Citation Impact
Citing Papers
Identification of the residues in human CD4 critical for the binding of HIV
1989 StandoutNobel
Receptor cross-linking restores an insulin metabolic effect altered by mutation on tyrosine 1162 and tyrosine 1163
1989
Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis
1994 StandoutScienceNobel
Odorant Receptors Govern the Formation of a Precise Topographic Map
1998 StandoutNobel
Immunosuppressive properties of synthetic peptides derived from CD4 and HLA-DR antigens
1988 StandoutNobel
Crystal structure of an HIV-binding recombinant fragment of human CD4
1990 StandoutNatureNobel
HIV infection does not require endocytosis of its receptor, CD4
1988 StandoutNobel
Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors
1991 StandoutNatureNobel
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
soluble form of CD4 (T4) protein inhibits AIDS virus infection
1988 StandoutNatureNobel
Synthetic tyrosine polymers as substrates and inhibitors of tyrosine-specific protein kinases.
1984
Ultrastructural evidence for the accumulation of insulin in nuclei of intact 3T3-L1 adipocytes by an insulin-receptor mediated process.
1987
Tyrosine-specific protein kinase activity is associated with the purified insulin receptor.
1983
Insulin action is blocked by a monoclonal antibody that inhibits the insulin receptor kinase.
1986
Molecular cloning, sequence, and tissue distribution of the human ubiquitin-activating enzyme E1.
1991 StandoutNobel
Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
1985 StandoutNature
Latent insulin receptors and possible receptor precursors in 3T3-L1 adipocytes.
1983
Molecular characteristics of recombinant human CD4 as deduced from polymorphic crystals.
1990 StandoutNobel
Serotonin-Mediated Endocytosis of apCAM: an Early Step of Learning-Related Synaptic Growth in Aplysia
1992 StandoutScienceNobel
Differences in the sites of phosphorylation of the insulin receptor in vivo and in vitro.
1985
The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain
1986 StandoutNobel
Characterization of insulin-mediated phosphorylation of the insulin receptor in a cell-free system.
1983
Effect of monoclonal antibodies on human insulin receptor autophosphorylation, negative cooperativity, and down-regulation.
1987
Effect of Microinjection of a Low-Mr Human Placenta Protein Tyrosine Phosphatase on Induction of Meiotic Cell Division in Xenopus Oocytes
1990 StandoutNobel
The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family
1985 StandoutNobel
Regulation of transmembrane signaling by receptor phosphorylation
1987 StandoutNobel
An adenovirus type 2 glycoprotein blocks cell surface expression of human histocompatibility class I antigens
1985
Purification and characterization of recombinant G16 alpha from Sf9 cells: activation of purified phospholipase C isozymes by G-protein alpha subunits.
1993 StandoutNobel
Role of glycosylation in the processing of newly translated insulin proreceptor in 3T3-L1 adipocytes.
1984
Mammalian beta-adrenergic receptors. Structural differences in beta 1 and beta 2 subtypes revealed by peptide maps.
1983 StandoutNobel
G-protein alpha-subunit expression, myristoylation, and membrane association in COS cells.
1990 StandoutNobel
Use of an anti-insulin receptor antibody to discriminate between metabolic and mitogenic effects of insulin: correlation with receptor autophosphorylation.
1988
Monoclonal antibodies to the human insulin receptor that activate glucose transport but not insulin receptor kinase activity.
1987
β-Adrenergic Receptor Kinase: Primary Structure Delineates a Multigene Family
1989 StandoutScienceNobel
The major histocompatibility complex class I heavy chain as a structural subunit of the human cell membrane insulin receptor: implications for the range of biological functions of histocompatibility antigens.
1986
Autophosphorylation of the insulin receptor in vitro. Designation of phosphorylation sites and correlation with receptor kinase activation.
1986
Selection of an RNA molecule that mimics a major autoantigenic epitope of human insulin receptor.
1995 StandoutNobel
Internalization-defective LDL receptors produced by genes with nonsense and frameshift mutations that truncate the cytoplasmic domain
1985 StandoutNobel
After Insulin Binds
1987 Science
Glycoproteins of the lysosomal membrane.
1985
Mammalian beta-adrenergic receptors. Distinct glycoprotein populations containing high mannose or complex type carbohydrate chains.
1984 StandoutNobel
Structural differences between insulin receptors in the brain and peripheral target tissues.
1983
A nonsense mutation causing decreased levels of insulin receptor mRNA: detection by a simplified technique for direct sequencing of genomic DNA amplified by the polymerase chain reaction.
1990
How N-linked oligosaccharides affect glycoprotein folding in the endoplasmic reticulum.
1994
Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor
1982 Science
Endocytosis and the recycling of plasma membrane.
1983 StandoutNobel
Insulin Receptor: Evidence That It Is a Protein Kinase
1983 Science
Pure β-adrenergic receptor: the single polypeptide confers catecholamine responsiveness to adenylate cyclase
1983 StandoutNatureNobel
Autophosphorylation and kinase activity of insulin receptor in diabetic rats
1986
Adenoviruses of subgenera B, C, D, and E modulate cell-surface expression of major histocompatibility complex class I antigens.
1986 StandoutNobel
Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin
1986 StandoutNatureNobel
Transport of Peptide-MHC Class II Complexes in Developing Dendritic Cells
2000 StandoutScienceNobel
Acute insulin action requires insulin receptor kinase activity: introduction of an inhibitory monoclonal antibody into mammalian cells blocks the rapid effects of insulin.
1987
Normal Development of Mice Deficient in β 2 M, MCClass I Proteins, and CD8 + T Cells
1990 StandoutScienceNobel
Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor
1986
The gene encoding the T-cell surface protein T4 is located on human chromosome 12.
1986 StandoutNobel
Reevaluation of the evidence that an antibody to the insulin receptor is insulinmimetic without activating the protein tyrosine kinase activity of the receptor.
1987
Syndromes of Autoimmunity and Hypoglycemia: Autoantibodies Directed Against insulinand Its Receptor
1989
p185, a product of the neu proto-oncogene, is a receptorlike protein associated with tyrosine kinase activity.
1986
Protein Sorting by Transport Vesicles
1996 StandoutScienceNobel
cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.
1987 StandoutNobel
Structure and expression of the human and mouse T4 genes.
1987 StandoutNobel
The Molecular Genetics of Cancer
1987 StandoutScienceNobel
Light-dependent phosphorylation of rhodopsin by β-adrenergic receptor kinase
1986 StandoutNatureNobel
Insulin stimulation of phosphorylation of the beta subunit of the insulin receptor. Formation of both phosphoserine and phosphotyrosine.
1982
Microinjection of a protein-tyrosine-phosphatase inhibits insulin action in Xenopus oocytes.
1990 StandoutNobel
Mechanisms of Membrane-Receptor Regulation
1984 StandoutNobel
Exposure of K562 cells to anti-receptor monoclonal antibody OKT9 results in rapid redistribution and enhanced degradation of the transferrin receptor.
1986
Insulin activates a tyrosine-specific protein kinase in extracts of 3T3-L1 adipocytes and human placenta.
1982
The protein-tyrosine kinase activity of the insulin receptor is necessary for insulin-mediated receptor down-regulation.
1987
Receptor-mediated phosphorylation of the hepatic insulin receptor: Evidence that the M r 95,000 receptor subunit is its own kinase
1983
Tyrosine phosphorylation of the insulin receptor beta subunit activates the receptor-associated tyrosine kinase activity.
1984
Phosphorylation of the hepatic insulin receptor
1982
daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans
1997 StandoutScienceNobel
Internalized insulin receptors are recycled to the cell surface in rat hepatocytes.
1982
Effects of amino acid replacements within the tetrabasic cleavage site on the processing of the human insulin receptor precursor expressed in Chinese hamster ovary cells.
1990
Insulin receptor tyrosine kinase is defective in skeletal muscle of insulin-resistant obese mice
1985 Nature
The role of antireceptor antibodies in stimulating phosphorylation of the insulin receptor.
1984
Rabbit liver growth hormone receptor and serum binding protein. Purification, characterization, and sequence.
1988
A short sequence in the COOH-terminus makes an adenovirus membrane glycoprotein a resident of the endoplasmic reticulum
1987 StandoutNobel
Internalization and degradation of macrophage Fc receptors during receptor-mediated phagocytosis.
1983 StandoutNobel
Inhibition of Adenylyl Cyclase by G iα
1993 StandoutScienceNobel
Increased phosphorylation of ribosomal protein S6 following microinjection of insulin receptor-kinase into Xenopus oocytes
1986 StandoutNatureNobel
Prohormone processing in Xenopus oocytes: characterization of cleavage signals and cleavage enzymes.
1991 StandoutNobel
Insulin stimulated phosphorylation of its own receptor. Activation of a tyrosine-specific protein kinase that is tightly associated with the receptor.
1983
Insulin receptor is an insulin-dependent tyrosine protein kinase: copurification of insulin-binding activity and protein kinase activity to homogeneity from human placenta.
1984
Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity.
1987
Biochemical and morphological evidence that the insulin receptor is internalized with insulin in hepatocytes.
1982
Lipid modifications of G proteins: alpha subunits are palmitoylated.
1993 StandoutNobel
The .beta. subunit of the insulin receptor kinase is an insulin-activated protein
1983
The Nature and Regulation of the Insulin Receptor: Structure and Function
1985
Phosphorylation of exogenous substrates by the insulin receptor-associated protein kinase.
1983
Immunoprecipitation of Insulin Receptors from Cultured Human Lymphocytes (IM-9 Cells) by Antibodies to pp60 src
1985 Science
pH and the recycling of transferrin during receptor-mediated endocytosis.
1983 StandoutNobel
Receptor regulation of G-protein palmitoylation.
1994 StandoutNobel
Insulin receptor phosphorylation in intact adipocytes and in a cell-free system
1982
G protein gamma subunits contain a 20-carbon isoprenoid.
1990 StandoutNobel
Works of J A Hedo being referenced
Defects in Human Insulin Receptor Gene Expression
1988
Internalization of insulin receptors in the isolated rat adipose cell. Demonstration of the vectorial disposition of receptor subunits.
1984
Insulin-induced receptor loss in cultured human lymphocytes is due to accelerated receptor degradation.
1981
Insulin-induced Internalization of the Insulin Receptor in the Isolated Rat Adipose Cell: Detection of Both Major Receptor Subunits Following Their Biosynthetic Labeling in Culture
1984
Binding of insulin receptors to lectins: evidence for common carbohydrate determinants on several membrane receptors
1981
Effects of castanospermine and 1-deoxynojirimycin on insulin receptor biogenesis. Evidence for a role of glucose removal from core oligosaccharides.
1987
Insulin-induced internalization of the insulin receptor in the isolated rat adipose cell. Detection of the internalized 138-kilodalton receptor subunit using a photoaffinity 125I-insulin.
1983
Insulin-Receptor Biosynthesis in Cultured Lymphocytes From an Insulin-Resistant Patient (Rabson-Mendenhall Syndrome): Evidence for Defect Before Insertion of Receptor Into Plasma Membrane
1986
Insulin receptor biosynthesis in cultured lymphocytes from insulin-resistant patients.
1985
Biosynthetic labeling of insulin receptor: studies of subunits in cultured human IM-9 lymphocytes.
1981
The structure of insulin receptor and its subunits. Evidence for multiple nonreduced forms and a 210,000 possible proreceptor.
1982
Insulin Receptor Phosphorylation May Not Be a Prerequisite for Acute Insulin Action
1984 Science
Decreased Insulin Binding in Cultured Lymphocytes from Two Patients with Extreme Insulin Resistance*
1982
Biosynthesis and glycosylation of the insulin receptor. Evidence for a single polypeptide precursor of the two major subunits.
1983
Myristyl and palmityl acylation of the insulin receptor.
1987
Direct demonstration of glycosylation of insulin receptor subunits by biosynthetic and external labeling: evidence for heterogeneity.
1981
The human growth hormone receptor of cultured human lymphocytes. Structural characteristics and glycosylation properties
1986