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Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage
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Structure of ribonucleotide reductase protein R1
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Considerations on the structure and biochemistry of bacterial polyhydroxyalkanoic acid inclusions
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Purification and Characterization of the Poly(Hydroxyalkanoic Acid) Synthase from Chromatium vinosum and Localization of the Enzyme at the Surface of Poly(Hydroxyalkanoic Acid) Granules
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Local Sequence Dependence of Polyhydroxyalkanoic Acid Degradation in Hydrogenophaga pseudoflava
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Enzymatic functionalization of carbon–hydrogen bonds
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In vitro selection of RNA aptamers specific for cyanocobalamin
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Structures of Cobalt(III)‐Pepleomycin and Cobalt(III)‐Deglycopepleomycin (green forms) Determined by NMR Studies
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In vitro evolution of a self-alkylatlng ribozyme
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In vitro evolution of new ribozymes with polynucleotide kinase activity
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Evidence by Site-Directed Mutagenesis Supports Long-Range Electron Transfer in Mouse Ribonucleotide Reductase
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The structure and function of lipoxygenase
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RNA Degradation by Bleomycin, a Naturally Occurring Bioconjugate
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High Levels of Bioplastic Are Produced in Fertile Transplastomic Tobacco Plants Engineered with a Synthetic Operon for the Production of Polyhydroxybutyrate
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p53 Mutations in Human Cancers
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pH Rate Profiles of FnY356−R2s (n = 2, 3, 4) in Escherichia coli Ribonucleotide Reductase: Evidence that Y356 Is a Redox-Active Amino Acid along the Radical Propagation Pathway
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Geometric and Electronic Structure/Function Correlations in Non-Heme Iron Enzymes
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Defining the Inside and Outside of a Catalytic RNA Molecule
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Efficient DNA Cleavage with an Iron Complex without Added Reductant
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Quantum Chemical Studies of Radical-Containing Enzymes
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The M06 suite of density functionals for main group thermochemistry, thermochemical kinetics, noncovalent interactions, excited states, and transition elements: two new functionals and systematic testing of four M06-class functionals and 12 other functionals
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Autocatalytic generation of Dopa in the engineered protein R2 F208Y from Escherichia coli ribonucleotide reductase and crystal structure of the Dopa-208 protein
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Diiron-cluster intermediates in biological oxygen activation reactions
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Peroxidase Activity of Myoglobin Is Enhanced by Chemical Mutation of Heme-Propionates
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Functions of the gene products of Escherichia coli
1993
Synthesis, structure and properties of polyhydroxyalkanoates: biological polyesters
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Cleavage of Nucleic Acids by Bleomycin
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Crystal Structure of a Group I Ribozyme Domain: Principles of RNA Packing
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[8] Enzymology of enol intermediates
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Dioxygen Activation by Enzymes Containing Binuclear Non-Heme Iron Clusters
1996
In Situ Click Chemistry: Enzyme Inhibitors Made to Their Own Specifications
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The Many Faces of Vitamin B12: Catalysis by Cobalamin-Dependent Enzymes
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A new paradigm for electrostatic catalysis of radical reactions in vitamin B 12 enzymes
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Covalent Modifiers: An Orthogonal Approach to Drug Design
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Strategies for the sustainable production of new biodegradable polyesters in plants: a review
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Differential Iron(II) Affinity of the Sites of the Diiron Cluster in Protein R2 of Escherichia coli Ribonucleotide Reductase: Tracking the Individual Sites through the O2 Activation Sequence
1997
Interactions of Deglycosylated Cobalt(III)−Pepleomycin (Green Form) with DNA Based on NMR Structural Studies,
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Control of poly-beta-hydroxybutyrate synthase mediated by acetyl phosphate in cyanobacteria
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Systematic Evolution of Ligands by Exponential Enrichment: RNA Ligands to Bacteriophage T4 DNA Polymerase
1990 StandoutScience
The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae
2002 StandoutNobel
Oxidative Strand Scission of Nucleic Acids: Routes Initiated by Hydrogen Abstraction from the Sugar Moiety
1998
Evidence that Cobalt−Carbon Bond Homolysis is Coupled to Hydrogen Atom Abstraction from Substrate in Methylmalonyl-CoA Mutase
1997
The DNA cleavage pathway of iron bleomycin. Strand scission precedes deoxyribose 3-phosphate bond cleavage
1994
Multisubstrate adduct inhibitors of glycinamide ribonucleotide transformylase: Synthetic and enzyme-assembled.
1991
Microsome-stimulated activation of ferrous bleomycin in the presence of DNA.
1987
Computer Simulation of the Chemical Catalysis of DNA Polymerases: Discriminating between Alternative Nucleotide Insertion Mechanisms for T7 DNA Polymerase
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Reconsideration of X, the Diiron Intermediate Formed during Cofactor Assembly in E. coli Ribonucleotide Reductase
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Chemistry and Enzymology of Vitamin B12
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The Core Structure of X Generated in the Assembly of the Diiron Cluster of Ribonucleotide Reductase: 17O2 and H217O ENDOR
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S-Adenosylmethionine: A Wolf in Sheep's Clothing, or a Rich Man's Adenosylcobalamin?
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Electron Injection through a Specific Pathway Determines the Outcome of Oxygen Activation at the Diiron Cluster in the F208Y Mutant of Escherichia coli Ribonucleotide Reductase Protein R2
1998
Ancient DNA: extraction, characterization, molecular cloning, and enzymatic amplification.
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Recent Studies of Nucleophilic, General-Acid, and Metal Ion Catalysis of Phosphate Diester Hydrolysis
1999
The Crystal Structure of an Azide Complex of the Diferrous R2 Subunit of Ribonucleotide Reductase Displays a Novel Carboxylate Shift with Important Mechanistic Implications for Diiron-Catalyzed Oxygen Activation
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Simulations of the Large Kinetic Isotope Effect and the Temperature Dependence of the Hydrogen Atom Transfer in Lipoxygenase
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NMR Studies of the Paramagnetic Complex Fe(II)−Bleomycin
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Engineering of the iron site in ribonucleotide reductase to a self-hydroxylating monooxygenase.
1992
Production of a polyhydroxyalkanoate biopolymer in insect cells with a modified eucaryotic fatty acid synthase
1996
Crystallization of ribozymes and small RNA motifs by a sparse matrix approach.
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Synthesis of medium-chain-length polyhydroxyalkanoates inArabidopsis thalianausing intermediates of peroxisomal fatty acid β-oxidation
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Enzyme-catalyzed synthesis of poly[(R)-(-)-3-hydroxybutyrate]: formation of macroscopic granules in vitro.
1995
The redox state of activated bleomycin.
1985
Modern metabolism as a palimpsest of the RNA world.
1989
Engineering the Diiron Site of Escherichia coli Ribonucleotide Reductase Protein R2 to Accumulate an Intermediate Similar to Hperoxo, the Putative Peroxodiiron(III) Complex from the Methane Monooxygenase Catalytic Cycle
1998
Enzymatic Polymerization of (R)-3-Hydroxyalkanoates by a Bacterial Polymerase
2000
Polynucleotide recognition and strand scission by Fe-bleomycin
1991
Quantum Chemical Studies of Radical-Containing Enzymes
2003
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Models for Nonheme Iron Intermediates: Structural Basis for Tuning the Spin States of Fe(TPA) Complexes
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Theoretical Study of the Substrate Mechanism of Ribonucleotide Reductase
1998
Reversal of DNA alkylation damage by two human dioxygenases
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X-Band ENDOR of the Liganding Environment from the Radical X Intermediate of Escherichia coli Ribonucleotide Reductase
1996
Electron Tunneling Pathways and Role of Adenine in Repair of Cyclobutane Pyrimidine Dimer by DNA Photolyase
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Genomic Expression Responses to DNA-damaging Agents and the Regulatory Role of the Yeast ATR Homolog Mec1p
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The Complete Genome Sequence of Escherichia coli K-12
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Redox cycling and kinetic analysis of single molecules of solution-phase nitrite reductase
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Bleomycins: A Structural Model for Specificity, Binding, and Double Strand Cleavage
1996
DESATURATION AND RELATED MODIFICATIONS OF FATTY ACIDS
1998
Identification of 5-hydroxyhexanoic acid, 4-hydroxyheptanoic acid and 4-hydroxyoctanoic acid as new constituents of bacterial polyhydroxyalkanoic acids
1996
Cloning and analysis of the poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) biosynthesis genes of Aeromonas caviae
1997
Protein Radicals in Enzyme Catalysis
1998 Standout
Regio- and Enantioselective Alkane Hydroxylation with Engineered Cytochromes P450 BM-3
2003 StandoutNobel
Structure and catalytic mechanism of methane monooxygenase and approaches to its modelling
1995
Nucleic Acid Recognition by Metal Complexes of Bleomycin
1999
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue
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Enzymic modification of a tyrosine residue to a stable free radical in ribonucleotide reductase.
1983
A Genomic Perspective on Protein Families
1997 StandoutScience
Metabolic Engineering of Poly(3-Hydroxyalkanoates): From DNA to Plastic
1999
Raman Evidence for a Weakened O−O Bond in Mononuclear Low-Spin Iron(III)−Hydroperoxides
1998 StandoutNobel
Activation of DNA Carbon−Hydrogen Bonds by Metal Complexes
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Metalloenzymes, Structural Motifs, and Inorganic Models
1993 Science
Intramolecular translocation of the protein radical formed in the reaction of recombinant sperm whale myoglobin with H2O2.
1992
Mechanism of bleomycin: evidence for a rate-determining 4'-hydrogen abstraction from poly(dA-dU) associated with the formation of both free base and base propenal
1985
Tryptophan radicals formed by iron/oxygen reaction with Escherichia coli ribonucleotide reductase protein R2 mutant Y122F.
1994
Ligand Field Circular Dichroism and Magnetic Circular Dichroism Studies of Component B and Substrate Binding to the Hydroxylase Component of Methane Monooxygenase
1997
O2 Activation by Non-Heme Diiron Proteins: Identification of a Symmetric μ-1,2-Peroxide in a Mutant of Ribonucleotide Reductase
1998
Water Affects the Stereochemistry and Dioxygen Reactivity of Carboxylate-Rich Diiron(II) Models for the Diiron Centers in Dioxygen-Dependent Non-Heme Enzymes
2005
Analysis of a 24-kilodalton protein associated with the polyhydroxyalkanoic acid granules in Alcaligenes eutrophus
1995
Magnetic circular dichroism spectroscopy as a probe of the geometric and electronic structure of non-heme ferrous enzymes
1995
From RNA to DNA, Why So Many Ribonucleotide Reductases?
1993 Science
Carbon—Hydrogen Bonds of DNA Sugar Units as Targets for Chemical Nucleases and Drugs
1995
Works of J. Stubbe being referenced
Alternative model for mechanism-based inhibition of Escherichia coli ribonucleotide reductase by 2'-azido-2'-deoxyuridine 5'-diphosphate
1993
Sequence Specific Double-Strand Cleavage of DNA by Fe-Bleomycin. 1. The Detection of Sequence-Specific Double-Strand Breaks Using Hairpin Oligonucleotides
1995
2'-Deoxy-2'-methylenecytidine and 2'-deoxy-2',2'-difluorocytidine 5'-diphosphates: potent mechanism-based inhibitors of ribonucleotide reductase
1991
Characterization of C439SR1, a mutant of Escherichia coli ribonucleotide diphosphate reductase: evidence that C439 is a residue essential for nucleotide reduction and C439SR1 is a protein possessing novel thioredoxin-like activity
1992
Overexpression and Purification of the Soluble Polyhydroxyalkanoate Synthase from Alcaligenes eutrophus: Evidence for a Required Posttranslational Modification for Catalytic Activity
1994
Mechanistic analyses of site-specific degradation in DNA-RNA hybrids by prototypic DNA cleavers
1997
Sequence-Specific Double-Strand Cleavage of DNA by Fe-Bleomycin. 2. Mechanism and Dynamics
1995
A model for the role of multiple cysteine residues involved in ribonucleotide reduction: amazing and still confusing
1992
Glycinamide ribonucleotide synthetase from Escherichia coli: cloning, overproduction, sequencing, isolation, and characterization
1990
Bleomycin mediated degradation of DNA-RNA hybrids does not involve C–1′ chemistry
1992
Formylglycinamide ribonucleotide synthetase from Escherichia coli: cloning, sequencing, overproduction, isolation, and characterization
1989
Interaction of C225SR1 mutant subunit of ribonucleotide reductase with R2 and nucleoside diphosphates: tales of a suicidal enzyme
1992
Purification and characterization of the purE, purK, and purC gene products: identification of a previously unrecognized energy requirement in the purine biosynthetic pathway
1992
Ribonucleotide reductases: amazing and confusing.
1990
Immunocytochemical analysis of poly-beta-hydroxybutyrate (PHB) synthase in Alcaligenes eutrophus H16: localization of the synthase enzyme at the surface of PHB granules
1993
Polyhydroxybutyrate Synthase: Evidence for Covalent Catalysis
1996
New insight into the mechanism of base propenal formation during bleomycin-mediated DNA degradation
1992
Electron Paramagnetic Resonance Investigations of a Kinetically Competent Intermediate Formed in Ribonucleotide Reduction: Evidence for a Thiyl Radical-Cob(II)alamin Interaction
1996
Cloning, sequencing, and expression of the adenosylcobalamin-dependent ribonucleotide reductase from Lactobacillus leichmannii.
1993
The mechanism of free base formation from DNA by bleomycin. A proposal based on site specific tritium release from Poly(dA.dU).
1983
Mechanism of ribonucleoside diphosphate reductase from Escherichia coli. Evidence for 3'-C--H bond cleavage.
1983
Substrate specificity of formylglycinamidine synthetase
1986
Mechanism-based inhibition of a mutant Escherichia coli ribonucleotide reductase (cysteine-225----serine) by its substrate CDP.
1989
Cloning, overproduction, and purification of the B2 subunit of ribonucleoside-diphosphate reductase
1986
Incorporation of 18O into glycolic acid obtained from the bleomycin-mediated degradation of DNA. Evidence for 4'-radical trapping by 18O2
1987
2'-Azido-2'-deoxynucleotide interaction with E. coli ribonucleotide reductase: generation of a new radical species
1984
Characterization of Y122F R2 of Escherichia coli Ribonucleotide Reductase by Time-Resolved Physical Biochemical Methods and X-ray Crystallography,
1998
Mechanism of Assembly of the Tyrosyl Radical-Dinuclear Iron Cluster Cofactor of Ribonucleotide Reductase
1991 Science
Are carboxylations involving biotin concerted or nonconcerted?
1980
Mechanism of ribonucleotide reductase from herpes simplex virus type 1. Evidence for 3' carbon-hydrogen bond cleavage and inactivation by nucleotide analogs.
1986
Ribonucleotide reductases: Radical enzymes with suicidal tendencies
1993
Mechanism of Assembly of the Diferric Cluster−Tyrosyl Radical Cofactor of Escherichia coli Ribonucleotide Reductase from the Diferrous Form of the R2 Subunit
1996