Citation Impact
Citing Papers
Multiplex PCR: Optimization and Application in Diagnostic Virology
2000
Pharmacology of Cannabinoid CB 1 and CB 2 Receptors
1997
Endocannabinoids potently protect the newborn brain against AMPA‐kainate receptor‐mediated excitotoxic damage
2006
The endocannabinoid system as a target for therapeutic drugs
2000
A cell-free platform for the prenylation of natural products and application to cannabinoid production
2019 StandoutNobel
The general anesthetic propofol increases brain N‐arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase
2003
Postsynaptic TRPV1 triggers cell type–specific long-term depression in the nucleus accumbens
2010
Cannabinoid receptor agonist and antagonist effects on motor function in normal and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP)-treated non-human primates
2001
Non-cannabinoid CB1, non-cannabinoid CB2 antinociceptive effects of several novel compounds in the PPQ stretch test in mice
2006
Role of the endocannabinoid system in Alzheimer's disease: New perspectives
2004
Genetic modulation of the pharmacological treatment of pain
2009
The Endogenous Cannabinoid System Regulates Seizure Frequency and Duration in a Model of Temporal Lobe Epilepsy
2003
Involvement of 5-HT1A receptors in behavioural effects of the cannabinoid receptor agonist CP 55,940 in male rats
2004
Understanding Synapses: Past, Present, and Future
2008 StandoutNobel
Cannabinoids and Ghrelin Have Both Central and Peripheral Metabolic and Cardiac Effects via AMP-activated Protein Kinase
2005
Haloperidol dose for the acute phase of schizophrenia
2002
The endocannabinoid anandamide is a direct and selective blocker of the background K+ channel TASK-1
2001
Cannabinoid CB1‐receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation
2001
The movement of N-arachidonoylethanolamine (anandamide) across cellular membranes
2000
GENDER DIFFERENCES IN SYMPATHETIC NERVOUS SYSTEM REGULATION
1999
Stimulation of voluntary ethanol intake by cannabinoid receptor agonists in ethanol-preferring sP rats
2001
Cannabinoid physiology and pharmacology: 30 years of progress
2004
Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2‐arachidonoyl glycerol
2002
Massive accumulation of N‐acylethanolamines after stroke. Cell signalling in acute cerebral ischemia?
2004
Cannabinoid-receptor 1 null mice are susceptible to neurofilament damage and caspase 3 activation
2005
Endocrine Effects of Marijuana
2002
Brain Cannabinoid Systems as Targets for the Therapy of Neurological Disorders
1998
Endocannabinoid system and alcohol addiction: Pharmacological studies
2005
Concurrent Stimulation of Cannabinoid CB1 and Dopamine D2 Receptors Enhances Heterodimer Formation: A Mechanism for Receptor Cross-Talk?
2005
AM404 and VDM 11 non-specifically inhibit C6 glioma cell proliferation at concentrations used to block the cellular accumulation of the endocannabinoid anandamide
2003
Chronic ▵9‐Tetrahydrocannabinol Treatment Produces a Time‐Dependent Loss of Cannabinoid Receptors and Cannabinoid Receptor‐Activated G Proteins in Rat Brain
1999
Structure—Activity Relationships Among N‐Arachidonylethanolamine (Anandamide) Head Group Analogues for the Anandamide Transporter
2000
Endocannabinoid signaling system and brain reward: Emphasis on dopamine
2005
Endocannabinoids Mediate Presynaptic Inhibition of Glutamatergic Transmission in Rat Ventral Tegmental Area Dopamine Neurons through Activation of CB1 Receptors
2004
The safety of cannabinoids for the treatment of multiple sclerosis
2005
Adverse Health Effects of Marijuana Use
2014 Standout
Leptin-regulated endocannabinoids are involved in maintaining food intake
2001 Nature
Effect of long-term cannabis use on axonal fibre connectivity
2012
Adverse health effects of non-medical cannabis use
2009
A therapeutic role for cannabinoid CB1 receptor antagonists in major depressive disorders
2005
Generation of 2-Arachidonoylglycerol, an Endogenous Cannabinoid Receptor Ligand, in Picrotoxinin-Administered Rat Brain
2000
Cannabinoid effects on anxiety-related behaviours and hypothalamic neurotransmitters
2001
Mechanisms Underlying Inflammation in Neurodegeneration
2010 Standout
Central nervous system control of food intake and body weight
2006 StandoutNature
Descending control of pain
2002 Standout
Endocannabinoid-Mediated Long-Term Plasticity Requires cAMP/PKA Signaling and RIM1α
2007 StandoutNobel
The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids
2005
Control of pain initiation by endogenous cannabinoids
1998 StandoutNature
Pharmacophores for Ligand Recognition and Activation / Inactivation of the Cannabinoid Receptors
2003
Dynorphin B and spinal analgesia: induction of antinociception by the cannabinoids CP55,940, Δ9-THC and anandamide1Published on the World Wide Web on 18 January 2000.1
2000
Schizophrenia
2009 Standout
Endocannabinoids as physiological regulators of colonic propulsion in mice
2002
Cocaine, but not morphine, induces conditioned place preference and sensitization to locomotor responses in CB1 knockout mice
2000
Time course of the enhancement and restoration of the analgesic efficacy of codeine and morphine by Δ9-tetrahydrocannabinol
2006
Ethanol self-administration and ethanol conditioned place preference are reduced in mice lacking cannabinoid CB1 receptors
2005
Changes in CB1 receptors in motor-related brain structures of chronic relapsing experimental allergic encephalomyelitis mice
2006
Receptor-independent depression of DA and 5-HT uptake by cannabinoids in rat neocortex—involvement of Na+/K+-ATPase
2003
Immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brain
2006
Rat Models of Prenatal and Adolescent Cannabis Exposure
2011
Cannabinoid signaling in glial cells
2004
Anxiolytic-Like Properties of the Anandamide Transport Inhibitor AM404
2006
Down-regulation of cannabinoid-1 (CB-1) receptors in specific extrahypothalamic regions of rats with dietary obesity: a role for endogenous cannabinoids in driving appetite for palatable food?
2002
Effect of Chronic Administration of R-(+)-[2,3-Dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl)methanone Mesylate (WIN55,212-2) or Δ9-Tetrahydrocannabinol on Cannabinoid Receptor Adaptation in Mice
2002
Biosynthesis and Inactivation of N-Arachidonoylethanolamine (Anandamide) and N-Docosahexaenoylethanolamine in Bovine Retina
1999
Selective inhibition of anandamide cellular uptake versus enzymatic hydrolysis—a difficult issue to handle
2004
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
1999 StandoutNatureNobel
μ opioid and CB1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesis
2006
Molecular Neurobiology of The Cannabinoid Receptor
1996
The cannabinoid receptor antagonist SR-141716A induces penile erection in male rats: Involvement of paraventricular glutamic acid and nitric oxide
2005
agriGO v2.0: a GO analysis toolkit for the agricultural community, 2017 update
2017 Standout
Anandamide – the other side of the coin
2000 StandoutNobel
Endocannabinoids and the control of energy balance
2006
Adolescent exposure to cannabinoids induces long-Lasting changes in the response to drugs of abuse of rat midbrain dopamine neurons
2004
The ontogeny of cannabinoid receptors in the brain of postnatal and aging rats
1995
The endocannabinoid system in the basal ganglia and in the mesolimbic reward system: implications for neurological and psychiatric disorders
2003
Cannabinoid Transmission and Reward-Related Events
1998
Delta-9-tetrahydrocannabinol differentially suppresses cisplatin-induced emesis and indices of motor function via cannabinoid CB1 receptors in the least shrew
2001
Nabilone as an Adjunctive to Gabapentin for Multiple Sclerosis-Induced Neuropathic Pain: A Randomized Controlled Trial
2014
Fatty Acid Amide Hydrolase Controls Mouse Intestinal Motility In Vivo
2005
Transient receptor potential channels: targeting pain at the source
2008 StandoutNobel
The Influence of Marijuana Use on Neurocognitive Functioning in Adolescents
2008
The adolescent brain and age-related behavioral manifestations
2000 Standout
Activation of G-proteins in brain by endogenous and exogenous cannabinoids
2006
A tale of two cannabinoids: The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol
2005
Mycolic Acids: Structures, Biosynthesis, and Beyond
2014
Intracerebral self-administration of the cannabinoid receptor agonist CP 55,940 in the rat: interaction with the opioid system
2001
Dopamine activation of endogenous cannabinoid signaling in dorsal striatum
1999
ELKS2α/CAST Deletion Selectively Increases Neurotransmitter Release at Inhibitory Synapses
2009 StandoutNobel
Chronic Pubertal, but not Adult Chronic Cannabinoid Treatment Impairs Sensorimotor Gating, Recognition Memory, and the Performance in a Progressive Ratio Task in Adult Rats
2003
Modulation of Δ9-THC-induced increase of cortical and hippocampal acetylcholine release by μ opioid and D1 dopamine receptors
2006
Cannabis in Movement Disorders
1999
Cannabinoids: possible role in patho‐physiology and therapy of Gilles de la Tourette syndrome
1998
Molecular biology of cannabinoid receptors
2002
Biochemistry and pharmacology of endovanilloids
2007
Aberrant cannabinoid signaling impairs oviductal transport of embryos
2004
Maternal Cannabis Use Alters Ventral Striatal Dopamine D2 Gene Regulation in the Offspring
2011
The endocannabinoid system and its therapeutic exploitation
2004
In vivo pharmacological actions of two novel inhibitors of anandamide cellular uptake
2003
Synergistic effects of cannabinoid inverse agonist AM251 and opioid antagonist nalmefene on food intake in mice
2004
Involvement of the endocannabinoid system in drug addiction
2006
Differential anxiogenic, aversive, and locomotor effects of THC in adolescent and adult rats
2007
The Endocannabinoid System Promotes Astroglial Differentiation by Acting on Neural Progenitor Cells
2006
Activation of spinal cannabinoid 1 receptors inhibits C‐fibre driven hyperexcitable neuronal responses and increases [35S]GTPγS binding in the dorsal horn of the spinal cord of noninflamed and inflamed rats
2000
Glial reactions in Parkinson's disease
2007
Anandamide content is increased and CB1 cannabinoid receptor blockade is protective during transient, focal cerebral ischemia
2004
Anandamide-induced sleep is blocked by SR141716A, a CB1 receptor antagonist and by U73122, a phospholipase C inhibitor
2001
Delta 9-Tetrahydrocannabinol (THC) is Effective in the Treatment of Tics in Tourette Syndrome
2003
Novel selective and metabolically stable inhibitors of anandamide cellular uptake
2003
New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis
2005
Role of the endocannabinoid system in MDMA intracerebral self‐administration in rats
2002
Motor actions of cannabinoids in the basal ganglia output nuclei
1999
Cannabinoid Tolerance and Dependence
2005
Cannabinoid Receptor Signaling
2005
Immunoregulation of a viral model of multiple sclerosis using the synthetic cannabinoid R(+)WIN55,212
2003
The endocannabinoid-CB1 receptor system in pre- and postnatal life
2004
Motivational Effects of Cannabinoids and Opioids on Food Reinforcement Depend on Simultaneous Activation of Cannabinoid and Opioid Systems
2005
Synaptotagmin-12 Phosphorylation by cAMP-Dependent Protein Kinase Is Essential for Hippocampal Mossy Fiber LTP
2013 StandoutNobel
The cannabinoid system: a role in both the homeostatic and hedonic control of eating?
2003
Central and peripheral mechanisms contribute to the antiemetic actions of delta-9-tetrahydrocannabinol against 5-hydroxytryptophan-induced emesis
2004
Involvement of CB1 cannabinoid receptors in emotional behaviour
2002
Independent Presynaptic and Postsynaptic Mechanisms Regulate Endocannabinoid Signaling at Multiple Synapses in the Ventral Tegmental Area
2004
The Endocannabinoid System as an Emerging Target of Pharmacotherapy
2006 Standout
The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review
2003 Standout
Cannabinoid Control of Motor Function at the Basal Ganglia
2005
Genetic Impairment of Frontocortical Endocannabinoid Degradation and High Alcohol Preference
2006
Autism-Associated Neuroligin-3 Mutations Commonly Disrupt Tonic Endocannabinoid Signaling
2013 StandoutNobel
Dual Modulation of Endocannabinoid Transport and Fatty Acid Amide Hydrolase Protects against Excitotoxicity
2005
Delayed onset of huntington′s disease in mice in an enriched environment correlates with delayed loss of cannabinoid CB1 receptors
2003
Role of the cannabinoid system in the effects induced by nicotine on anxiety-like behaviour in mice
2006
Cellular accumulation of anandamide: consensus and controversy
2003
Binding of the non-classical cannabinoid CP 55,940, and the diarylpyrazole AM251 to rodent brain cannabinoid receptors
1997
Cannabinoid CB1 receptors control conditioned drug seeking
2005
Dendritic signalling and homeostatic adaptation
2009
Cannabinoids and Multiple Sclerosis
2007
Unilateral 6-hydroxydopamine lesions of nigrostriatal dopaminergic neurons increased CB1 receptor mRNA levels in the caudate-putamen
2000
Stereochemical Selectivity of Methanandamides for the CB1 and CB2 Cannabinoid Receptors and Their Metabolic Stability
2001
‘Endocannabinoids’ and other fatty acid derivatives with cannabimimetic properties: biochemistry and possible physiopathological relevance
1998
Cannabinoid modulation of rat pup ultrasonic vocalizations
1996
Low dose anandamide affects food intake, cognitive function, neurotransmitter and corticosterone levels in diet-restricted mice
2000
Novelty and Anxiolytic Drugs Dissociate Two Components of Hippocampal Theta in Behaving Rats
2013 StandoutNobel
An Amino-terminal Variant of the Central Cannabinoid Receptor Resulting from Alternative Splicing
1995
Heterosynaptic LTD of Hippocampal GABAergic Synapses
2003
Pharmacokinetics and Pharmacodynamics of Cannabinoids
2003
Unconditioned and conditioned anxiogenic effects of the cannabinoid receptor agonist CP 55,940 in the social interaction test
2004
Neural contractions in colonic strips from patients with diverticular disease: role of endocannabinoids and substance P
2006
Interaction of anandamide with the M1 and M4 muscarinic acetylcholine receptors
2001
Cannabinoid receptor antagonist reduces heroin self-administration only in dependent rats
2004
Cannabidiolic‐acid synthase, the chemotype‐determining enzyme in the fiber‐type Cannabis sativa
2007
Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's disease
2000
TRPV1 structures in distinct conformations reveal activation mechanisms
2013 StandoutNatureNobel
Impaired action of anxiolytic drugs in mice deficient in cannabinoid CB1 receptors
2004
Cannabinoids and neuroprotection in CNS inflammatory disease
2005
Cannabinoid receptors and pain
2001
Role of the Endogenous Cannabinoid System in the Regulation of Motor Activity
1998
Cannabinoid receptor messenger RNA levels decrease in a subset of neurons of the lateral striatum, cortex and hippocampus of transgenic Huntington’s disease mice
2000
Opioid and cannabinoid receptor-mediated regulation of the increase in adrenocorticotropin hormone and corticosterone plasma concentrations induced by central administration of Δ9-tetrahydrocannabinol in rats
1999
Effects of levodopa on endocannabinoid levels in rat basal ganglia: implications for the treatment of levodopa‐induced dyskinesias
2003
Cannabinoids: potential anticancer agents
2003
Cannabinoid receptors in the human brain: a detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain
1997
Levels, Metabolism, and Pharmacological Activity of Anandamide in CB1 Cannabinoid Receptor Knockout Mice
2000
Studies on [3H]CP-55940 binding in the human central nervous system: regional specific changes in density of cannabinoid-1 receptors associated with schizophrenia and cannabis use
2001
The endocannabinoid system: function in survival of the embryo, the newborn and the neuron
2002
Clozapine decreases [3H] CP 55940 binding to the cannabinoid1 receptor in the rat nucleus accumbens
2005
The diverse CB1and CB2receptor pharmacology of three plant cannabinoids: Δ9‐tetrahydrocannabinol, cannabidiol and Δ9‐tetrahydrocannabivarin
2007 Standout
Cannabis and the brain
2003
Milk intake and survival in newborn cannabinoid CB1 receptor knockout mice: evidence for a “CB3” receptor
2003
Impulsivity as a vulnerability marker for substance-use disorders: Review of findings from high-risk research, problem gamblers and genetic association studies
2008 Standout
Possible direct effect of prolactin on catecholamine synthesis and release in rat adrenal medulla: in vitro studies
1988
Ontogenetic development of the response to anandamide and Δ9-tetrahydrocannabinol in mice
1996
Task specificity of cross-tolerance between Δ9-tetrahydrocannabinol and anandamide analogs in mice
2005
The CB1 cannabinoid receptor is coupled to the activation of protein kinase B/Akt
2000
Structural snapshots of TRPV1 reveal mechanism of polymodal functionality
2021 StandoutNobel
Modulation of Neurotransmission by Cannabinoids in the Basal Ganglia
1997
Endocannabinoid lipids and mediated system: Implications for alcoholism and neuropsychiatric disorders
2005
Control of Spasticity in a Multiple Sclerosis Model is mediated by CB1, not CB2, Cannabinoid Receptors
2007
Pharmacology of cannabinoid CB1 and CB2 receptors
1997
Antagonism of cannabinoid CB1 receptors in the paraventricular nucleus of male rats induces penile erection
2004
Distinct Subsets of Syt-IV/BDNF Vesicles Are Sorted to Axons versus Dendrites and Recruited to Synapses by Activity
2012 StandoutNobel
Reduction of opioid dependence by the CB1 antagonist SR141716A in mice: evaluation of the interest in pharmacotherapy of opioid addiction
2001
THE ENDOCANNABINOID SYSTEM: PHYSIOLOGY AND PHARMACOLOGY
2004
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
2006 StandoutNature
The molecular logic of endocannabinoid signalling
2003 Standout
Cannabinoid CB1 receptor blockade enhances the protective effect of melanocortins in hemorrhagic shock in the rat
2002
Increased ethanol consumption and preference and decreased ethanol sensitivity in female FAAH knockout mice
2006
Inhibition of Fatty-Acid Amide Hydrolase Accelerates Acquisition and Extinction Rates in a Spatial Memory Task
2006
On-demand activation of the endocannabinoid system in the control of neuronal excitability and epileptiform seizures
2004
Endovanilloids
2004
An endogenous cannabinoid tone attenuates cholera toxin-induced fluid accumulation in mice
2003
Periodontal diseases
2005 Standout
Cannabinoid receptors and their ligands
2002
Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review
2007 Standout
Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's disease
2003
Loss of cannabinoid receptor binding and messenger RNA levels and cannabinoid agonist-stimulated [35s]guanylyl-5′-O-(thio)-triphosphate binding in the basal ganglia of aged rats
1998
Role of the endogenous cannabinoid system as a modulator of dopamine transmission: Implications for Parkinson’s disease and schizophrenia
2001
Effects of Anandamide and Noxious Heat on Intracellular Calcium Concentration in Nociceptive DRG Neurons of Rats
2007
Oral nabilone capsules in the treatment of chemotherapy-induced nausea and vomiting and pain
2007
Cannabis-Associated Psychosis
2004
Developmental aspects of anandamide: ontogeny of response and prenatal exposure
1996
Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats
2001
Methods of detection of Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis and Tannerella forsythensis in periodontal microbiology, with special emphasis on advanced molecular techniques: a review
2004
15-Lipoxygenase Metabolism of 2-Arachidonylglycerol
2002
Lack of response suppression follows repeated ventral tegmental cannabinoid administration: an in vitro electrophysiological study
2000
The Biosynthesis, Fate and Pharmacological Properties of Endocannabinoids
2005
Trpv1 Reporter Mice Reveal Highly Restricted Brain Distribution and Functional Expression in Arteriolar Smooth Muscle Cells
2011 StandoutNobel
Cannabinoids and multiple sclerosis
2002
(AAT)n repeat in the cannabinoid receptor gene (CNR1): association with cocaine addiction in an African-Caribbean population
2005
Molecular mechanisms involved in the asymmetric interaction between cannabinoid and opioid systems
2005
Type-1 Cannabinoid Receptor Signaling in Neuronal Development
2012
Modulation of Neuropathic and Inflammatory Pain by the Endocannabinoid Transport Inhibitor AM404 [N-(4-Hydroxyphenyl)-eicosa-5,8,11,14-tetraenamide]
2006
Neuromodulatory role of the endocannabinoid signaling system in alcoholism: an overview
2002
Role of endocannabinoid system in mental diseases
2004
Reversal of Δ9-THC hyperphagia by SR141716 and naloxone but not dexfenfluramine
2002
Non-specific low back pain
2011 Standout
Depolarization‐induced suppression of excitation in murine autaptic hippocampal neurones
2005
The effects of cannabinoids on the brain
1999
Neurohumoral Features of Myocardial Stunning Due to Sudden Emotional Stress
2005 Standout
Evidence for presynaptic cannabinoid CB1 receptor-mediated inhibition of noradrenaline release in the guinea pig lung
2001
The endocannabinoid signalling system: Biochemical aspects
2005
Endocannabinoid system and opioid addiction: Behavioural aspects
2005
Cannabinoid modulation of dynorphin A: correlation to cannabinoid-induced antinociception
1999
Anandamide transport: A critical review
2005
Lipids, lipid rafts and caveolae: Their importance for GPCR signaling and their centrality to the endocannabinoid system
2005
Molecular and cellular basis of cannabinoid and opioid interactions
2005
Functional responses to the cannabinoid agonist WIN 55,212-2 in neonatal rats of both genders: influence of weaning
2004
A cannabinoid mechanism in relapse to cocaine seeking
2001
Synergistic and additive interactions of the cannabinoid agonist CP55,940 with μ opioid receptor and α2‐adrenoceptor agonists in acute pain models in mice
2005
Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry
2014 StandoutNobel
Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis
2013 Standout
Endocannabinoids affect neurological and cognitive function in thioacetamide-induced hepatic encephalopathy in mice
2005
THE CANNABINOID AGONIST HU 210 MODIFIES RAT BEHAVIOURAL RESPONSES TO NOVELTY AND STRESS
2000
The endogenous cannabinoid system protects against colonic inflammation
2004
Endocannabinoid system and stress and anxiety responses
2005
Involvement of the opioid system in the anxiolytic-like effects induced by Δ9-tetrahydrocannabinol
2002
A single in-vivo exposure to Δ9THC blocks endocannabinoid-mediated synaptic plasticity
2004
Functional consequences of the acute administration of the cannabinoid receptor antagonist, SR141716A, in cannabinoid-naive and -tolerant animals: a quantitative 2-[14C]deoxyglucose study
2003
Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum
2008
Cannabinoid CB1 receptor antagonism reduces conditioned reinstatement of ethanol‐seeking behavior in rats
2005
Arachidonoylserotonin and Other Novel Inhibitors of Fatty Acid Amide Hydrolase
1998
Downregulation of Endocannabinoid Signaling in the Hippocampus Following Chronic Unpredictable Stress
2004
Cannabis, cannabinoids and reproduction
2003
Increased cannabinoid CB1 receptor binding and activation of GTP‐binding proteins in the basal ganglia of patients with Parkinson's syndrome and of MPTP‐treated marmosets
2001
Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses
2010
Long-Lasting Increase of Alcohol Relapse by the Cannabinoid Receptor Agonist WIN 55,212-2 during Alcohol Deprivation
2004
Cannabinoids and neuroinflammation
2004
Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): multicentre randomised placebo-controlled trial
2003 Standout
Therapeutic Potential of Cannabinoids in CNS Disease
2003
Mechanisms of Endocannabinoid Inactivation: Biochemistry and Pharmacology
2001
The endocannabinoid system drives neural progenitor proliferation
2005
Cannabidivarin‐rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor‐independent mechanism
2013
Role of the endogenous cannabinoid system in the formalin test of persistent pain in the rat
2000
Involvement of the κ-opioid receptor in the anxiogenic-like effect of CP 55,940 in male rats
2003
Exploring drug-induced alterations in gene expression in Mycobacterium tuberculosis by microarray hybridization
1999
Tissue distribution and regulation of rat prolactin receptor gene expression. Quantitative analysis by polymerase chain reaction.
1994
The therapeutic potential of the cannabinoids in neuroprotection
2002
The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance
2005
Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's disease
2000
Comparison of Anandamide Transport in FAAH Wild-Type and Knockout Neurons: Evidence for Contributions by both FAAH and the CB1 Receptor to Anandamide Uptake
2004
Therapeutic potential of cannabinoid receptor agonists as analgesic agents
2005
Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB 1 Receptor Knockout Mice
1999 StandoutScience
Mechanisms of transcriptional dysregulation in Huntington's disease
2003
Immunoregulation of a viral model of multiple sclerosis using the synthetic cannabinoid R(+)WIN55,212
2003
Occurrence and Biosynthesis of Endogenous Cannabinoid Precursor,N-Arachidonoyl Phosphatidylethanolamine, in Rat Brain
1997
Activation of the endocannabinoid system as a therapeutic approach in a murine model of multiple sclerosis
2005
Motivational Effects of Cannabinoids Are Mediated by μ-Opioid and κ-Opioid Receptors
2002
CB1 Cannabinoid Receptors and On-Demand Defense Against Excitotoxicity
2003 Science
Neurobiological consequences of maternal cannabis on human fetal development and its neuropsychiatric outcome
2009
Exogenous Anandamide Protects Rat Brain against Acute Neuronal InjuryIn Vivo
2001
Cannabidiol in Inflammatory Bowel Diseases: A Brief Overview
2012
Endocannabinoid Signaling and Long-Term Synaptic Plasticity
2009
Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172
2004
Prolactin (PRL) and Its Receptor: Actions, Signal Transduction Pathways and Phenotypes Observed in PRL Receptor Knockout Mice
1998 Standout
Hyperprolactinaemia in hypophysectomized or intact male rats and the development of adjuvant arthritis.
1992
Three independent lines of evidence suggest retinoids as causal to schizophrenia
1998
A Critical Role for the Cannabinoid CB1Receptors in Alcohol Dependence and Stress-Stimulated Ethanol Drinking
2003
Endocannabinoids control spasticity in a multiple sclerosis model
2000
Visualization of mycobacterial membrane dynamics in live cells
2017 StandoutNobel
Delta-9-tetrahydrocannabinol effects in schizophrenia: Implications for cognition, psychosis, and addiction
2005
Role of Endogenous Cannabinoids in Synaptic Signaling
2003
The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments
2009 Standout
Intensely pleasurable responses to music correlate with activity in brain regions implicated in reward and emotion
2001 Standout
Cannabinoid Analgesia as a Potential New Therapeutic Option in the Treatment of Chronic Pain
2006
μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence
2000 StandoutNatureNobel
Suppression of Nerve Growth Factor Trk Receptors and Prolactin Receptors by Endocannabinoids Leads to Inhibition of Human Breast and Prostate Cancer Cell Proliferation1
2000
Novel Analogues of Arachidonylethanolamide (Anandamide): Affinities for the CB1 and CB2 Cannabinoid Receptors and Metabolic Stability
1998
Increased Seizure Susceptibility and Proconvulsant Activity of Anandamide in Mice Lacking Fatty Acid Amide Hydrolase
2003
Neuroprotection by Δ9-Tetrahydrocannabinol, the Main Active Compound in Marijuana, against Ouabain-InducedIn VivoExcitotoxicity
2001
The inhibitory effect of anandamide on luteinizing hormone-releasing hormone secretion is reversed by estrogen
2004
Prolactin mediates estradiol-induced inflammation in the lateral prostate of Wistar rats.
1993
Effects of Chronic Treatment with Δ9-Tetrahydrocannabinol on Cannabinoid-Stimulated [35S]GTPγS Autoradiography in Rat Brain
1996
Osmosensory signaling in Mycobacterium tuberculosis mediated by a eukaryotic-like Ser/Thr protein kinase
2013 StandoutNobel
Repeated cannabinoid exposure during perinatal, adolescent or early adult ages produces similar longlasting deficits in object recognition and reduced social interaction in rats
2006
Therapeutic Action of Cannabinoids in a Murine Model of Multiple Sclerosis
2003
A FAAH-Regulated Class of N-Acyl Taurines That Activates TRP Ion Channels
2006 StandoutNobel
Haloperidol dose for the acute phase of schizophrenia
2013
Enhanced Rewarding Properties of Morphine, but not Cocaine, in βarrestin-2 Knock-Out Mice
2003 StandoutNobel
Distribution of CB1 Cannabinoid Receptors in the Amygdala and their Role in the Control of GABAergic Transmission
2001
Sleep modulates cannabinoid receptor 1 expression in the pons of rats
2003
Cannabinoids in health and disease
2007
Experimental autoimmune encephalomyelitis disrupts endocannabinoid-mediated neuroprotection
2006
The endogenous cannabinoid system protects against colonic inflammation
2004
Functional Interaction between Opioid and Cannabinoid Receptors in Drug Self-Administration
2001
Anti-obesity effect of SR141716, a CB1 receptor antagonist, in diet-induced obese mice
2003
Endocannabinoid Signaling in the Brain
2002 Science
Early age-related cognitive impairment in mice lacking cannabinoid CB1 receptors
2005
Evidence against the presence of an anandamide transporter
2003
Increasing cannabinoid levels by pharmacological and genetic manipulation delays disease progression in SOD1 mice
2006
The endocannabinoid system and the molecular basis of paralytic ileus in mice
2002
The Vanilloid Receptor: A Molecular Gateway to the Pain Pathway
2001 StandoutNobel
Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning
2011 StandoutNobel
Protective effects of cannabinoid receptor agonists against cocaine and other convulsant-induced toxic behavioural symptoms
2001
Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor.
2001
Pharmacology of cannabinoids.
2004
Clinical endocannabinoid deficiency (CECD): can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?
2004
Potential roles of (endo)cannabinoids in the treatment of glaucoma: from intraocular pressure control to neuroprotection
2008
Cannabinoids for Medical Use
2015 Standout
CANNABINOID RECEPTORS AS THERAPEUTIC TARGETS
2005
Cannabinoids Promote Oligodendrocyte Progenitor Survival: Involvement of Cannabinoid Receptors and Phosphatidylinositol-3 Kinase/Akt Signaling
2002
Effects of intrapallidal cannabinoids on rotational behavior in rats: Interactions with the dopaminergic system
1998
Visualization of gene expression of short and long forms of prolactin receptor in the rat.
1993
ENDOCANNABINOID-MEDIATED SYNAPTIC PLASTICITY IN THE CNS
2006
Evidence for an Interaction between CB1 Cannabinoid and Melanocortin MCR-4 Receptors in Regulating Food Intake
2004
Acute Modulation of Mycobacterial Cell Envelope Biogenesis by Front‐Line Tuberculosis Drugs
2018 StandoutNobel
Plant, Synthetic, and Endogenous Cannabinoids in Medicine
2005
Absence of Δ-9-Tetrahydrocannabinol Dysphoric Effects in Dynorphin-Deficient Mice
2001
Trafficking of G Protein–Coupled Receptors
2006 StandoutNobel
Cannabinoid CB2Receptors and Fatty Acid Amide Hydrolase Are Selectively Overexpressed in Neuritic Plaque-Associated Glia in Alzheimer's Disease Brains
2003
Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action
2008
The Endocannabinoid System and the Brain
2012
Adenosine A2a blockade prevents synergy between μ-opiate and cannabinoid CB1 receptors and eliminates heroin-seeking behavior in addicted rats
2006
Characterization of the acute endocrine actions of (−)-11-hydroxy-Δ8-tetrahydrocannabinol-dimethylheptyl (HU-210), a potent synthetic cannabinoid in rats
1998
RIM1α phosphorylation at serine-413 by protein kinase A is not required for presynaptic long-term plasticity or learning
2008 StandoutNobel
Neural Systems Underlying Opiate Addiction
2002
A role for endocannabinoids in the generation of parkinsonism and levodopa‐induced dyskinesia in MPTP‐lesioned non‐human primate models of Parkinson's disease
2005
Identification of the role of endogenous cannabinoids in pain modulation: strategies and pitfalls
2000
Effects of intrastriatal cannabinoids on rotational behavior in rats: Interactions with the dopaminergic system
1998
InhA, a target of the antituberculous drug isoniazid, is involved in a mycobacterial fatty acid elongation system, FAS-II
2000
Cannabinoids for Tourette's Syndrome
2009
Works of J.A. Ramos being referenced
Changes in endocannabinoid contents in reward‐related brain regions of alcohol‐exposed rats, and their possible relevance to alcohol relapse
2004
Alleviation of motor hyperactivity and neurochemical deficits by endocannabinoid uptake inhibition in a rat model of Huntington's disease
2002
Down-regulation of the AMPA glutamate receptor subunits GluR1 and GluR2/3 in the rat cerebellum following pre- and perinatal Δ9-tetrahydrocannabinol exposure
2004
Is prolactin playing a role in the regulation of catecholamine synthesis and release from male rat adrenal medulla?
1991
UCM707, an inhibitor of the anandamide uptake, behaves as a symptom control agent in models of Huntington's disease and multiple sclerosis, but fails to delay/arrest the progression of different motor-related disorders
2005
Cannabinoids and gene expression during brain development
2004
Effects of rimonabant, a selective cannabinoid CB1 receptor antagonist, in a rat model of Parkinson's disease
2006
Perinatal Δ9-tetrahydrocannabinol exposure reduces proenkephalin gene expression in the caudate-putamen of adult female rats
1998
Determination of plasma haloperidol concentrations by radioreceptor assay in schizophrenia: Clinical utility
1989
Effects of chronic exposure to Δ9-tetrahydrocannabinol on cannabinoid receptor binding and mRNA levels in several rat brain regions
1997
Chronic administration of cannabinoids regulates proenkephalin mRNA levels in selected regions of the rat brain
1998
Maternal exposure to Δ9-tetrahydrocannabinol facilitates morphine self-administration behavior and changes regional binding to central μ opioid receptors in adult offspring female rats
1998
Extrapyramidal and neuroendocrine effects of AM404, an inhibitor of the carrier-mediated transport of anandamide
1999
Effects of Dibutyryl Cyclic AMP and Retinoic Acid on the Differentiation of Dopamine Neurons: Prevention of Cell Death by Dibutyryl Cyclic AMP
1995
Changes in cannabinoid CB1 receptors in striatal and cortical regions of rats with experimental allergic encephalomyelitis, an animal model of multiple sclerosis
2001
Identification of Endocannabinoids and Cannabinoid CB<sub>1</sub> Receptor mRNA in the Pituitary Gland
1999
Atypical location of cannabinoid receptors in white matter areas during rat brain development
1997
The endogenous cannabinoid receptor ligand, anandamide, inhibits the motor behavior: role of nigrostriatal dopaminergic neurons
1995
Reduced Glial Fibrillary Acidic Protein and Glutamine Synthetase Expression in Astrocytes and Bergmann Glial Cells in the Rat Cerebellum Caused by Δ<sup>9</sup>-Tetrahydrocannabinol Administration during Development
2002
Pharmacological and biochemical interactions between opioids and cannabinoids
1999
Prenatal Cannabinoid Exposure Down- Regulates Glutamate Transporter Expressions (GLAST and EAAC1) in the Rat Cerebellum
2004
Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: Relevance to Parkinson's disease
2005
Cannabinoid CB1 receptors colocalize with tyrosine hydroxylase in cultured fetal mesencephalic neurons and their activation increases the levels of this enzyme
2000
Changes in cannabinoid receptor binding and mRNA levels in several brain regions of aged rats
1998
Sex Steroid Influence on Cannabinoid CB1 Receptor mRNA and Endocannabinoid Levels in the Anterior Pituitary Gland
2000
Effects of cannabinoids on prolactin and gonadotrophin secretion: involvement of changes in hypothalamic γ-aminobutyric acid (GABA) inputs
1998
Rapid detection of Actinobacillus actinomycetemcomitans, Prevotella intermedia and Porphyromona gingivalis by multiplex PCR
1998
Loss of cannabinoid CB1 receptors in the basal ganglia in the late akinetic phase of rats with experimental Huntington’s disease
2002
Early changes in the development of dopaminergic neurotransmission after maternal exposure to cannabinoids
1992
Cannabinoid receptor and WIN-55,212-2-stimulated [35S]GTPγS binding and cannabinoid receptor mRNA levels in several brain structures of adult male rats chronically exposed to R-methanandamide
1999
Enhancement of Anandamide Formation in the Limbic Forebrain and Reduction of Endocannabinoid Contents in the Striatum of Δ9‐Tetrahydrocannabinol‐Tolerant Rats
2000
Cannabinoid CB1 receptors in the basal ganglia and motor response to activation or blockade of these receptors in parkin-null mice
2005
Exposure to cannabinoids in the development of endogenous cannabinoid system
2002
Changes in endocannabinoid contents in the brain of rats chronically exposed to nicotine, ethanol or cocaine
2002
Changes in tyrosine hydroxylase gene expression in mesencephalic catecholaminergic neurons of immature and adult male rats perinatally exposed to cannabinoids
1994
Endocannabinoids and basal ganglia functionality
2002
Prenatal cannabinoid exposure and gene expression for neural adhesion molecule L1 in the fetal rat brain
2003
Time-course of the effects of anandamide, the putative endogenous cannabinoid receptor ligand, on extrapyramidal function
1995
Characterization of an anandamide degradation system in prostate epithelial PC‐3 cells: synthesis of new transporter inhibitors as tools for this study
2004
Role of ovarian steroids on the catecholamine synthesis and release in female rat adrenal: and studies
1989
Behavioral and molecular changes elicited by acute administration of SR141716 to Δ9-tetrahydrocannabinol-tolerant rats: an experimental model of cannabinoid abstinence
2004
Involvement of vanilloid-like receptors in the effects of anandamide on motor behavior and nigrostriatal dopaminergic activity: in vivo and in vitro evidence
2004
UCM707, a potent and selective inhibitor of endocannabinoid uptake, potentiates hypokinetic and antinociceptive effects of anandamide
2002
Cannabinoid receptor binding did not vary in several hypothalamic nuclei after hypothalamic deafferentation
1998
Cannabinoids ameliorate disease progression in a model of multiple sclerosis in mice, acting preferentially through CB1 receptor-mediated anti-inflammatory effects
2012
Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: Importance of antioxidant and cannabinoid receptor-independent properties
2006
Acute effects of δ-9-tetrahydrocannabinol on dopaminergic activity in several rat brain areas
1992
?9-Tetrahydrocannabinol affects mesolimbic dopaminergic activity in the female rat brain: interactions with estrogens
1993
The endogenous cannabinoid system and the basal ganglia
2002
Prenatal Δ9-tetrahydrocannabinol exposure modifies proenkephalin gene expression in the fetal rat brain: sex-dependent differences
2000
Decreased endocannabinoid levels in the brain and beneficial effects of agents activating cannabinoid and/or vanilloid receptors in a rat model of multiple sclerosis
2005
Perinatal Δ9-Tetrahydrocannabinol Exposure Augmented the Magnitude of Motor Inhibition Caused by GABAB, but not GABAA, Receptor Agonists in Adult Rats
1999
Acute Effects of Δ<sup>9-</sup>Tetrahydrocannabinol on Tuberoinfundibular Dopamine Activity, Anterior Pituitary Sensitivity to Dopamine and Prolactin Release Vary as a Function of Estrous Cycle
1993
Presence of cannabinoid binding sites in the brain from early postnatal ages
1993
Cannabidiol reduced the striatal atrophy caused 3‐nitropropionic acidin vivoby mechanisms independent of the activation of cannabinoid, vanilloid TRPV1and adenosine A2Areceptors
2007
Time-dependent differences of repeated administration with Δ9-tetrahydrocannabinol in proenkephalin and cannabinoid receptor gene expression and G-protein activation by μ-opioid and CB1-cannabinoid receptors in the caudate–putamen
1999
Downregulation of rat brain cannabinoid binding sites after chronic Δ9-tetrahydrocannabinol treatment
1994
An acute dose of δ9-tetrahydrocannabinol affects behavioral and neurochemical indices of mesolimbic dopaminergic activity
1993
Role of endocannabinoids in brain development
1999
Antinociceptive, behavioural and neuroendocrine effects of CP 55,940 in young rats
2002
Changes in endocannabinoid transmission in the basal ganglia in a rat model of Huntington's disease
2001
Inhibition of Fatty Acid Amidohydrolase, the Enzyme Responsible for the Metabolism of the Endocannabinoid Anandamide, by Analogues of Arachidonoyl-serotonin
2003
Perinatal cannabinoid exposure modifies the sociosexual approach behavior and the mesolimbic dopaminergic activity of adult male rats
1996
Changes in rat brain cannabinoid binding sites after acute or chronic exposure to their endogenous agonist, anandamide, or to δ9-tetrahydrocannabinol
1995
Neuroprotective effects of phytocannabinoid‐based medicines in experimental models of Huntington's disease
2011
Changes in prodynorphin and POMC gene expression in several brain regions of rat fetuses prenatally exposed to Δ-tetrahydrocannabinol
2002
Extrapyramidal effects of methanandamide, an analog of anandamide, the endogenous CB1, receptor ligand
1996
Motor disturbances induced by an acute dose of Δ9-tetrahydrocannabinol: Possible involvement of nigrostriatal dopaminergic alterations
1993
Blockade of cannabinoid CB1 receptor function protects against in vivo disseminating brain damage following NMDA‐induced excitotoxicity
2002
The prenatal exposure to δ9-tetrahydrocannabinol affects the gene expression and the activity of tyrosine hydroxylase during early brain development
1995
Motor behavior and nigrostriatal dopaminergic activity in adult rats perinatally exposed to cannabinoids
1994
Estrogenic modulation of δ9-Tetrahydrocannabinol effects on nigrostriatal dopaminergic activity in the female rat brain
1992
Neuronal and Astroglial Response to Pre- and Perinatal Exposure to Delta-9-Tetra- Hydrocannabinol in the Rat Substantia nigra
2000
Effects of estrogens and progesterone on the catecholaminergic activity of the adrenal medulla in female rats
1988
Loss of mRNA levels, binding and activation of GTP-binding proteins for cannabinoid CB1 receptors in the basal ganglia of a transgenic model of Huntington’s disease
2002
Effects of pre- and perinatal exposure to hashish extracts on the ontogeny of brain dopaminergic neurons
1991
The endogenous cannabinoid system and brain development
2000
The Taq IA polymorphism linked to the DRD2 gene is related to lower attention and less inhibitory control in alcoholic patients
2005
Cannabinoid Receptor and WIN-55,212-2-Stimulated [<sup>35</sup>S]GTPγS Binding and Cannabinoid Receptor mRNA Levels in the Basal Ganglia and the Cerebellum of Adult Male Rats Chronically Exposed to Δ<sup>9</sup>-Tetrahydrocannabinol
1998
Localization of mRNA expression and activation of signal transduction mechanisms for cannabinoid receptor in rat brain during fetal development
1998
Autoradiographic analysis of cannabinoid receptor binding and cannabinoid agonist-stimulated [35S]GTPγS binding in morphine-dependent mice
1998
Design, Synthesis, and Biological Evaluation of New Inhibitors of the Endocannabinoid Uptake: Comparison with Effects on Fatty Acid Amidohydrolase
2003
Perinatal Δ9-Tetrahydrocannabinol Exposure Did Not Alter Dopamine Transporter and Tyrosine Hydroxylase mRNA Levels in Midbrain Dopaminergic Neurons of Adult Male and Female Rats
1998
Cannabinoid receptor binding and mRNA levels in several brain regions of adult male and female rats perinatally exposed to Δ9-tetrahydrocannabinol
1999
Brain Regional Distribution of Endocannabinoids: Implications for Their Biosynthesis and Biological Function
1999
Effects of perinatal exposure to Δ9-tetrahydrocannabinol on the fetal and early postnatal development of tyrosine hydroxylase-containing neurons in rat brain
1996
Design, synthesis and biological evaluation of new endocannabinoid transporter inhibitors
2003
Design, Synthesis and Biological Evaluation of Novel Arachidonic Acid Derivatives as Highly Potent and Selective Endocannabinoid Transporter Inhibitors
2001
Fatty acid synthetase activity in Mycobacterium smegmatis Characterization of the acyl carrier protein-dependent elongating system
1977
Arvanil, a hybrid endocannabinoid and vanilloid compound, behaves as an antihyperkinetic agent in a rat model of Huntington's disease
2005
Effect of Elevated Prolactin Levels on the Synthesis and Release of Catecholamines from the Adrenal Medulla in Female Rats
1987