Citation Impact
Citing Papers
Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro
2003 StandoutNobel
A Novel Orally Active Small Molecule Potently Induces G1 Arrest in Primary Myeloma Cells and Prevents Tumor Growth by Specific Inhibition of Cyclin-Dependent Kinase 4/6
2006
Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines
2009
Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism
2009 StandoutNobel
Sequential MCM/P1 Subcomplex Assembly Is Required to Form a Heterohexamer with Replication Licensing Activity
2000
Human Minichromosome Maintenance Proteins and Human Origin Recognition Complex 2 Protein on Chromatin
1998
Structure, Dynamics, and RNA Interaction Analysis of the Human SBDS Protein
2010
E2F mediates developmental and cell cycle regulation of ORC1 in Drosophila
1999
Association of the Origin Recognition Complex with Heterochromatin and HP1 in Higher Eukaryotes
1997
Subsets of Human Origin Recognition Complex (ORC) Subunits Are Expressed in Non-proliferating Cells and Associate with Non-ORC Proteins
2000
Cell Cycle- and Chromatin Binding State-dependent Phosphorylation of Human MCM Heterohexameric Complexes
1998
Phosphorylation of mammalian CDC6 by Cyclin A/CDK2 regulates its subcellular localization
1999
Xenopus Cdc45-dependent loading of DNA polymerase alpha onto chromatin under the control of S-phase cdk
1998
p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase
1995 StandoutNobel
Interactions between Two Catalytically Distinct MCM Subgroups Are Essential for Coordinated ATP Hydrolysis and DNA Replication
2001
Interactions between Mcm10p and other replication factors are required for proper initiation and elongation of chromosomal DNA replication in Saccharomyces cerevisiae
2000
Maintenance of G2 arrest in the Xenopus oocyte: a role for 14-3-3-mediated inhibition of Cdc25 nuclear import
1999
Cell cycle proteins as promising targets in cancer therapy
2017 Standout
ORC localization in Drosophila follicle cells and the effects of mutations in dE2F and dDP
1999
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
2001 StandoutNature
Mechanisms ensuring rapid and complete DNA replication despite random initiation in Xenopus early embryos
2000
Licensing of DNA replication by a multi-protein complex of MCM/P1 proteins in Xenopus eggs
1997
Reconstitution of an ATM-Dependent Checkpoint that Inhibits Chromosomal DNA Replication following DNA Damage
2000
ORC5L, a New Member of the Human Origin Recognition Complex, Is Deleted in Uterine Leiomyomas and Malignant Myeloid Diseases
1998
Geminin, an Inhibitor of DNA Replication, Is Degraded during Mitosis
1998
Nucleoplasmin-mediated chromatin remodelling is required for Xenopus sperm nuclei to become licensed for DNA replication
2000
Xenopus Mcm10 Binds to Origins of DNA Replication after Mcm2-7 and Stimulates Origin Binding of Cdc45
2002
Nucleosomes Positioned by ORC Facilitate the Initiation of DNA Replication
2001
Components and Dynamics of DNA Replication Complexes in S. cerevisiae: Redistribution of MCM Proteins and Cdc45p during S Phase
1997
Coordinate Binding of ATP and Origin DNA Regulates the ATPase Activity of the Origin Recognition Complex
1997
The Cdc7 protein kinase is required for origin firing during S phase
1998
Replication origins in yeast versus metazoa: separation of the haves and the have nots
1998
The ground state of embryonic stem cell self-renewal
2008 StandoutNature
Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation
1997
Building a Replisome from Interacting Pieces
1999 StandoutNobel
The nuclear envelope prevents reinitiation of replication by regulating the binding of MCM3 to chromatin in Xenopus egg extracts
1995
Cyclin-dependent kinase and initiation at eukaryotic origins: a replication switch?
1997
p65cdc18 Plays a major role controlling the initiation of DNA replication in fission yeast
1995 StandoutNobel
Gene Ontology: tool for the unification of biology
2000 Standout
Qualifying for the license to replicate
1995
The Stability of the Cdc6 Protein Is Regulated by Cyclin-dependent Kinase/Cyclin B Complexes inSaccharomyces cerevisiae
2000
A globular complex formation by Nda1 and the other five members of the MCM protein family in fission yeast
1997
A Long Twentieth Century of the Cell Cycle and Beyond
2000 StandoutNobel
A moving DNA replication factory in Caulobacter crescentus
2001
Loading of an Mcm Protein onto DNA Replication Origins Is Regulated by Cdc6p and CDKs
1997
The Structure of T. aquaticus DNA Polymerase III Is Distinct from Eukaryotic Replicative DNA Polymerases
2006 StandoutNobel
Binding of Human Minichromosome Maintenance Proteins with Histone H3
1996
Isolation and Characterization of Various Complexes of the Minichromosome Maintenance Proteins of Schizosaccharomyces pombe
2000
An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast
1996 Nature
hCDC47, a Human Member of the MCM Family
1996
The fission yeast origin recognition complex is constitutively associated with chromatin and is differentially modified through the cell cycle
1999 StandoutNobel
Cdc18 transcription and proteolysis couple S phase to passage through mitosis
1998
Evidence for Sequential Action of cdc7 and cdk2 Protein Kinases during Initiation of DNA Replication in Xenopus Egg Extracts
2000
Electron microscopic observation and single-stranded DNA binding activity of the Mcm4,6,7 complex
2000
The Xenopus Cdc6 Protein Is Essential for the Initiation of a Single Round of DNA Replication in Cell-Free Extracts
1996
Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin
2001
The Intrinsic DNA Helicase Activity of Methanobacterium thermoautotrophicum ΔH Minichromosome Maintenance Protein
2000
Once and only once upon a time: specifying and regulating origins of DNA replication in eukaryotic cells.
1996
Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts
2000
NEW EMBO MEMBER'S REVIEW: Control of chromosomal DNA replication in the early Xenopus embryo
2001
Initiation of Human DNA Replication in Vitro Using Nuclei from Cells Arrested at an Initiation-competent State
2000
Cyclin A‐dependent kinase activity affects chromatin binding of ORC, Cdc6, and MCM in egg extracts of Xenopus laevis
1999
Mcm2 is a target of regulation by Cdc7–Dbf4 during the initiation of DNA synthesis
1997
Interaction of Xenopus Cdc2·Cyclin A1 with the Origin Recognition Complex
2000
Isolation of Human and Fission Yeast Homologues of the Budding Yeast Origin Recognition Complex Subunit ORC5: Human Homologue (ORC5L) Maps to 7q22
1997
Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition
2010
Regulating S Phase: CDKs, Licensing and Proteolysis
1996 StandoutNobel
The Human Origin Recognition Complex Protein 1 Dissociates from Chromatin during S Phase in HeLa Cells
2001
Drosophila ORC specifically binds to ACE3, an origin of DNA replication control element
1999
Is the MCM2–7 complex the eukaryotic DNA replication fork helicase?
2001
The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G2 phase
2000
Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants
1997
Stability, chromatin association and functional activity of mammalian pre-replication complex proteins during the cell cycle
2001
Characterization of the Yeast Cdc7p/Dbf4p Complex Purified from Insect Cells
2000
Phosphorylation of Mcm4 at Specific Sites by Cyclin-dependent Kinase Leads to Loss of Mcm4,6,7 Helicase Activity
2001
DNA replication and damage checkpoints and meiotic cell cycle controls in the fission and budding yeasts
2000 StandoutNobel
Cell Cycle Regulation of Human CDC6 Protein
1999
The Cdt1 protein is required to license DNA for replication in fission yeast
2000 StandoutNatureNobel
Assembly of functionally active Drosophila origin recognition complex from recombinant proteins
1999
The DNA damage response: putting checkpoints in perspective
2000 StandoutNature
Cdc7p-Dbf4p kinase binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway
1999
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex
2004 StandoutNatureNobel
Premature Structural Changes at Replication Origins in a Yeast Minichromosome Maintenance (MCM) Mutant
2000
Stepwise Regulated Chromatin Assembly of MCM2–7 Proteins
2000
Unphosphorylatable mutants of Cdc6 disrupt its nuclear export but still support DNA replication once per cell cycle
2000
Association of Human Origin Recognition Complex 1 with Chromatin DNA and Nuclease-resistant Nuclear Structures
2000
XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis
2000 Nature
Mechanisms of Conformational Change for a Replicative Hexameric Helicase of SV40 Large Tumor Antigen
2004
Selective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M-G1 transition in mammals
2000
latheo Encodes a Subunit of the Origin Recognition Complex and Disrupts Neuronal Proliferation and Adult Olfactory Memory When Mutant
1999
Emerging fungal threats to animal, plant and ecosystem health
2012 StandoutNature
Expression of Cdc18/Cdc6 and Cdt1 during G2 phase induces initiation of DNA replication
2001
Histone Acetyltransferase HBO1 Interacts with the ORC1 Subunit of the Human Initiator Protein
1999
Architecture of the Human Origin Recognition Complex
2001
Assembly of the Human Origin Recognition Complex
2001
AAA+ superfamily ATPases: common structure–diverse function
2001
Polymerases and the Replisome: Machines within Machines
1998
The Molecular Architecture of Odor and Pheromone Sensing in Mammals
2000 StandoutNobel
tea1 and the Microtubular Cytoskeleton Are Important for Generating Global Spatial Order within the Fission Yeast Cell
1997 StandoutNobel
The regulation of replication origin activation
1999
Replication Factors MCM2 and ORC1 Interact with the Histone Acetyltransferase HBO1
2001
Cdc7 is required throughout the yeast S phasetoactivatereplication origins
1998
ATPase switches controlling DNA replication initiation
2000
The Orc4p and Orc5p Subunits of the Xenopus and Human Origin Recognition Complex Are Related to Orc1p and Cdc6p
1998 StandoutNobel
MCM3 complex required for cell cycle regulation of DNA replication in vertebrate cells
1995 Nature
Role for a Xenopus Orc2-related protein in controlling DNA replication
1996 Nature
A DNA Helicase Activity Is Associated with an MCM4, -6, and -7 Protein Complex
1997
Mutational analysis of conserved sequence motifs in the budding yeast cdc6 protein 1 1Edited by M. Yaniv
2001
Biochemical Analysis of the Intrinsic Mcm4-Mcm6-Mcm7 DNA Helicase Activity
1999
Both cyclin A and cyclin E have S-phase promoting (SPF) activity in Xenopus egg extracts
1996 StandoutNobel
Mechanisms for Initiating Cellular DNA Replication
2013
Cyclin E Uses Cdc6 as a Chromatin-Associated Receptor Required for DNA Replication
2001
Replication origins in eukaroytes
1996
A specific subdomain in φ29 DNA polymerase confers both processivity and strand-displacement capacity
2005 StandoutNobel
Purification and characterization of human DNA damage checkpoint Rad complexes
2001 StandoutNobel
Integrity of the P-site is probed during maturation of the 60S ribosomal subunit
2012 StandoutNobel
The Schizosaccharomyces pombe origin recognition complex interacts with multiple AT-rich regions of the replication origin DNA by means of the AT-hook domains of the spOrc4 protein
2001
Reconstitution of a human ATR-mediated checkpoint response to damaged DNA
2007 StandoutNobel
Human DNA replication initiation factors, ORC and MCM, associate with oriP of Epstein–Barr virus
2001
Regulation of Replicon Size in Xenopus Egg Extracts
1997 Science
Human CDC6/Cdc18 Associates with Orc1 and Cyclin-cdk and Is Selectively Eliminated from the Nucleus at the Onset of S Phase
1998
Cdk2 is Required for Breast Cancer Mediated by the Low-Molecular-Weight Isoform of Cyclin E
2011
The fission yeast homologue of Orc4p binds to replication origin DNA via multiple AT-hooks
1999
Mcm10 and the MCM2–7 complex interact to initiate DNA synthesis and to release replication factors from origins
2000
CELLULAR DNA REPLICASES: Components and Dynamics at the Replication Fork
2005
Nuclear Localization ofSchizosaccharomyces pombeMcm2/Cdc19p Requires MCM Complex Assembly
1999
Cell Cycle Control of Cdc7p Kinase Activity through Regulation of Dbf4p Stability
1999
Cell Cycle Control of DNA Replication
1996 Science
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression
2014 StandoutNobel
Cancer Cell Cycles
1996 StandoutScience
Dpb11 Controls the Association between DNA Polymerases α and ɛ and the Autonomously Replicating Sequence Region of Budding Yeast
2000
Chromatin Association of Human Origin Recognition Complex, Cdc6, and Minichromosome Maintenance Proteins during the Cell Cycle: Assembly of Prereplication Complexes in Late Mitosis
2000
Architecture of the Yeast Origin Recognition Complex Bound to Origins of DNA Replication
1997
AAA+: A Class of Chaperone-Like ATPases Associated with the Assembly, Operation, and Disassembly of Protein Complexes
1999 Standout
MCM Proteins in DNA Replication
1999
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Structure and Mechanism of Helicases and Nucleic Acid Translocases
2007
A Lesion in the DNA Replication Initiation Factor Mcm10 Induces Pausing of Elongation Forks through Chromosomal Replication Origins in Saccharomyces cerevisiae
1997
Human replication proteins hCdc21, hCdc46 and P1Mcm3 bind chromatin uniformly before S-phase and are displaced locally during DNA replication
1996
Phosphorylation of MCM4 by cdc2 protein kinase inhibits the activity of the minichromosome maintenance complex.
1996
Biologically active Phytophthora mating hormone prepared by catalytic asymmetric total synthesis
2008 StandoutNobel
Changes in association of the Xenopus origin recognition complex with chromatin on licensing of replication origins
1999
Requirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage
1998 StandoutScience
Processive DNA helicase activity of the minichromosome maintenance proteins 4, 6, and 7 complex requires forked DNA structures
2001
Neural Science
2000 StandoutNobel
Fluorescence bleaching reveals asymmetric compartment formation prior to cell division in Caulobacter
2003 StandoutNobel
The specificities of protein kinase inhibitors: an update
2003 Standout
Identification and reconstitution of the origin recognition complex from Schizosaccharomyces pombe
1999
Uninterrupted MCM2-7 Function Required for DNA Replication Fork Progression
2000 Science
Distinct Phosphoisoforms of the Xenopus Mcm4 Protein Regulate the Function of the Mcm Complex
2000
Xenopus Cdc7 function is dependent on licensing but not on XORC, XCdc6, or CDK activity and is required for XCdc45 loading
2000
THE DNA REPLICATION FORK IN EUKARYOTIC CELLS
1998
Mammalian Orc1 Protein Is Selectively Released from Chromatin and Ubiquitinated during the S-to-M Transition in the Cell Division Cycle
2002
A quantitative model for the cdc2 control of S phase and mitosis in fission yeast
1996 StandoutNobel
PATHOGEN POPULATION GENETICS , EVOLUTIONARY POTENTIAL, AND DURABLE RESISTANCE
2002 Standout
Cdc6p modulates the structure and DNA binding activity of the origin recognition complex in vitro
2000
The ORC1 homolog orp1 in fission yeast plays a key role in regulating onset of S phase.
1996 StandoutNobel
The Role of Nucleotide Binding and Hydrolysis in the Function of the Fission Yeast cdc18+ Gene Product
1999
A Role for Cdk2 Kinase in Negatively Regulating DNA Replication during S Phase of the Cell Cycle
1997
Replication Origins in XenopusEgg Extract Are 5–15 Kilobases Apart and Are Activated in Clusters That Fire at Different Times
2001
Schizosaccharomyces pombe cdc 20 + encodes DNA polymerase ɛ and is required for chromosomal replication but not for the S phase checkpoint
1997 StandoutNobel
A Fission Yeast Gene,him1+/dfp1+, Encoding a Regulatory Subunit for Hsk1 Kinase, Plays Essential Roles in S-Phase Initiation as Well as in S-Phase Checkpoint Control and Recovery from DNA Damage
1999
The single minichromosome maintenance protein of Methanobacterium thermoautotrophicum ΔH contains DNA helicase activity
1999
Regulation of Chromosome Replication
2000
Identification of a Preinitiation Step in DNA Replication That Is Independent of Origin Recognition Complex and cdc6, but Dependent on cdk2
1998
Hepatitis C Virus IRES RNA-Induced Changes in the Conformation of the 40 S Ribosomal Subunit
2001 StandoutScienceNobel
Neuroscience: Breaking Down Scientific Barriers to the Study of Brain and Mind
2000 StandoutScienceNobel
The selectivity of protein kinase inhibitors: a further update
2007 Standout
Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast
1997
Cell cycle control of replication initiation in eukaryotes
1996
CDC45, a Novel Yeast Gene That Functions with the Origin Recognition Complex and Mcm Proteins in Initiation of DNA Replication
1997
Association of RPA with chromosomal replication origins requires an Mcm protein, and is regulated by Rad53, and cyclin- and Dbf4-dependent kinases
1998
Cdc7p-Dbf4p becomes famous in the cell cycle
2000
The k43 gene, required for chorion gene amplification and diploid cell chromosome replication, encodes the Drosophila homolog of yeast origin recognition complex subunit 2
1997
CDC 45 is required in conjunction with CDC 7/ DBF 4 to trigger the initiation of DNA replication
1997
A Distinct G 1 Step Required to Specify the Chinese Hamster DHFR Replication Origin
1996 Science
Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutLα endonuclease activation
2013 StandoutNobel
The Molecular Biology of Axon Guidance
1996 StandoutScience
DNA Replication in Eukaryotic Cells
2002 Standout
Human DNA Repair Genes
2001 StandoutScienceNobel
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Association of Fission Yeast Orp1 and Mcm6 Proteins with Chromosomal Replication Origins
1999
Identification and characterization of a human protein kinase related to budding yeast Cdc7p
1997
Initiating DNA synthesis: from recruiting to activating the MCM complex
2001
Drosophila Double parked: a conserved, essential replication protein that colocalizes with the origin recognition complex and links DNA replication with mitosis and the down-regulation of S phase transcripts
2000
A human protein related to yeast Cdc6p
1997
INITIATION OF DNA REPLICATION IN EUKARYOTIC CELLS
1997
Chromatin binding, nuclear localization and phosphorylation of Xenopus cdc21 are cell-cycle dependent and associated with the control of initiation of DNA replication.
1996
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Synaptic Assembly of the Brain in the Absence of Neurotransmitter Secretion
2000 StandoutScienceNobel
Unique double-ring structure of the peroxisomal Pex1/Pex6 ATPase complex revealed by cryo-electron microscopy
2015 StandoutNobel
mcm5/cdc46-bob1 bypasses the requirement for the S phase activator Cdc7p
1997
Preferential binding of ATR protein to UV-damaged DNA
2002 StandoutNobel
Cell cycle control of eukaryotic DNA replication
1996
Simulating the electrostatic guidance of the vectorial translocations in hexameric helicases and translocases
2009 StandoutNobel
In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R‐roscovitine)
2002
Implications of climate change for diseases, crop yields and food security
2011
The Xenopus origin recognition complex is essential for DNA replication and MCM binding to chromatin
1996
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Where it all starts: eukaryotic origins of DNA replication
2001
Physical Interactions among Mcm Proteins and Effects of Mcm Dosage on DNA Replication in Saccharomyces cerevisiae
1996
Fission yeast cdc21, a member of the MCM protein family, is required for onset of S phase and is located in the nucleus throughout the cell cycle.
1996
Works of J. Chong being referenced
Conformational flexibility and molecular interactions of an archaeal homologue of the Shwachman-Bodian-Diamond syndrome protein
2009
Characterization of the Xenopus replication licensing system
1997
Purification of an MCM-containing complex as a component of the DNA replication licensing system
1995 Nature
Interaction between the Origin Recognition Complex and the Replication Licensing Systemin Xenopus
1996
Cryo‐electron microscopy reveals a novel DNA‐binding site on the MCM helicase
2008
The RLF-B component of the replication licensing system is distinct from Cdc6 and functions after Cdc6 binds to chromatin
1999
Biochemical and Cellular Effects of Roscovitine, a Potent and Selective Inhibitor of the Cyclin‐Dependent Kinases cdc2, cdk2 and cdk5
1997
A conserved mechanism for replication origin recognition and binding in archaea
2007
The role of MCM/P1 proteins in the licensing of DNA replication
1996
The role of MCM/P1 proteins in the licensing of DNA replication.
1996
An archaeal order with multiple minichromosome maintenance genes
2010
Virulence dynamics and phenotypic diversity of Puccinia coronata f.sp. avenae in Canada from 1974 to 1990
1993
Electron microscopy of susceptible and resistant near-isogenic (sr6/Sr6) lines of wheat infected by Puccinia graminis tritici. II. Expression of incompatibility in mesophyll and epidermal cells and the effect of temperature on host–parasite interactions in these cells
1979
Cell Cycle Regulation of the Replication Licensing System: Involvement of a Cdk-dependent Inhibitor
1997
A double-hexamer archaeal minichromosome maintenance protein is an ATP-dependent DNA helicase
2000
The role of MCM/P1 proteins in the licensing of DNA replication
1996