Standout Papers
Citation Impact
Citing Papers
Atg7 Overcomes Senescence and Promotes Growth of Braf V600E-Driven Melanoma
2015
Phthalimide conjugation as a strategy for in vivo target protein degradation
2015 Science
The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T reg Cell Homeostasis
2013 StandoutScience
ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation
2009 StandoutScience
Autophagy Sustains Pancreatic Cancer Growth through Both Cell-Autonomous and Nonautonomous Mechanisms
2018
Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis
2019
Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
2009 StandoutScience
Recurrent Fusion of TMPRSS2 and ETS Transcription Factor Genes in Prostate Cancer
2005 StandoutScience
Autophagy Supports Breast Cancer Stem Cell Maintenance by Regulating IL6 Secretion
2015
Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: Developmental culling and cancer
2005 StandoutNobel
Pharmacological Inhibition of ULK1 Kinase Blocks Mammalian Target of Rapamycin (mTOR)-dependent Autophagy
2015
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
Resistance to BET Bromodomain Inhibitors Is Mediated by Kinome Reprogramming in Ovarian Cancer
2016
HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species
2019 StandoutNobel
Therapeutic Targeting of Autophagy
2016
Combined autophagy and HDAC inhibition
2014
A view on drug resistance in cancer
2019 StandoutNature
Acetylation of intrinsically disordered regions regulates phase separation
2018
Histone deacetylases and cancer
2007
The von Hippel–Lindau tumour suppressor protein: O2 sensing and cancer
2008 StandoutNobel
Molecular biology of the Ets family of transcription factors
2003
Molecular Understanding and Modern Application of Traditional Medicines: Triumphs and Trials
2007 Standout
A novel HDAC6 inhibitor Tubastatin A: Controls HDAC6-p97/VCP-mediated ubiquitination-autophagy turnover and reverses Temozolomide-induced ER stress-tolerance in GBM cells
2017
Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function
2017
Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma
2014
Treatment of Obesity with Celastrol
2015 Standout
Cancer Epigenetics: From Mechanism to Therapy
2012 Standout
The Human Transcription Factors
2018 Standout
The changing landscape of atherosclerosis
2021 StandoutNature
Heat shock proteins as gatekeepers of proteolytic pathways—Implications for age-related macular degeneration (AMD)
2009
Soft-Tissue Sarcomas in Adults
2005 Standout
The Epigenomics of Cancer
2007 Standout
Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators
2006
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
Epigenetics in Cancer
2008 Standout
Anticancer activities of histone deacetylase inhibitors
2006 Standout
Recent insights into the function of autophagy in cancer
2016
Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets
2017 StandoutNobel
Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates
2019 Standout
Strategies to Inhibit Myc and Their Clinical Applicability
2017
Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites
2021 StandoutNobel
Acetylation and deacetylation of non-histone proteins
2005
HIF-1α Is Essential for Myeloid Cell-Mediated Inflammation
2003 Standout
A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations
2010 Standout
TET enzymes, TDG and the dynamics of DNA demethylation
2013 StandoutNature
Programmable synthetic receptors: the next-generation of cell and gene therapies
2024
An Acetylation Site in the Middle Domain of Hsp90 Regulates Chaperone Function
2007
Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy
2017 Standout
Histone deacetylase inhibitors: molecular mechanisms of action
2007
Identification of secreted proteins that reflect autophagy dynamics within tumor cells
2014
Phase I clinical trial and pharmacodynamic evaluation of combination hydroxychloroquine and doxorubicin treatment in pet dogs treated for spontaneously occurring lymphoma
2014
The origin and evolution of cell types
2016
The plasticity and stability of regulatory T cells
2013 StandoutNobel
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
Safety and Biologic Response of Pre-operative Autophagy Inhibition in Combination with Gemcitabine in Patients with Pancreatic Adenocarcinoma
2015
Hsp70 and CHIP Selectively Mediate Ubiquitination and Degradation of Hypoxia-inducible Factor (HIF)-1α but Not HIF-2α
2009 StandoutNobel
Targeting autophagy in cancer
2017 Standout
Molecular Genetic Pathways as Therapeutic Targets in Acute Myeloid Leukemia
2008
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Synthetic lethal therapies for cancer: what’s next after PARP inhibitors?
2018
Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
2006 Standout
The PI3K Pathway in Human Disease
2017 Standout
A decade of exploring the cancer epigenome — biological and translational implications
2011 Standout
Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
2008 StandoutNobel
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
2013 StandoutNature
HDAC6 Modulates Cell Motility by Altering the Acetylation Level of Cortactin
2007
The dTAG system for immediate and target-specific protein degradation
2018
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Lysine Acetylation: Codified Crosstalk with Other Posttranslational Modifications
2008
A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors
2018
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
2009 StandoutNobel
Progress in the Discovery of Small-Molecule Inhibitors of Bromodomain–Histone Interactions
2011
HIF activation identifies early lesions in VHL kidneys
2002 StandoutNobel
The cancer genome
2009 StandoutNature
Spermidine/Spermine N1-Acetyltransferase-1 Binds to Hypoxia-inducible Factor-1α (HIF-1α) and RACK1 and Promotes Ubiquitination and Degradation of HIF-1α
2007 StandoutNobel
A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme
2014
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
2013 Standout
Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer
2018 Standout
Explorative Study on Isoform-Selective Histone Deacetylase Inhibitors
2009
Lipid Nanoparticles Delivering Constitutively Active STING mRNA to Stimulate Antitumor Immunity
2022 StandoutNobel
Peptidic degron for IMiD-induced degradation of heterologous proteins
2019 StandoutNobel
Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma
2014
Histone Deacetylase Inhibitors Induce VHL and Ubiquitin-Independent Proteasomal Degradation of Hypoxia-Inducible Factor 1α
2006
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
2002 StandoutNobel
Class II Histone Deacetylases Are Associated with VHL-Independent Regulation of Hypoxia-Inducible Factor 1α
2006
Addition of rapamycin and hydroxychloroquine to metronomic chemotherapy as a second line treatment results in high salvage rates for refractory metastatic solid tumors: a pilot safety and effectiveness analysis in a small patient cohort
2015
Histone deacetylase inhibitors: molecular mechanisms of action and clinical trials as anti-cancer drugs.
2011
Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment
2016
The von Hippel-Lindau Tumor Suppressor Gene
2020
Immune regulation by histone deacetylases: a focus on the alteration of FOXP3 activity
2011
Spermidine in health and disease
2018 StandoutScience
Autophagy, a key mechanism of oncogenesis and resistance in leukemia
2016
Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes
2015
Metabolic reprogramming and cancer progression
2020 StandoutScience
HDACs and HDAC Inhibitors in Cancer Development and Therapy
2016
Genetics and biology of pancreatic ductal adenocarcinoma
2016
Histone deacetylase 10 promotes autophagy-mediated cell survival
2013
Palaeoproteomic evidence identifies archaic hominins associated with the Châtelperronian at the Grotte du Renne
2016 StandoutNobel
Impact of SYT-SSX fusion type on the clinical behavior of synovial sarcoma: a multi-institutional retrospective study of 243 patients.
2002
Histone Deacetylases 6 and 9 and Sirtuin-1 Control Foxp3 + Regulatory T Cell Function Through Shared and Isoform-Specific Mechanisms
2012
Diverse Effects of Mutations in Exon II of the von Hippel-Lindau (VHL) Tumor Suppressor Gene on the Interaction of pVHL with the Cytosolic Chaperonin and pVHL-Dependent Ubiquitin Ligase Activity
2002 StandoutNobel
Works of James E. Bradner being referenced
Histone Deacetylase 6 and Heat Shock Protein 90 Control the Functions of Foxp3 + T-Regulatory Cells
2011
Efficacy of BET Bromodomain Inhibition in Kras-Mutant Non–Small Cell Lung Cancer
2013
Differentiation of NUT Midline Carcinoma by Epigenomic Reprogramming
2011
BET Bromodomain Inhibition Promotes Anti-tumor Immunity by Suppressing PD-L1 Expression
2016
Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis
2017
An IMiD-inducible degron provides reversible regulation for chimeric antigen receptor expression and activity
2020
MYC, a downstream target of BRD-NUT, is necessary and sufficient for the blockade of differentiation in NUT midline carcinoma
2013
Tubacin suppresses proliferation and induces apoptosis of acute lymphoblastic leukemia cells
2011
Combined autophagy and proteasome inhibition
2014
BET Bromodomains Mediate Transcriptional Pause Release in Heart Failure
2013
Acetylation site specificities of lysine deacetylase inhibitors in human cells
2015
Inhibition of Histone Deacetylase 6 Acetylates and Disrupts the Chaperone Function of Heat Shock Protein 90
2005
HIF activation causes synthetic lethality between the VHL tumor suppressor and the EZH1 histone methyltransferase
2017 StandoutNobel
Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma
2012
Differential transactivation by alternative EWS-FLI1 fusion proteins correlates with clinical heterogeneity in Ewing's sarcoma.
1999
Abstract A49: Clinically efficacy of the BET bromodomain inhibitor TEN-010 in an open-label substudy with patients with documented NUT-midline carcinoma (NMC)
2015
Models of human core transcriptional regulatory circuitries
2016
HDAC6 inhibition enhances 17-AAG–mediated abrogation of hsp90 chaperone function in human leukemia cells
2008