Citation Impact
Citing Papers
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
1998 StandoutNature
Amyloid β Protein (Aβ) in Alzheimeri's Disease Brain
1995
Amyloid β protein (Aβ) deposition: Aβ42(43) precedes Aβ40 in down Syndrome
1995
The Carboxyl Termini of β-Amyloid Peptides 1-40 and 1-42 Are Generated by Distinct γ-Secretase Activities
1996
The Systemic Amyloidoses
1997 Standout
Proteolytic Processing of Amyloid-β Precursor Protein by Secretases Does Not Require Cell Surface Transport
2004 StandoutNobel
Cerebrovascular transport of Alzheimer's amyloidβ and apolipoproteins J and E: Possible anti-amyloidogenic role of the blood-brain barrier
1996
Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)
1994 Standout
Cerebrospinal fluid protein biomarkers for Alzheimer’s disease
2004
Amyloids and Are Generated Intracellularly in Cultured Human Neurons and Their Secretion Increases with Maturation
1996
Comparative Analysis of Amyloid-β Chemical Structure and Amyloid Plaque Morphology of Transgenic Mouse and Alzheimer's Disease Brains
2001
CSF markers for incipient Alzheimer's disease
2003
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
2002 StandoutNature
Aggregation of Secreted Amyloid β-Protein into Sodium Dodecyl Sulfate-stable Oligomers in Cell Culture
1995
The Alzheimer's Peptide Aβ Adopts a Collapsed Coil Structure in Water
2000
Preamyloid deposits in the cerebral cortex of patients with Alzheimer's disease and nondemented individuals
1988
The core Alzheimer's peptide NAC forms amyloid fibrils which seed and are seeded by β-amyloid: is NAC a common trigger or target in neurodegenerative disease?
1995
Neuropathological stageing of Alzheimer-related changes
1991 Standout
Prion Protein Isoforms, a Convergence of Biological and Structural Investigations
1995 StandoutNobel
Structure of the cross-β spine of amyloid-like fibrils
2005 StandoutNature
CSF Biomarkers for Alzheimer’s Disease: Levels of β-Amyloid, Tau, Phosphorylated Tau Relate to Clinical Symptoms and Survival
2006
The cell biology of β-amyloid precursor protein and presenilin in Alzheimer's disease
1998
The Effect of Aging on the Chaperone Concentrations in the Hepatic, Endoplasmic Reticulum of Male Rats: The Possible Role of Protein Misfolding Due to the Loss of Chaperones in the Decline in Physiological Function Seen With Age
2006
Kinesin-mediated axonal transport of a membrane compartment containing β-secretase and presenilin-1 requires APP
2001 Nature
Aqueous Dissolution of Alzheimer's Disease Aβ Amyloid Deposits by Biometal Depletion
1999
Water-soluble Aβ(N-40, N-42) Oligomers in Normal and Alzheimer Disease Brains
1996
Dominant and differential deposition of distinct β-amyloid peptide species, AβN3(pE), in senile plaques
1995
Alzheimer's disease
2006 Standout
The carboxy terminus of the .beta. amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease
1993 Standout
Anti-Aβ Drug Screening Platform Using Human iPS Cell-Derived Neurons for the Treatment of Alzheimer's Disease
2011 StandoutNobel
Mechanism of Cerebral β-Amyloid Angiopathy: Murine and Cellular Models
2006
Alzheimer's Disease
2010 Standout
Stable Association of Presenilin Derivatives and Absence of Presenilin Interactions with APP
1998
The Amyloid State of Proteins in Human Diseases
2012 Standout
Familial Danish Dementia
2005
Environmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice
2005 Standout
Enhanced Production and Oligomerization of the 42-residue Amyloid β-Protein by Chinese Hamster Ovary Cells Stably Expressing Mutant Presenilins
1997
Receptor-Mediated Transport of Human Amyloid β-Protein 1–40 and 1–42 at the Blood–Brain Barrier
1999
Rapid Communication: Characterization of β‐Amyloid Peptide from Human Cerebrospinal Fluid
1993
Amyloid β-peptide is produced by cultured cells during normal metabolism
1992 StandoutNature
Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein
1995 StandoutNobel
β-Amyloid Precursor Protein
1996
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity
1999 StandoutNature
Molecular Mechanisms of Amyloidosis
2003 Standout
Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?
1993 Standout
Down patients: Extracellular preamyloid deposits precede neuritic degeneration and senile plaques
1989
Translating cell biology into therapeutic advances in Alzheimer's disease
1999 Nature
A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
1999 StandoutNature
Notch receptor cleavage depends on but is not directly executed by presenilins
2002 StandoutNobel
Copper Mediates Dityrosine Cross-Linking of Alzheimer's Amyloid-β
2003
Protein Misfolding, Functional Amyloid, and Human Disease
2006 Standout
Prion-inducing domain 2–114 of yeast Sup35 protein transforms in vitro into amyloid-like filaments
1997 StandoutNobel
EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity
2010 Standout
Chemical chaperones interfere with the formation of scrapie prion protein.
1996 StandoutNobel
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice
1996 StandoutScience
Alzheimer's disease: a re-examination of the amyloid hypothesis
1998
An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp 717 ) Mutants
1994 StandoutScience
Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.
1993 Standout
A Century of Alzheimer's Disease
2006 StandoutScience
3D structure of Alzheimer's amyloid-β(1–42) fibrils
2005 Standout
Diffusible, nonfibrillar ligands derived from Aβ 1–42 are potent central nervous system neurotoxins
1998 Standout
Mass spectrometry of purified amyloid beta protein in Alzheimer's disease.
1992
Copper Homeostasis and Neurodegenerative Disorders (Alzheimer's, Prion, and Parkinson's Diseases and Amyotrophic Lateral Sclerosis)
2006 Standout
Prion protein (PrP) synthetic peptides induce cellular PrP to acquire properties of the scrapie isoform.
1995 StandoutNobel
Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage
2004 StandoutNobel
Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members
2001 StandoutNobel
A structural model for Alzheimer's β-amyloid fibrils based on experimental constraints from solid state NMR
2002 Standout
Regulation of APP-Dependent Transcription Complexes by Mint/X11s: Differential Functions of Mint Isoforms
2002 StandoutNobel
Alzheimer's Disease: Genes, Proteins, and Therapy
2001 Standout
Amyloid protein of Gerstmann-Sträussler-Scheinker disease (Indiana kindred) is an 11 kd fragment of prion protein with an N-terminal glycine at codon 58.
1991 StandoutNobel
The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
2011 Standout
Amyloid β40/42 clearance across the blood-brain barrier following intra-ventricular injections in wild-type, apoE knock-out and human apoE3 or E4 expressing transgenic mice
2001
Adapting Proteostasis for Disease Intervention
2008 StandoutScience
Alzheimer's Disease Is a Synaptic Failure
2002 StandoutScience
Small Molecule Microarrays Enable the Discovery of Compounds That Bind the Alzheimer’s Aβ Peptide and Reduce its Cytotoxicity
2010
Chemical characterization of A beta 17-42 peptide, a component of diffuse amyloid deposits of Alzheimer disease
1994
The 3D profile method for identifying fibril-forming segments of proteins
2006 StandoutNobel
Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor
1994
Full-length amyloid-beta (1-42(43)) and amino-terminally modified and truncated amyloid-beta 42(43) deposit in diffuse plaques.
1996
Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis
2003 StandoutScience
Characterization of New Polyclonal Antibodies Specific for 40 and 42 Amino Acid-Long Amyloid β Peptides: Their Use to Examine the Cell Biology of Presenilins and the Immunohistochemistry of Sporadic Alzheimer’s Disease and Cerebral Amyloid Angiopathy Cases
1997
A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission
2003 StandoutNobel
Prion protein preamyloid and amyloid deposits in Gerstmann-Sträussler-Scheinker disease, Indiana kindred.
1992 StandoutNobel
Metals in Neurobiology: Probing Their Chemistry and Biology with Molecular Imaging
2008 Standout
Surfactant properties of Alzheimer's A beta peptides and the mechanism of amyloid aggregation.
1994
Cleavage of Amyloid-β Precursor Protein and Amyloid-β Precursor-like Protein by BACE 1
2004 StandoutNobel
Works of J. Styles being referenced
The comparative immunoreactivities of brain amyloids in Alzheimer's disease and scrapie
1987
Peptide Compositions of the Cerebrovascular and Senile Plaque Core Amyloid Deposits of Alzheimer′s Disease
1993
CHARACTERIZATION OF THE CEREBRAL AMYLOID PEPTIDES AND THEIR PRECURSORS
1990
Purification and tissue level of the beta-amyloid peptide precursor of rat brain
1991