Standout Papers
Citation Impact
Citing Papers
Improvement of comparative model accuracy by free-energy optimization along principal components of natural structural variation
2004 StandoutNobel
Human cerebral organoids recapitulate gene expression programs of fetal neocortex development
2015 StandoutNobel
Anti-Markovnikov alkene oxidation by metal-oxo–mediated enzyme catalysis
2017 StandoutScienceNobel
Global phosphorylation analysis of β-arrestin–mediated signaling downstream of a seven transmembrane receptor (7TMR)
2010 StandoutNobel
Expansive discovery of chemically diverse structured macrocyclic oligoamides
2024 StandoutScienceNobel
Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons
2013 StandoutNobel
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
The Impact of Oncogenic EGFRvIII on the Proteome of Extracellular Vesicles Released from Glioblastoma Cells
2018
Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation
1999 StandoutNatureNobel
Engineering the CYP101 system for in vivo oxidation of unnatural substrates
2001
Uncoupling Oxygen Transfer and Electron Transfer in the Oxygenation of Camphor Analogues by Cytochrome P450-CAM
1995
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
2008 Standout
Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses
2012 StandoutNobel
The Active Site of the Thermophilic CYP119 from Sulfolobus solfataricus
2000
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
Associative Versus Dissociative Mechanisms of Phosphate Monoester Hydrolysis: On the Interpretation of Activation Entropies
2008 StandoutNobel
Understanding the recent evolution of the human genome: insights from human-chimpanzee genome comparisons
2006
TRIBE: Hijacking an RNA-Editing Enzyme to Identify Cell-Specific Targets of RNA-Binding Proteins
2016 StandoutNobel
Minimum energy reaction profiles for ATP hydrolysis in myosin
2011
Biocatalysts for the formation of three- to six-membered carbo- and heterocycles
2015
Enrichment Map: A Network-Based Method for Gene-Set Enrichment Visualization and Interpretation
2010 Standout
The oxidation of naphthalene and pyrene by cytochrome P450cam
1998
Mechanism of activation of elongation factor Tu by ribosome: Catalytic histidine activates GTP by protonation
2013
Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists
2008 Standout
Constraining Cyclic Peptides To Mimic Protein Structure Motifs
2014
Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways
2017 StandoutNobel
Non-B DNA conformations, mutagenesis and disease
2007
An Integrated Phosphoproteomics Work Flow Reveals Extensive Network Regulation in Early Lysophosphatidic Acid Signaling
2010
Optimization of Electrochemical and Peroxide‐Driven Oxidation of Styrene with Ultrathin Polyion Films Containing Cytochrome P450cam and Myoglobin
2003
Protein engineering of cytochrome P450cam (CYP101) for the oxidation of polycyclic aromatic hydrocarbons
2000
Cathepsin D—Many functions of one aspartic protease
2008
On the role of the axial ligand in heme proteins: a theoretical study
2004
Calculation of the electronic structure and spectra of model cytochrome P450 compound I
2001
Stereoselective Hydroxylation of Norcamphor by Cytochrome P450cam
1995
Roles of the axial push effect in cytochrome P450cam studied with the site-directed mutagenesis at the heme proximal site
2000
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
Oxidizing species in the mechanism of cytochrome P450
2002
How Does Ethene Inactivate Cytochrome P450 En Route to Its Epoxidation? A Density Functional Study
2001
The structural basis for substrate-induced changes in redox potential and spin equilibrium in cytochrome P-450CAM
1989
A shortcut to the lysosome: The mannose-6-phosphate-independent pathway
2012
Are Mixed Explicit/Implicit Solvation Models Reliable for Studying Phosphate Hydrolysis? A Comparative Study of Continuum, Explicit and Mixed Solvation Models
2009 StandoutNobel
Creation of a zymogen
2002
Non-B DNA structure-induced genetic instability and evolution
2009
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Why nature really chose phosphate
2013 StandoutNobel
A systems approach to infectious disease
2020
Models and mechanisms of O‐O bond activation by cytochrome P450
2004
Understanding Protein Flexibility through Dimensionality Reduction
2003
Algorithms and novel applications based on the isokinetic ensemble. I. Biophysical and path integral molecular dynamics
2003
Quantitative exploration of the molecular origin of the activation of GTPase
2013 StandoutNobel
Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design
1997 Standout
Converting structural information into an allosteric-energy-based picture for elongation factor Tu activation by the ribosome
2011 StandoutNobel
Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes
2012 StandoutNobel
On the Mechanism of Hydrolysis of Phosphate Monoesters Dianions in Solutions and Proteins
2006 StandoutNobel
High-valent iron porphyrins
2000
Relationship of active site topology to substrate specificity for cytochrome P450terp (CYP108).
1994
Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation
2011 StandoutNobel
Time-resolved FTIR studies provide activation free energy, activation enthalpy and activation entropy for GTPase reactions
2004
Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals
2022 StandoutNobel
Reconstructing the DNA Methylation Maps of the Neandertal and the Denisovan
2014 StandoutScienceNobel
Identification of Putative Peroxide Intermediates of Peroxidases by Electronic Structure and Spectra Calculations
1996
Molecular Recognition in (+)-α-Pinene Oxidation by Cytochrome P450cam
2002
AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination
2009 StandoutNobel
Electrostatic origin of the mechanochemical rotary mechanism and the catalytic dwell of F1-ATPase
2011 StandoutNobel
2.2 Å structure of oxy-peroxidase as a model for the transient enzyme: peroxide complex
1994
Modeling and design by hierarchical natural moves
2012 StandoutNobel
Solvent Dependence of Structure, Charge Distribution, and Absorption Spectrum in the Photochromic Merocyanine−Spiropyran Pair
2011
Calculations of the structure and spectra of the putative transient peroxide intermediates of peroxidases
1997
Enantioselective Imidation of Sulfides via Enzyme-Catalyzed Intermolecular Nitrogen-Atom Transfer
2014 StandoutNobel
Mechanistic Insights into the Hydrolysis of a Nucleoside Triphosphate Model in Neutral and Acidic Solution
2012
Update 1 of: Proteases Universally Recognize Beta Strands In Their Active Sites
2010
Metalloporphyrins as models for the cytochromes p-450
1991
Structure of a Model Transient Peroxide Intermediate of Peroxidases by ab Initio Methods
1996
De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures
2017 StandoutNobel
Addressing Open Questions about Phosphate Hydrolysis Pathways by Careful Free Energy Mapping
2012 StandoutNobel
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
Chromium− and Manganese−salen Promoted Epoxidation of Alkenes
2005
Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts
2015 StandoutNobel
Reduction of Dioxygen Catalyzed by Pyrene-Wired Heme Domain Cytochrome P450 BM3 Electrodes
2004 StandoutNobel
Catalytic Asymmetric Epoxidation of α-Branched Enals
2010 StandoutNobel
Engineering cytochrome P450cam into an alkane hydroxylase
2003
Behavior of Ylides Containing N, O, and C Atoms as Hydrogen Bond Acceptors
2000 Standout
Improving the Catalytic Performance of an Artificial Metalloenzyme by Computational Design
2015 StandoutNobel
Regio- and Enantioselective Alkane Hydroxylation with Engineered Cytochromes P450 BM-3
2003 StandoutNobel
Transcriptomes of germinal zones of human and mouse fetal neocortex suggest a role of extracellular matrix in progenitor self-renewal
2012 StandoutNobel
Mechanism of Triphosphate Hydrolysis in Aqueous Solution: QM/MM Simulations in Water Clusters
2006
Alkene epoxidation catalyzed by cytochrome P450 BM-3 139-3
2003 StandoutNobel
Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination
2010 StandoutNobel
From weak to strong interactions: A comprehensive analysis of the topological and energetic properties of the electron density distribution involving X–H⋯F–Y systems
2002 Standout
ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks
2009 Standout
Unraveling the Photoswitching Mechanism in Donor–Acceptor Stenhouse Adducts
2016 StandoutNobel
Investigation of the Proton-Assisted Pathway to Formation of the Catalytically Active, Ferryl Species of P450s by Molecular Dynamics Studies of P450eryF
1996
Reduced Oxy Intermediate Observed in D251N Cytochrome P450cam
1997
Immunopurification of Ago1 miRNPs selects for a distinct class of microRNA targets
2009 StandoutNobel
Enzyme-Controlled Nitrogen-Atom Transfer Enables Regiodivergent C–H Amination
2014 StandoutNobel
DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update)
2022 Standout
Role of the Heme Active Site and Protein Environment in Structure, Spectra, and Function of the Cytochrome P450s
2000
Structure and Chemistry of Cytochrome P450
2005 Standout
Structural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450
2015 StandoutNobel
Works of Jack Collins being referenced
On photoabsorption of the neutral form of the green fluorescent protein chromophore
2009
Long homopurine*homopyrimidine sequences are characteristic of genes expressed in brain and the pseudoautosomal region
2006
Abundance and length of simple repeats in vertebrate genomes are determined by their structural properties
2008
Structure‐based subsite specificity mapping of human cathepsin D using statine‐based inhibitors
1997
Flap opening in HIV-1 protease simulated by ‘activated’ molecular dynamics
1995
Mechanism of the chemical step for the guanosine triphosphate (GTP) hydrolysis catalyzed by elongation factor Tu
2008
Molecular dynamics simulations of the resting and hydrogen peroxide-bound states of cytochrome c peroxidase
1992
The DAVID Gene Functional Classification Tool: a novel biological module-centric algorithm to functionally analyze large gene lists
2007 Standout
Activated Dynamics of Flap Opening in Hiv-1 Protease
1995
Thioanisole Sulfoxidation by Cytochrome P450cam (CYP101): Experimental and Calculated Absolute Stereochemistries
1994
(Salen)Mn(III)-Catalyzed Epoxidation Reaction as a Multichannel Process with Different Spin States. Electronic Tuning of Asymmetric Catalysis: A Theoretical Study
2001
Theoretical investigations of terminal alkenes as putative suicide substrates of cytochrome P-450
1990
Calculated electronic spectra of model ferric cytochrome P450 complexes
1986
Theoretical study of the product specificity in the hydroxylation of camphor, norcamphor, 5,5-difluorocamphor, and pericyclocamphanone by cytochrome P-450cam.
1988
Theoretical Study of the Low Lying Electronic States of oxoX(salen) (X = Mn, Mn-, Fe, and Cr-) Complexes
2004
Calculated and experimental absolute stereochemistry of the styrene and .beta.-methylstyrene epoxides formed by cytochrome P 450cam
1992
Theoretical Studies on the Hydrolysis of Mono-Phosphate and Tri-Phosphate in Gas Phase and Aqueous Solution
2003
Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design.
1993
Structure and inhibition of plasmepsin II, a hemoglobin-degrading enzyme from Plasmodium falciparum.
1996
Helium chemistry: theoretical predictions and experimental challenge
1987
Valproic acid metabolism by cytochrome P450: a theoretical study of stereoelectronic modulators of product distribution
1991
Theoretical Studies of Cytochrome P-450
1986
Theoretical studies of cytochrome P-450. Characterization of stable and transient active states, reaction mechanisms and substrate-enzyme interactions.
1986
Magnesium porphyrin radical cations: a theoretical study of substituent effects on the ground state
1992
Quantum-mechanical studies of model peroxidase compound I complexes
1991