Standout Papers
Citation Impact
Citing Papers
Differential Antigen Processing by Dendritic Cell Subsets in Vivo
2007 StandoutScienceNobel
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells
2013 StandoutScienceNobel
Induction of CD4+ T Cell Alloantigen-Specific Hyporesponsiveness by IL-10 and TGF-β
1999
Presence of interleukin 10 (IL-10) in the ascites of patients with ovarian and other intra-abdominal cancers
1992
Adenoviral Transfer of the Viral IL-10 Gene Periarticularly to Mouse Paws Suppresses Development of Collagen-Induced Arthritis in Both Injected and Uninjected Paws
1999
IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways
1998
The regulation of IL-10 production by immune cells
2010 Standout
Exogenous and Endogenous IL-10 Regulate IFN-α Production by Peripheral Blood Mononuclear Cells in Response to Viral Stimulation
1998
Modulation of Formyl Peptide Receptor Expression by IL-10 in Human Monocytes and Neutrophils
1999
Human B cell precursors proliferate and express CD23 after CD40 ligation.
1993
Regulation of murine lymphokine production in vivo II. Dehydroepiandrosterone is a natural enhancer of interleukin 2 synthesis by helper T cells
1990
Igg subclass-restricted immune responses to allergens
1990
Interleukin-10 Stimulation of Phosphatidylinositol 3-Kinase and p70 S6 Kinase Is Required for the Proliferative but Not the Antiinflammatory Effects of the Cytokine
1996
Clinical and biologic effects of anti-interleukin-10 monoclonal antibody administration in systemic lupus erythematosus
2000
Design and Analysis of an Engineered Human Interleukin-10 Monomer
2000
IL-10 AS A THERAPEUTIC STRATEGY IN THE TREATMENT OF RHEUMATOID ARTHRITIS
1998
Inflammation and cancer
2002 StandoutNature
Relationship of Interleukin-10 Plasma Levels to Severity of Injury and Clinical Outcome in Injured Patients
1997
IL-10 inhibits metalloproteinase and stimulates TIMP-1 production in human mononuclear phagocytes.
1995
Increased mRNA Expression of IL‐10 in Mononuclear Cells in Multiple Sclerosis and Optic Neuritis
1995
RETROVIRAL DELIVERY OF VIRAL INTERLEUKIN-10 INTO MYELOID DENDRITIC CELLS MARKEDLY INHIBITS THEIR ALLOSTIMULATORY ACTIVITY AND PROMOTES THE INDUCTION OF T-CELL HYPORESPONSIVENESS1,2
1998
Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells
1994
Elevated interleukin-10 levels in patients with rheumatoid arthritis
1995
Interleukin‐10 controls interferon‐γ and tumor necrosis factor production during experimental endotoxemia
1994
The Hypothalamic–Pituitary–Adrenal Axis and Immune-Mediated Inflammation
1995 Standout
Disulfide bond assignments and secondary structure analysis of human and murine interleukin 10
1993
ICOS co-stimulatory receptor is essential for T-cell activation and function
2001 StandoutNatureNobel
In vivo production of interleukin‐10 by non–t cells in rheumatoid arthritis, sjöugren's syndrome, and systemic lupus erythematosus.
1994
Interleukin (IL)-10 Inhibits Nuclear Factor кB (NFкB) Activation in Human Monocytes
1995
Pathogenesis of Sjögren's Syndrome: Characteristics of Different Mouse Models for Autoimmune Exocrinopathy
2002
Pharmacodynamics of subcutaneous recombinant human interleukin-10 in healthy volunteers*
1997
IL-10 Up-Regulates CCR5 Gene Expression in Human Monocytes
1999
Interleukin‐10: Potential Benefits and Possible Risks in Clinical Infectious Diseases
1998
Interleukin-10 regulation in normal subjects and patients with asthma
1996
Staphylococcal enterotoxin B and tumor‐necrosis factor‐α‐induced relapses of experimental allergic encephalomyelitis: Protection by transforming growth factor‐β and interleukin‐10
1995
Suppressive Effects of Interleukin‐10 on Human Mononuclear Phagocyte Function againstCandida albicansandStaphylococcus aureus
1998
TECK: A Novel CC Chemokine Specifically Expressed by Thymic Dendritic Cells and Potentially Involved in T Cell Development
1997
Interleukin 10 production correlates with pathology in human Leishmania donovani infections.
1993
The Effect of Infections on Susceptibility to Autoimmune and Allergic Diseases
2002 Standout
Effects of single intravenous doses of recombinant human interleukin-10 on subsets of circulating leukocytes in humans
1999
Interleukin 10 prevents necrosis in murine experimental acute pancreatitis
1995
Mapping of the human IL10 gene and further characterization of the 5' flanking sequence
1997
IL-10 prevents the differentiation of monocytes to dendritic cells but promotes their maturation to macrophages
1998
Interleukin-10 Signaling Blocks Inhibitor of κB Kinase Activity and Nuclear Factor κB DNA Binding
1999
Interleukin‐10 inhibits cytokine generation from mast cells
1996
High Levels Of Interleukin-10 During The Initial Phase Of Fulminant Meningococcal Septic Shock
1995
Interleukin-10 is a growth factor for human melanoma cells and down-regulates HLA class-I, HLA class-II and ICAM-1 molecules
1997
Interleukin-10 inhibits neutrophil phagocytic and bactericidal activity
1996
Immune complexes inhibit antimicrobial responses through interleukin-10 production. Effects in severe combined immunodeficient mice during Listeria infection.
1995
CD4+ T-cell subsets in autoimmunity
1997
Identification and functional characterization of a second chain of the interleukin-10 receptor complex
1997
Regulatory T Cells
2000 StandoutNobel
Interleukin-6 in Biology and Medicine
1993
Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses.
1996
Epinephrine inhibits tumor necrosis factor-alpha and potentiates interleukin 10 production during human endotoxemia.
1996
Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies
1995
Interleukin 10 Treatment of Psoriasis
1999
Clinical and biological significance of interleukin-10 plasma levels in patients with septic shock
1995
Effect in vitro of gamma interferon and interleukin-10 on generation of oxidizing species by human granulocytes
1996
Experimental Leishmania major infection in mice: role of IL‐10
1999
Paralysis of B7 co-stimulation through the effect of viral IL-10 on T cells as a mechanism of local tolerance induction
1998
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
Association between polymorphisms at the human IL‐10 locus and systemic lupus erythematosus
1997
SYSTEMIC ADMINISTRATION OF ANTI-INTERLEUKIN-10 ANTIBODY PROLONGS ORGAN ALLOGRAFT SURVIVAL IN NORMAL AND PRESENSITIZED RECIPIENTS1,2
1998
Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.
1998 Standout
DC-SIGN
2000 StandoutNobel
Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis.
1995
Gene transfer of virally encoded chemokine antagonists vMIP-II and MC148 prolongs cardiac allograft survival and inhibits donor-specific immunity
2000
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
Interleukin-10 Down-Regulates MHC Class II αβ Peptide Complexes at the Plasma Membrane of Monocytes by Affecting Arrival and Recycling
1997
In vivo effects of interleukin-10 on human cytochrome P450 activity
2000
Interleukin‐10 inhibition of the progression of established collagen‐induced arthritis
1996
Modifications of CD8+ T Cell Function during In Vivo Memory or Tolerance Induction
1998
Synthesis and characterization of rat interleukin-10 (IL-10) cDNA clones from the RNA of cultured OX8− OX22− thoracic duct T cells
1992
Markers in the promoter region of interleukin-10 (IL-10) gene in myasthenia gravis: implications of diverse effects of IL-10 in the pathogenesis of the disease
1999
IL-10 immunosuppression in transplantation
1995
Enhanced Th1 Activity and Development of Chronic Enterocolitis in Mice Devoid of Stat3 in Macrophages and Neutrophils
1999
Interleukin 10 Inhibits the Release of CC Chemokines during Human Endotoxemia
2000
INTERLEUKIN-10 DOSE-DEPENDENT REGULATION OF CD4+ AND CD8+ T CELL-MEDIATED GRAFT-VERSUS-HOST DISEASE1
1998
Cytokine regulation of T-cell function: potential for therapeutic intervention
1993
Cytokine production in the central nervous system of Lewis rats with experimental autoimmune encephalomyelitis: dynamics of mRNA expression for interleukin-10, interleukin-12, cytolysin, tumor necrosis factor α and tumor necrosis factor β
1995
Interleukin-10 Enhances Tumor Necrosis Factor-α Activation of HIV-1 Transcription in Latently Infected T Cells
1998
Allograft transduction of IL-10 prolongs survival following orthotopic liver transplantation
1999
Interleukin-10 level in sputum is reduced in bronchial asthma, COPD and in smokers
1999
T‐cell cytokines may control the balance of functionally distinct macrophage populations
1997
Dendritic Cell Function in Vivo during the Steady State: A Role in Peripheral Tolerance
2003 StandoutNobel
The IL-6/sIL-6R complex as a novel target for therapeutic approaches
2007
In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma.
1993
Exogenous Human Recombinant Interleukin-10 Attenuates Hindlimb Ischemia–Reperfusion Injury
1997
Interleukin-10 in Non-Hodgkin's Lymphoma
1997
SYSTEMIC ADMINISTRATION OF CELLULAR INTERLEUKIN-10 CAN EXACERBATE CARDIAC ALLOGRAFT REJECTION IN MICE1,2
1996
Antigen-specific cellular hyporesponsiveness in a chronic human helminth infection is mediated by Th3/Tr1-type cytokines IL-10 and transforming growth factor-β but not by a Th1 to Th2 shift
2000
Interleukin-10 Is Associated with the Development of Sepsis in Trauma Patients
1996
Interleukin-10 and the Monocyte/Macrophage-Induced Inflammatory Response in Septic Shock
1995
IL-10: Evolving concepts☆☆☆★★★
1998
Clinical, hematologic, and immunologic effects of interleukin-10 in humans
1996
Administration of interleukin‐10 abolishes innate resistance to Listeria monocytogenes
1996
Increased Serum Concentrations of Interleukin-10 in Patients with Hepatosplenic Candidiasis
1998
Human Interleukin-10 Expression in T/Natural Killer-Cell Lymphomas
1998
Prospects for a vaccine against the hepatitis C virus
2005 StandoutNatureNobel
Interleukin-10 (IL-10) Augments Allograft Arterial Disease
1999
Inflammatory Markers and Physical Performance in Older Persons: The InCHIANTI Study
2004
Increased interleukin-10 serum levels in patients with solid tumours
1996
Contrasting effects of IL-4, IL-10 and corticosteroids on RANTES production by human monocytes
1996
Detection of Type 2–Like T–Helper Cells in Hepatitis C Virus Infection: Implications for Hepatitis C Virus Chronicity
1997
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
Interleukin‐10 prevents experimental allergic encephalomyelitis in rats
1994
Enhancement of endotoxin‐induced interleukin‐10 production by SR 31747A, a sigma ligand
1995
Interleukin 10 Treatment Does Not Prolong Experimental Corneal Allograft Survival
1999
Adenovirus-Mediated Gene Transfer of Viral Interleukin-10 Inhibits the Immune Response to Both Alloantigen and Adenoviral Antigen
1997
Interleukin-10 inhibits antigen-induced cellular recruitment into the airways of sensitized mice.
1995
Type 1/Type 2 Immunity in Infectious Diseases
2001
Interleukin (IL)-10 inhibits long-term IL-6 production but not preformed mediator release from rat peritoneal mast cells.
1996
A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
1997 StandoutNature
Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency
1998
Recipient pretreatment with mammalian IL-10 prolongs mouse cardiac allograft survival by inhibition of anti-donor T cell responses
1999
The human interleukin-10 receptor gene maps to chromosome 11q23.3
1995
Prevention and reversal of cartilage degradation in rheumatoid arthritis by interleukin‐10 and interleukin‐4
1996
CD4+ T Cell Clones Producing both Interferon-γ and Interleukin-10 Predominate in Bronchoalveolar Lavages of Active Pulmonary Tuberculosis Patients
1999
Interleukin-10 decreases tumor necrosis factor alpha and beta in alloreactions induced by human lung dendritic cells and macrophages.
1995
IL-10 expression is associated with the expression of platelet-derived endothelial cell growth factor and prognosis in oral and oropharyngeal carcinoma
1999
Restoring function in exhausted CD8 T cells during chronic viral infection
2005 StandoutNatureNobel
Virus-induced autoantibody response to a transgenic viral antigen
1990 StandoutNatureNobel
The Inhibition of HIV Replication in Monocytes by Interleukin 10 Is Linked to Inhibition of Cell Differentiation
1996
Cellular and Molecular Mechanisms of Pain
2009 StandoutNobel
HYALURONECTIN SECRETION BY MONOCYTES: DOWNREGULATION BY IL-4 AND IL-13, UPREGULATION BY IL-10
1999
Atherosclerosis — An Inflammatory Disease
1999 Standout
Pancreatic islet production of murine interleukin-10 does not inhibit immune-mediated tissue destruction.
1994
Crystal structure of human interleukin‐10 at 1.6 Å resolution and a model of a complex with its soluble receptor
1996
Regulation of Tumor Growth and Metastasis by Interleukin-10: The Melanoma Experience
1999
Helminth parasites – masters of regulation
2004 Standout
High level of interleukin‐10 production by the activated t cell population within the rheumatoid synovial membrane
1995
Human CD4+ T Lymphocytes with Remarkable Regulatory Functions on Dendritic Cells and Nickel-Specific Th1 Immune Responses
2000
T cell cytokine responses in persons with tuberculosis and human immunodeficiency virus infection.
1994
A PILOT TRIAL OF RECOMBINANT HUMAN INTERLEUKIN-10 IN KIDNEY TRANSPLANT RECIPIENTS RECEIVING OKT3 INDUCTION THERAPY1,2
1997
Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse
1995 StandoutNobel
Disposition of Recombinant Human Interleukin‐10 in Subjects with Various Degrees of Renal Function
1999
Interleukin 10 inhibits cytokine production of human AML cells
1996
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
Interieukin-10 Impairs Host Defense in Murine Pneumococcal Pneumonia
1996
Differential Regulation of the Stability of Cytokine mRNAs in Lipopolysaccharide-activated Blood Monocytes in Response to Interleukin-10
1996
Role of interleukin 10 in specific immunotherapy.
1998 Standout
High interleukin-10 serum levels are associated with fatal outcome in patients after bone marrow transplantation
1997
Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions
2004
Interleukin-10 (IL-10) secretion in systemic lupus erythematosus and rheumatoid arthritis: IL-10-dependent CD4+CD45RO+ T cell-B cell antibody synthesis
1996
C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia
1994 StandoutNobel
Interleukin‐10 inhibits B7 and intercellular adhesion molecule‐1 expression on human monocytes
1994
Effect of anthelmintic treatment on the allergic reactivity of children in a tropical slum
1993
Prognostic significance of increased IL-10 production in patients prior to allogeneic bone marrow transplantation
2000
Activation of the hypothalamus-pituitary-adrenal axis by bacterial endotoxins: Routes and intermediate signals
1994
The antipsoriatic activity of IL-10 is rather caused by effects on peripheral blood cells than by a direct effect on human keratinocytes
2000
IL-10 suppresses cell surface CD23/Fc?RII expression, not by enhancing soluble CD23 release, but by reducing CD23 mRNA expression in human monocytes
1996
Regulatory T cells and inflammatory bowel disease
1999
Systemic Release of Interleukin–10 During Orthotopic Liver Transplantation
1994
Effect of human lung allograft alveolar macrophages on IgG production: immunoregulatory role of interleukin-10, transforming growth factor-beta, and interleukin-6.
1995
Interleukin-10 prevents spontaneous death of germinal center B cells by induction of the bcl-2 protein.
1994
Antiinflammatory Cytokine Responses during Clinical Sepsis and Experimental Endotoxemia: Sequential Measurements of Plasma Soluble Interleukin (IL)-1 Receptor Type II, IL-10, and IL-13
1997
Dendritic cells and the control of immunity
1998 StandoutNatureNobel
Interleukin‐10‐secreting type 1 regulatory T cells in rodents and humans
2006
Decreased atopy in children infected with Schistosoma haematobium: a role for parasite-induced interleukin-10
2000
Cancer-related inflammation
2008 StandoutNature
AN INVESTIGATION OF POLYMORPHISM IN THE INTERLEUKIN‐10 GENE PROMOTER
1997
Programmed cell death and Bcl-2 protection in very low oxygen
1995 Nature
Expression of interleukin 10 in human melanoma
1994
The intensity of T cell receptor engagement determines the cytokine pattern of human allergen‐specific T helper cells
1997
Cytokines in relapsing experimental autoimmune encephalomyelitis in DA rats: persistent mRNA expression of proinflammatory cytokines and absent expression of interleukin-10 and transforming growth factor-β
1996
A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell
1998 StandoutNature
Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance.
1995
Selective enhancement of endothelial cell VCAM‐1 expression by interleukin‐10 in the presence of activated leucocytes
1997
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
1996 StandoutNatureNobel
Mechanisms of suppression by suppressor T cells
2005
Increased interleukin-10 messenger RNA expression in atopic allergy and asthma.
1996
Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
2008 Standout
Role of interleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus.
1994
Dehydroepiandrosterone enhances IL2 production and cytotoxic effector function of human T cells
1991
TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties
1989 Standout
High-dose cellular IL-10 exacerbates rejection and reverses effects of cyclosporine and tacrolimus in mouse cardiac transplantation
1997
Receptors for Interleukin (IL)-10 and IL-6-type Cytokines Use Similar Signaling Mechanisms for Inducing Transcription through IL-6 Response Elements
1996
Characterization of Recombinant Extracellular Domain of Human Interleukin-10 Receptor
1995
A review of the association between interleukin-10 and human B-cell malignancies
1998
IL-10 is a key cytokine in psoriasis. Proof of principle by IL-10 therapy: a new therapeutic approach.
1998
IL-10 Is an Autocrine Inhibitor of Human Placental Cytotrophoblast MMP-9 Production and Invasion
1999
Interleukin-13 Effectively Down-regulates the Monocyte Inflammatory Potential During Traumatic Stress
1995
Role of interleukin‐4 and interleukin‐10 in murine collagen‐induced arthritis. Protective effect of interleukin‐4 and interleukin‐10 treatment on cartilage destruction
1997
Enhanced Interleukin‐10 Production in Response toMycobacterium aviumProducts in Mononuclear Cells from Patients with Human Immunodeficiency Virus Infection
1998
Interleukin-10 Gene Transfer to the Airway Regulates Allergic Mucosal Sensitization in Mice
1999
Depletion of IL-10- and TGF-β-Producing Regulatory γδ T Cells by Administering a Daunomycin-Conjugated Specific Monoclonal Antibody in Early Tumor Lesions Augments the Activity of CTLs and NK Cells
1999
Impaired antigen presentation by human monocytes during endotoxin tolerance
2000
Interleukin-10 downregulates Mycobacterium tuberculosis-induced Th1 responses and CTLA-4 expression
1996
Aromatase-deficient mice spontaneously develop a lymphoproliferative autoimmune disease resembling Sjögren's syndrome
2004
MONOCYTES ARE TARGET CELLS FOR IL-10 INDUCTION BY HIV-1 NEF PROTEIN
2000
Establishment of NOD-Pdcd1-/-mice as an efficient animal model of type I diabetes
2005 StandoutNobel
A receptor for interleukin 10 is related to interferon receptors.
1993
CD40 Engagement Triggers Switching to IgA1 and IgA2 in Human B Cells Through Induction of Endogenous TGF-β: Evidence for TGF-β But Not IL-10-Dependent Direct Sμ→Sα and Sequential Sμ→Sγ, Sγ→Sα DNA Recombination
1998
Interleukin-10 induces E-selectin on small and large blood vessel endothelial cells.
1996
Exogenous and endogenous IL-10 regulate IFN-alpha production by peripheral blood mononuclear cells in response to viral stimulation.
1998
Generation of Lymphohematopoietic Cells from Embryonic Stem Cells in Culture
1994 StandoutScienceNobel
Interleukin-10–Treated Human Dendritic Cells Induce a Melanoma-Antigen–Specific Anergy in CD8+ T Cells Resulting in a Failure to Lyse Tumor Cells
1999
Regulation of parasite antigen-driven immune responses by interleukin-10 (IL-10) and IL-12 in lymphatic filariasis
1997
High levels of circulating IL-10 in human malaria
1994
IL-10 augments CD23 expression on U937 cells and down-regulates IL-4-driven CD23 expression on cultured human blood monocytes: effects of IL-10 and other cytokines on cell phenotype and phagocytosis.
1995
Mechanism of endotoxin desensitization: involvement of interleukin 10 and transforming growth factor beta.
1995
High levels of plasma IL-10 and expression of IL-10 by keratinocytes during visceral leishmaniasis predict subsequent development of post-kala-azar dermal leishmaniasis
1998
Expression of different combinations of interleukins by human T cell leukemic cell lines that are clonally related.
1989 StandoutNobel
IFN-α and IL-10 Induce the Differentiation of Human Type 1 T Regulatory Cells
2001
Interleukin 4 production by CD4+ T cells from allergic individuals is modulated by antigen concentration and antigen-presenting cell type.
1995
Selection of a human T helper type 1-like T cell subset by mycobacteria.
1991
A Single Amino Acid Determines the Immunostimulatory Activity of Interleukin 10
2000
Monocyte deactivation by interleukin 10 via inhibition of tyrosine kinase activity and the Ras signaling pathway.
1994
Modulation of host immune responses by nematode cystatins
2003
Single Cell Analysis Reveals That IL-4 Receptor/Stat6 Signaling Is Not Required for the In Vivo or In Vitro Development of CD4+ Lymphocytes with a Th2 Cytokine Profile
2000
Endogenous IL-10 protects mice from death during septic peritonitis
1995
Regulation of Macrophage Chemokine Expression by Lipopolysaccharide In Vitro and In Vivo
1999
The Cytokine Profile Expressed by Human Dendritic Cells Is Dependent on Cell Subtype and Mode of Activation
1998
Interleukin-10 and Gp130 Cytokines in Human Multiple Myeloma
1999
Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses.
1995
Endurance run increases circulating IL-6 and IL-1ra but downregulates ex vivo TNF-alpha and IL-1 beta production
1995
Interleukin-10 induces immunoglobulin G isotype switch recombination in human CD40-activated naive B lymphocytes.
1996
Interleukin-10 protects neonatal mice from lethal group B streptococcal infection
1996
Inhibition by interleukin-10 of inducible cyclooxygenase expression in lipopolysaccharide-stimulated monocytes: its underlying mechanism in comparison with interleukin-4
1995
Lack of interleukin 10 regulation of antigen presentation‐associated molecules expressed on colonic epithelial cells
1999
Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells.
1996
A Prominent Role for Sp1 During Lipopolysaccharide- Mediated Induction of the IL-10 Promoter in Macrophages
2000
Interleukin-10 Increases Th1 Cytokine Production and Cytotoxic Potential in Human Papillomavirus-Specific CD8+Cytotoxic T Lymphocytes
2000
Leukocyte extravasation into the pancreatic tissue in transgenic mice expressing interleukin 10 in the islets of Langerhans.
1993
Production of interleukin-10 by human bronchogenic carcinoma.
1994
Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.
1989 Standout
Serum levels of interleukin-10 in patients with diffuse large cell lymphoma: lack of correlation with prognosis [see comments]
1995
Identification of an IL-10-Producing HLA-DR-Negative Monocyte Subset in the Malignant Ascites of Patients with Ovarian Carcinoma That Inhibits Cytokine Protein Expression and Proliferation of Autologous T Cells
1999
Interleukin-10 inhibits tumor metastasis through an NK cell-dependent mechanism.
1996
Allergen immunotherapy decreases interleukin 4 production in CD4+ T cells from allergic individuals.
1993
Human peripheral blood basophils primed by interleukin 3 (IL-3) produce IL-4 in response to immunoglobulin E receptor stimulation.
1993
Interleukin 10 (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role of tumor necrosis factor and IL-1 beta in mediating the production of IL-8 triggered by lipopolysaccharide.
1993
Interleukin 10 Secretion and Impaired Effector Function of Major Histocompatibility Complex Class II–restricted T Cells Anergized In Vivo
1998
Serum interleukin 10 titers in systemic lupus erythematosus reflect disease activity
1995
Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI.
1991
Central Nervous System Expression of IL-10 Inhibits Autoimmune Encephalomyelitis
2001
Exogenous cytokine modulation or neutralization of interleukin‐10 enhance survival in lipopolysaccharide‐hyporesponsive C3H/HeJ mice with Klebsiella infection
1999
Human Dendritic Cells Skew Isotype Switching of CD40-activated Naive B Cells towards IgA1 and IgA2
1997
Regulation of interleukin 10 release by tumor necrosis factor in humans and chimpanzees.
1994
Interleukin-6 in acute exercise and training: what is the biological relevance?
2006
Interleukin 10 reduces mortality from severe peritonitis in mice
1995
Characterization of Early Cytokine Responses and an Interleukin (IL)-6–dependent Pathway of Endogenous Glucocorticoid Induction during Murine Cytomegalovirus Infection
1997
Treatment with anti-interleukin-10 monoclonal antibody enhances early resistance to but impairs complete clearance of Listeria monocytogenes infection in mice
1994
Immunoregulation in experimental murine Trypanosoma congolense infection: anti‐IL‐10 antibodies reverse trypanosome‐mediated suppression of lymphocyte proliferation in vitro and moderately prolong the lifespan of genetically susceptible BALB/c mice
1998
Interleukin 10 (IL-10) regulation of tumour necrosis factor alpha (TNF-alpha) from human alveolar macrophages and peripheral blood monocytes.
1996
Interleukin-10 is a proliferation factor but not a differentiation factor for human myeloma cells
1995
A Transgenic Model to Analyze the Immunoregulatory Role of IL-10 Secreted by Antigen-Presenting Cells
1999
Regulation by Interleukin-10 and Interleukin-4 of Cyclooxygenase-2 Expression in Human Neutrophils
1997
Effects of IL-10 on systemic inflammatory responses during sublethal primate endotoxemia.
1997
Role of interleukin-10 in regulation of T-cell-dependent and T-cell-independent mechanisms of resistance to Toxoplasma gondii
1997
Development of T H 1 CD4 + T Cells Through IL-12 Produced by Listeria -Induced Macrophages
1993 StandoutScience
Selective expression of interleukin 10, interferon gamma, and granulocyte-macrophage colony-stimulating factor in ovarian cancer biopsies.
1992
CD4+regulatory cells as a potential immunotherapy
2005 StandoutNobel
Interleukin-10 is a growth factor for human myeloma cells by induction of an oncostatin M autocrine loop
1996
IL-10-Secreting Regulatory T Cells Do Not Express Foxp3 but Have Comparable Regulatory Function to Naturally Occurring CD4+CD25+ Regulatory T Cells
2004
Differing Lymphokine Profiles of Functional Subsets of Human CD4 and CD8 T Cell Clones
1991 StandoutScience
Induction of hapten-specific tolerance by interleukin 10 in vivo.
1994
Regulatory Activity of Autocrine IL-10 on Dendritic Cell Functions
2001
Macrophage deactivation by interleukin 10.
1991
IL-10 neutralization augments mouse resistance to systemic Mycobacterium avium infections.
1993
Serum Interleukin-6 (IL-6), IL-10, Tumor Necrosis Factor (TNF) Alpha, Soluble Type II TNF Receptor, and Transforming Growth Factor Beta Levels in Human Immunodeficiency Virus Type 1-Infected Individuals withMycobacterium aviumComplex Disease
2001
Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.
1991 Standout
Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells.
1994
Human interleukin-10 can directly inhibit T-cell growth
1993
Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance
2002 StandoutNobel
Interleukin 10 inhibits lipopolysaccharide-induced survival and cytokine production by human peripheral blood eosinophils.
1994
Emerging Challenges in Regulatory T Cell Function and Biology
2007 StandoutScienceNobel
Interleukin-10 Inhibits Expression of Both Interferon – and Interferon γ– Induced Genes by Suppressing Tyrosine Phosphorylation of STAT1
1999
Interleukin-10 and the Interleukin-10 Receptor
2001 Standout
Interleukin 10 (IL-10) upregulates functional high affinity IL-2 receptors on normal and leukemic B lymphocytes.
1993
Signal Sequence Trap: a Cloning Strategy for Secreted Proteins and Type I Membrane Proteins
1993 StandoutScienceNobel
IgE Versus IgG4 Production Can Be Differentially Regulated by IL-10
1998
IL-10 Gene Expression Is Controlled by the Transcription Factors Sp1 and Sp3
2000
Serum interleukin-10 in non-Hodgkin's lymphoma: a prognostic factor
1993
IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In Vivo
2001
Concurrent production of interleukin-2, interleukin-10, and gamma interferon in the regional lymph nodes of mice with influenza pneumonia
1994 StandoutNobel
TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function
1997 Standout
B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation.
1994
CD40 engagement triggers switching to IgA1 and IgA2 in human B cells through induction of endogenous TGF-beta: evidence for TGF-beta but not IL-10-dependent direct S mu-->S alpha and sequential S mu-->S gamma, S gamma-->S alpha DNA recombination.
1998
Production of interleukin 10 by islet cells accelerates immune-mediated destruction of beta cells in nonobese diabetic mice.
1994
Induction of human IgE synthesis requires interleukin 4 and T/B cell interactions involving the T cell receptor/CD3 complex and MHC class II antigens.
1989
Depletion of IL-10- and TGF-beta-producing regulatory gamma delta T cells by administering a daunomycin-conjugated specific monoclonal antibody in early tumor lesions augments the activity of CTLs and NK cells.
1999
Mitochondria and Apoptosis
1998 StandoutScience
Staining of interleukin-10 predicts clinical outcome in patients with nasopharyngeal carcinoma
1999
Interleukin 10 suppresses tumor growth and metastasis of human melanoma cells: potential inhibition of angiogenesis.
1996
Interleukin-10 Upregulates Tumor Necrosis Factor Receptor Type-II (p75) Gene Expression in Endotoxin-Stimulated Human Monocytes
1997
Hypothalamic-pituitary-adrenal axis activation and stimulation of systemic vasopressin secretion by recombinant interleukin-6 in humans: potential implications for the syndrome of inappropriate vasopressin secretion.
1994
Human Cd25+Cd4+ T Regulatory Cells Suppress Naive and Memory T Cell Proliferation and Can Be Expanded in Vitro without Loss of Function
2001
Contrasting mechanisms for suppression of macrophage cytokine release by transforming growth factor-beta and interleukin-10
1992
Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.
1993
Characterization of a Novel CC Chemokine, HCC-4, Whose Expression Is Increased by Interleukin-10
1998
Posttranscriptional Regulation of IL-10 Gene Expression Through Sequences in the 3′-Untranslated Region
2000
Immunoregulatory role of interleukin 10 in rheumatoid arthritis.
1994
Mice incapable of making IL-4 or IL-10 display normal resistance to infection withMycobacterium tuberculosis
1998
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection
2004 StandoutNobel
Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.
1993
Interleukin-10 inhibits interleukin-8 production in human neutrophils
1994
Inhibitory and stimulatory effects of IL-10 on human CD8+ T cells.
1998
Tumor-induced immune dysfunction: the macrophage connection
1998
The Biology of Chemokines and their Receptors
2000 Standout
Cutting Edge: Clustered AU-Rich Elements Are the Target of IL-10-Mediated mRNA Destabilization in Mouse Macrophages
1999
High levels of interleukin 10 in serum are associated with fatality in meningococcal disease
1995
Induction of CD4+ T cell alloantigen-specific hyporesponsiveness by IL-10 and TGF-beta.
1999
Interleukin 10 protects mice from lethal endotoxemia.
1993
Multiple regulatory elements in the interleukin-6 gene mediate induction by prostaglandins, cyclic AMP, and lipopolysaccharide.
1994
Tolerogenic Dendritic Cells
2003 StandoutNobel
Human Cd4+ T Lymphocytes Consistently Respond to the Latent Epstein-Barr Virus Nuclear Antigen Ebna1
2000 StandoutNobel
Listeria meningitis: identification of a cerebrospinal fluid inhibitor of macrophage listericidal function as interleukin 10.
1993
Hematopoietic development of embryonic stem cells in vitro: cytokine and receptor gene expression.
1991
In Vitro Generation of Interleukin 10–producing Regulatory CD4+ T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines
2002
Stat3-Dependent Induction of p19INK4D by IL-10 Contributes to Inhibition of Macrophage Proliferation
2000
Tumor Necrosis Factor Alpha-Mediated Toxic Shock inTrypanosoma cruzi-Infected Interleukin 10-Deficient Mice
2000
HIV-1-infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation
2004 StandoutNobel
Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development
2011
Dual Role of Interleukin-10 in Murine Lyme Disease: Regulation of Arthritis Severity and Host Defense
1999
Interleukin 10 inhibits growth and granulocyte/macrophage colony-stimulating factor production in chronic myelomonocytic leukemia cells.
1996
Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia.
1993
Effect of interleukin-10 on NF-kB and AP-1 activities in interleukin-2 dependent CD8 T lymphoblasts
1994
Regulation by Interleukin-10 and Interleukin-4 of Cyclooxygenase-2 Expression in Human Neutrophils
1997
Interleukin 10 (IL-10) upregulates IL-1 receptor antagonist production from lipopolysaccharide-stimulated human polymorphonuclear leukocytes by delaying mRNA degradation.
1994
Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor alpha required as a costimulatory factor for interferon gamma-induced activation.
1992
The microbial mimic poly IC induces durable and protective CD4+T cell immunity together with a dendritic cell targeted vaccine
2008 StandoutNobel
Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells.
1993
Identification of functional domains on human interleukin 10
1997
Interleukin 10 suppression of monocyte prostaglandin H synthase-2. Mechanism of inhibition of prostaglandin-dependent matrix metalloproteinase production.
1994
Inhibitory and Stimulatory Effects of IL-10 on Human CD8+ T Cells
1998
Continuous anti-interleukin 10 antibody administration depletes mice of Ly-1 B cells but not conventional B cells.
1992
Release of interleukin-12 in experimental Escherichia coli septic shock in baboons: relation to plasma levels of interleukin-10 and interferon- gamma
1996
Importance of Interleukin-10 in Genetic Susceptibility of Mice toCoccidioides immitis
1998
Differentiation of a human eosinophilic leukemia cell line (EoL-1) by a human T-cell leukemia cell line (HIL-3)-derived factor
1991
Works of J S Abrams being referenced
Potential role for interleukin-10 in the immunosuppression associated with kala azar.
1993
Fractalkine protein localization and gene expression in mouse brain
2003
Cytokine control of parasite-specific anergy in human lymphatic filariasis. Preferential induction of a regulatory T helper type 2 lymphocyte subset.
1993
Synergistic roles of interleukin-6, interleukin-1, and tumor necrosis factor in the adrenocorticotropin response to bacterial lipopolysaccharide in vivo.
1993
High Levels of Spontaneous and Parasite Antigen-Driven Interieukin-10 Production Are Associated with Antigen-Specific Hyporesponsiveness in Human Lymphatic Filariasis
1996
Local cytokine production in a murine model of Escherichia coli pyelonephritis.
1992
Cytokine production induced by Mycobacterium tuberculosis lipoarabinomannan. Relationship to chemical structure
1992
Host-reactive CD4+ and CD8+ T cell clones isolated from a human chimera produce IL-5, IL-2, IFN-gamma and granulocyte/macrophage-colony-stimulating factor but not IL-4.
1990
Simultaneous production of IL-2, IL-4, and IFN-gamma by activated human CD4+ and CD8+ T cell clones.
1988
Cytokine secretion by CD4 T lymphocytes acquired in response to Mycobacterium tuberculosis infection.
1993
Lymphotactin is produced by NK cells and attracts both NK cells and T cells in vivo.
1997
92238400 Increased osteoclast development after estrogen loss: Mediation by interleukin-6
1993
IL-4- and IL-5-secreting lymphocyte populations are preferentially stimulated by parasite-derived antigens in human tissue invasive nematode infections.
1993
Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin 10.
1996
Isolation and characterization of an expressible cDNA encoding human IL-3. Induction of IL-3 mRNA in human T cell clones.
1988
Parallel regulation of IL-4 and IL-5 in human helminth infections
1992
Role of interleukin 6 (IL-6) in protection from lethal irradiation and in endocrine responses to IL-1 and tumor necrosis factor.
1992
High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells.
1994
Cytokine mRNA expression in salivary gland biopsies of Sjögren's syndrome.
1994
Endogenous IL-6 and IL-10 contribute to the differentiation of CD40-activated human B lymphocytes.
1995
IL-10 is produced by subsets of human CD4+ T cell clones and peripheral blood T cells
1992
Regulation of parasite-induced eosinophilia: selectively increased interleukin 5 production in helminth-infected patients.
1990
T-cell cytokine responses in human infection with Mycobacterium tuberculosis
1995
Molecular and functional characterization of mouse signaling lymphocytic activation molecule (SLAM): differential expression and responsiveness in Th1 and Th2 cells.
1999
Immunosuppressive roles for IL-10 and IL-4 in human infection. In vitro modulation of T cell responses in leprosy
1993
Induction of human IgE synthesis by CD4+ T cell clones. Requirement for interleukin 4 and low molecular weight B cell growth factor.
1989
Antibody against interleukin-6 reduces inflammation and numbers of cysts in brains of mice with toxoplasmic encephalitis
1994
Development of rat anti-mouse interleukin 3 monoclonal antibodies which neutralize bioactivity in vitro.
1988
Cytokine production at the site of disease in human tuberculosis
1993
Functional heterogeneity among human inducer T cell clones.
1988
Estrogen loss upregulates hematopoiesis in the mouse: a mediating role of IL-6.
1995
Cytokine mRNA in the central nervous system of SCID mice infected with Toxoplasma gondii: importance of T-cell-independent regulation of resistance to T. gondii
1993
Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.
1991 Standout
Granulocyte/macrophage colony-stimulating factor and interleukin 3 release from human peripheral blood eosinophils and neutrophils.
1991