Standout Papers
- A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF (1998)
- Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity (1995)
Citation Impact
Citing Papers
The Absence of Pericytes Does Not Increase the Sensitivity of Tumor Vasculature to Vascular Endothelial Growth Factor-A Blockade
2010
Sustained VEGF Blockade Results in Microenvironmental Sequestration of VEGF by Tumors and Persistent VEGF Receptor-2 Activation
2008
Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension
2011 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
HLF/HIF-2α is a key factor in retinopathy of prematurity in association with erythropoietin
2003
HIF-2α-Haploinsufficient Mice Have Blunted Retinal Neovascularization Due to Impaired Expression of a Proangiogenic Gene Battery
2008
Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors.
1997
Extracellular Cleavage of the Vascular Endothelial Growth Factor 189-Amino Acid Form by Urokinase Is Required for Its Mitogenic Effect
1997
Resident vascular progenitor cells: An emerging role for non-terminally differentiated vessel-resident cells in vascular biology
2008
Antiangiogenic Agents Are Effective Inhibitors of Endometriosis
2003
Intravitreous Injections of Vascular Endothelial Growth Factor Produce Retinal Ischemia and Microangiopathy in an Adult Primate
1996
The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis
2005 StandoutNobel
Vasculogenic Mimicry and Tumor Angiogenesis
2000
Anti-angiogenic therapy: Rationale, challenges and clinical studies
2002
Regulation of Vascular Endothelial Growth Factor by Oxygen in a Model of Retinopathy of Prematurity
1996
Oxidative stress, inflammation, and cancer: How are they linked?
2010 Standout
Targeting HIF-1 for cancer therapy
2003 StandoutNobel
VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation
1999 Standout
Ischemia-Driven Angiogenesis
1997
Advanced Glycation End Products Induce Expression of Vascular Endothelial Growth Factor by Retinal Müller Cells
1997
Suppression of Vascular Endothelial Growth Factor-Mediated Endothelial Cell Protection by Survivin Targeting
2001
New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF
1999
Impaired brain angiogenesis and neuronal apoptosis induced by conditional homozygous inactivation of vascular endothelial growth factor
2004
Clinical Application of Antiangiogenic Therapy: Microvessel Density, What It Does and Doesn't Tell Us
2002
Inducible Expression of Vascular Endothelial Growth Factor in Adult Mice Causes Severe Proliferative Retinopathy and Retinal Detachment
2002
Vascular endothelial growth factor is produced by peritoneal fluid macrophages in endometriosis and is regulated by ovarian steroids.
1996
Transplantation of Human Embryonic Stem Cell-Derived Photoreceptors Restores Some Visual Function in Crx-Deficient Mice
2009
Tumor angiogenesis: past, present and the near future
2000
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
Expression of angiogenesis‐related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis
2001 StandoutNobel
Insulin Stimulates Hypoxia-inducible Factor 1 through a Phosphatidylinositol 3-Kinase/Target of Rapamycin-dependent Signaling Pathway
2002 StandoutNobel
Polarized Vascular Endothelial Growth Factor Secretion by Human Retinal Pigment Epithelium and Localization of Vascular Endothelial Growth Factor Receptors on the Inner Choriocapillaris
1999
Self-Formation of Optic Cups and Storable Stratified Neural Retina from Human ESCs
2012
Integrins in angiogenesis and lymphangiogenesis
2008
Vascular Permeability Factor/Vascular Endothelial Growth Factor and the Significance of Microvascular Hyperpermeability in Angiogenesis
1999
Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway
1998 Standout
Alteration of Developmental and Pathological Retinal Angiogenesis in angptl4-deficient Mice
2011
Pericyte production of cell-associated VEGF is differentiation-dependent and is associated with endothelial survival
2003
Pericytes: gatekeepers in tumour cell metastasis?
2007
Angiogenesis in cancer and other diseases
2000 StandoutNature
The Hallmarks of Cancer
2000 Standout
Endothelial-pericyte interactions in angiogenesis
2003
Cellular abnormalities of blood vessels as targets in cancer
2004
Angiopoietin 1 Promotes Tumor Angiogenesis and Tumor Vessel Plasticity of Human Cervical Cancer in Mice
2002
Halting angiogenesis suppresses carcinoma cell invasion
1997
Angiogenesis in health and disease
2003 Standout
Oncogenes as inducers of tumor angiogenesis
1995
Rescue of Diabetes-Related Impairment of Angiogenesis by Intramuscular Gene Therapy with Adeno-VEGF
1999
Conditional switching of VEGF provides new insights into adult neovascularization and pro-angiogenic therapy
2002
DEVELOPMENT OF RANIBIZUMAB, AN ANTI–VASCULAR ENDOTHELIAL GROWTH FACTOR ANTIGEN BINDING FRAGMENT, AS THERAPY FOR NEOVASCULAR AGE-RELATED MACULAR DEGENERATION
2006
Role of Hypoxia-Inducible Factor 1 in Gastric Cancer Cell Growth, Angiogenesis, and Vessel Maturation
2004 StandoutNobel
Advanced glycation end products increase retinal vascular endothelial growth factor expression.
1998
Vascular Endothelial Growth Factor Induces Expression of the Antiapoptotic Proteins Bcl-2 and A1 in Vascular Endothelial Cells
1998
Vascular development and disorders: Molecular analysis and pathogenic insights
1998
Vascular permeability factor/vascular endothelial growth factor:A multifunctional angiogenic cytokine
1997
Role of endothelial cell survival and death signals in angiogenesis
1999
Vascular Endothelial Growth Factor: Molecular and Biological Aspects
1999
Microvascular Modifications in Diabetic Retinopathy
2011
Retinitis pigmentosa
2006 Standout
HIF-1alpha is required for solid tumor formation and embryonic vascularization
1998
Vascular Endothelial Growth Factor Is Sufficient to Produce Iris Neovascularization and Neovascular Glaucoma in a Nonhuman Primate
1996
VEGF as a Key Mediator of Angiogenesis in Cancer
2005
Angiopoietin-2 Is Required for Postnatal Angiogenesis and Lymphatic Patterning, and Only the Latter Role Is Rescued by Angiopoietin-1
2002
Akt Mediates Cytoprotection of Endothelial Cells by Vascular Endothelial Growth Factor in an Anchorage-dependent Manner
1999
Molecular and biological properties of vascular endothelial growth factor
1999
Endothelial–perivascular cell signaling in vascular development: lessons from knockout mice
1998
Defective Vascularization of HIF-1α-Null Embryos Is Not Associated with VEGF Deficiency but with Mesenchymal Cell Death
1999 StandoutNobel
Rapid vascular regrowth in tumors after reversal of VEGF inhibition
2006
Pericytes: Cell Biology and Pathology
2001
VEGF-A: a critical regulator of blood vessel growth
2009
Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
2003
Neutralization of Circulating Vascular Endothelial Growth Factor (VEGF) by Anti-VEGF Antibodies and Soluble VEGF Receptor 1 (sFlt-1) Induces Proteinuria
2003
Vascular-specific growth factors and blood vessel formation
2000 StandoutNature
Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms
2002
Mechanisms of angiogenesis
1997 StandoutNature
Fraser syndrome and cryptophthalmos: review of the diagnostic criteria and evidence for phenotypic modules in complex malformation syndromes
2002
Stimulation and Inhibition of Angiogenesis in Diabetic Retinopathy
2001
Cellular and Molecular Mechanisms of Vascular Lumen Formation
2009
Clinical applications of angiogenic growth factors and their inhibitors
1999
A Fresh Look at iPS Cells
2009 StandoutNobel
Blockade of Vascular Endothelial Cell Growth Factor Receptor Signaling Is Sufficient to Completely Prevent Retinal Neovascularization
2000
Biochemistry and molecular cell biology of diabetic complications
2001 StandoutNature
Transgenic mouse models in angiogenesis and cardiovascular disease
2000
Mechanisms of angiogenesis and arteriogenesis
2000 Standout
Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family
2001
Vascular Endothelial Growth Factor Stimulates Tyrosine Phosphorylation and Recruitment to New Focal Adhesions of Focal Adhesion Kinase and Paxillin in Endothelial Cells
1997
Analysis of the role of chemokines in angiogenesis
2003
Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
1996 StandoutNature
Cerebral organoids model human brain development and microcephaly
2013 StandoutNature
PDGFRβ+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival
2005
Endogenous VEGF Is Required for Visual Function: Evidence for a Survival Role on Müller Cells and Photoreceptors
2008
Signaling angiogenesis and lymphangiogenesis
1998
Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity
2000
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
Symmetrical Mutant Phenotypes of the Receptor EphB4 and Its Specific Transmembrane Ligand ephrin-B2 in Cardiovascular Development
1999
The anti-angiogenic basis of metronomic chemotherapy
2004 Standout
Relationship between RPE and Choriocapillaris in Age-Related Macular Degeneration
2009
Carboplatin selectively induces the VEGF stress response in endothelial cells: Potentiation of antitumor activity by combination treatment with antibody to VEGF
2004
Role of vascular endothelial growth factor in the regulation of angiogenesis
1999
Molecular mechanisms and clinical applications of angiogenesis
2011 StandoutNature
Inhibition of VEGF receptors causes lung cell apoptosis and emphysema
2000
Modes of resistance to anti-angiogenic therapy
2008 Standout
Ocular neovascularization: a valuable model system
2003
Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
1999
Vascular Endothelial Growth Factor Receptor-2-Mediated Mitogenesis Is Negatively Regulated by Vascular Endothelial Growth Factor Receptor-1 in Tumor Epithelial Cells
2001
The role of pericytes in blood-vessel formation and maintenance
2005
VEGF: an update on biological and therapeutic aspects
2000
Possible Mechanisms of Acquired Resistance to Anti-angiogenic Drugs: Implications for the Use of Combination Therapy Approaches
2001
Developmental and Pathological Angiogenesis
2011
Pericytes and vessel maturation during tumor angiogenesis and metastasis
2010
Tumorigenesis and the angiogenic switch
2003 Standout
VEGFs, receptors and angiogenesis
1999
Marked Induction of the IAP Family Antiapoptotic Proteins Survivin and XIAP by VEGF in Vascular Endothelial Cells
1999
Digoxin inhibits development of hypoxic pulmonary hypertension in mice
2012 StandoutNobel
Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative diabetic retinopathy
2015 StandoutNobel
Role of Akt Signaling in Vascular Homeostasis and Angiogenesis
2002
Endothelial-Mural Cell Signaling in Vascular Development and Angiogenesis
2009
Stabilization of Vascular Endothelial Growth Factor mRNA by Hypoxia and Hypoglycemia and Coregulation with Other Ischemia-Induced Genes
1995
Vascular Endothelial Growth Factor: Basic Science and Clinical Progress
2004 Standout
Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α
2002 StandoutNobel
Vascular remodeling and clinical resistance to antiangiogenic cancer therapy
2004
Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: Induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal
1997
Hypoxia-inducible factor 1α protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations
2000 StandoutNobel
Physiology meets biophysics: Visualizing the interaction of hypoxia-inducible factor 1α with p300 and CBP
2002 StandoutNobel
Angiopoietin-2 Causes Pericyte Dropout in the Normal Retina
2004
Polymeric system for dual growth factor delivery
2001
Translation of Vascular Endothelial Growth Factor mRNA by Internal Ribosome Entry: Implications for Translation under Hypoxia
1998
Differences in therapeutic indexes of combination metronomic chemotherapy and an anti-VEGFR-2 antibody in multidrug-resistant human breast cancer xenografts.
2002
Rapid Induction of Vascular Endothelial Growth Factor Gene Expression After Transient Middle Cerebral Artery Occlusion in Rats
1997
The Biology of Vascular Endothelial Growth Factor
1997 Standout
Intracerebral tumor-associated hemorrhage caused by overexpression of the vascular endothelial growth factor isoforms VEGF 121 and VEGF 165 but not VEGF 189
1997
Functional mapping of disease susceptibility loci using cell biology
2006 StandoutNobel
Microvascular patterning is controlled by fine-tuning the Akt signal
2004
Protracted low-dose effects on human endothelial cell proliferation and survival in vitro reveal a selective antiangiogenic window for various chemotherapeutic drugs.
2002
Regression of established tumors and metastases by potent vascular endothelial growth factor blockade
2003
The extracellular matrix geneFrem1is essential for the normal adhesion of the embryonic epidermis
2004 StandoutNobel
Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody
1996
Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms
2002
Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors.
1999
Role of PDGF-B and PDGFR-β in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse
1999
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability
2009 StandoutNobel
Increased Vascularization in Mice Overexpressing Angiopoietin-1
1998 Science
Impact of oncogenes in tumor angiogenesis: Mutant K- ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells
1998
Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
2003
Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein.
1996 StandoutNobel
Angiogenesis in Ischemic Disease
1999
Vascular development: cellular and molecular regulation
1997
Signaling mechanisms mediating vascular protective actions of vascular endothelial growth factor
2001
LRP: a new adhesion molecule for endothelial and smooth muscle cells
2001
VEGF Receptor Signal Transduction
2001
Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1α-deficient chimeric mice
2002 StandoutNobel
Vascular endothelial growth factor and vascular adjustments to perturbations in oxygen homeostasis
2001
Cancer Genome Landscapes
2013 StandoutScience
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
1997 StandoutNobel
Functional Upregulation of the Vascular Endothelial Growth Factor Receptor KDR by Hypoxia
1996
Lack of Pericytes Leads to Endothelial Hyperplasia and Abnormal Vascular Morphogenesis
2001
VEGF is required for growth and survival in neonatal mice
1999
Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy
2005 StandoutScience
VEGF165 mediates glomerular endothelial repair
1999
Placental growth factor is a survival factor for tumor endothelial cells and macrophages.
2002
Peptide blockade of HIFα degradation modulates cellular metabolism and angiogenesis
2002 StandoutNobel
Hypoxic retinal Müller cells promote vascular permeability by HIF-1–dependent up-regulation of angiopoietin-like 4
2013 StandoutNobel
ZD4190: an orally active inhibitor of vascular endothelial growth factor signaling with broad-spectrum antitumor efficacy.
2000
Induction of VEGF in perivascular cells defines a potential paracrine mechanism for endothelial cell survival
2001
A role for survivin in chemoresistance of endothelial cells mediated by VEGF
2002
Synergistic effect of HIF-1α gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia
2009 StandoutNobel
Transgenic mice with increased expression of vascular endothelial growth factor in the retina: a new model of intraretinal and subretinal neovascularization.
1997
Regulation of angiogenesis via vascular endothelial growth factor receptors.
2000
Adenoviral transfer of HIF-1α enhances vascular responses to critical limb ischemia in diabetic mice
2009 StandoutNobel
Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: Role of vascular endothelial growth factor
1998
Analysis of Mural Cell Recruitment to Tumor Vessels
2002
Combined inhibition of VEGF‐ and PDGF‐signaling enforces tumor vessel regression by interfering with pericyte‐mediated endothelial cell survival mechanisms
2003
Identification of a Human VPF/VEGF 3′ Untranslated Region Mediating Hypoxia-induced mRNA Stability
1998
Heterogeneity of angiogenesis and blood vessel maturation in human tumors: implications for antiangiogenic tumor therapies.
2000
The splice variants of vascular endothelial growth factor (VEGF) and their receptors
2001
SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors.
2000
Vascular endothelial growth factor (VEGF) and its receptors
1999 Standout
Age-Related Changes in Vascular Endothelial Growth Factor Dependency and Angiopoietin-1-Induced Plasticity of Adult Blood Vessels
2004
Role of the Vascular Endothelial Growth Factor Pathway in Tumor Growth and Angiogenesis
2004 Standout
Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning
2012 StandoutNobel
Insulin-induced vascular endothelial growth factor expression in retina.
1999
Works of Itzhak Hemo being referenced
Directed Differentiation of Human Embryonic Stem Cells into Functional Retinal Pigment Epithelium Cells
2009
Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity
1995 Standout
Survival Mechanisms of VEGF and PlGF during Microvascular Remodeling
2002
A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF
1998 Standout
Upregulated expression of vascular endothelial growth factor in proliferative diabetic retinopathy.
1996
Cryptophthalmos syndrome: Clinical and histopathological findings
1987
Vascular endothelial growth factor upregulation in human central retinal vein occlusion11The authors have no proprietary interest in any of the materials used in this study.
1998
Hypoxia-induced expression of vascular endothelial growth factor by retinal cells is a common factor in neovascularizing ocular diseases.
1995
Retinal Incorporation and Differentiation of Neural Precursors Derived from Human Embryonic Stem Cells
2005