Citation Impact
Citing Papers
Dendritic cell–expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice
2007 StandoutNobel
Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti–CTLA-4 antibodies
2009 StandoutNobel
Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of Autoimmunity
2013 StandoutScience
Statistical significance for genomewide studies
2003 Standout
Notch signalling controls pancreatic cell differentiation
1999 StandoutNatureNobel
A search for type 1 diabetes susceptibility genes in families from the United Kingdom
1998
Shared genetic susceptibility of Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetes mellitus: contributions of HLA and haptoglobin
1991
Inducible Nitric-oxide Synthase and Nitric Oxide Production in Human Fetal Astrocytes and Microglia
1997 StandoutNobel
The Effect of Dietary Supplementation with n—3 Polyunsaturated Fatty Acids on the Synthesis of Interleukin-1 and Tumor Necrosis Factor by Mononuclear Cells
1989 Standout
Factors predicting residual β-cell function in the first year after diagnosis of childhood type 1 diabetes
1991
Recombinant human tumor necrosis factor alpha suppresses autoimmune diabetes in nonobese diabetic mice.
1989
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
1999 StandoutNature
Tumor necrosis factor α in autoimmunity: pretty girl or old witch?
1992
An Autoimmune Disease-Associated CTLA-4 Splice Variant Lacking the B7 Binding Domain Signals Negatively in T Cells
2004
Induction by Toxic-Shock-Syndrome Toxin-1 of a Circulating Tumor Necrosis Factor-Like Substance in Rabbits and of Immunoreactive Tumor Necrosis Factor and Interleukin-1 from Human Mononuclear Cells
1988
Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor
1999 StandoutNobel
Nitric oxide as a potential pathological mechanism in demyelination: Its differential effects on primary glial cellsin vitro
1994 StandoutNobel
Genetic and environmental determinants of non‐insulin‐dependent diabetes mellitus (NIDDM)
1992
A Taql polymorphism in the human interleukin‐1β (IL‐1β) gene correlates with IL‐1β secretion in vitro
1992
Inflammatory cytokines: interleukin-1 and tumor necrosis factor as effector molecules in autoimmune diseases
1991
Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/NeuroD-deficient mice
1997
An Analysis of Linkage Disequilibrium in the Interleukin-1 Gene Cluster, Using a Novel Grouping Method for Multiallelic Markers
1998
Upregulation of insulin receptor substrate-2 in pancreatic β cells prevents diabetes
2003
Two Genetic Loci Regulate T Cell–Dependent Islet Inflammation and Drive Autoimmune Diabetes Pathogenesis
2000
The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry
1996
Diabetes epidemiology as a tool to trigger diabetes research and care
1999
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
1994 StandoutNature
Evidence for linkage of a candidate chromosome 1 region to human systemic lupus erythematosus.
1997
The Emerging Role of CTLA-4 as an Immune Attenuator
1997 StandoutNobel
Oxygen radical production in human mononuclear blood cells is not suppressed by drugs used in clinical islet transplantation
1999
Williams–Beuren Syndrome
2010 Standout
Lymphoid Hyperplasia, CD45RB high to CD45RB low T-cell imbalance, and suppression of Type I diabetes mellitus result from TNF blockade in NOD→NOD-scid adoptive T cell transfer
1998 StandoutNobel
Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family
2001 StandoutNobel
Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups
1997
Association between HLA‐DR2 and Production of Tumour Necrosis Factor α and Interleukin 1 by Mononuclear Cells Activated by Lipopolysaccharide
1988
CTLA4 gene polymorphism and autoimmunity
2005
Global and societal implications of the diabetes epidemic
2001 StandoutNature
Panning for gold: genome-wide scanning for linkage in type 1 diabetes
1996
Mechanisms linking obesity to insulin resistance and type 2 diabetes
2006 StandoutNature
A Community Cross-Sectional Survey of Medical Problems in 440 Children with Down Syndrome in New York State
2013
CTLA4 Alanine-17 Confers Genetic Susceptibility to Graves’ Disease and to Type 1 Diabetes Mellitus1
1997
Natural and induced cytotoxicity of oligodendrocytes by microglia is inhibitable by TGFβ
1991
Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results
1995 Standout
Analysis of tumor necrosis factor promoter responses to ultraviolet light.
1994 StandoutNobel
Ebselen and cytokine-induced nitric oxide synthase expression in insulin-producing cells
1996
Intrafamilial and Case-Control Association Analysis of D2S152 in Insulin-Dependent Diabetes
1995
Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen
2000 Standout
Periodontal diseases
2005 Standout
The CTLA-4 gene is associated with multiple sclerosis
1999
Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus
1995
Inhibition of insulin secretion by interleukin‐1β and tumour necrosis factor‐α via an L‐arginine‐dependent nitric oxide generating mechanism
1990
MHC class II-associated variation in the production of tumor necrosis factor in mice and humans: Relevance to the pathogenesis of autoimmune diseases
1991
Long-Term Potentiation Is Reduced in Mice That Are Doubly Mutant in Endothelial and Neuronal Nitric Oxide Synthase
1996 StandoutNobel
Genetics of Type 2 diabetes
2005
Prevention of Type 2 Diabetes Mellitus by Changes in Lifestyle among Subjects with Impaired Glucose Tolerance
2001 Standout
Atherosclerosis
2000 StandoutNature
The TNF and TNF Receptor Superfamilies
2001 Standout
Monocytic TNFα secretion patterns in IDDM patients with periodontal diseases*
1997
The epidemiology and natural history of niddm–lessons from the South Pacific
1990
Family-based linkage disequilibrium mapping using SNP marker haplotypes: application to a potential locus for schizophrenia at chromosome 22q11
2000
Hyperhomocysteinemia: An Independent Risk Factor for Vascular Disease
1991 Standout
Role of IL-1β in type 2 diabetes
2010
Genetics of autoimmune diseases in humans and in animal models
2002
Inflammasomes in health and disease
2012 StandoutNature
Genetic Control of Diabetes Progression
1997
The Tumor Necrosis Factor Ligand and Receptor Families
1996 StandoutNobel
Interleukin-1 polymorphisms associated with increased risk of gastric cancer
2000 StandoutNature
Establishment of NOD-Pdcd1-/-mice as an efficient animal model of type I diabetes
2005 StandoutNobel
Evidence for increased recombination near the human insulin gene: implication for disease association studies.
1986
Down Syndrome
2020 Standout
The Staphylococcal Enterotoxins and Their Relatives
1990 StandoutScience
Isolation of the human insulin-like growth factor genes: insulin-like growth factor II and insulin genes are contiguous.
1985
The Inherited Basis of Diabetes Mellitus: Implications for the Genetic Analysis of Complex Traits
2003
Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1.
1990
Induction of Tumor Immunity by Removing CD25+CD4+ T Cells: A Common Basis Between Tumor Immunity and Autoimmunity
1999 StandoutNobel
Genetic analysis of type 1 diabetes using whole genome approaches.
1995
Use of recombinant congenic and congenic strains of NOD mice to identify a new insulin-dependent diabetes resistance gene.
1994
Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Regulates the Unfolding of Autoimmune Diabetes
1998 StandoutNobel
Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model
2016 StandoutNobel
Genomics and human disease—variations on variation
1998 StandoutNobel
Functional mapping of disease susceptibility loci using cell biology
2006 StandoutNobel
Cyclodextrin Drug Carrier Systems
1998 Standout
Cytotoxic T lymphocyte antigen-4 (CTLA-4) limits the expansion of encephalitogenic T cells in experimental autoimmune encephalomyelitis (EAE)-resistant BALB/c mice
2002 StandoutNobel
Gene for non-insulin-dependent diabetes mellitus (maturity-onset diabetes of the young subtype) is linked to DNA polymorphism on human chromosome 20q.
1991
Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood
2016 StandoutNobel
Genetic aspects of arteriosclerosis.
1986
Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer.
1994 StandoutNobel
The Relationship Between Periodontal Diseases and Diabetes: An Overview
2001
Isoforms of nitric oxide synthase
1995
Genetic susceptibility for insulin-dependent diabetes mellitus in Caucasians revisited: the importance of diabetes registries in disclosing interactions between HLA-DQ- and insulin gene-linked risk. Belgian Diabetes Registry.
1995
Affected-sib-pair mapping of a novel susceptibility gene to insulin-dependent diabetes mellitus (IDDM8) on chromosome 6q25-q27.
1995
Diabetes mellitus in the pima indians: Incidence, risk factors and pathogenesis
1990
GENETIC SUSCEPTIBILITY TO SYSTEMIC LUPUS ERYTHEMATOSUS
1998
Genetic Dissection of Complex Traits
1994 StandoutScience
Effects of a polymorphism in the human tumor necrosis factor α promoter on transcriptional activation
1997 Standout
Chemistry of Biologically Important Synthetic Organoselenium Compounds
2001 Standout
A Common Dominant TLR5 Stop Codon Polymorphism Abolishes Flagellin Signaling and Is Associated with Susceptibility to Legionnaires' Disease
2003 StandoutNobel
Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells
2000 StandoutNobel
Effect of COMT Val 108/158 Met genotype on frontal lobe function and risk for schizophrenia
2001 Standout
Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b −/− Pdcd1 −/− mice
2005 StandoutNobel
Tissue-specific expression of B7x protects from CD4 T cell–mediated autoimmunity
2011 StandoutNobel
Susceptibility to Leishmania major Infection in Interleukin-4-Deficient Mice
1996 Science
Response : Nitric Oxide and Arginine-Evoked Insulin Secretion
1992 StandoutScienceNobel
Works of J. Nerup being referenced
Genetics of diabetes in Nauru: Effects of foreign admixture, HLA antigens and the insulin-gene-linked polymorphism
1983
The inducible nitric oxide synthase gene, Nos2, maps to mouse Chromosome 11
1994
Functional and morphological effects of interleukin-1? on the perfused rat pancreas
1990
Linkage analysis of the human insulin receptor gene and maturity onset diabetes of the young
1987
Increased prevalence of Down’s syndrome in individuals with type 1 diabetes in Denmark: a nationwide population-based study
2006
Cytokines and Free Radicals as Effector Molecules in the Destruction of Pancreatic Beta Cells
1990
Incidence of Insulin‐dependent Diabetes Mellitus in Age Groups Over 30 years in Denmark
1994
Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31–q33
1995
Linkage of type I diabetes to 15q26 (IDDM3) in the Danish population
1996
Increased reduction in fasting C-peptide is associated with islet cell antibodies in Type 1 (insulin-dependent) diabetic patients
1985
The HLA‐IDDM association: Implications for etiology and pathogenesis of IDDM
1987
Mechanisms of pancreatic beta-cell destruction in type I diabetes.
1989
DNA INSERTION SEQUENCES NEAR THE INSULIN GENE AFFECT GLUCOSE REGULATION
1982
Diabetes mellitus, atherosclerosis, and the 5′ flanking polymorphism of the human insulin gene
1986
A Genomewide Scan for Type 1–Diabetes Susceptibility in Scandinavian Families: Identification of New Loci with Evidence of Interactions
2001
DNA SEQUENCES FLANKING THE INSULIN GENE ON CHROMOSOME 11 CONFER RISK OF ATHEROSCLEROSIS
1984
Human tumor necrosis factor potentiates human interleukin 1-mediated rat pancreatic beta-cell cytotoxicity.
1987
POSSIBLE ASSOCIATION BETWEEN DNA SEQUENCES FLANKING THE INSULIN GENE AND ATHEROSCLEROSIS
1982