Citation Impact
Citing Papers
Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching
2008
Generation of knock-in primary human T cells using Cas9 ribonucleoproteins
2015 StandoutNobel
Recognition of a Ubiquitous Self Antigen by Prostate Cancer-Infiltrating CD8 + T Lymphocytes
2008 StandoutScienceNobel
Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis
2008
C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion
2014 StandoutNobel
Loss of cryptochrome reduces cancer risk in p53 mutant mice
2009 StandoutNobel
Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells
2013 StandoutScienceNobel
Classical and Alternative End-Joining Pathways for Repair of Lymphocyte-Specific and General DNA Double-Strand Breaks
2012
Evolution of the Immunoglobulin Heavy Chain Class Switch Recombination Mechanism
2007
Hallmarks of Cancer: The Next Generation
2011 Standout
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
The DNA-damage response in human biology and disease
2009 StandoutNature
A Pathway of Double-Strand Break Rejoining Dependent upon ATM, Artemis, and Proteins Locating to γ-H2AX Foci
2004
Probing p53 biological functions through the use of genetically engineered mouse models
2005
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
2006 StandoutNature
MFG-E8–mediated uptake of apoptotic cells by APCs links the pro- and antiinflammatory activities of GM-CSF
2007
The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α
2010
Cancer Immunosurveillance and Immunoediting: The Roles of Immunity in Suppressing Tumor Development and Shaping Tumor Immunogenicity
2006
p53: traffic cop at the crossroads of DNA repair and recombination
2005
The DNA-dependent Protein Kinase Catalytic Subunit Phosphorylation Sites in Human Artemis
2005
H2AX Haploinsufficiency Modifies Genomic Stability and Tumor Susceptibility
2003
Tying the loose ends together in DNA double strand break repair with 53BP1.
2006
Histone H2AX
2003
Role of AID in Tumorigenesis
2007 StandoutNobel
Formation of NHEJ-derived reciprocal chromosomal translocations does not require Ku70
2007
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
2005 StandoutNature
The nonhomologous end joining factor Artemis suppresses multi-tissue tumor formation and prevents loss of heterozygosity
2007
Telomeres and telomerase in cancer
2009
Indecent Exposure
2004
AID Is Required for c-myc/IgH Chromosome Translocations In Vivo
2004 StandoutNobel
Phosphorylation of Histone H2AX and Activation of Mre11, Rad50, and Nbs1 in Response to Replication-dependent DNA Double-strand Breaks Induced by Mammalian DNA Topoisomerase I Cleavage Complexes
2003
Nonoverlapping Functions of DNA Polymerases Mu, Lambda, and Terminal Deoxynucleotidyltransferase during Immunoglobulin V(D)J Recombination In Vivo
2006
Amplifying Mechanisms of Lymphomagenesis
2002
DNA Repair, Genome Stability, and Aging
2005
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
Macrophage Diversity Enhances Tumor Progression and Metastasis
2010 Standout
A DNA-PKcs mutation in a radiosensitive T–B– SCID patient inhibits Artemis activation and nonhomologous end-joining
2008
Immune surveillance of tumors
2007
Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function
2004 StandoutNobel
Mechanism of homologous recombination: mediators and helicases take on regulatory functions
2006
The mechanisms of immune diversification and their disorders
2003
Multiple functions of MRN in end-joining pathways during isotype class switching
2009
Cernunnos, a Novel Nonhomologous End-Joining Factor, Is Mutated in Human Immunodeficiency with Microcephaly
2006
PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer
2016 Standout
MMEJ repair of double-strand breaks (director’s cut): deleted sequences and alternative endings
2008
γH2AX and MDC1: Anchoring the DNA-damage-response machinery to broken chromosomes
2006
Immunity, Inflammation, and Cancer
2010 Standout
Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression
2003
PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways
2006
Replication protein A and γ-H2AX foci assembly is triggered by cellular response to DNA double-strand breaks
2004
Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions
2009 Nature
IgH class switching and translocations use a robust non-classical end-joining pathway
2007 Nature
Cytokines in cancer pathogenesis and cancer therapy
2004
Differential usage of non-homologous end-joining and homologous recombination in double strand break repair
2006
γH2AX and cancer
2008
Paradoxical roles of the immune system during cancer development
2006 Standout
The cellular response to general and programmed DNA double strand breaks
2004
Leukemia and lymphoma: a cost of doing business for adaptive immunity
2006
H2AX: the histone guardian of the genome
2004
Functional and biochemical dissection of the structure‐specific nuclease ARTEMIS
2004
Mechanism and Control of V(D)J Recombination versus Class Switch Recombination: Similarities and Differences
2005
SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging
2008
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
Coordinate 5′ and 3′ endonucleolytic trimming of terminally blocked blunt DNA double-strand break ends by Artemis nuclease and DNA-dependent protein kinase
2008
Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting
2012 StandoutNatureNobel
Identification of an AID-independent pathway for chromosomal translocations between the Igh switch region and Myc
2004
The Hallmarks of Aging
2013 Standout
Mechanisms promoting translocations in editing and switching peripheral B cells
2009 Nature
The role of the DNA double-strand break response network in meiosis
2004
The Artemis:DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps
2005
Biochemical mechanisms of chromosomal translocations resulting from DNA double-strand breaks
2006
Pathways that suppress programmed DNA breaks from progressing to chromosomal breaks and translocations
2006
Phosphorylation and Regulation of DNA Ligase IV Stability by DNA-dependent Protein Kinase
2004
Cancer-related inflammation
2008 StandoutNature
Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy
2016 StandoutNobel
Tetramerization and DNA Ligase IV Interaction of the DNA Double-strand Break Repair Protein XRCC4 are Mutually Exclusive
2003
Processing of 3′-Phosphoglycolate-terminated DNA Double Strand Breaks by Artemis Nuclease
2006
Mechanisms of intracellular protein transport
1994 StandoutNatureNobel
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70
2010
Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
2006 StandoutScience
AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements
2007 StandoutNobel
Accumulation of the FACT complex, as well as histone H3.3, serves as a target marker for somatic hypermutation
2013 StandoutNobel
Telomerase core components protect Candida telomeres from aberrant overhang accumulation
2007 StandoutNobel
ATM Is Required for Efficient Recombination between Immunoglobulin Switch Regions
2004
Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice
2007 StandoutNobel
The Three Es of Cancer Immunoediting
2004 Standout
Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes
2012 StandoutNobel
Telomere length is paternally inherited and is associated with parental lifespan
2007 StandoutNobel
Natural Innate and Adaptive Immunity to Cancer
2011 Standout
HVEM tomography of the trans-Golgi network: structural insights and identification of a lace-like vesicle coat.
1994
Integrated NY-ESO-1 antibody and CD8+T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab
2011 StandoutNobel
Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase
2015 StandoutNobel
Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation
2011 StandoutNobel
Genes and pathways downstream of telomerase in melanoma metastasis
2006 StandoutNobel
Following the Path of the Virus: The Exploitation of Host DNA Repair Mechanisms by Retroviruses
2006
Coat Proteins and Vesicle Budding
1996 StandoutScienceNobel
Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells
2004
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
53BP1 Cooperates with p53 and Functions as a Haploinsufficient Tumor Suppressor in Mice
2005
Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development
2006
Connecting Chromosomes, Crisis, and Cancer
2002 Science
Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients
2008 StandoutNobel
The Yeast Chromatin Remodeler RSC Complex Facilitates End Joining Repair of DNA Double-Strand Breaks
2005
The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination
2009 StandoutNobel
The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway
2010 Standout
Characterizing tumor-promoting T cells in chemically induced cutaneous carcinogenesis
2007
Evidence for Replicative Repair of DNA Double-Strand Breaks Leading to Oncogenic Translocation and Gene Amplification
2002
H2AX Is Required for Recombination Between Immunoglobulin Switch Regions but Not for Intra-Switch Region Recombination or Somatic Hypermutation
2003
Double-Strand Break End Resection and Repair Pathway Choice
2011
Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase
2014 StandoutNobel
Targeted Disruption of the Artemis Murine Counterpart Results in SCID and Defective V(D)J Recombination That Is Partially Corrected with Bone Marrow Transplantation
2005
Functional deficiencies of granulocyte-macrophage colony stimulating factor and interleukin-3 contribute to insulitis and destruction of β cells
2007 StandoutNobel
DNA Double-Strand Breaks
2002 StandoutNobel
PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
2010 StandoutNobel
Rejoining of DNA Double-Strand Breaks as a Function of Overhang Length
2005
Dissociation of in vitro DNA deamination activity and physiological functions of AID mutants
2008 StandoutNobel
Effector Memory T Cells, Early Metastasis, and Survival in Colorectal Cancer
2005 Standout
53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination
2010
Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination
2010 StandoutNobel
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination
2014 StandoutNobel
Interferons, immunity and cancer immunoediting
2006
Functional requirements of AID’s higher order structures and their interaction with RNA-binding proteins
2016 StandoutNobel
Works of James C. Fleming being referenced
Impaired Nonhomologous End-Joining Provokes Soft Tissue Sarcomas Harboring Chromosomal Translocations, Amplifications, and Deletions
2001
Direct observation of defect structure in protein crystals by atomic force and transmission electron microscopy
1992
Unrepaired DNA Breaks in p53-Deficient Cells Lead to Oncogenic Gene Amplification Subsequent to Translocations
2002
The Rad50 hook domain is a critical determinant of Mre11 complex functions
2005
Deficiencies of GM-CSF and Interferon γ Link Inflammation and Cancer
2003
Defective DNA Repair and Increased Genomic Instability in Artemis-deficient Murine Cells
2003
Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX
2002