
Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis
2003
23S rRNA 2058A→G Alteration Mediates Ketolide Resistance in Combination with Deletion in L22
2006 StandoutNobel
Organocatalytic Enantioselective Decarboxylative Aldol Reaction of Malonic Acid Half Thioesters with Aldehydes
2013 StandoutNobel
Chemical parameters influencing fine-tuning in the binding of macrolide antibiotics to the ribosomal tunnel
2007 StandoutNobel
Iterative catalyst controlled diastereodivergent synthesis of polypropionates
2016 StandoutNobel
Recent advances in the synthesis of pyrroles by multicomponent reactions
2014 Standout
Lomaiviticin Biosynthesis Employs a New Strategy for Starter Unit Generation
2014
Docking and scoring in virtual screening for drug discovery: methods and applications
2004 Standout
Aurachin‐Biosynthese im Gram‐negativen Bakterium Stigmatella aurantiaca: Beteiligung einer Typ‐II‐Polyketidsynthase
2007
Translation and Protein Synthesis: Macrolides
2005
Diversifying Carotenoid Biosynthetic Pathways by Directed Evolution
2005 StandoutNobel
Catalytic Dehydrogenative Cross-Coupling: Forming Carbon−Carbon Bonds by Oxidizing Two Carbon−Hydrogen Bonds
2011 Standout
Biosynthetic Pathway and Gene Cluster Analysis of Curacin A, an Antitubulin Natural Product from the Tropical Marine Cyanobacterium Lyngbya majuscula
2004
Ribosomal Crystallography: Peptide Bond Formation, Chaperone Assistance and Antibiotics Activity
2005 StandoutNobel
Straightforward Synthesis of α,β-Unsaturated Thioesters via Ruthenium-Catalyzed Olefin Cross-Metathesis with Thioacrylate
2008 StandoutNobel
Engineered Biosynthesis of Regioselectively Modified Aromatic Polyketides Using Bimodular Polyketide Synthases
2004
Total synthesis of borrelidin
2005 StandoutNobel
Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts
2015 StandoutNobel
Impact of Natural Products on Developing New Anti-Cancer Agents
2009 Standout
EngineeredStreptomyces avermitilisHost for Heterologous Expression of Biosynthetic Gene Cluster for Secondary Metabolites
2013 StandoutNobel
Translation and Protein Synthesis: Macrolides
2005
C-O Bond Formation by Polyketide Synthases
2002 Science
Cloning, Sequencing, and Functional Analysis of an Iterative Type I Polyketide Synthase Gene Cluster for Biosynthesis of the Antitumor Chlorinated Polyenone Neocarzilin in “ Streptomyces carzinostaticus ”
2004
Virtual Screening for Submicromolar Leads of tRNA-guanine Transglycosylase Based on a New Unexpected Binding Mode Detected by Crystal Structure Analysis
2003
Production of Polyunsaturated Fatty Acids by Polyketide Synthases in Both Prokaryotes and Eukaryotes
2001 Science
A Comprehensive Review on Medicinal Plants as Antimicrobial Therapeutics: Potential Avenues of Biocompatible Drug Discovery
2019 Standout
A C 35 Carotenoid Biosynthetic Pathway
2003 StandoutNobel
Structure and regulation of the omega-3 polyunsaturated fatty acid synthase genes from the deep-sea bacterium Photobacterium profundum strain SS9 The GenBank accession numbers for the sequences reported in this paper are AF409100 and AF467805.
2002
Flavonoid Biosynthesis. A Colorful Model for Genetics, Biochemistry, Cell Biology, and Biotechnology
2001 Standout
Polyketide Chain Length Control by Chain Length Factor
2003
Works of James Westcott being referenced
First in vitro directed biosynthesis of new compounds by a minimal type II polyketide synthase: evidence for the mechanism of chain length determinationElectronic supplementary information (ESI) available: LCMS spectra and detailed experimental procedures for all reported experiments. See http://www.rsc.org/suppdata/cc/b3/b300847a/
2003
A chain initiation factor common to both modular and aromatic polyketide synthases
1999 Nature
Synthesis and Characterisation of Acyl Carrier Protein Bound Polyketide Analogues
2002
Streptomyces coelicolor phosphopantetheinyl transferase: a promiscuous activator of polyketide and fatty acid synthase acyl carrier proteins
2002