Citation Impact
Citing Papers
Reassessing Epithelial to Mesenchymal Transition as a Prerequisite for Carcinoma Invasion and Metastasis
2006
Three habits of highly effective signaling pathways: principles of transcriptional control by developmental cell signaling
2002
BRCA1-Associated Epigenetic Regulation of p73 Mediates an Effector Pathway for Chemosensitivity in Ovarian Carcinoma
2010
Transcriptional Activation by the Zinc-Finger Homeodomain Protein δ EF1 in Estrogen Signaling Cascades
2004
Hallmarks of Cancer: The Next Generation
2011 Standout
Regulation of Type II Transmembrane Serine Proteinase TMPRSS6 by Hypoxia-inducible Factors
2010 StandoutNobel
Identification of Two Smad4 Proteins in Xenopus
1999
T‐box genes in early embryogenesis
2003
Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
2011 Standout
Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors
1998
Targeted Disruption in Murine Cells Reveals Variable Requirement for Smad4 in Transforming Growth Factor β-related Signaling
2000
Human genetic defects in class-switch recombination (hyper-IgM syndromes)
2001 StandoutNobel
Promoter-specific binding of Rap1 revealed by genome-wide maps of protein–DNA association
2001
SIP1 Mediates Cell-Fate Decisions between Neuroectoderm and Mesendoderm in Human Pluripotent Stem Cells
2010
Role of Transforming Growth Factor β in Human Disease
2000 Standout
Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus
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Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
Smads as transcriptional co-modulators
2000
Identification and Functional Characterization of a Smad Binding Element (SBE) in the JunB Promoter That Acts as a Transforming Growth Factor-β, Activin, and Bone Morphogenetic Protein-inducible Enhancer
1998
Differential Expression of the Epithelial-Mesenchymal Transition Regulators Snail, SIP1, and Twist in Gastric Cancer
2002
SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell-cell junctions
2005
Phosphorylation of Ser465 and Ser467 in the C Terminus of Smad2 Mediates Interaction with Smad4 and Is Required for Transforming Growth Factor-β Signaling
1997
TGF-β signaling in tumor suppression and cancer progression
2001 Standout
TGF-β signalling from cell membrane to nucleus through SMAD proteins
1997 StandoutNature
Actions of TGF-β as tumor suppressor and pro-metastatic factor in human cancer
2006
Epithelial-Mesenchymal Transitions
2004 Standout
Smad-dependent and Smad-independent pathways in TGF-β family signalling
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Synexpression groups in eukaryotes
1999 Nature
Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling
1997 StandoutNature
miR-200b mediates post-transcriptional repression of ZFHX1B
2007
Transforming Growth Factor β1 Induces Nuclear Export of Inhibitory Smad7
1998
Expression of Snail, Slug and Sip1 in malignant mesothelioma effusions is associated with matrix metalloproteinase, but not with cadherin expression
2006
Increased CD40 Expression Enhances Early STING-Mediated Type I Interferon Response and Host Survival in a Rodent Malaria Model
2016
Interaction and Functional Cooperation of NF-κB with Smads
2000
EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
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SMIF, a Smad4-interacting protein that functions as a co-activator in TGFβ signalling
2002
The Two-Handed E Box Binding Zinc Finger Protein SIP1 Downregulates E-Cadherin and Induces Invasion
2001
Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway
2003
Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins
2003
Intracellular BMP Signaling Regulation in Vertebrates: Pathway or Network?
2001
A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA
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E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer
2009
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
2007 StandoutNature
A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial–mesenchymal transition
2008
Functional genomic analysis of C. elegans chromosome I by systematic RNA interference
2000 StandoutNature
Activation of NF-κB by Akt upregulates Snail expression and induces epithelium mesenchyme transition
2007
BMP Induction of Id Proteins Suppresses Differentiation and Sustains Embryonic Stem Cell Self-Renewal in Collaboration with STAT3
2003 Standout
Alternatively Spliced Variant of Smad2 Lacking Exon 3
1999
Signal transduction of bone morphogenetic protein receptors
2003
Pc2-mediated Sumoylation of Smad-interacting Protein 1 Attenuates Transcriptional Repression of E-cadherin
2005
TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4
1997
Interaction and Functional Cooperation of PEBP2/CBF with Smads
1999
Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
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Calreticulin Represses E-cadherin Gene Expression in Madin-Darby Canine Kidney Cells via Slug
2006
Emerging Biological Principles of Metastasis
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Highly Integrated Single-Base Resolution Maps of the Epigenome in Arabidopsis
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EMT: 2016
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Transcriptional regulatory code of a eukaryotic genome
2004 StandoutNature
TGFβ in Cancer
2008 Standout
Snail, Slug, and Smad‐interacting protein 1 as novel parameters of disease aggressiveness in metastatic ovarian and breast carcinoma
2005
Signaling of transforming growth factor‐β family members through Smad proteins
2000
Interaction between Smad-interacting Protein-1 and the Corepressor C-terminal Binding Protein Is Dispensable for Transcriptional Repression of E-cadherin
2003
Computational identification of Cis -regulatory elements associated with groups of functionally related genes in Saccharomyces cerevisiae 1 1Edited by F. E. Cohen
2000
Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis
2004 Standout
Complilation and characteristics of dedicated transcription factors in Saccharomyces cerevisiae
1995
Polycomb complexes repress developmental regulators in murine embryonic stem cells
2006 StandoutNature
Interactions between subunits of the Mediator complex with gene-specific transcription factors
2011
Purification and Characterization of RNA Polymerase II Holoenzyme from Schizosaccharomyces pombe
2000
Aid
2004 StandoutNobel
Role of Transforming Growth Factor-beta Signaling in Cancer
2000
Collagen type I-induced Smad-interacting protein 1 expression downregulates E-cadherin in pancreatic cancer
2006
The basics of epithelial-mesenchymal transition
2009 Standout
A ncRNA Modulates Histone Modification and mRNA Induction in the Yeast GAL Gene Cluster
2008
A Novel X-Linked Disorder of Immune Deficiency and Hypohidrotic Ectodermal Dysplasia Is Allelic to Incontinentia Pigmenti and Due to Mutations in IKK-gamma (NEMO)
2000
Global regulators of ribosome biosynthesis in yeast
1995
TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders
2000 Standout
Mads and Smads in TGFβ signalling
1998
The Zinc Finger Protein Schnurri Acts as a Smad Partner in Mediating the Transcriptional Response to Decapentaplegic
2000
TGF-β signaling by Smad proteins
2000
c-Ski Acts as a Transcriptional Co-repressor in Transforming Growth Factor-β Signaling through Interaction with Smads
1999
Long Noncoding RNAs: Cellular Address Codes in Development and Disease
2013 Standout
NEW EMBO MEMBERS REVIEW: Transcriptional control by the TGF-beta/Smad signaling system
2000 Standout
Interaction of Smad Complexes with Tripartite DNA-binding Sites
1999
Eomesodermin is required for mouse trophoblast development and mesoderm formation
2000 StandoutNatureNobel
TGF-β signaling by Smad proteins
2000
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
2008 Standout
Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
2013 Standout
Controlling TGF-β signaling
2000
A mutation of Ikbkg causes immune deficiency without impairing degradation of IκBα
2010 StandoutNobel
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
2011 StandoutNobel
RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology
2020 StandoutNobel
TGF-β SIGNAL TRANSDUCTION
1998 Standout
NIH Image to ImageJ: 25 years of image analysis
2012 Standout
Gene Regulatory Networks and the Evolution of Animal Body Plans
2006 StandoutScience
A novel Smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-β signal transduction
2000
A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal transduction.
2000
Life with 6000 Genes
1996 StandoutScience
Metadata matters: access to image data in the real world
2010
A quantitative analysis of signal transduction from activin receptor to nucleus and its relevance to morphogen gradient interpretation
1999 StandoutNobel
Formation of a Carboxy-Terminal Domain Phosphatase (Fcp1)/TFIIF/RNA Polymerase II (pol II) Complex in Schizosaccharomyces pombe Involves Direct Interaction between Fcp1 and the Rpb4 Subunit of pol II
2002
A molecular basis for Smad specificity
1999
Mice Lacking Zfhx1b, the Gene That Codes for Smad-Interacting Protein-1, Reveal a Role for Multiple Neural Crest Cell Defects in the Etiology of Hirschsprung Disease–Mental Retardation Syndrome
2003
Signal Transduction by the TGF-β Superfamily
2002 StandoutScience
Mediator of Transcriptional Regulation
2000 StandoutNobel
SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS
2005 Standout
Complete, 12-subunit RNA polymerase II at 4.1-Å resolution: Implications for the initiation of transcription
2003 StandoutNobel
Regulation of ocular lens development by Smad-interacting protein 1 involvingFoxe3activation
2005
Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects
1999
Bix4is activated directly by VegT and mediates endoderm formation inXenopusdevelopment
1999
Restoring E-Cadherin Expression Increases Sensitivity to Epidermal Growth Factor Receptor Inhibitors in Lung Cancer Cell Lines
2006
Epithelial Plasticity: A Common Theme in Embryonic and Cancer Cells
2013 StandoutScience
Large-scale analysis of the human and mouse transcriptomes
2002 StandoutNobel
Losartan, an AT1 Antagonist, Prevents Aortic Aneurysm in a Mouse Model of Marfan Syndrome
2006 StandoutScience
Controlling TGF-beta signaling.
2000 Standout
Mutator-like Elements inArabidopsis thaliana: Structure, Diversity and Evolution
2000
The SLUG zinc-finger protein represses E-cadherin in breast cancer.
2002
Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene
1998 Standout
Works of Jacques Remacle being referenced
Three classes of mammalian transcription activation domain stimulate transcription in Schizosaccharomyces pombe
1997
SIP1, a Novel Zinc Finger/Homeodomain Repressor, Interacts with Smad Proteins and Binds to 5′-CACCT Sequences in Candidate Target Genes
1999
New mode of DNA binding of multi-zinc finger transcription factors: delta EF1 family members bind with two hands to two target sites
1999
TTRAP, a Novel Protein That Associates with CD40, Tumor Necrosis Factor (TNF) Receptor-75 and TNF Receptor-associated Factors (TRAFs), and That Inhibits Nuclear Factor-κB Activation
2000
Datin, a yeast poly(dA:dT)-binding protein, behaves as an activator of the wild-type ILV1 promoter and interacts synergistically with Reb1p
1998
The C-terminal domain of Mad-like signal transducers is sufficient for biological activity in the Xenopus embryo and transcriptional activation
1997
'Omics Data Sharing
2009 Science
Analysis of Schizosaccharomyces pombe Mediator reveals a set of essential subunits conserved between yeast and metazoan cells
2001
A REB1-binding site is required for GCN4-independent ILV1 basal level transcription and can be functionally replaced by an ABF1-binding site.
1992
Region-specific activation of theXenopus Brachyurypromoter involves active repression in ectoderm and endoderm: a study using transgenic frog embryos
2000