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Citing Papers
The human disease network
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Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease
1998 Standout
Presence of J chain in human lymphoid cells.
1980
Autoantibodies in coeliac disease: tissue transglutaminase—guilt by association?
1997
HLA-DR phenotypes in Spanish coeliac children: their contribution to the understanding of the genetics of the disease.
1983
CTLA-4 gene polymorphism is associated with predisposition to coeliac disease
1998
Getting to grips with gluten
2000
Nomenclature and listing of celiac disease relevant gluten T-cell epitopes restricted by HLA-DQ molecules
2012
Gliadin-specific, HLA-DQ(alpha 1*0501,beta 1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients.
1993
Production of a panel of recombinant gliadins for the characterisation of T cell reactivity in coeliac disease
2000
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2002
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2001
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1990
Identification of tissue transglutaminase as the autoantigen of celiac disease
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2003
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1989 Nature
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1993
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1997
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2010
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2001
Genes and Cellular Requirements for Autoimmune Diabetes Susceptibility in Nonobese Diabetic Mice
2001
Abnormal intestinal intraepithelial lymphocytes in refractory sprue
1998
Gluten Causes Gastrointestinal Symptoms in Subjects Without Celiac Disease: A Double-Blind Randomized Placebo-Controlled Trial
2011
Restriction fragment length polymorphism in HLA class II genes of Latin-American caucasian celiac disease patients
1989
A gene dosage effect of the DQA1∗0501/DQB1∗0201 allelic combination influences the clinical heterogeneity of celiac disease
1994
Reassessment of HLA association with celiac disease in special reference to the DP association
1990
A Ser365->Cys mutation of fibroblast growth factor receptor 3 in mouse downregulates Ihh/PTHrP signals and causes severe achondroplasia
2001
An Enigmatic Tail of CD28 Signaling
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2006
A high frequency of the A30, B18, DR3, DRw52, DQw2 extended haplotype in Sardinian celiac disease patients: Further evidence that disease susceptibility is conferred by DQ A1*0501, B1*0201
1992
Effective Detection of Human Leukocyte Antigen Risk Alleles in Celiac Disease Using Tag Single Nucleotide Polymorphisms
2008
HLA‐DR, DQ genotypes of celiac disease patients and healthy subjects from the West of Ireland
1996
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1992
Association of Insulin-Dependent Diabetes Mellitus and Celiac Disease: A Study Based on Serologic Markers
1998
Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3
1995
Prevalence of coeliac disease in Down's syndrome
2001
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2009
T cells from the small intestinal Mucosa of a DR4, DQ7/DR4. DQ8 celiac disease patient preferentially recognize gliadin when presented by DQ8
1994
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2000
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2012
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1995
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2002
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1997
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2006 StandoutNobel
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Serological Markers and HLA-DQ2 Haplotype Among First-Degree Relatives of Celiac Patients
1999
Role of Oxidative Modifications in Atherosclerosis
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On the HLA‐DQ(α1*0501, β1*0201)‐associated susceptibility in celiac disease: A possible gene dosage effect of DQB1*0201
1993
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2011
HLA‐DQ relative risks for coeliac disease in European populations: a study of the European Genetics Cluster on Coeliac Disease
2004
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Homozygosity for the HLA-DRB1 allele selects for extraarticular manifestations in rheumatoid arthritis.
1992
HLA class II alleles associated with celiac disease susceptibility in a Southern European population
1992
Immunobiology and immunopathology of human gut mucosa: Humoral immunity and intraepithelial lymphocytes
1989
Wheat peptide challenge in coeliac disease
1994
Function of DQ2 and DQ8 as HLA susceptibility molecules in celiac disease
1994
Transglutaminases: crosslinking enzymes with pleiotropic functions
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2001
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Risk of Celiac Disease Autoimmunity and Timing of Gluten Introduction in the Diet of Infants at Increased Risk of Disease
2005
Molecular mechanisms of T cell co-stimulation and co-inhibition
2013 Standout
Grains of truth: evolutionary changes in small intestinal mucosa in response to environmental antigen challenge.
1990
Type 1 diabetes
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Low specificity of anti‐tissue transglutaminase antibodies in patients with primary biliary cirrhosis
2006
Evidence-based interventions for improvement of maternal and child nutrition: what can be done and at what cost?
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Oral Enzyme Therapy for Celiac Sprue
2011
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Localization of central MHC genes influencing type I diabetes
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Diagnosis of Celiac Disease
2012
The blockade of immune checkpoints in cancer immunotherapy
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HLA class II‐associated genetic susceptibility in multiple sclerosis: A critical evaluation
1991
European Society for Pediatric Gastroenterology, Hepatology, and Nutrition Guidelines for the Diagnosis of Coeliac Disease
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Celiac disease is associated with an extended HLA-DR3 haplotype which includes HLA-DPw1
1990
CD28 and CTLA‐4 coreceptor expression and signal transduction
2009
Characterization of Antibodies Induced by Vaccination with Hepatitis C Virus Envelope Glycoproteins
2010 StandoutNobel
Regulation of type I interferon responses
2013 Standout
HLA-linked genes acting as additive susceptibility factors in celiac disease
1995
Genetic Background of Celiac Disease and Its Clinical Implications
2007
Intestinal IgA synthesis: regulation of front-line body defences
2003 StandoutNobel
A locus telomeric toHLA-DPB encodes susceptibility to coeliac disease
1989
Accuracy and cost-effectiveness of a new strategy to screen for celiac disease in children with Down syndrome
2000
Refractory Iron Deficiency Anemia as the Primary Clinical Manifestation of Celiac Disease
2003
Effects of Birth Spacing on Maternal, Perinatal, Infant, and Child Health: A Systematic Review of Causal Mechanisms
2012
Down's syndrome
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Coeliac disease: dissecting a complex inflammatory disorder
2002
Folate and human reproduction
2006
Cytochrome P450 ω-Hydroxylase Pathway of Tocopherol Catabolism
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Genomewide Linkage Analysis of Celiac Disease in Finnish Families
2002
Diagnostic Testing for Celiac Disease Among Patients With Abdominal Symptoms
2010
Polymorphism of antigen processing (TAP, LMP) and HLA class II genes in celiac disease
1994
Peptide binding characteristics of the coeliac disease-associated DQ(α1*0501, β1*0201) molecule
1996
Celiac Sprue
1991
Allele and haplotype frequencies for HLA class II (DQA1 and DQB1) loci in patients with celiac disease from Spain
2004
Defining the contribution of the HLA region to cis DQ2-positive coeliac disease patients
2004
High prevalence of celiac sprue-like HLA-DQ genes and enteropathy in patients with the microscopic colitis syndrome
2000
Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy
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HLA-DRB, -DQA, and -DQB polymorphism in celiac disease and enteropathy-associated T-cell lymphoma
1995
Genetic predisposition to autoimmunity – What have we learned?
2011
Regional specialization in the mucosal immune system: what happens in the microcompartments?
1999
Genetics of autoimmune diseases in humans and in animal models
2002
Celiac Disease Genetics: Current Concepts and Practical Applications
2005
The Human Cancer Antigen Mesothelin Is More Efficiently Presented to the Mouse Immune System when Targeted to the DEC‐205/CD205 Receptor on Dendritic Cells
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What are the sensitivity and specificity of serologic tests for celiac disease? Do sensitivity and specificity vary in different populations?
2005
Analysis of the CTLA4 Gene in Swedish Coeliac Disease Patients
2002
Irritable Bowel Syndrome
2015 Standout
Transport models for secretory IgA and secretory IgM.
1981
Establishment of NOD-Pdcd1-/-mice as an efficient animal model of type I diabetes
2005 StandoutNobel
Computational Design of an α-Gliadin Peptidase
2012 StandoutNobel
Structural Basis for Gluten Intolerance in Celiac Sprue
2002 StandoutScience
Clinical Benefit of a Gluten-Free Diet in Type 1 Diabetic Children With Screening-Detected Celiac Disease
2006 StandoutNobel
Comprehensive, Quantitative Mapping of T Cell Epitopes in Gluten in Celiac Disease
2010
HLA Genotypes and the Increased Incidence of Coeliac Disease in Sweden
1996
Oligotyping of Italian celiac patients with the 11th International Histocompatibility Workshop reagents*
1992
Comparative Analysis of Organ-Specific Autoantibodies and Celiac Disease—Associated Antibodies in Type 1 Diabetic Patients, Their First-Degree Relatives, and Healthy Control Subjects
2001
Coeliac disease
1997
Morphometric analysis of small intestinal mucosa
1984
B7x in the Periphery Abrogates Pancreas-Specific Damage Mediated by Self-reactive CD8 T Cells
2012 StandoutNobel
Distribution of HLA‐DPBl, ‐DQBI‐DQAl Alleles among Sardinian Celiac Patients
1994
Intraepithelial lymphocytes in celiac disease
2003
B7x: A widely expressed B7 family member that inhibits T cell activation
2003 StandoutNobel
The Intestinal T Cell Response to α-Gliadin in Adult Celiac Disease Is Focused on a Single Deamidated Glutamine Targeted by Tissue Transglutaminase
2000
Absorption, lipoprotein transport, and regulation of plasma concentrations of vitamin E in humans.
1993
Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model
2016 StandoutNobel
Understanding the molecular basis of celiac disease: What genetic studies reveal
2006
Critical Roles of Activation-Induced Cytidine Deaminase in the Homeostasis of Gut Flora
2002 StandoutScienceNobel
THE ASSOCIATION BETWEEN COELIAC DISEASE, DERMATITIS HERPETIFORMIS AND CERTAIN HLA‐ANTIGENS IN ICELANDERS
1994
Gluten, major histocompatibility complex, and the small intestine
1992 Standout
Analysis of Single Nucleotide Polymorphisms Identifies Major Type 1A Diabetes Locus Telomeric of the Major Histocompatibility Complex
2007
Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue').
1992 Standout
A Spontaneous Model for Autoimmune Myocarditis Using the Human MHC Molecule HLA-DQ8
2004
Possible role for a human adenovirus in the pathogenesis of celiac disease.
1984
Molecular Basis of Celiac Disease
2000
THE B7 FAMILY REVISITED
2005 Standout
The Diabetes Susceptibility Locus Idd5.1 on Mouse Chromosome 1 Regulates ICOS Expression and Modulates Murine Experimental Autoimmune Encephalomyelitis
2004
Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood
2016 StandoutNobel
Structural analysis of the HLA-DR, -DQ, and -DP alleles on the celiac disease-associated HLA-DR3 (DRw17) haplotype.
1989
High Prevalence of Celiac Disease in Patients with Type 1 Diabetes Detected by Antibodies to Endomysium and Tissue Transglutaminase
2001
HLA ‐ DQA1*05‐DQB 1*0201 positivity predisposes to coeliac disease in Czech diabetic children
2000
Peroxisome Biogenesis Disorders
2003
A study of Italian pediatric celiac disease patients confirms that the primary HLA association is to the DQ(α1∗0501, β1∗0201) heterodimer
1992
Antibody Avidity and Immunoglobulin G Isotype Distribution following Immunization with a Monovalent Meningococcal B Outer Membrane Vesicle Vaccine
2002
Increased Frequency of Surface IgA-Positive Plasma Cells in the Intestinal Lamina Propria and Decreased IgA Excretion in Hyper IgA (HIGA) Mice, a Murine Model of IgA Nephropathy with Hyperserum IgA
2000 StandoutNobel
Effects of a polymorphism in the human tumor necrosis factor α promoter on transcriptional activation
1997 Standout
Iron-Deficiency Anemia
2015 Standout
Identification of a Gliadin T‐Cell Epitope in Coeliac Disease: General Importance of Gliadin Deamidation for Intestinal T‐Cell Recognition
1998
The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells
1985 Standout
Antigliadin and antiendomysium antibody determination for coeliac disease.
1991
Cyclosporin in the treatment of adults with refractory coeliac disease—an open pilot study
2000
Endocrinological Disorders and Celiac Disease
2002
Human Leukocyte Antigen–DQ2 Homozygosity and the Development of Refractory Celiac Disease and Enteropathy-Associated T-Cell Lymphoma
2006
Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b −/− Pdcd1 −/− mice
2005 StandoutNobel
Celiac disease and HLA DQ in patients with IgA nephropathy
2002
Genetic differences in HLA-DQA1∗ and DQB1∗ allelic distributions between celiac and control children in Santiago, Chile
1999
Cutting Edge: CTLA-4 on Effector T Cells Inhibits In Trans
2012 StandoutNobel
Inflammatory component of celiac sprue mucosa. I. Mast cells, basophils, and eosinophils
1985
Engineering of Kuma030: A Gliadin Peptidase That Rapidly Degrades Immunogenic Gliadin Peptides in Gastric Conditions
2015 StandoutNobel
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A gene telomeric of the HLA class I region is involved in predisposition to both type 1 diabetes and coeliac disease
1999
HLA in coeliac disease families: A novel test of risk modification by the ‘other’ haplotype when at least one DQA1*05‐DQB1*02 haplotype is carried
2002
Infantile Refsum's disease: A generalized peroxisomal disorder
1988
The IL12B gene does not confer susceptibility to coeliac disease
2002
The CTLA4/CD28 gene region on chromosome 2q33 confers susceptibility to celiac disease in a way possibly distinct from that of type 1 diabetes and other chronic inflammatory disorders
2000
T Cells from the Peripheral Blood of Coeliac Disease Patients Recognize Gluten Antigens when Presented by HLA‐DR, ‐DQ, or ‐DP Molecules
1994
Association study of IL2/IL21 and FcgRIIa: significant association with the IL2/IL21 region in Scandinavian coeliac disease families
2008
Genetic analysis of the CD28/CTLA4/ICOS (CELIAC3) region in coeliac disease
2004
HLA Antigens in Dermatitis Herpetiformis and Coeliac Disease
1976
Immunoglobulin-Producing Cells in Jejunal Mucosa of Children with Coeliac Disease on a Gluten-Free Diet and after Gluten Challenge
1980
Measurements of Serum IgA and IgG Activities to Dietary Antigens
1990
Strong Association between the HLA-Dw3-Related B Cell Alloantigen -DRw3* and Coeliac Disease
1978
Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer.
1989
An infant with thanatophoric dwarfism surviving 169 days
1986
The Human Secretory Immune System Shows Striking Heterogeneity with Regard to Involvement of J Chain-Positive IgD Immunocytes
1979
Plasma tocopherol levels and vitamin E/β-lipoprotein relationships during pregnancy and in cord blood
1982
T lymphocyte recognition of a celiac disease-associated cis- or trans-encoded HLA-DQ alpha/beta-heterodimer.
1990
Immune response patterns in coeliac disease. Serum antibodies to dietary antigens measured by an enzyme linked immunosorbent assay (ELISA).
1984
Plasma, red cell, and breast milk folacin concentrations in lactating women
1983