J. Domin

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

Regulation of phosphoinositide 3-kinase expression in health and disease

Hallmarks of Cancer: The Next Generation

PI3-kinase inhibition: a target for drug development?

Inhibition of the Phosphoinositide 3-Kinase Pathway Induces a Senescence-like Arrest Mediated by p27Kip1

Phosphoinositide 3-Kinases and the Regulation of Vesicular Trafficking

Phosphoinositide kinases

Chapter 2 PI3K/PTEN Signaling in Angiogenesis and Tumorigenesis

Structure and function of phosphoinositide 3-kinases

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

Structural views of phosphoinositide-specific phospholipase C: signalling the way ahead

Gβγ Stimulates Phosphoinositide 3-Kinase-γ by Direct Interaction with Two Domains of the Catalytic p110 Subunit

COPII-Coated Vesicle Formation Reconstituted with Purified Coat Proteins and Chemically Defined Liposomes

Apoptosis in the nervous system

Characterization of p150, an Adaptor Protein for the Human Phosphatidylinositol (PtdIns) 3-Kinase

mTOR Signaling in Growth Control and Disease

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

Insulin Activates the α Isoform of Class II Phosphoinositide 3-Kinase

Characterizing the Interactions between the Two Subunits of the p101/p110γ Phosphoinositide 3-Kinase and Their Role in the Activation of This Enzyme by Gβγ Subunits

Oncogenic kinase signalling

Role of ERas in promoting tumour-like properties in mouse embryonic stem cells

Coupling of Coat Assembly and Vesicle Budding to Packaging of Putative Cargo Receptors

Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γ

Cell Signaling by Receptor Tyrosine Kinases

Mammalian phosphoinositide kinases and phosphatases

The Role of Phosphoinositide 3-Kinase Lipid Products in Cell Function

Requirement of Phosphatidylinositol 3-Kinase Activity for Bradykinin Stimulation of NF-κB Activation in Cultured Human Epithelial Cells

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

A Novel Integrin-activated Pathway Forms PKB/Akt- stimulatory Phosphatidylinositol 3,4-Bisphosphate via Phosphatidylinositol 3-Phosphate in Platelets

Rab proteins as membrane organizers

A Functional Phosphatidylinositol 3,4,5-Trisphosphate/Phosphoinositide Binding Domain in the Clathrin Adaptor AP-2 α Subunit. IMPLICATIONS FOR THE ENDOCYTIC PATHWAY

Mouse p170 Is a Novel Phosphatidylinositol 3-Kinase Containing a C2 Domain

Membrane fusion and the cell cycle: Cdc48p participates in the fusion of ER membranes

PI3K: Downstream AKTion Blocks Apoptosis

The role of lipid signaling in constitutive membrane traffic

Phosphatidylinositol 3,5-bisphosphate: metabolism and cellular functions

Thrombin signalling and protease-activated receptors

Autophosphorylation of p110delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases invitro and invivo

A Type II Phosphoinositide 3-Kinase Is Stimulated via Activated Integrin in Platelets

PIPkins1We introduce here the abbreviation PIPkin (an abbreviation we have used in our lab for years) for cogent reasons. Previously, PtdIns4P 5-kinase was the favoured abbreviation, but in view of the extensive revision and uncertainty as to substrates and products that we discuss in this review, only PtdInsP kinase would now suffice. Moreover, we have recently recorded evidence that type II PIPkin is subject to multiple phosphorylations by protein kinases [1]. As we progress in our characterisation of these kinases, we feel that ‘PtdInsP kinase kinases’ is a very confusing term for them, and using PIPkins for PtdInsP kinases (and thus PIPkin kinases for the protein kinases that phosphorylate them) is much to be preferred for general use. A fuller abbreviation, where the reaction catalysed is known, e.g. type I PtdIns4P 5-kinase, is of course a suitable alternative in many instances.1, their substrates and their products: new functions for old enzymes

Phosphoinositide 3-kinases: A conserved family of signal transducers

Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ

Vacuolar biogenesis in yeast: Sorting out the sorting proteins

Synaptojanin Is the Major Constitutively Active Phosphatidylinositol-3,4,5-trisphosphate 5-Phosphatase in Rodent Brain

Phosphatidylinositol 3-Kinase Mediates the Inhibitory Effect of Epidermal Growth Factor on Calcium-dependent Chloride Secretion

Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

Synaptotagmin I functions as a calcium regulator of release probability

Membrane Fusion

Human Phosphoinositide 3-Kinase C2β, the Role of Calcium and the C2 Domain in Enzyme Activity

Phosphoinositides, key molecules for regulation of actin cytoskeletal organization and membrane traffic from the plasma membrane

The Gβγ Sensitivity of a PI3K Is Dependent upon a Tightly Associated Adaptor, p101

Regulation of imaginal disc cell size, cell number and organ size by Drosophila class IA phosphoinositide 3-kinase and its adaptor

The Class II Phosphoinositide 3-Kinase C2α Is Activated by Clathrin and Regulates Clathrin-Mediated Membrane Trafficking

Insulin signalling and the regulation of glucose and lipid metabolism

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

Expression Cloning of Protein Targets for 3-Phosphorylated Phosphoinositides

Proliferative Defect and Embryonic Lethality in Mice Homozygous for a Deletion in the p110α Subunit of Phosphoinositide 3-Kinase

The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae

Crystal Structure of a Calcium-Phospholipid Binding Domain from Cytosolic Phospholipase A2

A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

The Class II Phosphoinositide 3-Kinase PI3K-C2α Is Concentrated in the Trans-Golgi Network and Present in Clathrin-coated Vesicles

Phospholipid-binding protein domains

Phosphoinositides in Constitutive Membrane Traffic

Identification of Wortmannin-sensitive Targets in 3T3-L1 Adipocytes

The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death

The hormone resistin links obesity to diabetes

Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase

Phosphoinositides in cell regulation and membrane dynamics

Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction

Localization of a Class II Phosphatidylinositol 3-Kinase, PI3KC2α, to Clathrin-Coated Vesicles

Distinct Mechanisms of α5β1 Integrin Activation by Ha-Ras and R-Ras

Structural insights into phosphoinositide 3-kinase catalysis and signalling

Structural Basis of 3-Phosphoinositide Recognition by Pleckstrin Homology Domains

Neuropeptide Y and neuropeptide Y receptor subtypes in brain and peripheral tissues

Selective Membrane Recruitment of EEA1 Suggests a Role in Directional Transport of Clathrin-coated Vesicles to Early Endosomes

Distinct Classes of Phosphatidylinositol 3′-Kinases Are Involved in Signaling Pathways That Control Macroautophagy in HT-29 Cells

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

Membrane transport in Caenorhabditis elegans: an essential role for VPS34 at the nuclear membrane

Phosphoinositide Involvement in Phagocytosis and Phagosome Maturation

Roles of Non-catalytic Subunits in Gβγ-induced Activation of Class I Phosphoinositide 3-Kinase Isoforms β and γ

Phosphoinositide signaling and the regulation of membrane trafficking in yeast

Phosphoinositide 3-Kinases and Their FYVE Domain-containing Effectors as Regulators of Vacuolar/Lysosomal Membrane Trafficking Pathways

Ras Promotes Cell Survival in Drosophila by Downregulating hid Expression

Beclin–phosphatidylinositol 3‐kinase complex functions at the trans ‐Golgi network

Phosphatidylinositol 3,5-bisphosphate defines a novel PI 3-kinase pathway in resting mouse fibroblasts

PHOSPHOINOSITIDE LIPIDS AS SIGNALING MOLECULES: Common Themes for Signal Transduction, Cytoskeletal Regulation, and Membrane Trafficking

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase

Cytoplasm-to-vacuole targeting and autophagy employ the same machinery to deliver proteins to the yeast vacuole.

Synthesis and Function of 3-Phosphorylated Inositol Lipids

Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin

Antiapoptotic Signalling by the Insulin-Like Growth Factor I Receptor, Phosphatidylinositol 3-Kinase, and Akt

Identification of an early endosomal protein regulated by phosphatidylinositol 3-kinase

The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth.

The autophagosome: origins unknown, biogenesis complex

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

Cloning and characterization of a 92 kDa soluble phosphatidylinositol 4-kinase

Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors.

ATG Systems from the Protein Structural Point of View

Membrane proteomics of phagosomes suggests a connection to autophagy

Signaling Through Scaffold, Anchoring, and Adaptor Proteins

Coat Proteins and Vesicle Budding

AKT/PKB and Other D3 Phosphoinositide-Regulated Kinases: Kinase Activation by Phosphoinositide-Dependent Phosphorylation

Marked decrease of neuropeptide Y Y2 receptor binding sites in the hippocampus in murine prion disease

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

Rabs and their effectors: Achieving specificity in membrane traffic

Signaling by Phosphoinositide-3,4,5-Trisphosphate Through Proteins Containing Pleckstrin and Sec7 Homology Domains

Cloning and Characterization of a G Protein-Activated Human Phosphoinositide-3 Kinase

VCP, the mammalian homolog of cdc48, is tyrosine phosphorylated in response to T cell antigen receptor activation.

Membrane Localization of Phosphatidylinositol 3-Kinase Is Sufficient To Activate Multiple Signal-Transducing Kinase Pathways

Lipid kinase and protein kinase activities of G-protein-coupled phosphoinositide 3-kinase γ: structure–activity analysis and interactions with wortmannin

d - myo -Inositol 1,4,5,6-tetrakisphosphate produced in human intestinal epithelial cells in response to Salmonella invasion inhibits phosphoinositide 3-kinase signaling pathways

Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1α-deficient chimeric mice

The Guanine Nucleotide-Binding Switch in Three Dimensions

Cellular Function of Phosphoinositide 3-Kinases: Implications for Development, Immunity, Homeostasis, and Cancer

Impaired B Cell Development and Proliferation in Absence of Phosphoinositide 3-Kinase p85α

Class II Phosphoinositide 3-Kinases Are Downstream Targets of Activated Polypeptide Growth Factor Receptors

An abundant and ubiquitous homo-oligomeric ring-shaped ATPase particle related to the putative vesicle fusion proteins Sec18p and NSF.

Phosphoinositides as Regulators in Membrane Traffic

The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins

Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration

The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis

Molecular Basis for Interactions of G Protein βγ Subunits with Effectors

Two Distinct Vps34 Phosphatidylinositol 3–Kinase Complexes Function in Autophagy and Carboxypeptidase Y Sorting inSaccharomyces cerevisiae

Autophagy as a Regulated Pathway of Cellular Degradation

Global Analysis of Protein Activities Using Proteome Chips

Wortmannin Inactivates Phosphoinositide 3-Kinase by Covalent Modification of Lys-802, a Residue Involved in the Phosphate Transfer Reaction

The Phosphoinositide 3-Kinase Pathway

Assortment of Phosphatidylinositol 3-Kinase Complexes—Atg14p Directs Association of Complex I to the Pre-autophagosomal Structure inSaccharomyces cerevisiae

p110δ, a novel phosphoinositide 3-kinase in leukocytes

PHOSPHOINOSITIDE KINASES

Structural and functional diversity of phosphoinositide 3-kinases

The generation of valosin-like peptides from a precursor protein in vitro as an extraction artifact

Using structure to define the function of phosphoinositide 3‐kinase family members

A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction

Is Peptide YY Trophic to the Intestinal Epithelium of Parentally Fed Rats?

Plasma enteroglucagon, peptide YY and gastrin in rats deprived of luminal nutrition, and after urogastrone-EGF administration. A proliferative role for PYY in the intestinal epithelium?

A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system.