James Luccarelli

Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging

De novo design of modular and tunable protein biosensors

Mechanisms, regulation and functions of the unfolded protein response

BCL-2 family proteins: changing partners in the dance towards death

The molecular machinery of regulated cell death

mTOR at the nexus of nutrition, growth, ageing and disease

RAS-targeted therapies: is the undruggable drugged?

Tau in physiology and pathology

Small-molecule Mcl-1 inhibitors: Emerging anti-tumor agents

Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites

Targeting apoptosis in cancer therapy

Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices

PROTAC targeted protein degraders: the past is prologue

The Hydrophobic Effect Revisited—Studies with Supramolecular Complexes Imply High‐Energy Water as a Noncovalent Driving Force

Effect of explicit water molecules on ligand-binding affinities calculated with the MM/GBSA approach

The MM/PBSA and MM/GBSA methods to estimate ligand-binding affinities

BCL-2 family isoforms in apoptosis and cancer

Glutamate Stimulates Local Protein Synthesis in the Axons of Rat Cortical Neurons by Activating α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors and Metabotropic Glutamate Receptors

Protein–Protein Interactions: Emerging Oncotargets in the RAS-ERK Pathway

Small-molecule allosteric inhibitors of BAX

Mitochondria as multifaceted regulators of cell death

Dopamine in Motivational Control: Rewarding, Aversive, and Alerting

Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial

Emerging Methods and Design Principles for Cell‐Penetrant Peptides

Macrocyclic Peptides as Drug Candidates: Recent Progress and Remaining Challenges

Cucurbituril-Based Molecular Recognition

VGLUT2 in dopamine neurons is required for psychostimulant-induced behavioral activation

Physiological release of endogenous tau is stimulated by neuronal activity

A Direct Comparison of the MM-GB/SA Scoring Procedure and Free-Energy Perturbation Calculations Using Carbonic Anhydrase as a Test Case: Strengths and Pitfalls of Each Approach

Cell Penetration Profiling Using the Chloroalkane Penetration Assay

A Large-Scale Test of Free-Energy Simulation Estimates of Protein–Ligand Binding Affinities

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

Stapled β-Hairpins Featuring 4-Mercaptoproline

Glutamate Controls Growth Rate and Branching of Dopaminergic Axons

Allosteric sensitization of proapoptotic BAX

Allosteric inhibition of antiapoptotic MCL-1

Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD

Cellular Uptake and Ultrastructural Localization Underlie the Pro-apoptotic Activity of a Hydrocarbon-stapled BIM BH3 Peptide

Effects of Water Placement on Predictions of Binding Affinities for p38α MAP Kinase Inhibitors

Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices