Standout Papers
Citation Impact
Citing Papers
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
2005 Standout
Identification of alternative splicing regulators by RNA interference in Drosophila
2004
The Melampsora lini AvrL567 Avirulence Genes Are Expressed in Haustoria and Their Products Are Recognized inside Plant Cells
2004
Cladosporium Avr2 Inhibits Tomato Rcr3 Protease Required for Cf-2 -Dependent Disease Resistance
2005 Science
The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases
2005
Activation of a Phytopathogenic Bacterial Effector Protein by a Eukaryotic Cyclophilin
2005 Science
Arabidopsis RIN4 Negatively Regulates Disease Resistance Mediated by RPS2 and RPM1 Downstream or Independent of the NDR1 Signal Modulator and Is Not Required for the Virulence Functions of Bacterial Type III Effectors AvrRpt2 or AvrRpm1
2004
A Pseudomonas syringae type III effector suppresses cell wall-based extracellular defense in susceptible Arabidopsis plants
2003
Haustorially Expressed Secreted Proteins from Flax Rust Are Highly Enriched for Avirulence Elicitors
2005
Direct protein interaction underlies gene-for-gene specificity and coevolution of the flax resistance genes and flax rust avirulence genes
2006
Yersinia YopJ Acetylates and Inhibits Kinase Activation by Blocking Phosphorylation
2006 Science
PTEN-Deficient Tumors Depend on AKT2 for Maintenance and Survival
2014
A Patch of Surface-Exposed Residues Mediates Negative Regulation of Immune Signaling by Tomato Pto Kinase[W]
2004
Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway
2002 Standout
Assaying the Drosophila Negative Feedback Loop with RNA Interference in S2 Cells
2005 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Increased phosphoinositide 3‐kinase activity induces a lymphoproliferative disorder and contributes to tumor generation in vivo
2000
The Role of Phosphatases in Inositol Signaling Reactions
1999
PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies
1999
Chapter 2 PI3K/PTEN Signaling in Angiogenesis and Tumorigenesis
2009
A Novel Positive Feedback Loop Mediated by the Docking Protein Gab1 and Phosphatidylinositol 3-Kinase in Epidermal Growth Factor Receptor Signaling
2000
Phosphoinositides and signal transduction
2002
Systems Biology of Growth Factor‐Induced Receptor Endocytosis
2008
Activation of a COI1‐dependent pathway in Arabidopsis by Pseudomonas syringae type III effectors and coronatine
2004
Type III effector proteins: doppelgangers of bacterial virulence
2006
The role and regulation of programmed cell death in plant-pathogen interactions
2004
The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis
2005 StandoutNobel
Analysis of the genome to personalize therapy for melanoma
2010
SAC1-like Domains of Yeast SAC1,INP52, and INP53 and of Human Synaptojanin Encode Polyphosphoinositide Phosphatases
1999
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
2006 Standout
Pseudomonas syringae effector AvrPtoB suppresses basal defence in Arabidopsis
2006
PTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells is mediated by p27kip1
2000
Regulation of Phosphorylation of Thr-308 of Akt, Cell Proliferation, and Survival by the B55α Regulatory Subunit Targeting of the Protein Phosphatase 2A Holoenzyme to Akt
2007
Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime
2002 Nature
Signal Transduction by the JNK Group of MAP Kinases
2000 Standout
Protein Targeting to Endosomes and Phagosomes via FYVE and PX Domains
2004
Mutagenesis of the catalytic subunit of rabbit muscle protein phosphatase-1
1993
Mutational Spectra of PTEN/MMAC1 Gene: a Tumor Suppressor With Lipid Phosphatase Activity
1999
A Double S Shape Provides the Structural Basis for the Extraordinary Binding Specificity of Dscam Isoforms
2008 StandoutNobel
Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway
1999
Pseudomonas type III effector AvrPtoB induces plant disease susceptibility by inhibition of host programmed cell death
2002
Sounding the Alarm: Protein Kinase Cascades Activated by Stress and Inflammation
1996
Expression and prognostic role of tumor suppressor gene PTEN/MMAC1/TEP1 in hepatocellular carcinoma
2003
Arabidopsis RIN4 Is a Target of the Type III Virulence Effector AvrRpt2 and Modulates RPS2-Mediated Resistance
2003
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer
2016
Dual Detection of Fungal Infections in Drosophila via Recognition of Glucans and Sensing of Virulence Factors
2006 StandoutNobel
Genetic and molecular evidence that the Pseudomonas syringae type III effector protein AvrRpt2 is a cysteine protease
2003
Pharmacological inhibitors of MAPK pathways
2002
The Role of Phosphoinositide 3-Kinase Lipid Products in Cell Function
1999
Control of β-Catenin Phosphorylation/Degradation by a Dual-Kinase Mechanism
2002 Standout
Basal Defenses Induced in Pepper by Lipopolysaccharides Are Suppressed by Xanthomonas campestris pv. vesicatoria
2004
A Vast Repertoire of Dscam Binding Specificities Arises from Modular Interactions of Variable Ig Domains
2007 StandoutNobel
Mechanisms of plant resistance to viruses
2005
The Drosophila Circadian Network Is a Seasonal Timer
2007 StandoutNobel
Plant and Animal Pathogen Recognition Receptors Signal through Non-RD Kinases
2006
Reversible Inactivation of Protein-tyrosine Phosphatase 1B in A431 Cells Stimulated with Epidermal Growth Factor
1998
PHLPP and a Second Isoform, PHLPP2, Differentially Attenuate the Amplitude of Akt Signaling by Regulating Distinct Akt Isoforms
2007
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
2004 StandoutNobel
Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance
2016
Characterization of the Xanthomonas AvrXv4 Effector, a SUMO Protease Translocated into Plant Cells
2004
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
2001 StandoutNature
Mutually Exclusive Splicing of the Insect Dscam Pre-mRNA Directed by Competing Intronic RNA Secondary Structures
2005
Complete nucleotide sequence of the rabbit β-like globin gene cluster
1989
Cellular survival: a play in three Akts
1999 Standout
Stochastic yet biased expression of multiple Dscam splice variants by individual cells
2004
Protein phosphatases and the regulation of mitogen-activated protein kinase signalling
2000
The role of protein phosphorylation in human health and disease.
2001
Combined Use of RNAi and Quantitative Proteomics to Study Gene Function in Drosophila
2008
Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer
2003 Standout
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
2006 Nature
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
1998 StandoutNobel
Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections
2001 StandoutNobel
PTEN: One Gene, Many Syndromes
2003
Crosstalk Between Pten and Ras Signaling Pathways in Tumor Development
2005
Phosphatidylinositol 3,5-bisphosphate: metabolism and cellular functions
2005
Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: Evidence for multiple roles of mitotic cyclins
1991
Identification of JAK/STAT signalling components by genome-wide RNA interference
2005 Nature
Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling
2002
Protein tyrosine phosphatases: from genes, to function, to disease
2006
Post-transcriptional gene silencing by double-stranded RNA
2001
SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival
1999
Variable window binding for mutually exclusive alternative splicing
2006
Analysis of the Catalytic Domain of Phosphatidylinositol 4-Kinase Type II
2002 StandoutNobel
Culture of Drosophila S2 cells and their use for RNAi-mediated loss-of-function studies and immunofluorescence microscopy
2008
Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease
2001 StandoutNobel
Identification of PHLPP1 as a Tumor Suppressor Reveals the Role of Feedback Activation in PTEN-Mutant Prostate Cancer Progression
2011
PTEN expression in non–small-cell lung cancer: evaluating its relation to tumor characteristics, allelic loss, and epigenetic alteration
2005
Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis
2005
The cdc25 protein contains an intrinsic phosphatase activity
1991
Negative receptor signalling
2003
Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN
1998 StandoutNobel
Specific Bacterial Suppressors of MAMP Signaling Upstream of MAPKKK in Arabidopsis Innate Immunity
2006
Subversion of phosphoinositide metabolism by intracellular bacterial pathogens
2004
Evolutionarily Conserved Multiple C2 Domain Proteins with Two Transmembrane Regions (MCTPs) and Unusual Ca2+ Binding Properties
2004 StandoutNobel
Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast
1995
Genetic Interaction Between NRAS and BRAF Mutations and PTEN/MMAC1 Inactivation in Melanoma
2004
Cultivar-specific avirulence and virulence functions assigned to avrPphF in Pseudomonas syringae pv. phaseolicola, the cause of bean halo-blight disease
2000
A gene mutated in X–linked myotubular myopathy defines a new putative tyrosine phosphatase family conserved in yeast
1996
Signaling—2000 and Beyond
2000 Standout
Phosphoinositides, key molecules for regulation of actin cytoskeletal organization and membrane traffic from the plasma membrane
2001
Modulation of cellular apoptotic potential: contributions to oncogenesis
1999
Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein
1991 Nature
Expansion of the eukaryotic proteome by alternative splicing
2010 StandoutNature
The N‐terminal domains of tensin and auxilin are phosphatase homologues
1996
Host-Microbe Interactions: Shaping the Evolution of the Plant Immune Response
2006 Standout
Regulation of Membrane Targeting of the G Protein-coupled Receptor Kinase 2 by Protein Kinase A and Its Anchoring Protein AKAP79
2001 StandoutNobel
Endocrine Regulation of Energy Metabolism by the Skeleton
2007 Standout
Both the Establishment and the Maintenance of Neuronal Polarity Require Active Mechanisms
2005
Akt regulates growth by directly phosphorylating Tsc2
2002 Standout
PTEN: Life as a Tumor Suppressor
2001
Listening to silence and understanding nonsense: exonic mutations that affect splicing
2002 Standout
RNA Interference and Small Interfering RNAs
2001
Initiation of RPS2-Specified Disease Resistance in Arabidopsis Is Coupled to the AvrRpt2-Directed Elimination of RIN4
2003
Are innate immune signaling pathways in plants and animals conserved?
2005
Phosphoinositides in Constitutive Membrane Traffic
2004
The bacterial injection kit: Type III secretion systems
2005
A Core Complex of BBS Proteins Cooperates with the GTPase Rab8 to Promote Ciliary Membrane Biogenesis
2007 Standout
From Form to Function: Signaling by Protein Tyrosine Phosphatases
1996
cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2
1991
Structural basis for inhibition of receptor protein-tyrosine phosphatase-α by dimerization
1996 Nature
Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy
2004 Nature
twine, a cdc25 homolog that functions in the male and female germline of drosophila
1992 StandoutNobel
Phosphoinositides in cell regulation and membrane dynamics
2006 StandoutNature
The role of phosphoinositides in membrane transport
2001
PTEN function in mammalian cell size regulation
2002
AKT/PKB Signaling: Navigating the Network
2017 Standout
Calumenin, a Ca2+-binding Protein Retained in the Endoplasmic Reticulum with a Novel Carboxyl-terminal Sequence, HDEF
1997 StandoutNobel
Plant innate immunity – direct and indirect recognition of general and specific pathogen-associated molecules
2003
Basic local alignment search tool
1990 Standout
A regulator of Dscam mutually exclusive splicing fidelity
2007
PHLPP: A Phosphatase that Directly Dephosphorylates Akt, Promotes Apoptosis, and Suppresses Tumor Growth
2005
The PTEN, Mdm2, p53 tumor suppressor–oncoprotein network
2002
Global, In Vivo, and Site-Specific Phosphorylation Dynamics in Signaling Networks
2006 Standout
Two Pseudomonas syringae Type III Effectors Inhibit RIN4-Regulated Basal Defense in Arabidopsis
2005
Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC
1998
The PI3K Pathway in Human Disease
2017 Standout
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
1997 Standout
Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1
1995 StandoutNature
Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease
2001
Targeting PI3K signalling in cancer: opportunities, challenges and limitations
2009 Standout
The Mixed Lineage Kinase DLK Utilizes MKK7 and Not MKK4 as Substrate
1999
Innate immunity in plants and animals: striking similarities and obvious differences
2004
SGK3 Mediates INPP4B-Dependent PI3K Signaling in Breast Cancer
2014
Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice
2007 StandoutNobel
Multiple positive and negative regulators of signaling by the EGF-receptor
1999
The Doubletime and CKII Kinases Collaborate to Potentiate Drosophila PER Transcriptional Repressor Activity
2004 StandoutNobel
Germline and germline mosaic PTEN mutations associated with a Proteus-like syndrome of hemihypertrophy, lower limb asymmetry, arteriovenous malformations and lipomatosis
2000
The associations between Parkinson’s disease and cancer: the plot thickens
2015
Mosaic Disorders of the PI3K/PTEN/AKT/TSC/mTORC1 Signaling Pathway
2016
Structure and function of theprotein tyrosine phosphatases
1996
Temporal and Spatial Regulation of Chemotaxis
2002
Lack of PTEN sequesters CHK1 and initiates genetic instability
2005
Phosphoinositide Involvement in Phagocytosis and Phagosome Maturation
2004
PTEN Modulates Vascular Endothelial Growth Factor-Mediated Signaling and Angiogenic Effects
2002
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
2004
The Tumor Suppressor PTEN Negatively Regulates Insulin Signaling in 3T3-L1 Adipocytes
2000
Bacterial elicitation and evasion of plant innate immunity
2006
Neurotrophic factor receptor RET: structure, cell biology, and inherited diseases
2007
MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification
2008 Standout
Quantitative analysis of the activation mechanism of the multicomponent growth-factor receptor Ret
2006
The plant immune system
2006 StandoutNature
Conservation analysis and structure prediction of the protein serine/threonine phosphatases
1994
Oncogenic PI3K deregulates transcription and translation
2005
Alternative splicing and RNA selection pressure — evolutionary consequences for eukaryotic genomes
2006
T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance
2001 StandoutNobel
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
1997 Standout
Cell Signaling by Receptor Tyrosine Kinases
2000 Standout
Complementary Chimeric Isoforms Reveal Dscam1 Binding Specificity In Vivo
2012 StandoutNobel
The Tomato NBARC-LRR Protein Prf Interacts with Pto Kinase in Vivo to Regulate Specific Plant Immunity
2006
Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis
1986 StandoutScience
Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production
2003 StandoutNobel
Nutrients Suppress Phosphatidylinositol 3-Kinase/Akt Signaling via Raptor-Dependent mTOR-Mediated Insulin Receptor Substrate 1 Phosphorylation
2005
A Novel Proteomic Screen for Peptide-Protein Interactions
2004
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
1999 Standout
Contrasting Mechanisms of Defense Against Biotrophic and Necrotrophic Pathogens
2005 Standout
Common and Contrasting Themes of Plant and Animal Diseases
2001 Science
Synthesis and Function of 3-Phosphorylated Inositol Lipids
2001 Standout
Diverse Evolutionary Mechanisms Shape the Type III Effector Virulence Factor Repertoire in the Plant Pathogen Pseudomonas syringae
2004
Discovery of a Small Molecule Insulin Mimetic with Antidiabetic Activity in Mice
1999 Science
HOW CELLS RESPOND TO INTERFERONS
1998 Standout
Dynamics of Phosphoinositides in Membrane Retrieval and Insertion
2003
Inhibition of Cell Migration, Spreading, and Focal Adhesions by Tumor Suppressor PTEN
1998 Science
clr-1 encodes a receptor tyrosine phosphatase that negatively regulates an FGF receptor signaling pathway in Caenorhabditis elegans
1998 StandoutNobel
Epidermal Growth Factor (EGF)-induced Generation of Hydrogen Peroxide
1997 Standout
Stability of Catecholamines and Propranolol Covalently Bound to Sepharose and Glass Beads
1973 Science
Ramshackle (Brwd3) promotes light-induced ubiquitylation of Drosophila Cryptochrome by DDB1-CUL4-ROC1 E3 ligase complex
2013 StandoutNobel
Sequence of protein disulphide isomerase and implications of its relationship to thioredoxin
1985 Nature
Synergistic Interaction of MEK Kinase 2, c-Jun N-Terminal Kinase (JNK) Kinase 2, and JNK1 Results in Efficient and Specific JNK1 Activation
2000
A Telomeric Avirulence Gene Determines Efficacy for the Rice Blast Resistance Gene Pi-ta
2000
Characterization of the carboxyl-terminal sequences responsible for protein retention in the endoplasmic reticulum
1991
Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation.
2003 StandoutNobel
Purification and expression of gCap39. An intracellular and secreted Ca2(+)-dependent actin-binding protein enriched in mononuclear phagocytes.
1990 StandoutNobel
Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: The MPAKT model
2003
Balancing Akt with S6K
2004
Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers
1999 Standout
Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland
2002
Critical Roles of Pten in B Cell Homeostasis and Immunoglobulin Class Switch Recombination
2003 StandoutNobel
Impaired Fas Response and Autoimmunity in Pten +/− Mice
1999 Science
An isoform-specific allele of Drosophila N-cadherin disrupts a late step of R7 targeting
2005
Cab45, a novel (Ca2+)-binding protein localized to the Golgi lumen.
1996
Tumor Suppressor PTEN Inhibits Integrin- and Growth Factor–mediated Mitogen-activated Protein (MAP) Kinase Signaling Pathways
1998
Integrin Signaling
1999 StandoutScience
NEW INSIGHTS TO THE FUNCTION OF PHYTOPATHOGENIC BACTERIAL TYPE III EFFECTORS IN PLANTS
2005
Adipocyte beta-adrenergic receptors. Identification and subcellular localization by (-)-[3H]dihydroalprenolol binding.
1976 StandoutNobel
Shc and Fak Differentially Regulate Cell Motility and Directionality Modulated by Pten
1999
Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain
1997
Isolation, characterization, and inactivation of the APA1 gene encoding yeast diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase
1989
PRL-1, a Unique Nuclear Protein Tyrosine Phosphatase, Affects Cell Growth
1994
Molecular characterization of proteolytic cleavage sites of the Pseudomonas syringae effector AvrRpt2
2005
PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1cell cycle entry
2005
Inositol-lipid binding motifs: signal integrators through protein-lipid and protein-protein interactions
2005
Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases
2002 StandoutScience
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase
1997
Development of “substrate-trapping” mutants to identify physiological substrates of protein tyrosine phosphatases
1997
PTEN and phosphatidylinositol 3'-kinase inhibitors up-regulate p53 and block tumor-induced angiogenesis: evidence for an effect on the tumor and endothelial compartment.
2003
E-Syts, a family of membranous Ca 2+ -sensor proteins with multiple C 2 domains
2007 StandoutNobel
Subterfuge and Manipulation: Type III Effector Proteins of Phytopathogenic Bacteria
2006
Loss of PTEN expression leading to high Akt activation in human multiple myelomas
2000
Specific Inhibition of PTEN Expression Reverses Hyperglycemia in Diabetic Mice
2002
Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis
2002
The lipid phosphatase activity of PTEN is critical for its tumor supressor function
1998
THE CROONIAN LECTURE 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and disease
1998
Physiological Functions of Pten in Mouse Tissues.
2003 StandoutNobel
Cellular Function of Phosphoinositide 3-Kinases: Implications for Development, Immunity, Homeostasis, and Cancer
2001
PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer
1997 StandoutScience
Signaling by the Phosphoinositide 3-Kinase Family in Immune Cells
2013
Posttranslational Modification of Bcl-2 Facilitates Its Proteasome-Dependent Degradation: Molecular Characterization of the Involved Signaling Pathway
2000
Expression of Active Protein Kinase B in T Cells Perturbs Both T and B Cell Homeostasis and Promotes Inflammation
2001
Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human
1999 Standout
Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells
2000
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
2018 StandoutNobel
PTENGene Targeting Reveals a Radiation-Induced Size Checkpoint in Human Cancer Cells
2004
Mutation ofPten/Mmac1in mice causes neoplasia in multiple organ systems
1999
Activation of Mammalian Target of Rapamycin in Transformed B Lymphocytes Is Nutrient Dependent but Independent of Akt, Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase, Insulin Growth Factor-I, and Serum
2005
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway
1999
Extracellular Signal-Regulated Kinase 7 (ERK7), a Novel ERK with a C-Terminal Domain That Regulates Its Activity, Its Cellular Localization, and Cell Growth
1999
Signaling Specificity by Ras Family GTPases Is Determined by the Full Spectrum of Effectors They Regulate
2004
Mechanism of phagolysosome biogenesis block by viable Mycobacterium tuberculosis
2005
Dimerization-Induced Inhibition of Receptor Protein Tyrosine Phosphatase Function Through an Inhibitory Wedge
1998 Science
The baculovirus Autographa californica encodes a protein tyrosine phosphatase.
1993
Regulation of G1progression by thePTENtumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway
1999
Phosphoproteome Analysis of HeLa Cells Using Stable Isotope Labeling with Amino Acids in Cell Culture (SILAC)
2005
MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway
1996
PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development
1999
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten
2004 StandoutNobel
Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks
2011
A Role for Nuclear PTEN in Neuronal Differentiation
2000
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
2004 StandoutNobel
High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice.
2000 StandoutNobel
Map-Based Cloning of a Protein Kinase Gene Conferring Disease Resistance in Tomato
1993 StandoutScience
CATERPILLER: A Novel Gene Family Important in Immunity, Cell Death, and Diseases
2004
YERSINIA OUTER PROTEINS: Role in Modulation of Host Cell Signaling Responses and Pathogenesis
2005
Works of Jack E. Dixon being referenced
Cleavage of Arabidopsis PBS1 by a Bacterial Type III Effector
2003 Science
Selective Activation of MEK1 but Not MEK2 by A-Raf from Epidermal Growth Factor-stimulated Hela Cells
1996
PTEN Protects p53 from Mdm2 and Sensitizes Cancer Cells to Chemotherapy
2002
A Single Mutation Converts a Novel Phosphotyrosine Binding Domain into a Dual-specificity Phosphatase
1995
Drosophila Dscam Is an Axon Guidance Receptor Exhibiting Extraordinary Molecular Diversity
2000
Gathering STYX: phosphatase-like form predicts functions for unique protein-interaction domains
1998
Protein tyrosine phosphatases: characterization of extracellular and intracellular domains
1994
Form and Function in Protein Dephosphorylation
1996
Crystal Structure of a Phosphoinositide Phosphatase, MTMR2
2003
Components of a New Human Protein Kinase Signal Transduction Pathway
1995
A Novel Cytoplasmic Dual Specificity Protein Tyrosine Phosphatase Implicated in Muscle and Neuronal Differentiation
1996 Nobel
Identification of a Bacterial Type III Effector Family with G Protein Mimicry Functions
2006
An Assay for Phosphoinositide Phosphatases Utilizing Fluorescent Substrates
2001
Drosophila Ack Targets Its Substrate, the Sorting Nexin DSH3PX1, to a Protein Complex Involved in Axonal Guidance
2002
The Phosphoinositide-3-phosphatase MTMR2 Associates with MTMR13, a Membrane-associated Pseudophosphatase Also Mutated in Type 4B Charcot-Marie-Tooth Disease
2005
Mitochondrial modulation: reversible phosphorylation takes center stage?
2005
The Yersinia Virulence Factor YopM Forms a Novel Protein Complex with Two Cellular Kinases
2003
Phoxy Lipids
2001
PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease
2002
Glial Cell Line-derived Neurotrophic Factor Signals through the RET Receptor and Activates Mitogen-activated Protein Kinase
1996
Myotubularin and MTMR2, Phosphatidylinositol 3-Phosphatases Mutated in Myotubular Myopathy and Type 4B Charcot-Marie-Tooth Disease
2002
The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate
1998 Standout
PTEN and myotubularin phosphoinositide phosphatases: bringing bioinformatics to the lab bench
2001
The structure and regulation of myotubularin phosphatases
2005
A Family of Putative Tumor Suppressors Is Structurally and Functionally Conserved in Humans and Yeast
1997
Oncogenic RET Receptors Display Different Autophosphorylation Sites and Substrate Binding Specificities
1996
PROTEIN TYROSINE PHOSPHATASES
1993
Protein Tyrosine Phosphatases in the Human Genome
2004 Standout
Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathway
2001
A Yersinia Effector and a Pseudomonas Avirulence Protein Define a Family of Cysteine Proteases Functioning in Bacterial Pathogenesis
2002
A ligand-induced conformational change in theyersiniaprotein tyrosine phosphatase
1995
Myotubularin phosphatases: policing 3-phosphoinositides
2006
Functions of the Yersinia effector proteins in inhibiting host immune responses
2005
Multiple Dual Specificity Protein Tyrosine Phosphatases Are Expressed and Regulated Differentially in Liver Cell Lines
1995
The SH2 Domain-containing Tyrosine Phosphatase PTP1D Is Required for Interferon α/β-induced Gene Expression
1996
Sorting out the cellular functions of sorting nexins
2002
PTEN
2014
Active site labeling of a receptor-like protein tyrosine phosphatase.
1992
Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase
2003
Protein Tyrosine Phosphatase Activity of an Essential Virulence Determinant in Yersinia
1990 Science
Molecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase
2006
Transfected human neuropeptide Y cDNA expression in mouse pituitary cells. Inducible high expression, peptide characterization, and secretion.
1987
Z-DNA in the rat somatostatin gene.
1985
Mutational analysis of a Ser/Thr phosphatase. Identification of residues important in phosphoesterase substrate binding and catalysis
1994
Protein tyrosine phosphatases: mechanisms of catalysis and regulation
1998
A distinctive role for the Yersinia protein kinase: Actin binding, kinase activation, and cytoskeleton disruption
2000
Biologically Active Catecholamines Covalently Bound to Glass Beads
1972
Biochemical characterization of the Yersinia YopT protease: Cleavage site and recognition elements in Rho GTPases
2003
A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1
2001
Identification of a hormonally regulated protein tyrosine phosphatase associated with bone and testicular differentiation.
1994
Cloning and expression of a yeast protein tyrosine phosphatase
1991
Interchangeable forms of thiol:protein disulfide oxidoreductase.
1979
Disruption of Signaling by Yersinia Effector YopJ, a Ubiquitin-Like Protein Protease
2000 Science
PTEN and Myotubularin: Novel Phosphoinositide Phosphatases
2001
Crystal Structure of the PTEN Tumor Suppressor
1999
The catalytic role of Cys124 in the dual specificity phosphatase VHR.
1994
The archetype STYX/dead-phosphatase complexes with a spermatid mRNA-binding protein and is essential for normal sperm production
2002
Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways
2000
Immobilized Catecholamine and Cocaine Effects on Contractility of Cardiac Muscle
1973
Myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate
2000
Yersinia effectors target mammalian signalling pathways
2002
The Yersinia tyrosine phosphatase: specificity of a bacterial virulence determinant for phosphoproteins in the J774A.1 macrophage.
1992
Crystal Structure of the Dual Specificity Protein Phosphatase VHR
1996 Science
Immunochemical characterization of a proline endopeptidase from rat brain. Its relationship to proline endopeptidase from other tissues and from other species.
1982
Dissecting the catalytic mechanism of protein-tyrosinephosphatases.
1994
Isolation and characterization of a human dual specificity protein-tyrosine phosphatase gene.
1994
A procedure for in situ alkylation of cystine residues on glass fiber prior to protein microsequence analysis
1987
A sodium channel signaling complex: modulation by associated receptor protein tyrosine phosphatase β
2000
Cloning, bacterial expression, purification, and characterization of the cytoplasmic domain of rat LAR, a receptor-like protein tyrosine phosphatase.
1991
Tyrosine phosphate hydrolysis of host proteins by an essential Yersinia virulence determinant.
1991
Cloning, characterization, and DNA sequence of a human cDNA encoding neuropeptide tyrosine.
1984
Inhibition of the Mitogen-Activated Protein Kinase Kinase Superfamily by a Yersinia Effector
1999 Science
Variants of the carboxyl-terminal KDEL sequence direct intracellular retention.
1990
A Tyr/Ser protein phosphatase encoded by vaccinia virus
1991 Nature
RNA Interference of Gene Expression (RNAi) in Cultured Drosophila Cells
2001
Protein-tyrosine phosphatases.
1994
The crystal structure of Pseudomonas avirulence protein AvrPphB: A papain-like fold with a distinct substrate-binding site
2003
Visualization of intermediate and transition-state structures in protein-tyrosine phosphatase catalysis.
1996
Evidence for protein-tyrosine-phosphatase catalysis proceeding via a cysteine-phosphate intermediate.
1991
Substrate specificity of the protein tyrosine phosphatases.
1993
Roles of Aspartic Acid-181 and Serine-222 in Intermediate Formation and Hydrolysis of the Mammalian Protein-Tyrosine-Phosphatase PTP1
1997