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Citing Papers
A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche
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2009
Foxo3 Is Essential for the Regulation of Ataxia Telangiectasia Mutated and Oxidative Stress-mediated Homeostasis of Hematopoietic Stem Cells
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Foxo3 is required for the regulation of oxidative stress in erythropoiesis
2007
High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome
2013 StandoutNatureNobel
Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
1995 Nature
Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche
2011 StandoutNobel
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
2007 Nature
Signal Transduction by Mitochondrial Oxidants
2011
Identification and characterization of stem cells in prepubertal spermatogenesis in mice☆☆Supplementary data associated with this article can be found at doi:10.1016/S0012-1606(03)00111-8.
2003
Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo.
1994
Modulation of oxidative stress as an anticancer strategy
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Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
1995 StandoutNature
Vascularization of the mouse embryo: A study of flk‐1, tek, tie, and vascular endothelial growth factor expression during development
1995
Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning
1996 Standout
mTOR Activation Induces Tumor Suppressors that Inhibit Leukemogenesis and Deplete Hematopoietic Stem Cells after Pten Deletion
2010
Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells
1998
Tie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche
2004 Standout
DNA Repair, Genome Stability, and Aging
2005
Lentiviral Transduction of Human Postnatal Skeletal (Stromal, Mesenchymal) Stem Cells: In Vivo Transplantation and Gene Silencing
2006
ROS Function in Redox Signaling and Oxidative Stress
2014 Standout
Apoptotic mechanisms in the control of erythropoiesis
2004
Mitochondria: In Sickness and in Health
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How stem cells age and why this makes us grow old
2007
DNA-Damage Response in Tissue-Specific and Cancer Stem Cells
2011
Redox Regulation by Keap1 and Nrf2 Controls Intestinal Stem Cell Proliferation in Drosophila
2011
FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress
2007
Regulation of reactive oxygen species in stem cells and cancer stem cells
2011
Acquisition of G0 state by CD34-positive cord blood cells after bone marrow transplantation
2010
Chapter 1 Physiological Roles of Ribosomal Protein S6: One of Its Kind
2008
Redox regulation of stem/progenitor cells and bone marrow niche
2012
Bmi1 regulates mitochondrial function and the DNA damage response pathway
2009 Nature
Polycomb Group Proteins: Multi-Faceted Regulators of Somatic Stem Cells and Cancer
2010
Stems Cells and the Pathways to Aging and Cancer
2008
Human occludin is a hepatitis C virus entry factor required for infection of mouse cells
2009 StandoutNatureNobel
The common biology of cancer and ageing
2007 Nature
Enhanced Activation of Memory, but Not Naïve, B Cells in Chronic Hepatitis C Virus-Infected Patients with Cryoglobulinemia and Advanced Liver Fibrosis
2013 StandoutNobel
Reducing Mitochondrial ROS Improves Disease-related Pathology in a Mouse Model of Ataxia-telangiectasia
2012
Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
1995 StandoutNature
Vascular-specific growth factors and blood vessel formation
2000 StandoutNature
A Requirement for Flk1 in Primitive and Definitive Hematopoiesis and Vasculogenesis
1997
ROS Are Required for Mouse Spermatogonial Stem Cell Self-Renewal
2013
Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis
1996 Standout
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
2006
FoxOs Cooperatively Regulate Diverse Pathways Governing Neural Stem Cell Homeostasis
2009
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
MicroRNA expression profiles classify human cancers
2005 StandoutNatureNobel
Transmembrane proteins of tight junctions
2007
The ATM–BID pathway regulates quiescence and survival of haematopoietic stem cells
2012
The Hallmarks of Aging
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The AID Dilemma
2012 StandoutNobel
Tumor suppressor genes and ROS: complex networks of interactions
2011
Protein-based human iPS cells efficiently generate functional dopamine neurons and can treat a rat model of Parkinson disease
2011
Cellular mechanisms and physiological consequences of redox-dependent signalling
2014 Standout
Piezo2 senses airway stretch and mediates lung inflation-induced apnoea
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Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system
2009
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
2009 Standout
Mdm2 Is Required for Survival of Hematopoietic Stem Cells/Progenitors via Dampening of ROS-Induced p53 Activity
2010
Tie2-Cre Transgenic Mice: A New Model for Endothelial Cell-Lineage Analysis in Vivo
2001 Standout
Increased CD13 Expression Reduces Reactive Oxygen Species, Promoting Survival of Liver Cancer Stem Cells via an Epithelial–Mesenchymal Transition-like Phenomenon
2011
Stem Cell Defects in ATM-Deficient Undifferentiated Spermatogonia through DNA Damage-Induced Cell-Cycle Arrest
2008
Mechanisms that Regulate Stem Cell Aging and Life Span
2013
Reactive Oxygen Species in Cancer Stem Cells
2012
Redox Regulation and Its Emerging Roles in Stem Cells and Stem-Like Cancer Cells
2008
Regulation of Reactive Oxygen Species and Genomic Stability in Hematopoietic Stem Cells
2008
Oxidative Stress Regulation of Stem and Progenitor Cells
2009
Novel Role of NADPH Oxidase in Angiogenesis and Stem/Progenitor Cell Function
2009
Oxidative Stress in the Regulation of Normal and Neoplastic Hematopoiesis
2008
Carboxy-terminal domain of AID required for its mRNA complex formation in vivo
2009 StandoutNobel
Isolation of Putative Progenitor Endothelial Cells for Angiogenesis
1997 StandoutScience
Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family
2008
The Tie receptor tyrosine kinase is expressed by human hematopoietic progenitor cells and by a subset of megakaryocytic cells
1996
Predominant expression of a receptor tyrosine kinase, TIE, in hematopoietic stem cells and B cells
1996
Vascular Endothelial Growth Factor and Angiopoietin-1 Stimulate Postnatal Hematopoiesis by Recruitment of Vasculogenic and Hematopoietic Stem Cells
2001
Vascular endothelial cell lineage-specific promoter in transgenic mice
1995
Endothelial receptor tyrosine kinases involved in angiogenesis.
1995
Tracing the first waves of lymphopoiesis in mice
2006
Telomere length is paternally inherited and is associated with parental lifespan
2007 StandoutNobel
ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair
2010
Foxo3a is essential for maintenance of the hematopoietic stem cell pool
2009
Evidence for Circulating Bone Marrow-Derived Endothelial Cells
1998 Standout
Telomerase reverse transcriptase protects ATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere-independent mechanism
2011
Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene
2001 StandoutNobel
Conditional Vascular Cell Adhesion Molecule 1 Deletion in Mice
2001
Signal transduction by reactive oxygen species
2011 Standout
Vessel Cooption, Regression, and Growth in Tumors Mediated by Angiopoietins and VEGF
1999 StandoutScience
AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination
2009 StandoutNobel
Somatic Progenitor Cell Vulnerability to Mitochondrial DNA Mutagenesis Underlies Progeroid Phenotypes in Polg Mutator Mice
2012
Human RPS19, the gene mutated in Diamond-Blackfan anemia, encodes a ribosomal protein required for the maturation of 40S ribosomal subunits
2006
The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination
2009 StandoutNobel
Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair
2011
Hematopoietic stem cells express Tie-2 receptor in the murine fetal liver
2000
Triomics Analysis of Imatinib-Treated Myeloma Cells Connects Kinase Inhibition to RNA Processing and Decreased Lipid Biosynthesis
2015
ESOP-1, a secreted protein expressed in the hematopoietic, nervous, and reproductive systems of embryonic and adult mice
2000 StandoutNobel
TSC–mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
2008
Pharmacologic stabilization of HIF-1α increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation
2012
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling
2007 StandoutNobel
Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation
2018 StandoutNobel
The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells.
1995
Tie2 Expression and Phosphorylation in Angiogenic and Quiescent Adult Tissues
1997
Ribosomopathies: human disorders of ribosome dysfunction
2010
Peptide blockade of HIFα degradation modulates cellular metabolism and angiogenesis
2002 StandoutNobel
Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth
2014 StandoutNobel
Hypoxic retinal Müller cells promote vascular permeability by HIF-1–dependent up-regulation of angiopoietin-like 4
2013 StandoutNobel
Grafted human-induced pluripotent stem-cell–derived neurospheres promote motor functional recovery after spinal cord injury in mice
2011 StandoutNobel
RNA editing of hepatitis B virus transcripts by activation-induced cytidine deaminase
2013 StandoutNobel
Mechanism and Regulation of Class Switch Recombination
2008
Enhanced expression of the tie receptor tyrosine kinase mesenger RNA in the vascular endothelium of metastatic melanomas.
1994
Cell autonomous functions of the receptor tyrosine kinase TIE in a late phase of angiogenic capillary growth and endothelial cell survival during murine development
1996
Requirement for the TIE family of receptor tyrosine kinases in adult but not fetal hematopoiesis
2003
Hematopoietic stem cells express Tie-2 receptor in the murine fetal liver
2000
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
An RNA interference model of RPS19 deficiency in Diamond-Blackfan anemia recapitulates defective hematopoiesis and rescue by dexamethasone: identification of dexamethasone-responsive genes by microarray
2005
Mesenchymal Stem Cells in Perichondrium Express Activated Leukocyte Cell Adhesion Molecule and Participate in Bone Marrow Formation
2002
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination
2014 StandoutNobel
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
2008 StandoutNobel
Signaling and Functions of Angiopoietin-1 in Vascular Protection
2006
Top-down design of protein architectures with reinforcement learning
2023 StandoutScienceNobel
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Predominant expression of a receptor tyrosine kinase, TIE, in hematopoietic stem cells and B cells
1996
Functional requirements of AID’s higher order structures and their interaction with RNA-binding proteins
2016 StandoutNobel
Stem Cells and Their Niches
2006 Science
Heme oxygenase-1 deficiency leads to disrupted response to acute stress in stem cells and progenitors
2008
Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning
2012 StandoutNobel
Works of Isao Hamaguchi being referenced
Possible Recruitment of Peripheral Blood CXCR3 + CD27 + CD19 + B Cells to the Liver of Chronic Hepatitis C Patients
2010
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
2004 Nature
Critical Role of the TIE2 Endothelial Cell Receptor in the Development of Definitive Hematopoiesis
1998
Molecular Cloning and Characterization of Mouse TIE and TEK Receptor Tyrosine Kinase Genes and Their Expression in Hematopoietic Stem Cells
1993
Gene transfer improves erythroid development in ribosomal protein S19–deficient Diamond-Blackfan anemia
2002
Ribosomal Protein S19 Deficiency Leads to Reduced Proliferation and Increased Apoptosis but Does Not Affect Terminal Erythroid Differentiation in a Cell Line Model of Diamond-Blackfan Anemia
2007
Identification of cancer stem cells in a Tax-transgenic (Tax-Tg) mouse model of adult T-cell leukemia/lymphoma
2009
A CTX Family Cell Adhesion Molecule, JAM4, Is Expressed in Stem Cell and Progenitor Cell Populations of both Male Germ Cell and Hematopoietic Cell Lineages
2006
In Vitro Hematopoietic and Endothelial Cell Development From Cells Expressing TEK Receptor in Murine Aorta-Gonad-Mesonephros Region
1999
Lentivirus Vector Gene Expression during ES Cell-Derived Hematopoietic Development In Vitro
2000
Targeted Disruption of the Ribosomal Protein S19 Gene Is Lethal Prior to Implantation
2004
In Vitro Hematopoietic and Endothelial Cell Development From Cells Expressing TEK Receptor in Murine Aorta-Gonad-Mesonephros Region
1999
HMGA1a is involved in specific splice site regulation of human immunodeficiency virus type 1
2011
Proliferation deficiency of multipotent hematopoietic progenitors in ribosomal protein S19 (RPS19)-deficient diamond–Blackfan anemia improves following RPS19 gene transfer
2003