Citation Impact
Citing Papers
Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: Assessment of an oral agent that stimulates erythropoietin production
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The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
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Interaction of the Grb10 Adapter Protein with the Raf1 and MEK1 Kinases
1998
Signal Transduction Pathways Regulated by Mitogen-activated/Extracellular Response Kinase Kinase Kinase Induce Cell Death
1996
MST/MLK2, a Member of the Mixed Lineage Kinase Family, Directly Phosphorylates and Activates SEK1, an Activator of c-Jun N-terminal Kinase/Stress-activated Protein Kinase
1997
The c-Jun N-Terminal Kinase Cascade Plays a Role in Stress-Induced Apoptosis in Jurkat Cells by Up-Regulating Fas Ligand Expression
1998
LOK Is a Novel Mouse STE20-like Protein Kinase That Is Expressed Predominantly in Lymphocytes
1997
Activation of Store-Operated Ca2+ Current in Xenopus Oocytes Requires SNAP-25 but Not a Diffusible Messenger
1999 StandoutNobel
From molecular to modular cell biology
1999 StandoutNatureNobel
Characterization of the Structure and Function of a New Mitogen-activated Protein Kinase (p38β)
1996
3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase
1997
Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1
1998
Cloning and Characterization of a Human STE20-like Protein Kinase with Unusual Cofactor Requirements
1997
Cyclin D1 suppresses retinoblastoma protein-mediated inhibition of TAFII250 kinase activity
2000 StandoutNobel
Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway
1996
Molecular Cloning and Characterization of a Novel p38 Mitogen-activated Protein Kinase
1997
Activation of the Hematopoietic Progenitor Kinase-1 (HPK1)-dependent, Stress-activated c-Jun N-terminal Kinase (JNK) Pathway by Transforming Growth Factor β (TGF-β)-activated Kinase (TAK1), a Kinase Mediator of TGF β Signal Transduction
1997
Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis
1997 Nobel
Molecular Cloning and Characterization of aDrosophila p38 Mitogen-activated Protein Kinase
1998
Evidence for Multiple Activators for Stress-activated Protein Kinases/c-Jun Amino-terminal Kinases.
1995
Activation of ternary complex factor Elk-1 by stress-activated protein kinases
1995
Identification of Two Essential Phosphorylated Threonine Residues In the Catalytic Domain of Mekk1
1997
MKK7 Is A Stress-activated Mitogen-activated Protein Kinase Kinase Functionally Related to hemipterous
1997
Activation of the Ste20-like Oxidant Stress Response Kinase-1 during the Initial Stages of Chemical Anoxia-induced Necrotic Cell Death
1997
Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3
1997 Nature
Components of a New Human Protein Kinase Signal Transduction Pathway
1995
Regulation of transcription by MAP kinase cascades
1996
Activation of the IκBα Kinase Complex by MEKK1, a Kinase of the JNK Pathway
1997
Direct Activation of the Stress-activated Protein Kinase (SAPK) and Extracellular Signal-regulated Protein Kinase (ERK) Pathways by an Inducible Mitogen-activated Protein Kinase/ERK Kinase Kinase 3 (MEKK) Derivative
1997
Role of the stress-activated protein kinases in endothelin-induced cardiomyocyte hypertrophy.
1998
Oxidative stress and gene regulation
2000
Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
1995 Standout
Sounding the Alarm: Protein Kinase Cascades Activated by Stress and Inflammation
1996
The Mixed Lineage Kinase SPRK Phosphorylates and Activates the Stress-activated Protein Kinase Activator, SEK-1
1996
Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38)
1997
Tumor Necrosis Factor Signaling to Stress-activated Protein Kinase (SAPK)/Jun NH2-terminal Kinase (JNK) and p38
1998
Differential Regulation of Mitogen-activated Protein Kinase Kinase 4 (MKK4) and 7 (MKK7) by Signaling from G Protein βγ Subunit in Human Embryonal Kidney 293 Cells
1999
Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
1997 Nature
MEKKs, GCKs, MLKs, PAKs, TAKs, and Tpls: upstream regulators of the c-Jun amino-terminal kinases?
1997
Role of MEKK1 in Cell Survival and Activation of JNK and ERK Pathways Defined by Targeted Gene Disruption
1998
Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways
1996
A novel Jun N‐terminal kinase (JNK)‐binding protein that enhances the activation of JNK by MEK kinase 1 and TGF‐β‐activated kinase 1
1999
SH2/SH3 Adaptor Proteins Can Link Tyrosine Kinases to a Ste20-related Protein Kinase, HPK1
1997
Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses
2012 StandoutNobel
SAP kinase‐3, a new member of the family of mammalian stress‐activated protein kinases
1996
Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development
1998
Regulation of cardiac hypertrophy in vivo by the stress-activated protein kinases/c-Jun NH2-terminal kinases
1999
MEKK1 Binds Directly to the c-Jun N-terminal Kinases/Stress-activated Protein Kinases
1997
Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases
1997
Synergistic activation of SAPK1/JNK1 by two MAP kinase kinases in vitro
1998
TNIK, a Novel Member of the Germinal Center Kinase Family That Activates the c-Jun N-terminal Kinase Pathway and Regulates the Cytoskeleton
1999
MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates
1997
The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway
1995 Standout
Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1)
1999
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα
1997 Standout
Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2
1999
PSK, a Novel STE20-like Kinase Derived from Prostatic Carcinoma That Activates the c-Jun N-terminal Kinase Mitogen-activated Protein Kinase Pathway and Regulates Actin Cytoskeletal Organization
2000
Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine
1995 Standout
Regulation and function of the JNK subgroup of MAP kinases
1997
Nrk: a murine X-linked NIK (Nck-interacting kinase)-related kinase gene expressed in skeletal muscle
1999
How MAP Kinases Are Regulated
1995 Standout
Visualizing the mechanical activation of Src
2005 StandoutNatureNobel
A Novel Human STE20-related Protein Kinase, HGK, That Specifically Activates the c-Jun N-terminal Kinase Signaling Pathway
1999
JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension
1998
T Cell Proliferation in Response to Interleukins 2 and 7 Requires p38MAP Kinase Activation
1997
Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
1996 StandoutNature
Protein kinase cascades activated by stress and inflammatory cytokines
1996
Identification of c-Jun NH2-terminal Protein Kinase (JNK)-activating Kinase 2 as an Activator of JNK but Not p38
1997
Dual Leucine Zipper-bearing Kinase (DLK) Activates p46SAPK and p38 but Not ERK2
1996
Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation
1995
Cellular Stresses and Cytokines Activate Multiple Mitogen‐Activated‐Protein Kinase Kinase Homologues in PC12 and KB Cells
1996
NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain
1997
Actin-biding Protein-280 Binds the Stress-activated Protein Kinase (SAPK) Activator SEK-1 and Is Required for Tumor Necrosis Factor-α Activation of SAPK in Melanoma Cells
1997
von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF
2001
MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42
1997
Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms
1995 Science
The Ste20-like Protein Kinase, Mst1, Dimerizes and Contains an Inhibitory Domain
1996
A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways
1997
The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases
1995 Standout
Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN
1998 StandoutNobel
Differential Activation of Two JNK Activators, MKK7 and SEK1, by MKN28-derived Nonreceptor Serine/Threonine Kinase/Mixed Lineage Kinase 2
1998
Activation of p38 Mitogen-activated Protein Kinase by c-Abl-dependent and -independent Mechanisms
1996
Extracellular Signal-Regulated Kinase and c-Jun NH2-Terminal Kinase Activities Are Continuously and Differentially Increased in Aorta of Hypertensive Rats
1997 StandoutNobel
Rho GTPases and signaling networks
1997 Standout
MEK Kinase 3 Directly Activates MKK6 and MKK7, Specific Activators of the p38 and c-Jun NH2-terminal Kinases
1999
Human Mitogen-activated Protein Kinase Kinase 7 (MKK7) Is a Highly Conserved c-Jun N-terminal Kinase/Stress-activated Protein Kinase (JNK/SAPK) Activated by Environmental Stresses and Physiological Stimuli
1998
Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast
1995
Direct Interaction between Ras and the Kinase Domain of Mitogen-activated Protein Kinase Kinase Kinase (MEKK1)
1995
Induction of Apoptosis by DPC4, a Transcriptional Factor Regulated by Transforming Growth Factor-β through Stress-activated Protein Kinase/c-Jun N-terminal Kinase (SAPK/JNK) Signaling Pathway
1997
Regulation and Interaction of pp90 Isoforms with Mitogen-activated Protein Kinases
1996
SEK1/MKK4 Is Required for Maintenance of a Normal Peripheral Lymphoid Compartment but Not for Lymphocyte Development
1998
Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1
1995
A Novel Kinase Cascade Mediated by Mitogen-activated Protein Kinase Kinase 6 and MKK3
1996
Dynamics and organization of MAP kinase signal pathways
1995
Cloning of mammalian Ire1 reveals diversity in the ER stress responses
1998
Concentration-dependent positive and negative regulation of a MAP kinase by a MAP kinase kinase
1999
Tumor necrosis factor alpha -induced activation of c-jun N-terminal kinase is mediated by TRAF2
1997
Synapse-Specific, Long-Term Facilitation of Aplysia Sensory to Motor Synapses: A Function for Local Protein Synthesis in Memory Storage
1997 StandoutNobel
Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activationofCREB
1998
An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior
2005 StandoutNobel
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
Signaling from the Small GTP-binding Proteins Rac1 and Cdc42 to the c-Jun N-terminal Kinase/Stress-activated Protein Kinase Pathway
1996
Cdc42Hs, but Not Rac1, Inhibits Serum-stimulated Cell Cycle Progression at G1/S through a Mechanism Requiring p38/RK
1997
Conditional Expression of the Mitogen-activated Protein Kinase (MAPK) Phosphatase MKP-1 Preferentially Inhibits p38 MAPK and Stress-activated Protein Kinase in U937 Cells
1997
Ischemia and Reperfusion Enhance ATF-2 and c-Jun Binding to cAMP Response Elements and to an AP-1 Binding Site from the c-jun Promoter
1995
Interaction between c-Rel and the Mitogen-activated Protein Kinase Kinase Kinase 1 Signaling Cascade in Mediating B Enhancer Activation
1996
Caspase-dependent Cleavage of Signaling Proteins during Apoptosis
1998
JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development
1999
Molecular Cloning, Functional Expression in Escherichia coli, and Characterization of Multiple Mitogen‐Activated‐Protein Kinases from Tobacco
1995
A novel SAPK/JNK kinase, MKK7, stimulated by TNFalpha and cellular stresses
1997
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex
2004 StandoutNatureNobel
Signaling by the Germinal Center Kinase Family of Protein Kinases
1999
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
MEKK1 interacts with ?-actinin and localizes to stress fibers and focal adhesions
1999
CED-1 Is a Transmembrane Receptor that Mediates Cell Corpse Engulfment in C. elegans
2001 StandoutNobel
The Evolution of the MAP Kinase Pathways: Coduplication of Interacting Proteins Leads to New Signaling Cascades
1999
Human JIK, a Novel Member of the STE20 Kinase Family That Inhibits JNK and Is Negatively Regulated by Epidermal Growth Factor
1999
Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2
1997
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
2002 StandoutNobel
A role for JNK/SAPK in proliferation, but not apoptosis, of IL-3-dependent cells
1997
The Retinoblastoma Binding Protein RBP2 Is an H3K4 Demethylase
2007 StandoutNobel
Cloning of a Novel Mitogen-activated Protein Kinase Kinase Kinase, MEKK4, That Selectively Regulates the c-Jun Amino Terminal Kinase Pathway
1997
WRM-1 Activates the LIT-1 Protein Kinase to Transduce Anterior/Posterior Polarity Signals in C. elegans
1999 StandoutNobel
The Drosophila Ste20-related kinase misshapen is required for embryonic dorsal closure and acts through a JNK MAPK module on an evolutionarily conserved signaling pathway
1998
The Small GTP-binding Protein Rho Activates c-Jun N-terminal Kinases/Stress-activated Protein Kinases in Human Kidney 293T Cells
1996
Hypertrophic Agonists Stimulate the Activities of the Protein Kinases c-Raf and A-Raf in Cultured Ventricular Myocytes
1995
The stress-activated protein kinase pathways
1999
Isolation of MEK5 and Differential Expression of Alternatively Spliced Forms
1995
3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro
1998
The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat
1996
Regulation of Interleukin-2 Transcription by Inducible Stable Expression of Dominant Negative and Dominant Active Mitogen-activated Protein Kinase Kinase Kinase in Jurkat T Cells
1996
Isolation of TAO1, a Protein Kinase That Activates MEKs in Stress-activated Protein Kinase Cascades
1998
A new Rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappa B signalling pathways
1998
ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK
1999
Characterization of the Structure and Function of a Novel MAP Kinase Kinase (MKK6)
1996
Intramolecular Masking of Nuclear Import Signal on NF-AT4 by Casein Kinase I and MEKK1
1998
Purification and Identification of a Major Activator for p38 from Osmotically Shocked Cells
1996
T Lymphocyte Activation Signals for Interleukin-2 Production Involve Activation of MKK6-p38 and MKK7-SAPK/JNK Signaling Pathways Sensitive to Cyclosporin A
1998
Activation of Stress-activated Protein Kinases/c-Jun N-terminal Protein Kinases (SAPKs/JNKs) by a Novel Mitogen-activated Protein Kinase Kinase (MKK7)
1997
The Seven-transmembrane-spanning Receptors for Endothelin and Thrombin Cause Proliferation of Airway Smooth Muscle Cells and Activation of the Extracellular Regulated Kinase and c-Jun NH2-terminal Kinase Groups of Mitogen-activated Protein Kinases
1996
Transforming growth factor-β in acute renal failure: receptor expression, effects on proliferation, cellularity, and vascularization after recovery from injury
2004
Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1
1994 Nature
Induction of Mitogen-activated Protein Kinase Phosphatase 1 by the Stress-activated Protein Kinase Signaling Pathway but Not by Extracellular Signal-regulated Kinase in Fibroblasts
1996
A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila.
1996
Protein Synthesis Inhibitors Reveal Differential Regulation of Mitogen-Activated Protein Kinase and Stress-Activated Protein Kinase Pathways That Converge on Elk-1
1995
Mitogen-activated Protein Kinase Phosphatases Inactivate Stress-activated Protein Kinase Pathways in Vivo
1997
Mechanism-Based Profiling of Enzyme Families
2006
Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice
2002 StandoutNobel
The JNK Pathway Regulates the In Vivo Deletion of Immature CD4+CD8+ Thymocytes
1998
Integrin function: molecular hierarchies of cytoskeletal and signaling molecules.
1995
The Stress Kinase Mitogen-Activated Protein Kinase Kinase (Mkk)7 Is a Negative Regulator of Antigen Receptor and Growth Factor Receptor–Induced Proliferation in Hematopoietic Cells
2001 StandoutNobel
rac1 Regulates a Cytokine-Stimulated, Redox-Dependent Pathway Necessary for NF-κB Activation
1996
Molecular Cloning and Characterization of Human JNKK2, a Novel Jun NH2-Terminal Kinase-Specific Kinase
1997
Selective interaction of JNK protein kinase isoforms with transcription factors.
1996
TNF-Mediated Activation of the Stress-Activated Protein Kinase Pathway: TNF Receptor-Associated Factor 2 Recruits and Activates Germinal Center Kinase Related
1999
Age-related Decline in Mitogen-activated Protein Kinase Activity in Epidermal Growth Factor-stimulated Rat Hepatocytes
1996
Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress- and cytokine-stimulated monocytes and epithelial cells.
1996
3pK, a Novel Mitogen-Activated Protein (MAP) Kinase-Activated Protein Kinase, Is Targeted by Three MAP Kinase Pathways
1996
Functional analysis of the interaction between the small GTP binding protein Cdc42 and the Ste20 protein kinase in yeast.
1996
Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH 2 -terminal kinase
1997
Preferential activation of the p46 isoform of JNK/SAPK in mouse macrophages by TNFα
1997
Impaired TCR-Mediated Apoptosis and Bcl-XL Expression in T Cells Lacking the Stress Kinase Activator SEK1/MKK4
1998
Tumor Necrosis Factor ä-Induced E-selectin Expression Is Activated by the Nuclear Factor-κB and c-JUN N-terminal Kinase/p38 Mitogen-activated Protein Kinase Pathways
1997
Role of transforming growth factor-α in von Hippel– Lindau (VHL) −/− clear cell renal carcinoma cell proliferation: A possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis
2001
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
1995 StandoutScience
DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells
2000 StandoutNobel
Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2
1995 Science
A Conserved p38 Mitogen-Activated Protein Kinase Pathway Regulates Drosophila Immunity Gene Expression
1998
Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4
1999
An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G 1
1995 Science
A Proline-Rich Sequence Unique to MEK1 and MEK2 Is Required for Raf Binding and Regulates MEK Function
1995
Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*
2001 Standout
FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2.
1996
Integration of MAP Kinase Signal Transduction Pathways at the Serum Response Element
1995 Science
von Hippel-Lindau Disease
2006 StandoutNobel
Ribotoxic Stress Response: Activation of the Stress-Activated Protein Kinase JNK1 by Inhibitors of the Peptidyl Transferase Reaction and by Sequence-Specific RNA Damage to the α-Sarcin/Ricin Loop in the 28S rRNA
1997
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
2002 StandoutNobel
Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer
2005 Standout
HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway.
1996
Activation of Apoptosis Signal-Regulating Kinase 1 (ASK1) by the Adapter Protein Daxx
1998 ScienceNobel
Stress-Activated Protein Kinases in Cardiovascular Disease
1996
β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3
2000 StandoutScienceNobel
Lack of a Role for Jun Kinase and AP-1 in Fas-Induced Apoptosis
1997
Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1
2000 StandoutScience
Kinase requirements in human cells: III. Altered kinase requirements inVHL−/− cancer cells detected in a pilot synthetic lethal screen
2008 StandoutNobel
Interleukin-6-induced STAT3 transactivation and Ser727 phosphorylation involves Vav, Rac-1 and the kinase SEK-1/MKK-4 as signal transduction components
2000
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability
2009 StandoutNobel
The von Hippel-Lindau Tumor Suppressor Gene
2020
Jun N-Terminal Kinase/Stress-Activated Protein Kinase (JNK/SAPK) Is Required for Lipopolysaccharide Stimulation of Tumor Necrosis Factor Alpha (TNF-α) Translation: Glucocorticoids Inhibit TNF-α Translation by Blocking JNK/SAPK
1997
Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation.
1995
JSAP1, a Novel Jun N-Terminal Protein Kinase (JNK)-Binding Protein That Functions as a Scaffold Factor in the JNK Signaling Pathway
1999
pVHL 19 is a biologically active product of the von Hippel–Lindau gene arising from internal translation initiation
1998 StandoutNobel
Emerging from the Pak: the p21-activated protein kinase family
1997
VHL-mediated hypoxia regulation of cyclin D1 in renal carcinoma cells.
2002
CYCLIN-DEPENDENT KINASES: Engines, Clocks, and Microprocessors
1997 Standout
Regulation of the activity of MEK kinase 1 (MEKK1) by autophosphorylation within the kinase activation domain
1997
Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH 2 -terminal kinase activation, and defects in AP-1 transcriptional activity
1997
The MKK7 Gene Encodes a Group of c-Jun NH2-Terminal Kinase Kinases
1999
Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
2000 StandoutScienceNobel
Transforming growth factor alpha is a target for the von Hippel-Lindau tumor suppressor.
1998
Embryonic morphogenesis signaling pathway mediated by JNK targets the transcription factor JUN and the TGF-β homologuedecapentaplegic
1997
Cross-linking CD40 on B cells preferentially induces stress-activated protein kinases rather than mitogen-activated protein kinases.
1996
Expression of Constitutively Active α-PAK Reveals Effects of the Kinase on Actin and Focal Complexes
1997
Protein-Damaging Stresses Activate c-Jun N-Terminal Kinase via Inhibition of Its Dephosphorylation: a Novel Pathway Controlled by HSP72
1999
Ultraviolet Light and Osmotic Stress: Activation of the JNK Cascade Through Multiple Growth Factor and Cytokine Receptors
1996 Science
Multiple Signaling Pathways for the Activation of JNK in Mast Cells: Involvement of Bruton’s Tyrosine Kinase, Protein Kinase C, and JNK Kinases, SEK1 and MKK7
1998
Repeated pulses of serotonin required for long-term facilitation activate mitogen-activated protein kinase in sensory neurons of Aplysia
1998 StandoutNobel
Selective response of ternary complex factor Sap1a to different mitogen-activated protein kinase subgroups.
1996
Angiotensin II Stimulates Calcium-Dependent Activation of c-Jun N-Terminal Kinase
1995
Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human
1999 Standout
Identification of MAP Kinase Domains by Redirecting Stress Signals into Growth Factor Responses
1996 Science
MATURE T LYMPHOCYTE APOPTOSIS—Immune Regulation in a Dynamic and Unpredictable Antigenic Environment
1999
Fission yeast orb 6, a ser/thr protein kinase related to mammalian rho kinase and myotonic dystrophy kinase, is required for maintenance of cell polarity and coordinates cell morphogenesis with the cell cycle
1998 StandoutNobel
Insulin signal transduction through protein kinase cascades
1998
A Drosophila Homolog of the Rac- and Cdc42-Activated Serine/Threonine Kinase PAK Is a Potential Focal Adhesion and Focal Complex Protein That Colocalizes with Dynamic Actin Structures
1996
Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction
1995 Science
Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury
2007 StandoutNobel
MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration
2000
MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6.
1996
A synthetic inhibitor of the mitogen-activated protein kinase cascade.
1995 Standout
Role of p38 and JNK Mitogen-Activated Protein Kinases in the Activation of Ternary Complex Factors
1997
Differential calcium dependence in the activation of c-Jun kinase and mitogen-activated protein kinase by muscarinic acetylcholine receptors in rat 1a cells
1995
A Conserved Cyclin-Binding Domain Determines Functional Interplay between Anaphase-Promoting Complex–Cdh1 and Cyclin A-Cdk2 during Cell Cycle Progression
2001
Multiple Mitogen-Activated Protein Kinase Signaling Pathways Connect the Cot Oncoprotein to the c-junPromoter and to Cellular Transformation
2000
pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.
1997
Activation of Stress-activated Protein Kinase/c-Jun N-terminal Kinase, but Not NF-κB, by the Tumor Necrosis Factor (TNF) Receptor 1 through a TNF Receptor-associated Factor 2- and Germinal Center Kinase Related-dependent Pathway
1997
Activation of Yeast PBS2 MAPKK by MAPKKKs or by Binding of an SH3-Containing Osmosensor
1995 Science
Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase
1997
Actions of Rho Family Small G Proteins and p21-Activated Protein Kinases on Mitogen-Activated Protein Kinase Family Members
1996
The p38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c-fos transcription in response to UV light.
1996
Cu-Catalyzed Azide−Alkyne Cycloaddition
2008 StandoutNobel
HIV-1-infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation
2004 StandoutNobel
MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway
1996
Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
2000 StandoutScienceNobel
A Network of Mitogen-Activated Protein Kinases Links G Protein-Coupled Receptors to the c-jun Promoter: a Role for c-Jun NH2-Terminal Kinase, p38s, and Extracellular Signal-Regulated Kinase 5
1999
Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade.
1996
Stress-Induced Phosphorylation and Activation of the Transcription Factor CHOP (GADD153) by p38 MAP Kinase
1996 Science
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET).
1995
Dissecting Fas signaling with an altered-specificity death-domain mutant: Requirement of FADD binding for apoptosis but not Jun N-terminal kinase activation
1999 Nobel
Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation
2001 Standout
Signal Transduction through MAP Kinase Cascades
1998 Standout
CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation
1998
The Mcs4 response regulator coordinately controls the stress-activated Wak1-Wis1-Sty1 MAP kinase pathway and fission yeast cell cycle.
1997
Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta.
1995
Newly identified stress-responsive protein kinases, Krs-1 and Krs-2.
1996
SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis
1998
TANK, a co-inducer with TRAF2 of TNF- and CD 40L-mediated NF-kappaB activation.
1996 Nobel
Preferential binding of ATR protein to UV-damaged DNA
2002 StandoutNobel
Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase.
1996
Activation of a human Ste20-like kinase by oxidant stress defines a novel stress response pathway.
1996
The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins
1999
TANK Potentiates Tumor Necrosis Factor Receptor-Associated Factor-Mediated c-Jun N-Terminal Kinase/Stress-Activated Protein Kinase Activation through the Germinal Center Kinase Pathway
1999
Interaction of a Mitogen-Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3
2000
Impaired CD28-mediated Interleukin 2 Production and Proliferation in Stress Kinase SAPK/ERK1 Kinase (SEK1)/Mitogen-activated Protein Kinase Kinase 4 (MKK4)-deficient T Lymphocytes
1997
Another p53 Doppelgänger?
1998 StandoutScienceNobel
Interaction of Hematopoietic Progenitor Kinase 1 with Adapter Proteins Crk and CrkL Leads to Synergistic Activation of c-Jun N-Terminal Kinase
1999
Works of Irma Sánchez being referenced
Transcriptional control of the cell cycle
1996
New insights into cyclins, CDKs, and cell cycle control
2005
Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun
1994 Nature
Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase
1995 Nature
Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway
1997
p130 and p107 Use a Conserved Domain To Inhibit Cellular Cyclin-Dependent Kinase Activity†
1997
Effects of transforming growth factor-beta, transforming growth factor-alpha, and other growth factors on renal proximal tubule cells.
1991