Citation Impact
Citing Papers
p53: puzzle and paradigm.
1996 Standout
C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion
2014 StandoutNobel
An enzymatic toolkit for selective proteolysis, detection, and visualization of mucin-domain glycoproteins
2020 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Differential p53 phosphorylation and activation of apoptosis-promoting genes Bax and Fas/APO-1 by irradiation and ara-C treatment
1998
John Snow's legacy: epidemiology without borders
2013 StandoutNobel
Mdm2 promotes the rapid degradation of p53
1997 StandoutNature
Differential involvement of the CD95 (Fas/APO-1) receptor/ligand system on apoptosis induced by the wild-type p53 gene transfer in human cancer cells
1999
Apoptosis in cancer
2000 Standout
Targeting HIF-1 for cancer therapy
2003 StandoutNobel
p53 in growth control and neoplasia
1996
Death Signal-induced Localization of p53 Protein to Mitochondria
2000
p53-Mdm2--the affair that never ends
2002
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
NF-κB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF
2006
Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
2012 Standout
Cooperation between STAT3 and c-Jun Suppresses Fas Transcription
2001
EMT and Dissemination Precede Pancreatic Tumor Formation
2012 Standout
Molecular mechanisms of drug resistance
2005
Tumor necrosis factor, cancer and anticancer therapy
2004
NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression
2004
NF-κB in cancer: from innocent bystander to major culprit
2002 Standout
Altered Tumor-Cell Glycosylation Promotes Metastasis
2014
Inhibition of NF-κB in cancer cells converts inflammation- induced tumor growth mediated by TNFα to TRAIL-mediated tumor regression
2004
PUMA, a Novel Proapoptotic Gene, Is Induced by p53
2001 Standout
Apoptosis regulators and their role in tumorigenesis
2001
E6 and E7 Gene Silencing and Transformed Phenotype of Human Papillomavirus 16-Positive Oropharyngeal Cancer Cells
2009
Ubiquitin ligases: cell-cycle control and cancer
2006
AP-1 as a regulator of cell life and death
2002 Standout
The Hallmarks of Cancer
2000 Standout
Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response
2012
p53 Induces Apoptosis by Caspase Activation through Mitochondrial Cytochrome c Release
2000
Genetically programmed chiral organoborane synthesis
2017 StandoutNatureNobel
The role of p53 in regulating genomic stability when DNA and RNA synthesis are inhibited
1995
E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer
2009
Mechanisms of p53-mediated apoptosis
1999
The C. elegans Protein EGL-1 Is Required for Programmed Cell Death and Interacts with the Bcl-2–like Protein CED-9
1998 StandoutNobel
Immunity, Inflammation, and Cancer
2010 Standout
Expression of the NF-κB target gene IEX-1 (p22/PRG1) does not prevent cell death but instead triggers apoptosis in Hela cells
2001
A transcriptional activation function of p53 is dispensable for and inhibitory of its apoptotic function
2001
Osteoclast differentiation and activation
2003 StandoutNature
Live or let die: the cell's response to p53
2002 Standout
Death and anti-death: tumour resistance to apoptosis
2002 Standout
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
2006 StandoutNature
Paradoxical roles of the immune system during cancer development
2006 Standout
A cornucopia of human polyomaviruses
2013
The Hallmarks of Aging
2013 Standout
Macrophage biology in development, homeostasis and disease
2013 StandoutNature
Cancer-related inflammation
2008 StandoutNature
Poly(ADP-ribose) polymerase and XPF–ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells
2011
Tissue and cell-specific expression of the p53-target genes: bax, fas, mdm2 and waf1/p21, before and following ionising irradiation in mice
2000
Control of apoptosis by p53
2003
Restoration of p53 expression sensitizes human papillomavirus type 16 immortalized human keratinocytes to CD95-mediated apoptosis
2002 StandoutNobel
Repair of and checkpoint response to topoisomerase I-mediated DNA damage
2003
Role of YAP/TAZ in mechanotransduction
2011 StandoutNature
Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21
2015 StandoutNobel
Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant.
1996
Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice
2002 StandoutNobel
Boron Chemicals in Diagnosis and Therapeutics
2013
Dysregulation of Apoptosis in Cancer
1999
Life, death, and the pursuit of apoptosis.
1996
Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
2006 StandoutScience
A systems approach to cancer therapy
1996
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
2011 StandoutNobel
Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells
2001 StandoutNobel
The Bcl-2 Protein Family: Arbiters of Cell Survival
1998 StandoutScience
Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth
2008 StandoutNobel
Differential Activation of Target Cellular Promoters by p53 Mutants with Impaired Apoptotic Function
1996
Cancer Cell Cycles
1996 StandoutScience
NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression
2004
Genes and pathways downstream of telomerase in melanoma metastasis
2006 StandoutNobel
Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion
2011 StandoutScience
p53 Activates the CD95 (APO-1/Fas) Gene in Response to DNA Damage by Anticancer Drugs
1998
Activation and activities of the p53 tumour suppressor protein
2001
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Death Receptors: Signaling and Modulation
1998 StandoutScience
PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family
2000
Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway.
2002
Apaf-1 and Caspase-9 in p53-Dependent Apoptosis and Tumor Inhibition
1999 Science
Unique potential of 4-1BB agonist antibody to promote durable regression of HPV + tumors when combined with an E6/E7 peptide vaccine
2015 StandoutNobel
Surfing the p53 network
2000 StandoutNature
Identification of gene function and functional pathways by systemic plasmid-based ribozyme targeting in adult mice
2002
Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy
2005 StandoutScience
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
2003 StandoutNobel
Cell type-specific inhibition of p53-mediated apoptosis by mdm2.
1996
High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6
2001 StandoutNobel
Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment
2014 StandoutNobel
hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage
1999 StandoutNobel
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination
2014 StandoutNobel
Photopharmacology: Beyond Proof of Principle
2014 StandoutNobel
Involvement of the Mismatch Repair System in Temozolomide-Induced Apoptosis
1998
Caspases: Enemies Within
1998 StandoutScience
ei24, a p53 Response Gene Involved in Growth Suppression and Apoptosis
2000
A Matter of Life and Cell Death
1998 Science
Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis
2004 StandoutScience
Works of James C. Cusack being referenced
Activation of PI3K Signaling in Merkel Cell Carcinoma
2012
The influence of angiogenesis inhibitor AGM‐1470 on immune system status and tumor growth in vitro
1993
Rationale for the treatment of solid tumors with the proteasome inhibitor bortezomib
2003
Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB
1999
Inducible chemoresistance to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothe cin (CPT-11) in colorectal cancer cells and a xenograft model is overcome by inhibition of nuclear factor-kappaB activation.
2000
Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-kappaB inhibition.
2001
Wild-Type Human p53 and a Temperature-Sensitive Mutant Induce Fas/APO-1 Expression
1995
Expression of human alpha(1,3)fucosyltransferase antisense sequences inhibits selectin-mediated adhesion and liver metastasis of colon carcinoma cells.
1999
In vivo adenovirus-mediated p53 tumor suppressor gene therapy for colorectal cancer.
1997
Membrane-Bound Heparin-Binding Epidermal Growth Factor–Like Growth Factor Regulates E-Cadherin Expression in Pancreatic Carcinoma Cells
2007