Standout Papers
Citation Impact
Citing Papers
Global analysis of protein folding using massively parallel design, synthesis, and testing
2017 StandoutScienceNobel
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
2010 StandoutScienceNobel
Conformational Switch of Syntaxin-1 Controls Synaptic Vesicle Fusion
2008 StandoutScienceNobel
PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex
2018 StandoutScienceNobel
Structure of the human epithelial sodium channel by cryo-electron microscopy
2018
Piezo1 ion channel pore properties are dictated by C-terminal region
2015 StandoutNobel
Contribution of Residues in Second Transmembrane Domain of ASIC1a Protein to Ion Selectivity
2012
ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures
2003 StandoutNobel
Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors
2014 StandoutNatureNobel
A proton-gated cation channel involved in acid-sensing
1997 Nature
A stomatin-like protein necessary for mechanosensation in C. elegans
1995 StandoutNatureNobel
Mechanisms of taste transduction
1996
A Nonproton Ligand Sensor in the Acid-Sensing Ion Channel
2010
Epithelial Sodium Channel Pore Region
2001
Functional Degenerin-containing Chimeras Identify Residues Essential for Amiloride-sensitive Na- Channel Function
1995
Discoveries in structure and physiology of mechanically activated ion channels
2020 StandoutNatureNobel
Chapter 14 Methods for the Study of Cell Death in the Nematode Caenorhabditis elegans
1995
A New Member of the Amiloride-Sensitive Sodium Channel Family inDrosophila melanogasterPeripheral Nervous System
1998
X-Ray Structure of Acid-Sensing Ion Channel 1–Snake Toxin Complex Reveals Open State of a Na+-Selective Channel
2014 StandoutNobel
Water and Ion Permeation of Aquaporin-1 in Planar Lipid Bilayers
2001 StandoutNobel
A family of candidate taste receptors in human and mouse
2000 StandoutNatureNobel
Molecular mechanisms of nociception
2001 StandoutNatureNobel
The capsaicin receptor: a heat-activated ion channel in the pain pathway
1997 StandoutNatureNobel
Neuropeptide FF and FMRFamide Potentiate Acid-Evoked Currents from Sensory Neurons and Proton-Gated DEG/ENaC Channels
2000
Amiloride Docking to Acid-sensing Ion Channel-1
2010
Molecular Mechanisms of Human Hypertension
2001 Standout
A capsaicin-receptor homologue with a high threshold for noxious heat
1999 StandoutNatureNobel
Ion currents of Xenopus laevis oocytes: state of the art
1999
Potassium channels and their evolving gates
1994 Nature
Piezo proteins are pore-forming subunits of mechanically activated channels
2012 StandoutNatureNobel
A Modulatory Subunit of Acid Sensing Ion Channels in Brain and Dorsal Root Ganglion Cells
1997
Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors
1995 StandoutNatureNobel
Regulation of Caenorhabditis elegans degenerin proteins by a putative extracellular domain
1995 StandoutNobel
A Molecular Component of the Arterial Baroreceptor Mechanotransducer
1998
Molecular Cloning of a Non-inactivating Proton-gated Na+ Channel Specific for Sensory Neurons
1997
A Pore Segment in DEG/ENaC Na+ Channels
1999
Extracellular Proteins Needed for C. elegans Mechanosensation
1996 StandoutNobel
Gene interactions affecting mechanosensory transduction in Caenorhabditis elegans
1994 StandoutNatureNobel
Sensory Functions for Degenerin/Epithelial Sodium Channels (DEG/ENaC)
2011
New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor
1994 StandoutNatureNobel
Identification of genes expressed in C. elegans touch receptor neurons
2002 StandoutNatureNobel
A mutated acetylcholine receptor subunit causes neuronal degeneration in C. elegans
1995 StandoutNobel
A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain
2011 StandoutNatureNobel
The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel
2002 StandoutNatureNobel
Syntaxin 1A Regulates ENaC Channel Activity
2004
Piezo2 is the major transducer of mechanical forces for touch sensation in mice
2014 StandoutNatureNobel
The Nematode Degenerin UNC-105 Forms Ion Channels that Are Activated by Degeneration- or Hypercontraction-Causing Mutations
1998
Structure of acid-sensing ion channel 1 at 1.9 Å resolution and low pH
2007 Nature
Structure of the mechanically activated ion channel Piezo1
2017 StandoutNatureNobel
The DRASIC Cation Channel Contributes to the Detection of Cutaneous Touch and Acid Stimuli in Mice
2001
Outlines of the pore in open and closed conformations describe the gating mechanism of ASIC1
2011
Identification of a cold receptor reveals a general role for TRP channels in thermosensation
2002 StandoutNatureNobel
A TRP Channel that Senses Cold Stimuli and Menthol
2002 StandoutNobel
Cellular and Molecular Mechanisms of Pain
2009 StandoutNobel
MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation
2002 StandoutNatureNobel
Molecular Cloning and Functional Expression of a Novel Amiloride-sensitive Na+ Channel
1995
unc-8, a DEG/ENaC Family Member, Encodes a Subunit of a Candidate Mechanically Gated Channel That Modulates C. elegans Locomotion
1997
Characterization of the Selectivity Filter of the Epithelial Sodium Channel
2000
H+‐Gated Cation Channelsa
1999
Pore architecture and ion sites in acid-sensing ion channels and P2X receptors
2009 Nature
Epithelial Na+ channels and stomatin are expressed in rat trigeminal mechanosensory neurons
2000
The menthol receptor TRPM8 is the principal detector of environmental cold
2007 StandoutNatureNobel
Localization of β and γ subunits of ENaC in sensory nerve endings in the rat foot pad
2000
The role of Drosophila Piezo in mechanical nociception
2012 StandoutNatureNobel
An Expanded WW Domain Recognition Motif Revealed by the Interaction between Smad7 and the E3 Ubiquitin Ligase Smurf2
2006
Spider toxins activate the capsaicin receptor to produce inflammatory pain
2006 StandoutNatureNobel
Paradoxical Stimulation of a DEG/ENaC Channel by Amiloride
1999
The receptor site of the spider toxin PcTx1 on the proton‐gated cation channel ASIC1a
2005
A new class of ligand-gated ion channel defined by P2X receptor for extracellular ATP
1994 Nature
Side Chain Orientation of Residues Lining the Selectivity Filter of Epithelial Na+ Channels
2004
Cloning and Expression of a Novel Human Brain Na+ Channel
1996
The Mammalian Degenerin MDEG, an Amiloride-sensitive Cation Channel Activated by Mutations Causing Neurodegeneration in Caenorhabditis elegans
1996
A transmembrane domain of the putative channel subunit MEC-4 influences mechanotransduction and neurodegeneration in C. elegans
1994 Nature
Neurosensory mechanotransduction
2008 StandoutNobel
What is the hair cell transduction channel?
2006
MEC-2 and MEC-6 in the Caenorhabditis elegans Sensory Mechanotransduction Complex: Auxiliary Subunits that Enable Channel Activity
2008
The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na + channels
2004 StandoutNobel
A Conformation Change in the Extracellular Domain that Accompanies Desensitization of Acid-sensing Ion Channel (ASIC) 3
2007
Cloning and expression of the beta- and gamma-subunits of the human epithelial sodium channel
1995
Eukaryotic Mechanosensitive Channels
2010 Nobel
Structure and activity of the acid-sensing ion channels
2012
Mechanosensitive Ion Channels: Structural Features Relevant to Mechanotransduction Mechanisms
2020
Regulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-Arrestin
2001 StandoutScienceNobel
Abnormal Vascular Function and Hypertension in Mice Deficient in Estrogen Receptor β
2002 StandoutScienceNobel
MOD-1 is a serotonin-gated chloride channel that modulates locomotory behaviour in C. elegans
2000 StandoutNatureNobel
Subunit composition of a DEG/ENaC mechanosensory channel of Caenorhabditis elegans
2015 Nobel
DEG/ENaC ion channels involved in sensory transduction are modulated by cold temperature
2001
Inactivation of a Serotonin-Gated Ion Channel by a Polypeptide Toxin from Marine Snails
1998 StandoutScienceNobel
Transport and Localization of the DEG/ENaC Ion Channel BNaC1α to Peripheral Mechanosensory Terminals of Dorsal Root Ganglia Neurons
2001
Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor
2000 StandoutScienceNobel
Structure, function, and pharmacology of acid-sensing ion channels (ASICs): focus on ASIC1a.
2010
Acid-Evoked Currents in Cardiac Sensory Neurons
1999
Evidence that neuronal G-protein-gated inwardly rectifying K+ channels are activated by G beta gamma subunits and function as heteromultimers.
1995
Heteromultimers of DEG/ENaC subunits form H + -gated channels in mouse sensory neurons
2002
UBIQUITIN AND THE CONTROL OF PROTEIN FATE IN THE SECRETORY AND ENDOCYTIC PATHWAYS
1998
Genetically targeted cell disruption in Caenorhabditis elegans
1997 StandoutNobel
Molecular Basis of Mechanotransduction in Living Cells
2001
Neuropathology of degenerative cell death in Caenorhabditis elegans.
1997 StandoutNobel
Genetic interactions affecting touch sensitivity in Caenorhabditis elegans.
1996 StandoutNobel
Membrane topology of the amiloride-sensitive epithelial sodium channel.
1994
Diversity of Channels Generated by Different Combinations of Epithelial Sodium Channel Subunits
1997
CELLULAR MECHANISMS OF TASTE TRANSDUCTION
1999
Sequence and transmembrane topology of MEC-4, an ion channel subunit required for mechanotransduction in Caenorhabditis elegans.
1996 StandoutNobel
An SH3 binding region in the epithelial Na+ channel (alpha rENaC) mediates its localization at the apical membrane.
1994
Revealing the Architecture of a K + Channel Pore Through Mutant Cycles with a Peptide Inhibitor
1995 StandoutScienceNobel
Ripped Pocket and Pickpocket, Novel Drosophila DEG/ENaC Subunits Expressed in Early Development and in Mechanosensory Neurons
1998
MOLECULAR MODELING OF MECHANOTRANSDUCTION IN THE NEMATODE CAENORHABDITIS ELEGANS
1997
Neuropathology of Degenerative Cell Death inCaenorhabditis elegans
1997 StandoutNobel
BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels
1997
Shear force sensing of epithelial Na + channel (ENaC) relies on N -glycosylated asparagines in the palm and knuckle domains of αENaC
2019
Genetics of Sensory Mechanotransduction
2002 StandoutNobel
Interaction Between a Putative Mechanosensory Membrane Channel and a Collagen
1996 Science
Works of Ivan Gautschi being referenced
Cadmium Trapping in an Epithelial Sodium Channel Pore Mutant
2007
A Gating Mutation in the Internal Pore of ASIC1a
2006
Mutations in the Epithelial Na+ Channel ENaC Outer Pore Disrupt Amiloride Block by Increasing Its Dissociation Rate
2003
Identification of a highly conserved sequence at the N-terminus of the epithelial Na+ channel α subunit involved in gating
1999
Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits
1994 StandoutNature
Affinity and Specificity of Interactions between Nedd4 Isoforms and the Epithelial Na+ Channel
2003
Mutations causing Liddle syndrome reduce sodium-dependent downregulation of the epithelial sodium channel in the Xenopus oocyte expression system.
1998
An External Site Controls Closing of the Epithelial Na+ Channel ENaC
2002
Cell surface expression of the epithelial Na channel and a mutant causing Liddle syndrome: A quantitative approach
1996
Permeability Properties of Enac Selectivity Filter Mutants
2001
A mutation in the epithelial sodium channel causing Liddle disease increases channel activity in the Xenopus laevis oocyte expression system.
1995
A Missense Mutation in the Extracellular Domain of αENaC Causes Liddle Syndrome
2017
On the Molecular Basis of Ion Permeation in the Epithelial Na+ Channel
1999
A single point mutation in the pore region of the epithelial Na + channel changes ion selectivity by modifying molecular sieving
1999
Identification of Amino Acid Residues in the α, β, and γ Subunits of the Epithelial Sodium Channel (ENaC) Involved in Amiloride Block and Ion Permeation
1997
A de novo missense mutation of the beta subunit of the epithelial sodium channel causes hypertension and Liddle syndrome, identifying a proline-rich segment critical for regulation of channel activity.
1995
Identification of a PY motif in the epithelial Na channel subunits as a target sequence for mutations causing channel activation found in Liddle syndrome.
1996