Citation Impact
Citing Papers
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
2018 StandoutScienceNobel
Preferential Generation of Follicular B Helper T Cells from Foxp3 + T Cells in Gut Peyer's Patches
2009 StandoutScienceNobel
Protein interaction networks revealed by proteome coevolution
2019 StandoutScienceNobel
Targeting Cytokine Therapy to the Pancreatic Tumor Microenvironment Using PD-L1–Specific VHHs
2018
Tumor-reactive CD4+ T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts
2010 StandoutNobel
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
A sex-biased imbalance between Tfr, Tph, and atypical B cells determines antibody responses in COVID-19 patients
2023 StandoutNobel
Reciprocal T H 17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid
2007 StandoutScience
Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model
2007 StandoutNobel
The challenges and molecular approaches surrounding interleukin-2-based therapeutics in cancer
2018
A next-generation tumor-targeting IL-2 preferentially promotes tumor-infiltrating CD8+ T-cell response and effective tumor control
2019
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy
2022 StandoutNobel
The Histone Methyltransferase Ezh2 Controls Mechanisms of Adaptive Resistance to Tumor Immunotherapy
2017
TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells
2006 Standout
Re-establishing immunological self-tolerance in autoimmune disease
2012 StandoutNobel
Elements of cancer immunity and the cancer–immune set point
2017 StandoutNature
The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells
2006 Standout
mRNA vaccines — a new era in vaccinology
2018 StandoutNobel
TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation
2012
Foxp3+ Regulatory T Cells Promote T Helper 17 Cell Development In Vivo through Regulation of Interleukin-2
2011
Transforming Growth Factor-β Signaling in Immunity and Cancer
2019 Standout
Enhancement of anti‐tumor immunity through local modulation of CTLA‐4 and GITR by dendritic cells
2011
Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms
2015
A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses
2008
The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases
2015
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
Multifarious Determinants of Cytokine Receptor Signaling Specificity
2014
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
2009 Standout
A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity
2008 StandoutNature
Interleukin-2 Activity Can Be Fine Tuned with Engineered Receptor Signaling Clamps
2015
Cell-autonomous and -non-autonomous roles of CTLA-4 in immune regulation
2011 StandoutNobel
IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells
2007 StandoutNature
Inflammatory Bowel Disease
2009 Standout
Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection
2017
Late Developmental Plasticity in the T Helper 17 Lineage
2009
Engineering interferons and interleukins for cancer immunotherapy
2022
Transforming growth factor-β induces development of the TH17 lineage
2006 StandoutNature
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
2006 StandoutNature
Th17: An Effector CD4 T Cell Lineage with Regulatory T Cell Ties
2006
TGF-β signaling in T cells: roles in lymphoid and epithelial neoplasia
2005
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
2015 Standout
The advent of de novo proteins for cancer immunotherapy
2020
Targeting T Cell Immunometabolism for Cancer Immunotherapy; Understanding the Impact of the Tumor Microenvironment
2014
The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity
2017 StandoutNobel
TGFβ in Cancer
2008 Standout
Induction of T cell anergy: integration of environmental cues and infectious tolerance
2010
Modulation of EZH2 expression in T cells improves efficacy of anti–CTLA-4 therapy
2018 StandoutNobel
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
2011 StandoutNobel
Pro- and Antiinflammatory Cytokine Signaling: Reciprocal Antagonism Regulates Interferon-gamma Production by Human Natural Killer Cells
2006
Cytokines in Cancer Immunotherapy
2017
Genetics and pathogenesis of inflammatory bowel disease
2011 StandoutNature
Foxo Transcription Factors Control Regulatory T Cell Development and Function
2010
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
AKT/PKB Signaling: Navigating the Network
2017 Standout
Requirements and Challenges of a Preclinical Autoimmune Hepatitis Mouse Model
2011
Eomesodermin is required for antitumor immunity mediated by 4-1BB-agonist immunotherapy
2014
Immune escape to PD-L1/PD-1 blockade: seven steps to success (or failure)
2016
Anti-CD28-induced co-stimulation and TCR avidity regulates the differential effect of TGF- 1 on CD4+ and CD8+ naive human T-cells
2004
Regulation of the Immune Response by TGF-β: From Conception to Autoimmunity and Infection
2017
TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function
2008 StandoutNature
Cellular Mechanisms of Fatal Early-Onset Autoimmunity in Mice with the T Cell-Specific Targeting of Transforming Growth Factor-β Receptor
2006
Engineered IL-21 Cytokine Muteins Fused to Anti-PD-1 Antibodies Can Improve CD8+ T Cell Function and Anti-tumor Immunity
2020
Treg cell-based therapies: challenges and perspectives
2019
Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
2006 StandoutNature
Modular design of synthetic receptors for programmed gene regulation in cell therapies
2022
Atezolizumab for First-Line Treatment of Metastatic Nonsquamous NSCLC
2018 Standout
TGF-β Activation and Function in Immunity
2013
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
ALKS 4230: a novel engineered IL-2 fusion protein with an improved cellular selectivity profile for cancer immunotherapy
2020
Distinct Effects of TGF-β1 on CD4+ and CD8+ T Cell Survival, Division, and IL-2 Production: A Role for T Cell Intrinsic Smad3
2005
Dendritic cells with TGF-β1 differentiate naïve CD4+CD25−T cells into islet-protective Foxp3+regulatory T cells
2007 StandoutNobel
Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy
2018
Treg functional stability and its responsiveness to the microenvironment
2014
Modulation of Dendritic Cell Function by Naive and Regulatory CD4+ T Cells
2006
A role for Dicer in immune regulation
2006 StandoutNobel
Transforming Growth Factor-β and the Immune Response: Implications for Anticancer Therapy
2007
Insights into Cytokine–Receptor Interactions from Cytokine Engineering
2014
TGFβ1 Inhibits Ca2+-Calcineurin-Mediated Activation in Thymocytes
2003
Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood
2016 StandoutNobel
Foxp3+natural regulatory T cells preferentially form aggregates on dendritic cellsin vitroand actively inhibit their maturation
2008 StandoutNobel
Emerging Challenges in Regulatory T Cell Function and Biology
2007 StandoutScienceNobel
Unique potential of 4-1BB agonist antibody to promote durable regression of HPV + tumors when combined with an E6/E7 peptide vaccine
2015 StandoutNobel
Targeting an engineered cytokine with interleukin-2 and interleukin-15 activity to the neovasculature of solid tumors
2020
Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation
2020 StandoutNobel
TGF-β1 Regulates Lymphocyte Homeostasis by Preventing Activation and Subsequent Apoptosis of Peripheral Lymphocytes
2003
Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+regulatory T cells, evoking antitumor immune responses in humans
2013 StandoutNobel
TGF-β1 Regulates Antigen-Specific CD4+ T Cell Responses in the Periphery
2007
TRANSFORMING GROWTH FACTOR-β REGULATION OF IMMUNE RESPONSES
2005 Standout
Cutting Edge: Chronic Inflammatory Liver Disease in Mice Expressing a CD28-Specific Ligand
2012 StandoutNobel
Animal models of autoimmune hepatitis
2010
A distinct subpopulation of CD25−T-follicular regulatory cells localizes in the germinal centers
2017 StandoutNobel
p21Cip1 and p27Kip1 Act in Synergy to Alter the Sensitivity of Naive T Cells to TGF-β-Mediated G1 Arrest through Modulation of IL-2 Responsiveness
2004
Predicting protein–protein interactions through sequence-based deep learning
2018
Cutting Edge: IL-2 Is Essential for TGF-β-Mediated Induction of Foxp3+ T Regulatory Cells
2007
T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis
2007 StandoutNobel
Works of Jack T. Lin being referenced
Naive CD4 T Cell Proliferation Is Controlled by Mammalian Target of Rapamycin Regulation of GRAIL Expression
2009
CD28 co-stimulation regulates the effect of transforming growth factor-β1 on the proliferation of naıve CD4+ T cells
2003
Differential mTOR and ERK pathway utilization by effector CD4 T cells suggests combinatorial drug therapy of arthritis
2011
GRAIL Is Up-regulated in CD4+ CD25+ T Regulatory Cells and Is Sufficient for Conversion of T Cells to a Regulatory Phenotype
2007
Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’
2012 Nature
MHC-independent genetic regulation of liver damage in a mouse model of autoimmune hepatocellular injury
2005
Necroinflammatory Liver Disease in BALB/c Background, TGF-β1-Deficient Mice Requires CD4+ T Cells
2003
Genetic Regulation of Autoimmune Disease: BALB/c Background TGF-β1-Deficient Mice Develop Necroinflammatory IFN-γ-Dependent Hepatitis
2001
Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by Treg depletion
2009
TGF-β1 Uses Distinct Mechanisms to Inhibit IFN-γ Expression in CD4+ T Cells at Priming and at Recall: Differential Involvement of Stat4 and T-bet
2005