Citation Impact
Citing Papers
A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles
2002 Standout
Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoei
2004 Standout
antiSMASH 6.0: improving cluster detection and comparison capabilities
2021 Standout
Genome sequence of an industrial microorganism Streptomyces avermitilis : Deducing the ability of producing secondary metabolites
2001 StandoutNobel
SPAdes: A New Genome Assembly Algorithm and Its Applications to Single-Cell Sequencing
2012 Standout
Integrated catalysis opens new arylation pathways via regiodivergent enzymatic C–H activation
2016
Evolutionary History of a Specialized P450 Propane Monooxygenase
2008 StandoutNobel
The re-emergence of natural products for drug discovery in the genomics era
2015 Standout
The 1.92-Å Structure of Streptomyces coelicolor A3(2) CYP154C1
2003
Optimizing the heterologous production of epothilone D in Myxococcus xanthus
2002
Isolation of High Molecular Weight DNA from Marine Sponge Bacteria for BAC Library Construction
2009
Multimodular biocatalysts for natural product assembly
2001
Biosynthesis of polyketide synthase extender units
2008
Biosynthesis of Volatiles by the Myxobacterium Myxococcus xanthus
2004
Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA
2014 Standout
Natural products: A continuing source of novel drug leads
2013 Standout
Combinatorial and computational challenges for biocatalyst design
2001 StandoutNatureNobel
Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes
2001
Isolation and characterization of the epothilone biosynthetic gene cluster from Sorangium cellulosum
2000
Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting
2011 Standout
Deciphering regulatory mechanisms for secondary metabolite production in the myxobacterium Sorangium cellulosum So ce56
2007
Computational Enzyme Design
2013 StandoutNobel
Organization of the Biosynthetic Gene Cluster for the Polyketide Antitumor Macrolide, Pladienolide, inStreptomyces platensisMer-11107
2008
Hydroxylation of macrolactones YC-17 and narbomycin is mediated by the pikC-encoded cytochrome P450 in Streptomyces venezuelae
1998
Discovery of microbial natural products by activation of silent biosynthetic gene clusters
2015
ClustScan : an integrated program package for the semi-automatic annotation of modular biosynthetic gene clusters and in silico prediction of novel chemical structures
2008
antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters
2015 Standout
Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases
1995 Nature
Combinatorial biosynthesis of reduced polyketides
2005
Anticancer drugs from nature—natural products as a unique source of new microtubule-stabilizing agents
2007
Cytochrome P450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2)
2003 StandoutNobel
Libraries of hybrid proteins from distantly related sequences
2001 StandoutNobel
Alternative Sigma Factor Over-Expression Enables Heterologous Expression of a Type II Polyketide Biosynthetic Pathway in Escherichia coli
2013
Catalysis, Specificity, and ACP Docking Site of Streptomyces coelicolor Malonyl-CoA:ACP Transacylase
2003
Molecular Insights into the Biosynthesis of Guadinomine: A Type III Secretion System Inhibitor
2012 StandoutNobel
Asymmetric spiroacetalization catalysed by confined Brønsted acids
2012 StandoutNatureNobel
The structural biology of biosynthetic megaenzymes
2015
Engineering an allosteric transcription factor to respond to new ligands
2015 StandoutNobel
A brief tour of myxobacterial secondary metabolism
2008
The biosynthesis, molecular genetics and enzymology of the polyketide-derived metabolites
2005
The Science of Antibiotic Discovery
2020 Standout
Golden Gate Shuffling: A One-Pot DNA Shuffling Method Based on Type IIs Restriction Enzymes
2009
Optimal Determination of Particle Orientation, Absolute Hand, and Contrast Loss in Single-particle Electron Cryomicroscopy
2003 StandoutNobel
Organocatalytic Enantioselective Decarboxylative Aldol Reaction of Malonic Acid Half Thioesters with Aldehydes
2013 StandoutNobel
Metabolic diversity in myxobacteria: identification of the myxalamid and the stigmatellin biosynthetic gene cluster of Stigmatella aurantiaca Sg a15 and a combined polyketide-(poly)peptide gene cluster from the epothilone producing strain Sorangium cellulosum So ce90
1999
Lessons from natural molecules
2004 Nature
Small molecule-dependent genetic selection in stochastic nanodroplets as a means of detecting protein-ligand interactions on a large scale
1997
Protein–Protein Interactions in Multienzyme Megasynthetases
2008
Overexpression of the Nocardia lactamduransα‐Aminoadipyl‐Cysteinyl‐Valine Synthetase in Streptomyces lividans
1996
The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases
1999
Characterization of the Mupirocin Biosynthesis Gene Cluster from Pseudomonas fluorescens NCIMB 10586
2003
Molecular breeding of carotenoid biosynthetic pathways
2000 StandoutNobel
DKxanthene Biosynthesis—Understanding the Basis for Diversity-Oriented Synthesis in Myxobacterial Secondary Metabolism
2008
Biosynthesis of Natural Products on Modular Peptide Synthetases
2001
The Impact of Bacterial Genomics on Natural Product Research
2005
Directed evolution of a magnetic resonance imaging contrast agent for noninvasive imaging of dopamine
2010 StandoutNobel
The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase
2000
A genomics-guided approach for discovering and expressing cryptic metabolic pathways
2003
Novel features in a combined polyketide synthase/non-ribosomal peptide synthetase: the myxalamid biosynthetic gene cluster of the myxobacterium Stigmatella aurantiaca Sga15
2001
Formation of 1,3‐Cyclohexanediones and Resorcinols Catalyzed by a Widely Occuring Ketosynthase
2013
Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways
2008
Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate ‘Streptomyces maritimus’: evidence for the derailment of an aromatic polyketide synthase
2000
Directed enzyme evolution: climbing fitness peaks one amino acid at a time
2009 StandoutNobel
Recent developments in natural product synthesis using metal-catalysed C–H bond functionalisation
2011 Standout
Cytochromes P450 as versatile biocatalysts
2006
Structure and Biosynthesis of the Jamaicamides, New Mixed Polyketide-Peptide Neurotoxins from the Marine Cyanobacterium Lyngbya majuscula
2004
The structure of the cytochrome p450BM-3 haem domain complexed with the fatty acid substrate, palmitoleic acid
1997
The type I fatty acid and polyketide synthases: a tale of two megasynthases
2007
The Crystal Structure of Yeast Fatty Acid Synthase, a Cellular Machine with Eight Active Sites Working Together
2007 StandoutNobel
Reveromycin A biosynthesis uses RevG and RevJ for stereospecific spiroacetal formation
2011
Laboratory evolution of a soluble, self-sufficient, highly active alkane hydroxylase
2002 StandoutNobel
Automated genome mining for natural products
2009
Evolution of protein function by Domain swapping
2001
Engineering the third wave of biocatalysis
2012 StandoutNature
Engineered Alkane‐Hydroxylating Cytochrome P450BM3 Exhibiting Nativelike Catalytic Properties
2007 StandoutNobel
Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806: an integrated peptide–polyketide synthetase system
2000
Harnessing the Biosynthetic Code: Combinations, Permutations, and Mutations
1998 Science
3d Transition Metals for C–H Activation
2018 Standout
Ribosomal Synthesis of N-Methyl Peptides
2008 StandoutNobel
Retro-Diels−Alder Femtosecond Reaction Dynamics
1996 StandoutNobel
Drug Discovery and Natural Products: End of an Era or an Endless Frontier?
2009 StandoutScience
Assembly-Line Enzymology for Polyketide and Nonribosomal Peptide Antibiotics: Logic, Machinery, and Mechanisms
2006
Evolution of polyketide synthases in bacteria
2008
Antitumor Antibiotics: Bleomycin, Enediynes, and Mitomycin
2005 Standout
Substrate Tolerance of Module 6 of the Epothilone Synthetase
2007
Pentalenolactone Biosynthesis. Molecular Cloning and Assignment of Biochemical Function to PtlH, A Non-Heme Iron Dioxygenase of Streptomyces avermitilis
2006 StandoutNobel
Molecular Mechanisms Underlying Nonribosomal Peptide Synthesis: Approaches to New Antibiotics
2005
Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism
2010 StandoutNobel
Development of Halogenase Enzymes for Use in Synthesis
2017
Biosynthetic Pathway and Gene Cluster Analysis of Curacin A, an Antitubulin Natural Product from the Tropical Marine Cyanobacterium Lyngbya majuscula
2004
Unlocking Reactivity of TrpB: A General Biocatalytic Platform for Synthesis of Tryptophan Analogues
2017 StandoutNobel
Biosynthesis of Erythromycin and Rapamycin
1997
Hydroxymalonyl-acyl carrier protein (ACP) and aminomalonyl-ACP are two additional type I polyketide synthase extender units
2006
Biosynthetic Origin of the Antibiotic Pseudopyronines A and B in Pseudomonas putida BW11M1
2015
Natural product drug discovery in the genomic era: realities, conjectures, misconceptions, and opportunities
2018
Forty years of genetics with Streptomyces: from in vivo through in vitro to in silico
1999
Identification of Mechanism-Based Inactivation in P450-Catalyzed Cyclopropanation Facilitates Engineering of Improved Enzymes
2016 StandoutNobel
Combinatorial biosynthesis: Lesson learned from nature
1998
Pentalenolactone Biosynthesis. Molecular Cloning and Assignment of Biochemical Function to PtlI, a Cytochrome P450 of Streptomyces avermitilis
2006 StandoutNobel
Impact of Natural Products on Developing New Anti-Cancer Agents
2009 Standout
A Gene Cluster for Biosynthesis of the Sesquiterpenoid Antibiotic Pentalenolactone inStreptomyces avermitilis
2006 StandoutNobel
A multifunctional polyketide–peptide synthetase essential for albicidin biosynthesis in Xanthomonas albilineans The GenBank accession number for the sequence determined in this work is AF239749.
2001
Identification and Characterization of a Gene Cluster for Synthesis of the Polyketide Antibiotic 2,4-Diacetylphloroglucinol fromPseudomonas fluorescensQ2-87
1999
Modular Construction of a Functional Artificial Epothilone Polyketide Pathway
2012
Expression and isolation of antimicrobial small molecules from soil DNA libraries.
2001
Swinging Arms and Swinging Domains in Multifunctional Enzymes: Catalytic Machines for Multistep Reactions
2000
Involvement of a Cytochrome P450 Monooxygenase in Thaxtomin A Biosynthesis by Streptomyces acidiscabies
2002
Systems biology of cyanobacterial secondary metabolite production and its role in drug discovery
2008
Organocatalytic α‐Addition of Isocyanides to Aldehydes
2014 StandoutNobel
Protacs: Chimeric molecules that target proteins to the Skp1–Cullin–F box complex for ubiquitination and degradation
2001 Standout
Arac/XylS family of transcriptional regulators
1997
Mechanism of Oxidation Reactions Catalyzed by Cytochrome P450 Enzymes
2004 Standout
Natural Product Biosynthesis: A New Interface between Enzymology and Medicine
2000
Engineering of modular polyketide synthases to produce novel polyketides
1998
A C 35 Carotenoid Biosynthetic Pathway
2003 StandoutNobel
Enzymatic Halogenation and Dehalogenation Reactions: Pervasive and Mechanistically Diverse
2017
Terpene synthases are widely distributed in bacteria
2014 StandoutNobel
Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis
1999
Application of Designed Enzymes in Organic Synthesis
2011
antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline
2019 Standout
Structural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450
2015 StandoutNobel
Works of István Molnár being referenced
Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: Analysis of the enzymatic domains in the modular polyketide synthase
1996
Fungal cyclooligomerdepsipeptides: From classical biochemistry to combinatorial biosynthesis
2010
The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90
2000
Characterization of the biosynthetic gene cluster for the antifungal polyketide soraphen A from Sorangium cellulosum So ce26
2002
Functional Characterization of the Biosynthesis of Radicicol, an Hsp90 Inhibitor Resorcylic Acid Lactone from Chaetomium chiversii
2008
Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: Analysis of genes flanking the polyketide synthase
1996
Divergent sequence motifs correlated with the substrate specificity of (methyl)malonyl‐CoA:acyl carrier protein transacylase domains in modular polyketide synthases
1995
The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin.
1995
nucleotide sequence analysis of a region upstream of the cholesterol oxidase-cytochrome p450 operon of streptomyces sp. SA-COO revealing repeating units coding for putative transmembrane and DNA-binding proteins
1993
Biocatalytic conversion of avermectin into 4″-oxo-avermectin: discovery, characterization, heterologous expression and specificity improvement of the cytochrome P450 enzyme
2006
2,5-Dialkylresorcinol Biosynthesis in Pseudomonas aurantiaca : Novel Head-to-Head Condensation of Two Fatty Acid-Derived Precursors
2003
Biocatalytic Conversion of Avermectin to 4″-Oxo-Avermectin: Improvement of Cytochrome P450 Monooxygenase Specificity by Directed Evolution
2007
Heterologous production of the antifungal polyketide antibiotic soraphen A of Sorangium cellulosum So ce26 in Streptomyces lividans
2004