Standout Papers
Citation Impact
Citing Papers
Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro
2006 StandoutNobel
Neutralizing antibody response during acute and chronic hepatitis C virus infection
2004 StandoutNobel
Hunter-gatherer genomic diversity suggests a southern African origin for modern humans
2011
A genomic region associated with protection against severe COVID-19 is inherited from Neandertals
2021 StandoutNobel
A "Silent" Polymorphism in the MDR 1 Gene Changes Substrate Specificity
2006 StandoutScience
Evidence for a functional RNA element in the hepatitis C virus core gene
2007 StandoutNobel
Mouse models of acute and chronic hepacivirus infection
2017 StandoutScienceNobel
Proteomics of HCV virions reveals an essential role for the nucleoporin Nup98 in virus morphogenesis
2016 StandoutNobel
Kinetic differences in the induction of interferon stimulated genes by interferon-α and interleukin 28B are altered by infection with hepatitis C virus
2013
Immunomodulatory Function of Interleukin 28B During Primary Infection With Cytomegalovirus
2014 StandoutNobel
Hepatic ISG Expression Is Associated With Genetic Variation in Interleukin 28B and the Outcome of IFN Therapy for Chronic Hepatitis C
2010
IFN-λ4: The Paradoxical New Member of the Interferon Lambda Family
2014
Immune Cell Profiling of IFN-λ Response Shows pDCs Express Highest Level of IFN-λR1 and Are Directly Responsive via the JAK-STAT Pathway
2016
The impact of rare and low-frequency genetic variants in common disease
2017
Hepatitis-C-virus-induced microRNAs dampen interferon-mediated antiviral signaling
2016
Distinct haplotype profiles and strong linkage disequilibrium at the MDR1 multidrug transporter gene locus in three ethnic Asian populations
2002
Validation of TaqMan® SNP genotyping specificity for rs12979860 of IL-28B: Modeling primer specificity in vitro
2014
Benefits and limitations of genome-wide association studies
2019
Interferon-Induced Gene Expression Is a Stronger Predictor of Treatment Response Than IL28B Genotype in Patients With Hepatitis C
2010
Comprehensive analysis for viral elements and interleukin-28B polymorphisms in response to pegylated interferon plus ribavirin therapy in hepatitis C virus 1B infection
2012
SEC14L2 enables pan-genotype HCV replication in cell culture
2015 StandoutNatureNobel
Analysis of the Complete Open Reading Frame of Genotype 2b Hepatitis C Virus in Association with the Response to Peginterferon and Ribavirin Therapy
2011
Murine models of hepatitis C: What can we look forward to?
2014
Hepatitis C virus resistance to protease inhibitors
2011
Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
2009 StandoutNature
Recapitulation of the hepatitis C virus life-cycle in engineered murine cell lines
2013 StandoutNobel
Comparative Analysis of the Lambda-Interferons IL-28A and IL-29 regarding Their Transcriptome and Their Antiviral Properties against Hepatitis C Virus
2010
Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and Type III Interferons
2019
Impact of IL28B gene polymorphisms on interferon- 3 plasma levels during pegylated interferon- /ribavirin therapy for chronic hepatitis C in patients coinfected with HIV
2012
Treatment triumphs
2014 StandoutNatureNobel
Type III Interferons, IL-28 and IL-29, Are Increased in Chronic HCV Infection and Induce Myeloid Dendritic Cell-Mediated FoxP3+ Regulatory T Cells
2012
Structure and Mechanism of Receptor Sharing by the IL-10R2 Common Chain
2010
Hepatic interferon-stimulated genes are differentially regulated in the liver of chronic hepatitis C patients with different interleukin-28B genotypes
2014
Hepatitis C virus induces interferon-λ and interferon-stimulated genes in primary liver cultures
2010 StandoutNobel
Regulation of hepatic innate immunity by hepatitis C virus
2013
Analysis of the complete open reading frame of hepatitis C virus in genotype 2a infection reveals critical sites influencing the response to peginterferon and ribavirin therapy
2011
Combined effects of different interleukin-28B gene variants on the outcome of dual combination therapy in chronic hepatitis C virus type 1 infection
2012
Dysregulation of innate immunity in hepatitis C virus genotype 1 IL28B -unfavorable genotype patients: Impaired viral kinetics and therapeutic response
2012
Type I interferons in infectious disease
2015 Standout
IL28B Genetic Variation Is Associated with Spontaneous Clearance of Hepatitis C Virus, Treatment Response, Serum IL-28B Levels in Chinese Population
2012
Genome-wide association studies for complex traits: consensus, uncertainty and challenges
2008 Standout
New direct-acting antiviral agents for the treatment of hepatitis C virus infection and perspectives
2012
Natural selection and infectious disease in human populations
2014
IL28B and the Control of Hepatitis C Virus Infection
2010
New advances in the molecular biology of hepatitis C virus infection: towards the identification of new treatment targets
2012
The protease inhibitor, GS-9256, and non-nucleoside polymerase inhibitor tegobuvir alone, with ribavirin, or pegylated interferon plus ribavirin in hepatitis C
2011
Crystal Structure of Human Interferon-λ1 in Complex with Its High-Affinity Receptor Interferon-λR1
2010
Siglecs at the Host–Pathogen Interface
2020
Hepatitis C virus and microRNAs: miRed in a host of possibilities
2014
Identifying Recent Adaptations in Large-Scale Genomic Data
2013
Preliminary Study of Two Antiviral Agents for Hepatitis C Genotype 1
2012
The Course of Posttransplant Hepatitis C Infection
2012
Sequence heterogeneity of NS5A and core proteins of hepatitis C virus and virological responses to pegylated-interferon/ribavirin combination therapy
2011
Sex and gender: modifiers of health, disease, and medicine
2020 Standout
Association of IL28B genotype with fibrosis progression and clinical outcomes in patients with chronic hepatitis C: A longitudinal analysis
2013
IFN-λ3 Inhibits HIV Infection of Macrophages through the JAK-STAT Pathway
2012
A role of PIEZO1 in iron metabolism in mice and humans
2021 StandoutNobel
Interferon Lambda Alleles Predict Innate Antiviral Immune Responses and Hepatitis C Virus Permissiveness
2014 StandoutNobel
MDR1 haplotypes significantly minimize intracellular uptake and transcellular P‐gp substrate transport in recombinant LLC‐PK1 cells
2006
Immune Responses to HCV and Other Hepatitis Viruses
2014
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
2020 Standout
Importance of IL28B gene polymorphisms in hepatitis C virus genotype 2 and 3 infected patients
2010
Guarding the frontiers: the biology of type III interferons
2015
Coronavirus Disease 2019 (COVID-19) pandemic, lessons to be learned!
2020
Acute hepatitis C in HIV-infected men who have sex with men: an emerging sexually transmitted infection
2010
Single nucleotide polymorphism at exon 7 splice acceptor site of OAS1 gene determines response of hepatitis C virus patients to interferon therapy
2010
Pathogenesis of chronic viral hepatitis: differential roles of T cells and NK cells
2013
Inverse association of IL28B genotype and liver mRNA expression of genes promoting or suppressing antiviral state
2011
Genetic Variation of the IL-28B Promoter Affecting Gene Expression
2011
Interferon lambdas: the next cytokine storm
2011
Update on hepatitis C virus resistance to direct-acting antiviral agents
2014
Hepatitis C virus: How genetic variability affects pathobiology of disease
2011
Interferon-stimulated genes and their role in controlling hepatitis C virus
2013
Genes and hepatitis C: susceptibility, fibrosis progression and response to treatment
2011
A diverse range of gene products are effectors of the type I interferon antiviral response
2011 StandoutNatureNobel
The impact of sex, gender and pregnancy on 2009 H1N1 disease
2010
USP18-Based Negative Feedback Control Is Induced by Type I and Type III Interferons and Specifically Inactivates Interferon α Response
2011
IL-28B is a Key Regulator of B- and T-Cell Vaccine Responses against Influenza
2014 StandoutNobel
Structure and function of interleukin-22 and other members of the interleukin-10 family
2010
A novel method for detection of IFN-lambda 3 binding to cells for quantifying IFN-lambda receptor expression
2017 Nobel
A Single Nucleotide Polymorphism Associated with Hepatitis C Virus Infections Located in the Distal Region of the IL28B Promoter Influences NF-κB-Mediated Gene Transcription
2013
Differential expression of interferon-lambda receptor 1 splice variants determines the magnitude of the antiviral response induced by interferon-lambda 3 in human immune cells
2020 StandoutNobel
Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity
2015 StandoutNature
The HCV Life Cycle: In vitro Tissue Culture Systems and Therapeutic Targets
2014 Standout
Convergent Evolution of Escape from Hepaciviral Antagonism in Primates
2012
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade
2017 StandoutNobel
Interferon lambda 4 signals via the IFNλ receptor to regulate antiviral activity against HCV and coronaviruses
2013
Host genetic basis for hepatitis C virus clearance: a role for blood collection centers
2010
Hepatitis C pharmacogenetics: State of the art in 2010
2010
Sex and Gender Differences in Clinical Medicine
2012
Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy
2016 StandoutNobel
Hepatitis C Virus Pathogen Associated Molecular Pattern (PAMP) Triggers Production of Lambda-Interferons by Human Plasmacytoid Dendritic Cells
2013
Changes in sequences of core region, interferon sensitivity‐determining region and interferon and ribavirin resistance‐determining region of hepatitis C virus genotype 1 during interferon‐alpha and ribavirin therapy, and efficacy of retreatment
2012
ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data
2010 Standout
The Human Condition—A Molecular Approach
2014 StandoutNobel
Innate immune responses in hepatitis C virus infection
2012
Innate Immune Responses to Hepatitis C Virus
2013 StandoutNobel
Loss of function of the new interferon IFN-λ4 may confer protection from hepatitis C
2013
Prime–boost immunization with poxvirus or adenovirus vectors as a strategy to develop a protective vaccine for HIV-1
2010
IFN-λ inhibits HIV-1 integration and post-transcriptional events in vitro, but there is only limited in vivo repression of viral production
2012
25 years of interferon-based treatment of chronic hepatitis C: an epoch coming to an end
2013
IL-29 is the dominant type III interferon produced by hepatocytes during acute hepatitis C virus infection
2012
HepG2 cells mount an effective antiviral interferon-lambda based innate immune response to hepatitis C virus infection
2014
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Review article: specifically targeted anti‐viral therapy for hepatitis C – a new era in therapy
2010
Treatment of HCV Infection by Targeting MicroRNA
2013 Standout
Identification of improved IL28B SNPs and haplotypes for prediction of drug response in treatment of hepatitis C using massively parallel sequencing in a cross-sectional European cohort
2011
A Randomized, Double-Blind, Placebo-Controlled Assessment of BMS-936558, a Fully Human Monoclonal Antibody to Programmed Death-1 (PD-1), in Patients with Chronic Hepatitis C Virus Infection
2013
Hepatitis C Virus RNA Functionally Sequesters miR-122
2015 StandoutNobel
Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles
2003 StandoutNobel
Prolonged activation of innate antiviral gene signature after childbirth is determined byIFNL3genotype
2016
Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates
2011 StandoutNobel
Genetic Variation at IFNL4 Influences Extrahepatic Interferon-Stimulated Gene Expression in Chronic HCV Patients
2017 StandoutNobel
Polymorphisms in melanoma differentiation‐associated gene 5 link protein function to clearance of hepatitis C virus
2014 StandoutNobel
IL28B expression depends on a novel TT/-G polymorphism which improves HCV clearance prediction
2013
Effect of the IL28B Rs12979860 C/T polymorphism on the incidence and features of active cytomegalovirus infection in allogeneic stem cell transplant patients
2013
The impact of the interferon-lambda family on the innate and adaptive immune response to viral infections
2014 StandoutNobel
Increased Risk of Severe Hepatitis C Virus Recurrence After Liver Transplantation in Patients With a T Allele of IL28B rs12979860
2012
IL-29 and IFNα differ in their ability to modulate IL-12 production by TLR-activated human macrophages and exhibit differential regulation of the IFNγ receptor expression
2010
Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems
2014 StandoutNobel
IFN-λ receptor 1 expression is induced in chronic hepatitis C and correlates with the IFN-λ3 genotype and with nonresponsiveness to IFN-α therapies
2014
2013
Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains
2012
Characterization of nonprimate hepacivirus and construction of a functional molecular clone
2015 StandoutNobel
Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus
2012 StandoutNobel
Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability
2005
Modeling hepatitis C virus infection using human induced pluripotent stem cells
2012 StandoutNobel
A bacterial Argonaute with noncanonical guide RNA specificity
2016 StandoutNobel
Pleistocene North African genomes link Near Eastern and sub-Saharan African human populations
2018 StandoutScienceNobel
IFNL3 mediates interaction between innate immune cells: Implications for hepatitis C virus pathogenesis
2013
Antisense Gets a Grip on miR-122 in Chimpanzees
2010 StandoutNobel
The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients
2018 StandoutScience
Response of Hepatitis C Virus to Long-Term Passage in the Presence of Alpha Interferon: Multiple Mutations and a Common Phenotype
2013 StandoutNobel
Mouse CD8α+ DCs and human BDCA3+ DCs are major producers of IFN-λ in response to poly IC
2010
Cellular cofactors affecting hepatitis C virus infection and replication
2007 StandoutNobel
Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs
2002 StandoutNobel
Viral persistence, liver disease, and host response in a hepatitis C–like virus rat model
2017 StandoutNobel
Activation of naïve B lymphocytes via CD81, a pathogenetic mechanism for hepatitis C virus-associated B lymphocyte disorders
2005 StandoutNobel
Mechanistic Pathways of Sex Differences in Cardiovascular Disease
2016
IFN‐λ‐mediated IL‐12 production in macrophages induces IFN‐γ production in human NK cells
2014
Viral Quasispecies Evolution
2012
IFN-λ Exerts Opposing Effects on T Cell Responses Depending on the Chronicity of the Virus Infection
2014
Regulation and Functions of the IL-10 Family of Cytokines in Inflammation and Disease
2011 Standout
Accurate proteome-wide missense variant effect prediction with AlphaMissense
2023 StandoutScienceNobel
Works of Jacques Fellay being referenced
ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C
2010 Nature
Variants in the ITPA Gene Protect Against Ribavirin-Induced Hemolytic Anemia and Decrease the Need for Ribavirin Dose Reduction
2010
Identification of Siglec-1 null individuals infected with HIV-1
2016
Gender medicine and oncology: report and consensus of an ESMO workshop
2019
Inosine Triphosphate Protects Against Ribavirin-Induced Adenosine Triphosphate Loss by Adenylosuccinate Synthase Function
2011
WGAViewer: Software for genomic annotation of whole genome association studies: Figure 1.
2008
Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study
2002
COVID-19 epidemic in Switzerland: on the importance of testing, contact tracing and isolation
2020 Standout
Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
2009 StandoutNature
Host Determinants of HIV‐1 Control in African Americans
2010
TheHCP5Single‐Nucleotide Polymorphism: A Simple Screening Tool for Prediction of Hypersensitivity Reaction to Abacavir
2008
X Chromosomal Variation Is Associated with Slow Progression to AIDS in HIV-1-Infected Women
2009
Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population
2010
IL28B Genotype Is Associated With Differential Expression of Intrahepatic Interferon-Stimulated Genes in Patients With Chronic Hepatitis C
2010
Estimating the net contribution of interleukin-28B variation to spontaneous hepatitis C virus clearance
2011