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Citing Papers
Integrative genomic and functional analyses reveal neuronal subtype differentiation bias in human embryonic stem cell lines
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Complete Replication of Hepatitis C Virus in Cell Culture
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The role of hedgehog signalling in tumorigenesis
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Activating Smoothened mutations in sporadic basal-cell carcinoma
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Direct conversion of fibroblasts to functional neurons by defined factors
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Differentiating the functional role of hypoxia‐inducible factor (HIF)‐1α and HIF‐2α (EPAS‐1) by the use of RNA interference: erythropoietin is a HIF‐2α target gene in Hep3B and Kelly cells
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The human erythropoietin-encoding gene contains a CAAT box, TATA boxes and other transcriptional regulatory elements in its 5' flanking region
1993
Identification of the renal erythropoietin-producing cells using transgenic mice
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Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
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Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein
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Hedgehog and Patched in Neural Development and Disease
1998
Cell Entry of Hepatitis C Virus Requires a Set of Co-receptors That Include the CD81 Tetraspanin and the SR-B1 Scavenger Receptor
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CATs and HATs: the SLC7 family of amino acid transporters
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Oxygen-regulated Transferrin Expression Is Mediated by Hypoxia-inducible Factor-1
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Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
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Conserved Receptor-binding Domains of Lake Victoria Marburgvirus and Zaire Ebolavirus Bind a Common Receptor
2006
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody
1998 StandoutNature
Burkitt's lymphoma cell lines reveal different degrees of tumorigenicity in nude mice
1988
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
1999 StandoutNatureNobel
Cell entry of hepatitis C virus
2006
The Interpretation of Position in a Morphogen Gradient as Revealed by Occupancy of Activin Receptors
1998 StandoutNobel
A Hedgehog-Insensitive Form of Patched Provides Evidence for Direct Long-Range Morphogen Activity of Sonic Hedgehog in the Neural Tube
2001
Cellular and molecular control of neurogenesis in the mammalian telencephalon
2005
Purification and cDNA sequence of an inducible nitric oxide synthase from a human tumor cell line
1993
Linkage of a prion protein missense variant to Gerstmann–Sträussler syndrome
1989 StandoutNatureNobel
Hedgehog Induces Opposite Changes in Turnover and Subcellular Localization of Patched and Smoothened
2000
Erythropoietin Gene Expression in Human, Monkey and Murine Brain
1996
Proteolysis That Is Inhibited by Hedgehog Targets Cubitus interruptus Protein to the Nucleus and Converts It to a Repressor
1997
Cellular Entry of Ebola Virus Involves Uptake by a Macropinocytosis-Like Mechanism and Subsequent Trafficking through Early and Late Endosomes
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The Energetics of Membrane Fusion from Binding, through Hemifusion, Pore Formation, and Pore Enlargement
2004
Plasma Membrane Is the Site of Productive HIV-1 Particle Assembly
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Ebola virus entry requires the cholesterol transporter Niemann–Pick C1
2011 StandoutNature
The role of the near upstream sequence in hypoxia-induced expression of the erythropoietin gene
1996
MX2 is an interferon-induced inhibitor of HIV-1 infection
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Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase
1995
Molecular biology of erythropoietin
1993 StandoutNobel
Transducing Hedgehog: the story so far
1998
Hedgehog signaling in animal development: paradigms and principles
2001 Standout
Recent advances in hedgehog signalling
1997
Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry
2007 StandoutNatureNobel
Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein
2000
Ebolavirus Is Internalized into Host Cells via Macropinocytosis in a Viral Glycoprotein-Dependent Manner
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Wingless Repression of Drosophila frizzled 2 Expression Shapes the Wingless Morphogen Gradient in the Wing
1998
Revealing the world of RNA interference
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Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
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Functional Requirement of the Hypoxia-responsive Element in the Activation of the Inducible Nitric Oxide Synthase Promoter by the Iron Chelator Desferrioxamine
1997
Lysosome-targeting chimaeras for degradation of extracellular proteins
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Hypoxia-induced accumulation of erythropoietin mRNA in isolated hepatocytes is inhibited by protein kinase C
1994
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
2002 Standout
Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term potentiation
1994 StandoutNatureNobel
Organoid single-cell genomic atlas uncovers human-specific features of brain development
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Nitric oxide and arthritis
1993
Hypoxic Induction of the Human Erythropoietin Gene: Cooperation between the Promoter and Enhancer, Each of Which Contains Steroid Receptor Response Elements
1992
Transformation of quail embryo fibroblasts by a retrovirus carrying a normal human c-myc gene.
1986
The long and the short of long–term memory—a molecular framework
1986 StandoutNatureNobel
Cellular Oncogenes and Multistep Carcinogenesis
1983 Science
Three different activated ras genes in mouse tumours; evidence for oncogene activation during progression of a mouse lymphoma.
1984
T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus
2011
Checkpoints: Controls That Ensure the Order of Cell Cycle Events
1989 StandoutScienceNobel
A 24-base-pair sequence 3' to the human erythropoietin gene contains a hypoxia-responsive transcriptional enhancer.
1993
Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform.
1992
A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter.
1995
Regulatory elements of the erythropoietin gene
1991
The Action of Oncogenes in the Cytoplasm and Nucleus
1985 Science
Fibroblast lines expressing activated c-myc oncogenes are tumorigenic in nude mice and syngeneic animals
1984
Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte.
1993
THE MOLECULAR GENETICS OF CELLULAR ONCOGENES
1984
Human erythropoietin gene expression in transgenic mice: multiple transcription initiation sites and cis-acting regulatory elements.
1990 StandoutNobel
Comparison of the human and mouse erythropoietin genes shows extensive homology in the flanking regions
1993 StandoutNobel
Amplification of N- myc in Untreated Human Neuroblastomas Correlates with Advanced Disease Stage
1984 StandoutScienceNobel
Rbx1, a Component of the VHL Tumor Suppressor Complex and SCF Ubiquitin Ligase
1999 StandoutScienceNobel
Inhibition of mitochondrial respiration elevates oxygen concentration but leaves regulation of hypoxia-inducible factor (HIF) intact
2005
Biological properties of human c-Ha-ras1 genes mutated at codon 12
1984 Nature
The Chromosomal Basis of Human Neoplasia
1983 Science
Characterization of hypoxia-responsive enhancer in the human erythropoietin gene shows presence of hypoxia-inducible 120-Kd nuclear DNA-binding protein in erythropoietin-producing and nonproducing cells
1993
Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents
1995 StandoutNobel
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Embryonal Carcinoma P19 Cells Produce Erythropoietin Constitutively But Express Lactate Dehydrogenase in an Oxygen-Dependent Manner
1998 StandoutNobel
Augmented expression of normal c-myc is sufficient for cotransformation of rat embryo cells with a mutant ras gene.
1985
Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2
2012 StandoutNobel
Ebolavirus Glycoprotein Structure and Mechanism of Entry
2009
Pathogenesis of Burkitt lymphoma: Expression of an activated c-myc oncogene causes the tumorigenic conversion of EBV-infected human B lymphoblasts
1987
The teratogenic Veratrum alkaloid cyclopamine inhibits Sonic hedgehog signal transduction
1998
Structural Determinants of Ion Flow Through Recombinant Glutamate Receptor Channels
1991 StandoutScienceNobel
Expression of a homologously recombined erythopoietin-SV40 T antigen fusion gene in mouse liver: evidence for erythropoietin production by Ito cells
1994 StandoutNobel
Oncogene amplification during tumorigenesis of established rat fibroblasts reversibly transformed by activated human ras oncogenes.
1986
The Cationic Properties of SEVI Underlie Its Ability To Enhance Human Immunodeficiency Virus Infection
2008
Small molecule modulation of Smoothened activity
2002 Standout
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.
1992 StandoutNobel
Role of Endosomal Cathepsins in Entry Mediated by the Ebola Virus Glycoprotein
2006
Hepatitis C Virus Entry Depends on Clathrin-Mediated Endocytosis
2006
Evolution of tumours and the impact of molecular oncology
1985 Nature
A novel combination of K-ras and myc amplification accompanied by point mutational activation of K-ras in a human lung cancer.
1984
Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism.
1993 StandoutNobel
Regulation of the Erythropoietin Gene: Evidence That the Oxygen Sensor Is a Heme Protein
1988 Science
Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin.
1994
A Nuclear Factor Induced by Hypoxia via De Novo Protein Synthesis Binds to the Human Erythropoietin Gene Enhancer at a Site Required for Transcriptional Activation
1992 StandoutNobel
Structure of the VHL-ElonginC-ElonginB Complex: Implications for VHL Tumor Suppressor Function
1999 StandoutScienceNobel
Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice.
1991 StandoutNobel
Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein.
1996 StandoutNobel
Evolution and cell-type specificity of human-specific genes preferentially expressed in progenitors of fetal neocortex
2018
Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer.
1994 StandoutNobel
Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death.
1995 StandoutNobel
Viruses in Human Cancers
1991 StandoutScienceNobel
Sonic Hedgehog Induces the Segregation of Patched and Smoothened in Endosomes
2002
Human Erythropoietin Gene Expression in Transgenic Mice: Multiple Transcription Initiation Sites and cis-Acting Regulatory Elements
1990 StandoutNobel
The Molecular Genetics of Cancer
1987 StandoutScienceNobel
Carbon Monoxide: a Putative Neural Messenger
1993 StandoutScience
Consequences of widespread deregulation of the c-myc gene in transgenic mice: Multiple neoplasms and normal development
1986
Characterization of the Early Steps of Hepatitis C Virus Infection by Using Luciferase Reporter Viruses
2006
NIH/3T3 cells transfected with human tumor DNA containing activated ras oncogenes express the metastatic phenotype in nude mice.
1985
Enhancer element at the 3'-flanking region controls transcriptional response to hypoxia in the human erythropoietin gene
1991
The Orphan Receptor Hepatic Nuclear Factor 4 Functions as a Transcriptional Activator for Tissue-Specific and Hypoxia-Specific Erythropoietin Gene Expression and Is Antagonized by EAR3/COUP-TF1
1995
Adverse Effects of Cigarette Smoke on NO Bioavailability
2006
Smoothened Mutants Reveal Redundant Roles for Shh and Ihh Signaling Including Regulation of L/R Asymmetry by the Mouse Node
2001
Hypoxic induction of the human erythropoietin gene: cooperation between the promoter and enhancer, each of which contains steroid receptor response elements.
1992
Time- and Temperature-Dependent Activation of Hepatitis C Virus for Low-pH-Triggered Entry
2006 StandoutNobel
Membrane Fusion: Grappling with SNARE and SM Proteins
2009 StandoutScienceNobel
Oncogene Amplification in Tumor Cells
1986
Molecular cloning, structure, and chromosomal localization of the human inducible nitric oxide synthase gene.
1994
Enhancement by hypoxia of human erythropoietin gene transcription in vitro.
1990
A novel site of erythropoietin production. Oxygen-dependent production in cultured rat astrocytes.
1994
A Forward Genetic Strategy Reveals Destabilizing Mutations in the Ebolavirus Glycoprotein That Alter Its Protease Dependence during Cell Entry
2009
Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for Patched
1999
Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene.
1991 StandoutNobel
Hepatitis C Virus Entry Requires a Critical Postinternalization Step and Delivery to Early Endosomes via Clathrin-Coated Vesicles
2006
Polycythemia in transgenic mice expressing the human erythropoietin gene.
1989 StandoutNobel
Phorbol ester inhibits erythropoietin production in human hepatoma cells (Hep G2)
1992 StandoutNobel
Erythropoietin mRNA levels are governed by both the rate of gene transcription and posttranscriptional events
1991
Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants
1997 StandoutScience
Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia.
1993 StandoutNobel
The position of lysosomes within the cell determines their luminal pH
2016
Induction of Hypoxia-Inducible Factor-1, Erythropoietin, Vascular Endothelial Growth Factor, and Glucose Transporter-1 by Hypoxia: Evidence Against a Regulatory Role for Src Kinase
1997 StandoutNobel
Morphogen gradient interpretation
2001 StandoutNatureNobel
In vivo and in vitro regulation of erythropoietin mRNA: measurement by competitive polymerase chain reaction
1993
Desferrioxamine induces erythropoietin gene expression and hypoxia- inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction
1993
Nitric oxide synthases in mammals
1994 Standout
Small interfering RNA production by enzymatic engineering of DNA (SPEED)
2004
Works of James M. Cunningham being referenced
Endosomal Proteolysis of the Ebola Virus Glycoprotein Is Necessary for Infection
2005 Science
Retroviral Entry Mediated by Receptor Priming and Low pH Triggering of an Envelope Glycoprotein
2000
Visualization of Retroviral Replication in Living Cells Reveals Budding into Multivesicular Bodies
2003
Biochemical evidence that Patched is the Hedgehog receptor
1996 StandoutNature
Sequential phases of cortical specification involve Neurogenin‐dependent and ‐independent pathways
2004
A putative murine ecotropic retrovirus receptor gene encodes a multiple membrane-spanning protein and confers susceptibility to virus infection
1989
Activated Oncogenes in Burkitt’s Lymphoma
1984
A Virus-Virus Interaction Circumvents the Virus Receptor Requirement for Infection by Pathogenic Retroviruses
2003
Modular organization of the Friend murine leukemia virus envelope protein underlies the mechanism of infection
2001
Characterization of a human colon/lung carcinoma oncogene
1983 Nature
Structure and Mechanism of a Coreceptor for Infection by a Pathogenic Feline Retrovirus
2003
The N-rasoncogene assigned to the short arm of human chromosome 1
1983
The regulated expression of erythropoietin by two human hepatoma cell lines.
1987
Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.
1992
The Mature Avian Leukosis Virus Subgroup A Envelope Glycoprotein Is Metastable, and Refolding Induced by the Synergistic Effects of Receptor Binding and Low pH Is Coupled to Infection
2004
Anemia and perinatal death result from loss of the murine ecotropic retrovirus receptor mCAT-1.
1997
Structure of a Murine Leukemia Virus Receptor-Binding Glycoprotein at 2.0 Angstrom Resolution
1997 Science
The HL-60 transforming sequence: A ras oncogene coexisting with altered myc genes in hematopoietic tumors
1983