Standout Papers
Citation Impact
Citing Papers
High-throughput characterization of protein–protein interactions by reprogramming yeast mating
2017 StandoutNobel
Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble
2018 StandoutNobel
Designed protein logic to target cells with precise combinations of surface antigens
2020 StandoutScienceNobel
The Selective Incorporation of Alkenes into Proteins in Escherichia coli
2002
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
β-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation
2009 StandoutNobel
Catalytic Asymmetric Three‐Component Synthesis of Homoallylic Amines
2013 StandoutNobel
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
2009 StandoutNobel
Recent advances in the catalytic asymmetric synthesis of β-amino acids
2010 StandoutNobel
A view on drug resistance in cancer
2019 StandoutNature
Reaching for high-hanging fruit in drug discovery at protein–protein interfaces
2007 StandoutNature
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
2013 StandoutNature
Structure Determination and Total Synthesis of Bottromycin A2: A Potent Antibiotic against MRSA and VRE
2008 StandoutNobel
Rethinking amide bond synthesis
2011 StandoutNature
Determinants of BH3 Binding Specificity for Mcl-1 versus Bcl-xL
2010
Small‐Molecule Affinity Ligands for Protein Purification: Combined Computational Enrichment and Automated In‐line Screening of an Optically Encoded Library
2010 StandoutNobel
Computational Enzyme Design
2013 StandoutNobel
Cysteine Promoted C‐Terminal Hydrazinolysis of Native Peptides and Proteins
2013 StandoutNobel
Suitanes
2006 StandoutNobel
How Can Folded Biopolymers and Synthetic Foldamers Recognize Each Other?
2009
Inhibition of α-helix-mediated protein–protein interactions using designed molecules
2013
CRISPR-Cas9 screens identify regulators of antibody–drug conjugate toxicity
2019 StandoutNobel
One Crystal, Two Temperatures: Cryocooling Penalties Alter Ligand Binding to Transient Protein Sites
2015
Structure‐Based Design of Inhibitors of Protein–Protein Interactions: Mimicking Peptide Binding Epitopes
2015
Synthetic foldamers
2011
Targeting protein–protein interactions: Lessons from p53/MDM2
2007
Foldamers as versatile frameworks for the design and evolution of function
2007
Modeling Backbone Flexibility to Achieve Sequence Diversity: The Design of Novel α-Helical Ligands for Bcl-xL
2007
A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells
2014 StandoutNobel
Comparative α‐Helicity of Cyclic Pentapeptides in Water
2014
The coming of age of de novo protein design
2016 StandoutNatureNobel
Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites
2021 StandoutNobel
Constraining Cyclic Peptides To Mimic Protein Structure Motifs
2014
Mcl‐1–Bim complexes accommodate surprising point mutations via minor structural changes
2010
Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus BHRF1
2010
Protein binding specificity versus promiscuity
2010
De novo design of bioactive protein switches
2019 StandoutNatureNobel
Template‐Directed Syntheses of Rigid Oligorotaxanes under Thermodynamic Control
2010 StandoutNobel
Survey of the year 2003 commercial optical biosensor literature
2004
The Bcl-2 apoptotic switch in cancer development and therapy
2007 Standout
Allostery in Disease and in Drug Discovery
2013
Peptidic foldamers: ramping up diversity
2011
Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands
2009
Consecutive Cyclic Pentapeptide Modules Form Short α‐Helices that are Very Stable to Water and Denaturants
2004
Efficient Microwave-Assisted Tandem N- to S-Acyl Transfer and Thioester Exchange for the Preparation of a Glycosylated Peptide Thioester
2006
Chemical Topology: Complex Molecular Knots, Links, and Entanglements
2011 StandoutNobel
Molecular Determinants of Bim(BH3) Peptide Binding to Pro-Survival Proteins
2012
Three-Dimensional Porous Coordination Polymer Functionalized with Amide Groups Based on Tridentate Ligand: Selective Sorption and Catalysis
2007 StandoutNobel
Resolution of Diols via Catalytic Asymmetric Acetalization
2015 StandoutNobel
Olefin metathesis
2004 StandoutNobel
Highly Diastereoselective Asymmetric Mannich Reactions of 1,3-Dicarbonyls with Acyl Imines
2006
Nucleophilic Chiral Amines as Catalysts in Asymmetric Synthesis
2003
Foldamers with Heterogeneous Backbones
2008
Aromatizing Olefin Metathesis by Ligand Isolation inside a Metal– Organic Framework
2013 StandoutNobel
The Current State of Peptide Drug Discovery: Back to the Future?
2017
Engineered Biosynthesis of β‐Alkyl Tryptophan Analogues
2018 StandoutNobel
Stereostructure of luminamicin, an anaerobic antibiotic, via molecular dynamics, NMR spectroscopy, and the modified Mosher method
2005 StandoutNobel
Engineering enzymes for noncanonical amino acid synthesis
2018 StandoutNobel
A Hydrogen Bond Surrogate Approach for Stabilization of Short Peptide Sequences in α-Helical Conformation
2008
Organocatalytic Asymmetric Mannich Reactions: New Methodology, Catalyst Design, and Synthetic Applications
2007
α/β-Peptide Foldamers Targeting Intracellular Protein–Protein Interactions with Activity in Living Cells
2015
Structural and Co-conformational Effects of Alkyne-Derived Subunits in Charged Donor−Acceptor [2]Catenanes
2007 StandoutNobel
Maintaining Biological Activity by Using Triazoles as Disufide Bond Mimetics
2011 StandoutNobel
Folding of Oligoviologens Induced by Radical–Radical Interactions
2014 StandoutNobel
Development and Applications of Disulfonimides in Enantioselective Organocatalysis
2015 StandoutNobel
Template-Directed One-Step Synthesis of Cyclic Trimers by ADMET
2006 StandoutNobel
Reprogramming homing endonuclease specificity through computational design and directed evolution
2013 StandoutNobel
Hydrogen Bond Surrogate Stabilization of β-Hairpins
2018
Macrocyclic Control in Helix Mimetics
2019
Iterative, Aqueous Synthesis of β3-Oligopeptides without Coupling Reagents
2006
De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures
2017 StandoutNobel
A Pictet-Spengler ligation for protein chemical modification
2012 StandoutNobel
Computational Design of a β-Peptide That Targets Transmembrane Helices
2011
Folding of a Linear Array of α-Amino Acids within a Helical Aromatic Oligoamide Frame
2013
Rational Tuning of Fluorobenzene Probes for Cysteine‐Selective Protein Modification
2018 StandoutNobel
Fluorescence Polarization/Anisotropy in Diagnostics and Imaging
2010
Catalytic Asymmetric Synthesis of Unprotected β2-Amino Acids
2021 StandoutNobel
Immobilization of Sodium Ions on the Pore Surface of a Porous Coordination Polymer
2006 StandoutNobel
Template-Directed Olefin Cross Metathesis
2005 StandoutNobel
Helix Formation in Preorganized β/γ-Peptide Foldamers: Hydrogen-Bond Analogy to the α-Helix without α-Amino Acid Residues
2010
A Push-Button Molecular Switch
2009 StandoutNobel
Discovery of multiple hidden allosteric sites by combining Markov state models and experiments
2015
Surface Plasmon Resonance Sensors for Detection of Chemical and Biological Species
2008 Standout
Disulfonimide-Catalyzed Asymmetric Synthesis of β3-Amino Esters Directly from N-Boc-Amino Sulfones
2013 StandoutNobel
Unusual Amino Acids in Medicinal Chemistry
2016
Peptide Ligands for Pro-survival Protein Bfl-1 from Computationally Guided Library Screening
2013
Comparative α‐Helicity of Cyclic Pentapeptides in Water
2014
Allosteric Modulation of Substrate Binding within a Tetracationic Molecular Receptor
2015 StandoutNobel
Stereospecific Synthesis of Conformationally Constrained γ-Amino Acids: New Foldamer Building Blocks That Support Helical Secondary Structure
2009
Stapled β-Hairpins Featuring 4-Mercaptoproline
2021 StandoutNobel
Differential Effects of β3‐ versus β2‐Amino Acid Residues on the Helicity and Recognition Properties of Bim BH3‐Derived α/β‐Peptides
2018
Synthesis of Biologically Active Dicarba Analogues of the Peptide Hormone Oxytocin Using Ring-Closing Metathesis
2002
Structural Chemistry of Peptides Containing Backbone Expanded Amino Acid Residues: Conformational Features of β, γ, and Hybrid Peptides
2010
Works of Jack Sadowsky being referenced
Chimeric (α/β + α)-Peptide Ligands for the BH3-Recognition Cleft of Bcl-x L : Critical Role of the Molecular Scaffold in Protein Surface Recognition
2005
Cathepsin B Is Dispensable for Cellular Processing of Cathepsin B-Cleavable Antibody–Drug Conjugates
2017
A fluorescence polarization assay for identifying ligands that bind to vascular endothelial growth factor
2008
Exploration of Backbone Space in Foldamers Containing α‐ and β‐Amino Acid Residues: Developing Protease‐Resistant Oligomers that Bind Tightly to the BH3‐Recognition Cleft of Bcl‐xL
2007
Hydrophile scanning as a complement to alanine scanning for exploring and manipulating protein–protein recognition: Application to the Bim BH3 domain
2008
High‐Resolution Structural Characterization of a Helical α/β‐Peptide Foldamer Bound to the Anti‐Apoptotic Protein Bcl‐xL
2009
Ring-Closing Metathesis of Olefinic Peptides: Design, Synthesis, and Structural Characterization of Macrocyclic Helical Peptides
2001 StandoutNobel
Efficient Synthesis of a β-Peptide Combinatorial Library with Microwave Irradiation
2005
High‐Resolution Structural Characterization of a Helical α/β‐Peptide Foldamer Bound to the Anti‐Apoptotic Protein Bcl‐xL
2009
(α/β+α)-Peptide Antagonists of BH3 Domain/Bcl-xL Recognition: Toward General Strategies for Foldamer-Based Inhibition of Protein−Protein Interactions
2006
Determination of the aqueous‐phase structure of 6‐O‐methylerythromycin from NMR constraints
2001
Turning a protein kinase on or off from a single allosteric site via disulfide trapping
2011