Standout Papers
Citation Impact
Citing Papers
Formation of the First Peptide Bond: The Structure of EF-P Bound to the 70 S Ribosome
2009 StandoutScienceNobel
Structural Roles for Human Translation Factor eIF3 in Initiation of Protein Synthesis
2005 StandoutScienceNobel
From molecular to modular cell biology
1999 StandoutNatureNobel
Growth Factor‐Stimulated Phosphorylation Cascades: Activation of Growth Factor‐Stimulated Map Kinase
2007
Recent progress in characterization of protein kinase cascades for phosphorylation of ribosomal protein S6
1991
Raf-1 activates MAP kinase-kinase
1992 Nature
Communication Between Eukaryotic Translation Initiation Factors 1 and 1A on the Yeast Small Ribosomal Subunit
2003
ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
1991 Standout
Translation initiation: structures, mechanisms and evolution
2004
The Cryo-EM Structure of a Translation Initiation Complex from Escherichia coli
2005 StandoutNobel
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
1995 StandoutNature
Monokine production by microglial cell clones
1989
Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen‐activated protein (MAP) kinase and MAP‐kinase‐activated kinases 1 and 2
1993
MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo
1993
What recent ribosome structures have revealed about the mechanism of translation
2009 StandoutNatureNobel
Photochemical Regulation of DNA‐Binding Specificity of MyoD
2005
Purification and properties of extracellular regulated kinase 1, an insulin-stimulated microtubule-associated protein 2 kinase
1991
TPA‐induced activation of MAP kinase
1991
ERKs, extracellular signal-regulated MAP-2 kinases
1991
The MAP kinase cascade. Discovery of a new signal transduction pathway
1993
Initiation of mRNA translation in prokaryotes
1990
Central nervous system control of food intake
2000 StandoutNature
A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
1994 StandoutNobel
Evidence for communication between nerve growth factor and protein tyrosine phosphorylation
1990
Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation
1995 Standout
Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins
1994 StandoutScience
Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases
1991 Nature
Structure of mammalian eIF3 in the context of the 43S preinitiation complex
2015 StandoutNatureNobel
Heterogeneous expression of four MAP kinase isoforms in human tissues
1992
Identification of an Activator of the Microtubule‐Associated Protein 2 Kinases ERK1 and ERK2 in PC12 Cells Stimulated with Nerve Growth Factor or Bradykinin
1992 StandoutNobel
Purification and characterisation of the insulin‐stimulated protein kinase from rabbit skeletal muscle; close similarity to S6 kinase II
1991
Insulin signalling and the regulation of glucose and lipid metabolism
2001 StandoutNature
The Translational Fidelity Function of IF3 During Transition from the 30 S Initiation Complex to the 70 S Initiation Complex
2007
Oncogenes and signal transduction
1991 Standout
RF3 Induces Ribosomal Conformational Changes Responsible for Dissociation of Class I Release Factors
2007 StandoutNobel
Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva
1991 StandoutNatureNobel
Inositol trisphosphate and calcium signalling
1993 StandoutNature
Mitogen-Activated Protein Kinase and Cytoskeleton in Mitogenic Signal Transduction
1992
WRM-1 Activates the LIT-1 Protein Kinase to Transduce Anterior/Posterior Polarity Signals in C. elegans
1999 StandoutNobel
Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase
1994 StandoutScience
lin-35 and lin-53, Two Genes that Antagonize a C. elegans Ras Pathway, Encode Proteins Similar to Rb and Its Binding Protein RbAp48
1998 StandoutNobel
Ribosome Structure and the Mechanism of Translation
2002 StandoutNobel
Insulin Action and the Insulin Signaling Network*
1995
cPLA2 is phosphorylated and activated by MAP kinase
1993 Standout
Structure of the Mammalian Ribosomal 43S Preinitiation Complex Bound to the Scanning Factor DHX29
2013 StandoutNobel
The MAP Kinase Cascade
1995 Nobel
Protein Tyrosine Phosphatases: A Diverse Family of Intracellular and Transmembrane Enzymes
1991 Science
Physical contact between lipopolysaccharide and Toll-like receptor 4 revealed by genetic complementation
2000 StandoutNobel
Activation of mitogen-activated protein kinase in BC3H1 myocytes by fluoroaluminate
1991
Gamma interferon induces rapid and coordinate activation of mitogen-activated protein kinase (extracellular signal-regulated kinase) and calcium-independent protein kinase C in human monocytes
1994
Structural insights on the translation initiation complex: ghosts of a universal initiation complex
2006 StandoutNobel
Cytokinetic failure and asynchronous nuclear division in BHK cells overexpressing a truncated protein-tyrosine-phosphatase.
1992 StandoutNobel
Regulation of Protein Serine-Threonine Phosphatase Type-2A by Tyrosine Phosphorylation
1992 Science
The G-protein-coupled receptor phosphatase: a protein phosphatase type 2A with a distinct subcellular distribution and substrate specificity.
1995 StandoutNobel
Differentiation of Monocytes into Dendritic Cells in a Model of Transendothelial Trafficking
1998 StandoutScienceNobel
Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro.
1993
Epidermal growth factor (EGF) receptor T669 peptide kinase from 3T3-L1 cells is an EGF-stimulated "MAP" kinase.
1991
Protein-protein interactions: methods for detection and analysis
1995
Erks: their fifteen minutes has arrived.
1992
Tyrosine phosphorylation and activation of homologous protein kinases during oocyte maturation and mitogenic activation of fibroblasts.
1991
Photocontrol of DNA Binding Specificity of a Miniature Engrailed Homeodomain
2005
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
1995 StandoutScience
Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase).
1991
Isolation and characterization of two growth factor-stimulated protein kinases that phosphorylate the epidermal growth factor receptor at threonine 669
1991
Growth factor-induced activation of a kinase activity which causes regulatory phosphorylation of p42/microtubule-associated protein kinase.
1992
Nerve growth factor stimulates a novel protein kinase in PC-12 cells that phosphorylates and activates mitogen-activated protein kinase kinase (MEK)
1995
Xenopus MAP kinase activator: identification and function as a key intermediate in the phosphorylation cascade.
1992
Phosphorylation/dephosphorylation of the beta-adrenergic receptor regulates its functional coupling to adenylate cyclase and subcellular distribution.
1986 StandoutNobel
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).
1994 Standout
Binding of the cyclic AMP receptor protein of Escherichia coli to RNA polymerase
1988
Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C
1992 StandoutScience
Crystal Structure of an Initiation Factor Bound to the 30 S Ribosomal Subunit
2001 StandoutScienceNobel
Renaturation and partial peptide sequencing of mitogen-activated protein kinase (MAP kinase) activator from rabbit skeletal muscle
1992
Requirements for Phosphorylation of Map Kinase During Meiosis in Xenopus Oocytes
1992 Science
Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells.
1992
MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase.
1992
Thyrotropin-releasing hormone stimulates MAP kinase activity in GH3 cells by divergent pathways. Evidence of a role for early tyrosine phosphorylation.
1994
G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein.
1995 StandoutNobel
X-ray crystallography shows that translational initiation factor IF3 consists of two compact alpha/beta domains linked by an alpha-helix.
1995 StandoutNobel
Bipartite Ca 2+ -Binding Motif in C 2 Domains of Synaptotagmin and Protein Kinase C
1996 StandoutScienceNobel
Xenopus MAP kinase activator is a serine/threonine/tyrosine kinase activated by threonine phosphorylation.
1992
MAP kinase activator from insulin-stimulated skeletal muscle is a protein threonine/tyrosine kinase.
1992
Bacterial lipopolysaccharide stimulates protein tyrosine phosphorylation in macrophages.
1991
Rapid stimulation of Ser/Thr protein kinases following treatment of Swiss 3T3 cells with bombesin. Involvement of casein kinase-2 in the signaling pathway of bombesin.
1992
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Do agonists promote rapid internalization of beta-adrenergic receptors?
1985
Overexpression of mitogen-activated protein kinase kinase (MAPKK) and its mutants in NIH 3T3 cells. Evidence that MAPKK involvement in cellular proliferation is regulated by phosphorylation of serine residues in its kinase subdomains VII and VIII.
1994 Nobel
Crystal Structure of a CAP-DNA Complex: the DNA Is Bent by 90°
1991 StandoutScienceNobel
Activation of Mitogen-Activated Protein Kinase Kinase by v-Raf in NIH 3T3 Cells and in Vitro
1992 StandoutScience
Multiple components in an epidermal growth factor-stimulated protein kinase cascade
1991
Repeated pulses of serotonin required for long-term facilitation activate mitogen-activated protein kinase in sensory neurons of Aplysia
1998 StandoutNobel
Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies.
1991
Genetic interactions affecting touch sensitivity in Caenorhabditis elegans.
1996 StandoutNobel
Tumor necrosis factor stimulates multiple serine/threonine protein kinases in Swiss 3T3 and L929 cells. Implication of casein kinase-2 and extracellular signal-regulated kinases in the tumor necrosis factor signal transduction pathway.
1992
Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds
2001 StandoutNobel
Phorbol ester stimulates a protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product.
1992
Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation.
1991
The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells.
1995
Involvement of Protein Kinase C in Platelet-activating Factor-stimulated Diacylglycerol Accumulation in Murine Peritoneal Macrophages
1989
A synthetic inhibitor of the mitogen-activated protein kinase cascade.
1995 Standout
Evidence for an epidermal growth factor-stimulated protein kinase cascade in Swiss 3T3 cells. Activation of serine peptide kinase activity by myelin basic protein kinases in vitro.
1990
The process of mRNA–tRNA translocation
2007 StandoutNobel
The phorbol ester-dependent activator of the mitogen-activated protein kinase p42mapk is a kinase with specificity for the threonine and tyrosine regulatory sites.
1992
Activation of MAP kinases by calcium-dependent and calcium-independent pathways. Stimulation by thapsigargin and epidermal growth factor.
1992
Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85
1984 StandoutNobel
Binding of Escherichia coli protein synthesis initiation factor IF1 to 30S ribosomal subunits measured by fluorescence polarization
1986
Interleukin-1 represents a new modality for the activation of extracellular signal-regulated kinases/microtubule-associated protein-2 kinases.
1991
Extracellular signal-regulated kinases: ERKs in progress.
1991
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Location of translational initiation factor IF3 on the small ribosomal subunit
1999 StandoutNobel
Metabolism of ubiquitinated histones.
1981 StandoutNobel
Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein.
1992
Nuclear localization and regulation of erk- and rsk-encoded protein kinases.
1992
Macrosialin, a macrophage-restricted membrane sialoprotein differentially glycosylated in response to inflammatory stimuli.
1991
Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase.
1994
ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ.
1992
Bombesin and epidermal growth factor stimulate the mitogen-activated protein kinase through different pathways in Swiss 3T3 cells
1993
Okadaic acid induces interphase to mitotic-like microtubule dynamic instability by inactivating rescue.
1992
Works of James E. Weiel being referenced
Phorbol esters and calcium ionophore can prime murine peritoneal macrophages for tumor cell destruction.
1986
Regulation of S6 kinase activity in Madin-Darby canine kidney renal epithelial cells.
1990
Biochemical models of gamma-interferon action: altered expression of transferrin receptors on murine peritoneal macrophages after treatment in vitro with PMA or A23187.
1985
Quiescent lymphocytes express intracellular transferrin receptors
1984
Effects of bacterial lipopolysaccharide on the hydrolysis of phosphatidylinositol-4,5-bisphosphate in murine peritoneal macrophages.
1987
Expression of the transferrin receptor in murine peritoneal macrophages is modulated in the different stages of activation.
1984
LPS induces altered phosphate labeling of proteins in murine peritoneal macrophages.
1986
Identification of multiple epidermal growth factor-stimulated protein serine/threonine kinases from Swiss 3T3 cells.
1990
Microinjection of a protein-tyrosine-phosphatase inhibits insulin action in Xenopus oocytes.
1990 StandoutNobel
The binding of fluorescein-labeled protein synthesis initiation factor 2 to Escherichia coli 30 S ribosomal subunits determined by fluorescence polarization.
1982
Okadaic acid mimics the action of insulin in stimulating protein kinase activity in isolated adipocytes. The role of protein phosphatase 2a in attenuation of the signal.
1990 StandoutNobel