Standout Papers
Citation Impact
Citing Papers
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
Molecular Determinants of Vanilloid Sensitivity in TRPV1
2004
N-Oleoyldopamine, a Novel Endogenous Capsaicin-like Lipid That Produces Hyperalgesia
2003
Control of excitatory synaptic transmission by capsaicin is unaltered in TRPV1 vanilloid receptor knockout mice
2007
Phosphorylation and Activation of β-Adrenergic Receptor Kinase by Protein Kinase C
1995
Association of β-Arrestin with G Protein-coupled Receptors during Clathrin-mediated Endocytosis Dictates the Profile of Receptor Resensitization
1999
G Protein–Coupled Receptor Kinase Mediates Desensitization of Norepinephrine-Induced Ca2+ Channel Inhibition
1996 StandoutNobel
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A
1997 StandoutNatureNobel
A cDNA that suppresses MPP+ toxicity encodes a vesicular amine transporter
1992
Reduced Anxiety, Conditioned Fear, and Hippocampal Long-Term Potentiation in Transient Receptor Potential Vanilloid Type 1 Receptor-Deficient Mice
2007
p38 MAPK Activation by NGF in Primary Sensory Neurons after Inflammation Increases TRPV1 Levels and Maintains Heat Hyperalgesia
2002
The diversity in the vanilloid (TRPV) receptor family of ion channels
2002
Selectivity of β‐adrenergic receptor kinase 2 for G protein βγ subunits
1997
Projection structure of rhodopsin
1993 StandoutNatureNobel
Molecular mechanisms of nociception
2001 StandoutNatureNobel
A novel calcium-sensing domain in the BK channel
1997
Molecular Understanding and Modern Application of Traditional Medicines: Triumphs and Trials
2007 Standout
Role of primary afferent nerves in allodynia caused by diabetic neuropathy in rats
2002
Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain
2016 StandoutNatureNobel
Effect of Different G Protein-coupled Receptor Kinases on Phosphorylation and Desensitization of the α1B-Adrenergic Receptor
1996
ThermoTRP channels and beyond: mechanisms of temperature sensation
2003 StandoutNobel
Opposite thermosensor in fruitfly and mouse
2003 StandoutNatureNobel
Immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brain
2006
[3H]Resiniferatoxin autoradiography in the CNS of wild-type and TRPV1 null mice defines TRPV1 (VR-1) protein distribution
2003
A Peptide Derived from a β2-Adrenergic Receptor Transmembrane Domain Inhibits Both Receptor Dimerization and Activation
1996
Crystal structure and mechanism of a calcium-gated potassium channel
2002 StandoutNatureNobel
Anandamide and vanilloid TRPV1 receptors
2003
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
1999 StandoutNatureNobel
Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and ß-arrestin proteins
2002
Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with aδ/c‐fibers and colocalization with trk receptors
2005
Phosphopeptide Mapping of Cholecystokinin Receptors on Agonist-stimulated Native Pancreatic Acinar Cells
1995
Agonist Recognition Sites in the Cytosolic Tails of Vanilloid Receptor 1
2002
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
2012 StandoutNatureNobel
G Protein-coupled Receptor Kinase GRK2 Is a Phospholipid-dependent Enzyme That Can Be Conditionally Activated by G Protein βγ Subunits
1996
A Central Role for -Arrestins and Clathrin-coated Vesicle-mediated Endocytosis in 2-Adrenergic Receptor Resensitization
1997
TRPV1
2014
TRPV1 structures in distinct conformations reveal activation mechanisms
2013 StandoutNatureNobel
Induction of vanilloid receptor channel activity by protein kinase C
2000 Nature
Molecular basis of infrared detection by snakes
2010 StandoutNatureNobel
Four Consecutive Serines in the Third Intracellular Loop Are the Sites for β-Adrenergic Receptor Kinase-mediated Phosphorylation and Desensitization of the α2A-Adrenergic Receptor
1995
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
2001 StandoutNatureNobel
Temperature-dependent activation of recombinant rat vanilloid VR1 receptors expressed in HEK293 cells by capsaicin and anandamide
2001
The TRPV1 receptor and nociception
2006
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013 StandoutNatureNobel
TRPV1‐lineage neurons are required for thermal sensation
2010
Identification of a cold receptor reveals a general role for TRP channels in thermosensation
2002 StandoutNatureNobel
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action
2016 StandoutNatureNobel
TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus
2010
G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins
1996
The Role of Sequestration in G Protein-coupled Receptor Resensitization
1997 StandoutNobel
Expression and distribution of vanilloid receptor 1 (TRPV1) in the adult rat brain
2005
Activation of a GTP‐Binding Protein and a GTP‐Binding‐Protein‐Coupled Receptor Kinase (β‐Adrenergic‐Receptor Kinase‐1) by a Muscarinic Receptor m2 Mutant Lacking Phosphorylation Sites
1994
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
Molecular Basis for Species-Specific Sensitivity to “Hot” Chili Peppers
2002 StandoutNobel
Binding of the β2 Adrenergic Receptor toN-Ethylmaleimide-sensitive Factor Regulates Receptor Recycling
2001 StandoutNobel
Endovanilloids
2004
Lack of evidence for functional TRPV1 vanilloid receptors in rat hippocampal nerve terminals
2006
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
The β2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange
1998 StandoutNatureNobel
Sensing with TRP channels
2005
Anandamide: some like it hot
2001
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
2004 StandoutNatureNobel
High Affinity Binding of β-Adrenergic Receptor Kinase to Microsomal Membranes
1996
Trpv1 Reporter Mice Reveal Highly Restricted Brain Distribution and Functional Expression in Arteriolar Smooth Muscle Cells
2011 StandoutNobel
Spider toxins activate the capsaicin receptor to produce inflammatory pain
2006 StandoutNatureNobel
Systematic analysis of genes required for synapse structure and function
2005 StandoutNatureNobel
Activity-Dependent IGF-1 Exocytosis Is Controlled by the Ca2+-Sensor Synaptotagmin-10
2011 StandoutNobel
Ca2+-dependent Interaction of Recoverin with Rhodopsin Kinase
1995 StandoutNobel
Pharmacology of Vanilloid Transient Receptor Potential Cation Channels
2009
TRPV1 Channels Mediate Long-Term Depression at Synapses on Hippocampal Interneurons
2008
The synaptic vesicle cycle: a cascade of protein–protein interactions
1995 StandoutNatureNobel
Activation of the cloned muscarinic potassium channel by G protein βγ subunits
1994 StandoutNatureNobel
Inhibition of G Protein-coupled Receptor Kinase Subtypes by Ca2+/Calmodulin
1996
The ligand that came from within
2001
THE ROLE OF RECEPTOR KINASES AND ARRESTINS IN G PROTEIN–COUPLED RECEPTOR REGULATION
1998
Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2
1999 StandoutScienceNobel
Molecular cloning and expression of GRK6. A new member of the G protein-coupled receptor kinase family.
1993
Expression, purification, and characterization of the G protein-coupled receptor kinase GRK6.
1994
Regulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-Arrestin
2001 StandoutScienceNobel
Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides
1990 StandoutScience
The proliferative and antiapoptotic effects of substance P are facilitated by formation of a β-arrestin-dependent scaffolding complex
2000
β-Arrestin–Dependent Endocytosis of Proteinase-Activated Receptor 2 Is Required for Intracellular Targeting of Activated Erk1/2
2000
Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5.
1994
High expression of beta-adrenergic receptor kinase in human peripheral blood leukocytes. Isoproterenol and platelet activating factor can induce kinase translocation.
1992
Protein kinase cross-talk: membrane targeting of the beta-adrenergic receptor kinase by protein kinase C.
1996
μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence
2000 StandoutNatureNobel
β-arrestin- but not G protein-mediated signaling by the “decoy” receptor CXCR7
2009 StandoutNobel
Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor
2000 StandoutScienceNobel
β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3
2000 StandoutScienceNobel
Vanilloid (Capsaicin) Receptors and Mechanisms
1999 Standout
Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor.
1995
Impaired Thermosensation in Mice Lacking TRPV3, a Heat and Camphor Sensor in the Skin
2005 StandoutScienceNobel
Identification and characterization of a novel human vanilloid receptor-like protein, VRL-2
2001
Assembly of functional rhodopsin requires a disulfide bond between cysteine residues 110 and 187.
1990
Uncovering Molecular Mechanisms Involved in Activation of G Protein-Coupled Receptors
2000
Hot Receptors in the Brain
2006
Role of cytoplasmic tail phosphorylation sites of platelet-activating factor receptor in agonist-induced desensitization.
1994
Cyclosporine A-induced hypertension involves synapsin in renal sensory nerve endings
2000 StandoutNobel
G PROTEIN–COUPLED RECEPTOR KINASES
1998 StandoutNobel
AN INTRODUCTION TO TRP CHANNELS
2005 Standout
Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor
1995 StandoutScienceNobel
The Vanilloid Receptor: A Molecular Gateway to the Pain Pathway
2001 StandoutNobel
An approach to the study of G-protein-coupled receptor kinases: an in vitro-purified membrane assay reveals differential receptor specificity and regulation by G beta gamma subunits.
1994
A beta-adrenergic receptor kinase dominant negative mutant attenuates desensitization of the beta 2-adrenergic receptor.
1994
Synergistic activation of a G protein-coupled receptor kinase by G protein beta gamma subunits and mastoparan or related peptides.
1994
Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases.
1994 StandoutNobel
RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease
1996 StandoutNature
A Heat-Sensitive TRP Channel Expressed in Keratinocytes
2002 StandoutScienceNobel
Truncation of the receptor carboxyl terminus impairs agonist-dependent phosphorylation and desensitization of the alpha 1B-adrenergic receptor.
1994
Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases.
1994
Ca2+-Dependent Inhibition of G Protein-Coupled Receptor Kinase 2 by Calmodulin
1997
Separation of Gating Properties from Permeation and Block in mslo Large Conductance Ca-activated K+ Channels
1997
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Structure and mechanism of the G protein-coupled receptor kinases.
1993 StandoutNobel
Autoradiographic localization and characterization of tachykinin receptor binding sites in the rat brain and peripheral tissues
1989
Works of James E. Krause being referenced
Mechanisms of desensitization and resensitization of G protein-coupled neurokinin1 and neurokinin2 receptors.
1996
Functional Wild‐Type and Carboxy‐Terminal‐Tagged Rat Substance P Receptors Expressed in Baculovirus‐Infected Insect Sf9 Cells
1995
Identification of Methionine as the Site of Covalent Attachment of a p-Benzoyl-Phenylalanine-containing Analogue of Substance P on the Substance P (NK-1) Receptor
1996
The distribution and regulation of vanilloid receptor VR1 and VR1 5′ splice variant RNA expression in rat
2001
Tachykinin Systems in the Spinal Cord and Basal Ganglia: Influence of Neonatal Capsaicin Treatment or Dopaminergic Intervention on Levels of Peptides, Substance P–Encoding mRNAs, and Substance P Receptor mRNA
1992
Yohimbine inhibits firing activities of rat dorsal root ganglion neurons by blocking Na+ channels and vanilloid VR1 receptors
2003
Effects of systemic resiniferatoxin treatment on substance P mRNA in rat dorsal root ganglia and substance P receptor mRNA in the spinal dorsal horn
1999
Expression of substance P/neurokinin A-encoding preprotachykinin messenger ribonucleic acids in the rat enteric nervous system
1989
A non‐pungent triprenyl phenol of fungal origin, scutigeral, stimulates rat dorsal root ganglion neurons via interaction at vanilloid receptors
1999
The Tissue Distribution and Functional Characterization of Human VR1
2001
Dialdehyde sesquiterpenes and other terpenoids as vanilloids
1998
Aminoquinazolines as TRPV1 antagonists: Modulation of drug-like properties through the exploration of 2-position substitution
2008
Inflammation-induced upregulation of NK1 receptor mRNA in dorsal horn neurones
1993
The Cloned Rat Vanilloid Receptor VR1 Mediates Both R-Type Binding and C-Type Calcium Response in Dorsal Root Ganglion Neurons
1999
gamma-Preprotachykinin-(72-92)-peptide amide: an endogenous preprotachykinin I gene-derived peptide that preferentially binds to neurokinin-2 receptors.
1990
A substance P (neurokinin-1) receptor mutant carboxyl-terminally truncated to resemble a naturally occurring receptor isoform displays enhanced responsiveness and resistance to desensitization
1997
The distribution of substance P in turtle nervous system: A radioimmunoassay and immunohistochemical study
1984
Resiniferatoxin‐type phorboid vanilloids display capsaicin‐like selectivity at native vanilloid receptors on rat DRG neurons and at the cloned vanilloid receptor VR1
1999
Differential expression of insulin-like growth factor genes in rat central nervous system.
1988
Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human
2000
TRP channels and pain
2007
C5L2, a Nonsignaling C5A Binding Protein
2003
Molecular basis for the species selectivity of the substance P antagonist CP-96,345.
1993
Three rat preprotachykinin mRNAs encode the neuropeptides substance P and neurokinin A.
1987
The peptide binding site of the substance P (NK-1) receptor localized by a photoreactive analogue of substance P: presence of a disulfide bond.
1996
The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2
1993 StandoutNobel
A human calcium-activated potassium channel gene expressed in vascular smooth muscle
1995
Amyloid-beta peptide, substance P, and bombesin bind to the serpin-enzyme complex receptor.
1991
Molecular Characterization of a Functional cDNA Encoding the Rat Substance P Receptor
1990 Science