Citation Impact
Citing Papers
Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner
2017
RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition
2014
Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors
2015
Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis
2014
Pyroptosis versus necroptosis: similarities, differences, and crosstalk
2018
Comprehensive genomic characterization of head and neck squamous cell carcinomas
2015 StandoutNature
Cellular IAP proteins and LUBAC differentially regulate necrosome-associated RIP1 ubiquitination
2015
An outline of necrosome triggers
2016
Poly-ubiquitination in TNFR1-mediated necroptosis
2016
Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists
2024 StandoutScienceNobel
MLKL and FADD Are Critical for Suppressing Progressive Lymphoproliferative Disease and Activating the NLRP3 Inflammasome
2016
The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR–IL-1R by controlling degradation of regnase-1
2011
MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death
2017
NF-κB in inflammation and renal diseases
2015
Signaling in Innate Immunity and Inflammation
2012
Cell death in chronic inflammation: breaking the cycle to treat rheumatic disease
2020
TNF and ROS Crosstalk in Inflammation
2016
It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival
2011
Myeloid-derived suppressor cells coming of age
2018 Standout
Autophagy in infection, inflammation and immunity
2013 Standout
Atypical ubiquitylation — the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages
2012
NF-κB signaling in inflammation
2017 Standout
RIP3: a molecular switch for necrosis and inflammation
2013
Ubiquitination in signaling to and activation of IKK
2012
Ferroptosis: Death by Lipid Peroxidation
2015 Standout
Necroptosis and its role in inflammation
2015 StandoutNature
Pseudomonas aeruginosa cleaves the decoding center of Caenorhabditis elegans ribosomes
2020 StandoutNobel
Dying cells actively regulate adaptive immune responses
2017
Mechanism and medical implications of mammalian autophagy
2018 Standout
Bacillus thuringiensis Crystal Protein Cry6Aa Triggers Caenorhabditis elegans Necrosis Pathway Mediated by Aspartic Protease (ASP-1)
2016
Chronic inflammation in the etiology of disease across the life span
2019 Standout
Sphingolipid metabolism in cancer signalling and therapy
2017
Regulated cell death and inflammation: an auto-amplification loop causes organ failure
2014
Death by TNF: a road to inflammation
2022
Targeting Ferroptosis to Iron Out Cancer
2019 Standout
MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death
2017
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
2019 Standout
Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis
2017
The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease
2015 Standout
NF-κB, the first quarter-century: remarkable progress and outstanding questions
2012 Standout
TRAF2 Sets a Threshold for Extrinsic Apoptosis by Tagging Caspase-8 with a Ubiquitin Shutoff Timer
2012
DNA damage-induced nuclear factor-kappa B activation and its roles in cancer progression
2017
NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling
2015
The increasing complexity of the ubiquitin code
2016
Kinase inhibition in autoimmunity and inflammation
2020
RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis
2014 Nature
Necroptosis and neutrophil-associated disorders
2018
The E3 Ligase Parkin Maintains Mitochondrial Integrity by Increasing Linear Ubiquitination of NEMO
2013
Immunogenic cell death in cancer and infectious disease
2016 Standout
The molecular machinery of regulated cell death
2019 Standout
p47 negatively regulates IKK activation by inducing the lysosomal degradation of polyubiquitinated NEMO
2012
The complexity of NF-κB signaling in inflammation and cancer
2013 Standout
HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death
2016
Necroptosis: A new way of dying?
2016
The non-canonical NF-κB pathway in immunity and inflammation
2017
IL-6 in Inflammation, Immunity, and Disease
2014 Standout
A long-awaited merger of the pathways mediating host defence and programmed cell death
2014
Necroptosis
2014
RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition
2013
Glutaminolysis and Transferrin Regulate Ferroptosis
2015 Standout
Integrin inactivators: balancing cellular functions in vitro and in vivo
2013
Drug repurposing: progress, challenges and recommendations
2018 Standout
Caspase Functions in Cell Death and Disease
2013 Standout
Emerging roles for Lys11-linked polyubiquitin in cellular regulation
2011
cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms
2011
RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation
2016 Nature
Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity
2018 StandoutNobel
Emerging Biological Principles of Metastasis
2017 Standout
RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis
2014 Nature
Non-kinase targets of protein kinase inhibitors
2017
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
2016 StandoutNature
Regulation of tumour necrosis factor signalling: live or let die
2015
Linear ubiquitination in NF-κB signaling and inflammation: What we do understand and what we do not
2011
Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways
2011
Activation of apoptosis signalling pathways by reactive oxygen species
2016 Standout
PROTAC targeted protein degraders: the past is prologue
2022 Standout
Ferroptosis: process and function
2016 Standout
LUBAC, a novel ubiquitin ligase for linear ubiquitination, is crucial for inflammation and immune responses
2012
RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3
2014
LUBAC-synthesized linear ubiquitin chains restrict cytosol-invading bacteria by activating autophagy and NF-κB
2017
Crosstalk in NF-κB signaling pathways
2011 Standout
The noncanonical NF‐κB pathway
2012
Developmental checkpoints guarded by regulated necrosis
2016
Mitochondria as multifaceted regulators of cell death
2019 Standout
CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3
2016
SHARPIN is an endogenous inhibitor of β1-integrin activation
2011
Ferroptosis: mechanisms, biology and role in disease
2021 Standout
The Ripoptosome, a Signaling Platform that Assembles in Response to Genotoxic Stress and Loss of IAPs
2011
Ferroptosis and Necroptosis in the Kidney
2020
Inflammasomes: mechanism of action, role in disease, and therapeutics
2015 Standout
Toll-Like Receptor Signaling Pathways
2014 Standout
Fluorescence-Based Sensors to Monitor Localization and Functions of Linear and K63-Linked Ubiquitin Chains in Cells
2012
NF-κB, inflammation, immunity and cancer: coming of age
2018 Standout
Tumor Necrosis Factor Inhibits Spread of Hepatitis C Virus Among Liver Cells, Independent From Interferons
2017 StandoutNobel
Dispensable roles of Gsdmd and Ripk3 in sustaining IL-1β production and chronic inflammation in Th17-mediated autoimmune arthritis
2021 StandoutNobel
CLOCK deubiquitylation by USP8 inhibits CLK/CYC transcription in Drosophila
2012 StandoutNobel
The intersection of cell death and inflammasome activation
2016
Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration
2017 StandoutNobel
Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation
2017
Exosomes
2019 Standout
Control of Life-or-Death Decisions by RIP1 Kinase
2013
Two independent pathways of regulated necrosis mediate ischemia–reperfusion injury
2013
Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses
2011 StandoutNobel
Molecular crosstalk between apoptosis, necroptosis, and survival signaling
2015
DAMP-sensing receptors in sterile inflammation and inflammatory diseases
2019 Standout
Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis
2016
The interplay of IKK , NF ‐κB and RIPK 1 signaling in the regulation of cell death, tissue homeostasis and inflammation
2017
Cytokine Storm
2020 Standout
Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis
2014
Essential Roles of K63-Linked Polyubiquitin-Binding Proteins TAB2 and TAB3 in B Cell Activation via MAPKs
2013
Copper induces cell death by targeting lipoylated TCA cycle proteins
2022 StandoutScience
The Biological Basis for Cardiac Repair After Myocardial Infarction
2016 Standout
Ferroptosis as a target for protection against cardiomyopathy
2019 Standout
The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension
2012
Inflammatory responses and inflammation-associated diseases in organs
2017 Standout
Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis
2016 Nature
Ubiquitin-Binding Proteins: Decoders of Ubiquitin-Mediated Cellular Functions
2012
Cutting Edge: RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice
2014
The Ubiquitin Code
2012 Standout
The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation
2014
Caspase‐8: regulating life and death
2017 Standout
Works of James Rickard being referenced
Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways
2017
In TNF-stimulated Cells, RIPK1 Promotes Cell Survival by Stabilizing TRAF2 and cIAP1, which Limits Induction of Non-canonical NF-κB and Activation of Caspase-8
2011
The diverse role of RIP kinases in necroptosis and inflammation
2015
Linear ubiquitination prevents inflammation and regulates immune signalling
2011 Nature
RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development
2018
TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1
2015
Inhibitor of Apoptosis Proteins (IAPs) Limit RIPK1-Mediated Skin Inflammation
2017