Citation Impact
Citing Papers
On the relationship between folding and chemical landscapes in enzyme catalysis
2008 StandoutNobel
Confirmation of intersubunit connectivity and topology of designed protein complexes by native MS
2018 StandoutNobel
A Transient and Low-Populated Protein-Folding Intermediate at Atomic Resolution
2010 Science
Loss of conformational entropy in protein folding calculated using realistic ensembles and its implications for NMR-based calculations
2014 StandoutNobel
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
2019 StandoutNobel
Atomic-Level Characterization of the Structural Dynamics of Proteins
2010 StandoutScienceNobel
Augmenting neurotransmitter release by enhancing the apparent Ca 2+ affinity of synaptotagmin 1
2005 StandoutNobel
Consistent blind protein structure generation from NMR chemical shift data
2008 StandoutNobel
Structures of invisible, excited protein states by relaxation dispersion NMR spectroscopy
2008
Exploiting conformational dynamics to modulate the function of designed proteins
2023 StandoutNobel
Computational design of closely related proteins that adopt two well-defined but structurally divergent folds
2020 StandoutNobel
TROSY-NMR reveals interaction between ERp57 and the tip of the calreticulin P-domain
2002 StandoutNobel
The Dynamic Energy Landscape of Dihydrofolate Reductase Catalysis
2006 Science
Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions
2011 StandoutNobel
NMR Structure Determination for Larger Proteins Using Backbone-Only Data
2010 StandoutScienceNobel
Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors
2022 StandoutNobel
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
Side chain NMR assignments in the membrane protein OmpX reconstituted in DHPC micelles
2002 StandoutNobel
The role of dynamic conformational ensembles in biomolecular recognition
2009 Standout
Dynamic personalities of proteins
2007 StandoutNature
NMR measurement of the off rate from the first calcium‐binding site of the synaptotagmin I C2A domain
2002
The Highly Cooperative Folding of Small Naturally Occurring Proteins Is Likely the Result of Natural Selection
2007 StandoutNobel
Intrinsic dynamics of an enzyme underlies catalysis
2005 Nature
Estimation of the available free energy in a LOV2-Jα photoswitch
2008
Atomic model of the type III secretion system needle
2012 StandoutNatureNobel
Probing Slow Chemical Exchange at Carbonyl Sites in Proteins by Chemical Exchange Saturation Transfer NMR Spectroscopy
2013
The ensemble nature of allostery
2014 Nature
Fractional 13C enrichment of isolated carbons using [1-13C]- or [2-13C]-glucose facilitates the accurate measurement of dynamics at backbone Cα and side-chain methyl positions in proteins
2007
Solution Structure of Alg13: The Sugar Donor Subunit of a Yeast N-Acetylglucosamine Transferase
2008
Protein dynamics and conformational disorder in molecular recognition
2009
Revisiting 1HN CPMG relaxation dispersion experiments: a simple modification can eliminate large artifacts
2019
Evolution of dynamical networks enhances catalysis in a designer enzyme
2021
Atom-by-atom analysis of global downhill protein folding
2006 Nature
Structure and dynamics of a molten globular enzyme
2007
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
NMR spectroscopy of large molecules and multimolecular assemblies in solution
1999 StandoutNobel
Chemical shift-based methods in NMR structure determination
2018
Dynamics connect substrate recognition to catalysis in protein kinase A
2010
Role of the Biomolecular Energy Gap in Protein Design, Structure, and Evolution
2012 StandoutNobel
NMR methods for characterizing microsecond to millisecond dynamics in recognition and catalysis
2002
Quantifying Lipari–Szabo modelfree parameters from 13CO NMR relaxation experiments
2006
NMR spectroscopy captures the essential role of dynamics in regulating biomolecular function
2021
Impact of Transverse Relaxation Optimized Spectroscopy (TROSY) on NMR as a technique in structural biology
2000
NMR: prediction of protein flexibility
2006
The role of dynamics in allosteric regulation
2003
[15N,1H]/[13C,1H]-TROSY for simultaneous detection of backbone 15N–1H, aromatic 13C–1H and side-chain 15N–1H2 correlations in large proteins
2000 StandoutNobel
Clusters of Branched Aliphatic Side Chains Serve As Cores of Stability in the Native State of the HisF TIM Barrel Protein
2013
Intrinsic motions along an enzymatic reaction trajectory
2007 Nature
The EVB as a quantitative tool for formulating simulations and analyzing biological and chemical reactions
2009 StandoutNobel
Multiple frequency saturation pulses reduce CEST acquisition time for quantifying conformational exchange in biomolecules
2018
Protein flexibility and rigidity predicted from sequence
2005
Solution structure of a minor and transiently formed state of a T4 lysozyme mutant
2011 StandoutNatureNobel
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
2012 StandoutNobel
Design of protein switches based on an ensemble model of allostery
2015
NMR analysis of a 900K GroEL–GroES complex
2002 StandoutNatureNobel
A new class of CEST experiment based on selecting different magnetization components at the start and end of the CEST relaxation element: an application to 1H CEST
2018
De novo design of bioactive protein switches
2019 StandoutNatureNobel
Protein–water interactions in a dynamic world
2002
A 15N CPMG relaxation dispersion experiment more resistant to resonance offset and pulse imperfection
2015
Low-populated folding intermediates of Fyn SH3 characterized by relaxation dispersion NMR
2004 Nature
A hierarchy of timescales in protein dynamics is linked to enzyme catalysis
2007 Nature
A phase cycle scheme that significantly suppresses offset-dependent artifacts in the R2-CPMG 15N relaxation experiment
2004
The Contribution of Entropy, Enthalpy, and Hydrophobic Desolvation to Cooperativity in Repeat-Protein Folding
2011
Transient Non-native Hydrogen Bonds Promote Activation of a Signaling Protein
2009
At the dawn of the 21st century: Is dynamics the missing link for understanding enzyme catalysis?
2009 StandoutNobel
Computational design of ligand-binding proteins with high affinity and selectivity
2013 StandoutNatureNobel
Tom20 recognizes mitochondrial presequences through dynamic equilibrium among multiple bound states
2007
Visualizing Side Chains of Invisible Protein Conformers by Solution NMR
2013
Quadruplex DNA: sequence, topology and structure
2006 Standout
Structure and Dynamics of a Processive Brownian Motor: The Translating Ribosome
2010 StandoutNobel
Transverse relaxation-optimized NMR spectroscopy with the outer membrane protein OmpX in dihexanoyl phosphatidylcholine micelles
2001 StandoutNobel
Reply to Karplus: Conformational dynamics have no role in the chemical step
2010 StandoutNobel
Dynamical Contributions to Enzyme Catalysis: Critical Tests of A Popular Hypothesis
2006 StandoutNobel
Structural characterization of mRNA-tRNA translocation intermediates
2012 StandoutNobel
Converting structural information into an allosteric-energy-based picture for elongation factor Tu activation by the ribosome
2011 StandoutNobel
Nanoscale distribution of mitochondrial import receptor Tom20 is adjusted to cellular conditions and exhibits an inner-cellular gradient
2011 StandoutNobel
Studying “Invisible” Excited Protein States in Slow Exchange with a Major State Conformation
2012
Lipid–protein interactions in DHPC micelles containing the integral membrane protein OmpX investigated by NMR spectroscopy
2002 StandoutNobel
What Is So Special about Arg 55 in the Catalysis of Cyclophilin A? Insights from Hybrid QM/MM Simulations
2003
Linkage between dynamics and catalysis in a thermophilic-mesophilic enzyme pair
2004
Extreme stability in de novo-designed repeat arrays is determined by unusually stable short-range interactions
2018 StandoutNobel
Ketosteroid isomerase provides further support for the idea that enzymes work by electrostatic preorganization
2010 StandoutNobel
Free-Energy Landscape of Enzyme Catalysis
2008
Ultrafast solvation dynamics at binding and active sites of photolyases
2010 StandoutNobel
Measurement of bond vector orientations in invisible excited states of proteins
2007
Protein Side-Chain Dynamics and Residual Conformational Entropy
2008
Electrostatic origin of the mechanochemical rotary mechanism and the catalytic dwell of F1-ATPase
2011 StandoutNobel
Spotlight on the Ballet of Proteins: The Structural Dynamic Properties of Proteins Illuminated by Solution NMR
2020
Solution NMR Techniques for Large Molecular and Supramolecular Structures
2002 StandoutNobel
Trajectories of the ribosome as a Brownian nanomachine
2014 StandoutNobel
Simulations of RNA base pairs in a nanodroplet reveal solvation-dependent stability
2007 StandoutNobel
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Disulfide Bond Isomerization in Basic Pancreatic Trypsin Inhibitor: Multisite Chemical Exchange Quantified by CPMG Relaxation Dispersion and Chemical Shift Modeling
2003
Investigating the Structural Compaction of Biomolecules Upon Transition to the Gas-Phase Using ESI-TWIMS-MS
2017
Perspective: Defining and quantifying the role of dynamics in enzyme catalysis
2016 Nobel
An Analysis of the Effects of 1HN−1HN Dipolar Couplings on the Measurement of Amide Bond Vector Orientations in Invisible Protein States by Relaxation Dispersion NMR
2009
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Fluctuating Enzymes: Lessons from Single-Molecule Studies
2005
Networks of electrostatic and hydrophobic interactions modulate the complex folding free energy surface of a designed βα protein
2019 StandoutNobel
New directions in single-molecule imaging and analysis
2007 StandoutNobel
Discovery of multiple hidden allosteric sites by combining Markov state models and experiments
2015
Principles of Allosteric Interactions in Cell Signaling
2014
New Tools Provide New Insights in NMR Studies of Protein Dynamics
2006 Science
An Improved 15N Relaxation Dispersion Experiment for the Measurement of Millisecond Time-Scale Dynamics in Proteins
2007
Enzyme millisecond conformational dynamics do not catalyze the chemical step
2009 StandoutNobel
Enzyme Dynamics During Catalysis
2002 Science
Out of hot water
2004
Measurement of Proton Chemical Shifts in Invisible States of Slowly Exchanging Protein Systems by Chemical Exchange Saturation Transfer
2012
Ultrafast Dynamics and Anionic Active States of the Flavin Cofactor in Cryptochrome and Photolyase
2008 StandoutNobel
Transition state theory can be used in studies of enzyme catalysis: lessons from simulations of tunnelling and dynamical effects in lipoxygenase and other systems
2006 StandoutNobel
Measurement of Slow (μs−ms) Time Scale Dynamics in Protein Side Chains by 15N Relaxation Dispersion NMR Spectroscopy: Application to Asn and Gln Residues in a Cavity Mutant of T4 Lysozyme
2001
Exploring challenges in rational enzyme design by simulating the catalysis in artificial kemp eliminase
2010 StandoutNobel
Nonnative Interactions in the FF Domain Folding Pathway from an Atomic Resolution Structure of a Sparsely Populated Intermediate: An NMR Relaxation Dispersion Study
2011 StandoutNobel
Works of J. Patrick Loria being referenced
Conformational Motions Regulate Phosphoryl Transfer in Related Protein Tyrosine Phosphatases
2013 Science
205 Tl NMR Methods for the Characterization of Monovalent Cation Binding to Nucleic Acids
2005
The mechanism of rate-limiting motions in enzyme function
2007
Nuclear Magnetic Resonance Methods for Quantifying Microsecond-to-Millisecond Motions in Biological Macromolecules
2001
NMR insights into protein allostery
2011
Sensitivity Improvement of Transverse Relaxation-Optimized Spectroscopy
1999
Protein Dynamics from Solution NMR
2002
FAST-Modelfree: A program for rapid automated analysis of solution NMR spin-relaxation data
2003
1H, 15N and 13C resonance assignment of imidazole glycerol phosphate (IGP) synthase protein HisF from Thermotoga maritima
2008
Nanometer Propagation of Millisecond Motions in V-Type Allostery
2010
Transverse-Relaxation-Optimized (TROSY) Gradient-Enhanced Triple-Resonance NMR Spectroscopy
1999
Multiple Time Scale Backbone Dynamics of Homologous Thermophilic and Mesophilic Ribonuclease HI Enzymes
2004
A TROSY CPMG sequence for characterizing chemical exchange in large proteins
1999
Solution Structure of an rRNA Substrate Bound to the Pseudouridylation Pocket of a Box H/ACA snoRNA
2007
Allosteric pathways in imidazole glycerol phosphate synthase
2012
Evidence for Flexibility in the Function of Ribonuclease A
2002
Enzyme Dynamics along the Reaction Coordinate: Critical Role of a Conserved Residue
2006
Conservation of μs−ms Enzyme Motions in the Apo- and Substrate-Mimicked State
2005
A Relaxation-Compensated Carr−Purcell−Meiboom−Gill Sequence for Characterizing Chemical Exchange by NMR Spectroscopy
1999
The Static Magnetic Field Dependence of Chemical Exchange Linebroadening Defines the NMR Chemical Shift Time Scale
2000
Altering the allosteric pathway in IGPS suppresses millisecond motions and catalytic activity
2017
Characterization of Enzyme Motions by Solution NMR Relaxation Dispersion
2008
Solution NMR and Computational Methods for Understanding Protein Allostery
2013
Longitudinal and Transverse 1H−15N Dipolar/15N Chemical Shift Anisotropy Relaxation Interference: Unambiguous Determination of Rotational Diffusion Tensors and Chemical Exchange Effects in Biological Macromolecules
1998