Standout Papers
Citation Impact
Citing Papers
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble
2018 StandoutNobel
Design, Synthesis, Structural and Functional Characterization of Novel Melanocortin Agonists Based on the Cyclotide Kalata B1
2012
Structure–activity relationships of piperazinebenzylamines as potent and selective agonists of the human melanocortin-4 receptor
2004
The human fatty acid-binding protein family: Evolutionary divergences and functions
2011
Exchange factors directly activated by cAMP mediate melanocortin 4 receptor-induced gene expression
2016
Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
1997 StandoutNature
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
2009 StandoutNobel
The Natural Inverse Agonist Agouti-related Protein Induces Arrestin-mediated Endocytosis of Melanocortin-3 and -4 Receptors
2006
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
2000 StandoutNature
Nicastrin Functions as a γ-Secretase-Substrate Receptor
2005 StandoutNobel
Lipid-Binding Proteins: A Family of Fatty Acid and Retinoid Transport Proteins
1994
Constitutive Activity in Melanocortin-4 Receptor
2014
Role of central melanocortin pathways in energy homeostasis
2009
Hypothalamic regulation of sleep and circadian rhythms
2005 StandoutNature
Anatomy and regulation of the central melanocortin system
2005 Standout
Ghrelin stimulates neurogenesis in the dorsal motor nucleus of the vagus
2004
Biochemical and pharmacological control of the multiplicity of coupling at G-protein-coupled receptors
2003
Leptin Differentially Regulates NPY and POMC Neurons Projecting to the Lateral Hypothalamic Area
1999
Potent and selective MC-4 receptor agonists based on a novel disulfide scaffold
2005
Melanin Pigmentation in Mammalian Skin and Its Hormonal Regulation
2004 Standout
Sequence Alignment of the G-Protein Coupled Receptor Superfamily
1992
MC4R Agonists: Structural Overview on Antiobesity Therapeutics
2018 StandoutNobel
Central nervous system control of food intake and body weight
2006 StandoutNature
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
2001 StandoutNature
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
2004 Nature
Melanocortin Signalling Mechanisms
2010
Melanocortin-4 receptor-mediated inhibition of apoptosis in immortalized hypothalamic neurons via mitogen-activated protein kinase
2006
Selective deletion of leptin receptor in neurons leads to obesity
2001
Toward the active conformations of rhodopsin and the β2‐adrenergic receptor
2004
Advances in the molecular genetics of obesity
1999
Ghrelin: An orexigenic and somatotrophic signal from the stomach
2001
Development of a high throughput screen for allosteric modulators of melanocortin-4 receptor signaling using a real time cAMP assay
2011
Pertussis Toxin-sensitive Signaling of Melanocortin-4 Receptors in Hypothalamic GT1-7 Cells Defines Agouti-related Protein as a Biased Agonist
2009
Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid
1993 StandoutNature
Afamelanotide: A Review in Erythropoietic Protoporphyria
2016
Neuroendocrine regulation of eating behavior
2002
Identification of CC Chemokine Receptor 7 Residues Important for Receptor Activation
2004
G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons
2015 Nature
Fasting Induces a Large, Leptin-Dependent Increase in the Intrinsic Action Potential Frequency of Orexigenic Arcuate Nucleus Neuropeptide Y/Agouti-Related Protein Neurons
2005
Evaluation of Melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study
1996
Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin
1999
Selectivity of [Phe-I 7 ], [Ala 6 ], and [ d -Ala 4 ,Gln 5 ,Tyr 6 ] Substituted ACTH(4-10) Analogues for the Melanocortin Receptors
1997
Structure-function studies on the cyclic peptide MT-II, lactam derivative of α-melanotropin
1999
Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice
1997 Standout
Binding of cyclic and linear MSH core peptides to the melanocortin receptor subtypes
1997
Mechanism of N-terminal modulation of activity at the melanocortin-4 receptor GPCR
2012
Distribution and phenotype of neurons containing the ATP-sensitive K+ channel in rat brain
1998
The melanocortin receptors and their accessory proteins
2013
Views on the co-evolution of the melanocortin-2 receptor, MRAPs, and the hypothalamus/pituitary/adrenal-interrenal axis
2015
Functional Selectivity of Melanocortin 4 Receptor Peptide and Nonpeptide Agonists: Evidence for Ligand-Specific Conformational States
2005
Neuropeptide Y-Mediated Inhibition of Proopiomelanocortin Neurons in the Arcuate Nucleus Shows Enhanced Desensitization in ob/ob Mice
2004
Central nervous system control of food intake
2000 StandoutNature
Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor
1994 Nature
PI3K integrates the action of insulin and leptin on hypothalamic neurons
2005
Physiological roles of the melanocortin MC3 receptor
2011
Mapping of the ACTH, MSH, and neural (MC3 and MC4) melanocortin receptors in the mouse and human
1994
Glial and neuronal control of brain blood flow
2010 StandoutNature
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
2003 StandoutNatureNobel
Extensive structure–activity studies of lactam derivatives of MT‐II and SHU‐9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5
2003
The role of proopiomelanocortin (POMC) neurones in feeding behaviour
2007
Epoxyeicosatrienoic Acids Function as Selective, Endogenous Antagonists of Native Thromboxane Receptors: Identification of a Novel Mechanism of Vasodilation
2008
Mechanisms linking obesity to insulin resistance and type 2 diabetes
2006 StandoutNature
Structure–Activity relationship of linear peptide Bu-His6-DPhe7-Arg8-Trp9-Gly10-NH2 at the human melanocortin-1 and -4 receptors: DPhe7 and Trp9 substitution
2003
A role for ghrelin in the central regulation of feeding
2001 StandoutNature
Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat
2003
Design of a new peptidomimetic agonist for the melanocortin receptors based on the solution structure of the peptide ligand, Ac-Nle-cyclo[Asp-Pro-dPhe-Arg-Trp-Lys]-NH2
2003
A Multigene Family Encoding a Diverse Array of Putative Pheromone Receptors in Mammals
1997 StandoutNobel
Melanocortin Receptors and Erectile Function
2004
Effect of an alpha-melanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction
2000
Synthesis and evaluation of bivalent ligands for binding to the human melanocortin-4 receptor
2014
Melanocortin control of energy balance: evidence from rodent models
2011
Design of new small cyclic melanocortin receptor-binding peptides using molecular modelling: Role of the His residue in the melanocortin peptide core
2001
The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines
2008
Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans
2004
“The role of melanocortins in body weight regulation: opportunities for the treatment of obesity”
2002
Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency
2000
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
The hormone resistin links obesity to diabetes
2001 StandoutNature
End-capping of the modified melanocortin tetrapeptide (p-Cl)Phe-D-Phe-Arg-Trp-NH2 as a route to hMC4R agonists
2004
Mice lacking melanin-concentrating hormone are hypophagic and lean
1998 Nature
Synthesis and biological evaluation of α-MSH analogues substituted with alanine
1994
A novel family of genes encoding putative pheromone receptors in mammals
1995 StandoutNobel
Characterization of melanocortin receptor ligands on cloned brain melanocortin receptors and on grooming behavior in the rat
1999
From Lesions to Leptin
1999
Obesity and the Regulation of Energy Balance
2001 Standout
MOLECULAR EVOLUTION OF GPCRS: Melanocortin/melanocortin receptors
2014
Satiety effect and sympathetic activation of leptin are mediated by hypothalamic melanocortin system
1998
The Drosophila takeout Gene Is a Novel Molecular Link between Circadian Rhythms and Feeding Behavior
2000 StandoutNobel
Leptin in human physiology and therapeutics
2010
Structure-Activity Relationships (SAR) of Melanocortin and Agouti-Related (AGRP) Peptides
2010
Exocrine Gland Dysfunction in MC5-R-Deficient Mice: Evidence for Coordinated Regulation of Exocrine Gland Function by Melanocortin Peptides
1997
Structure–activity relationships of the melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH2 at the mouse melanocortin receptors
2003
Response of melanocortin–4 receptor–deficient mice to anorectic and orexigenic peptides
1999
Leptin and the regulation of body weight in mammals
1998 StandoutNature
MC4R oligomerizes independently of extracellular cysteine residues
2005
Evaluation of the safety, pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra®
2004
The regulation of food intake by selective stimulation of the type 3 melanocortin receptor (MC3R)
2005
Structure, function and regulation of the melanocortin receptors
2011
Ghrelin: Structure and Function
2005 Standout
Unraveling the central nervous system pathways underlying responses to leptin
1998
Agouti-related peptide–expressing neurons are mandatory for feeding
2005
Melanocortin-4 receptor–regulated energy homeostasis
2016
The molecular neurobiology of depression
2008 StandoutNature
Analogs of Lactam Derivatives of α-Melanotropin with Basic and Acidic Residues
2000
Activation of the Melanocortin-4 Receptor Mobilizes Intracellular Free Calcium in Immortalized Hypothalamic Neurons
2006
Integration of NPY, AGRP, and Melanocortin Signals in the Hypothalamic Paraventricular Nucleus
1999
The Molecular Architecture of Odor and Pheromone Sensing in Mammals
2000 StandoutNobel
Obesity Wars
2004
Body weight is regulated by the brain: a link between feeding and emotion
2005
Effects of Hypothalamic Neurodegeneration on Energy Balance
2005
Molecular characterization of the melanin-concentrating-hormone receptor
1999 Nature
Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms
2003
Adipose Tissue as an Endocrine Organ
2004 Standout
Anti-inflammatory actions of the neuroimmunomodulator α-MSH
1997
Obesity and the Hypothalamus: Novel Peptides for New Pathways
1998
Analogs of MTII, Lactam Derivatives of α-Melanotropin, Modified at the N-Terminus, and Their Selectivity at Human Melanocortin Receptors 3, 4, and 5
1999
Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity
2000
Genetics of body-weight regulation
2000 Nature
Leptin Activates Hypothalamic CART Neurons Projecting to the Spinal Cord
1998
Body Mass Index‐Related Human Adipocyte agouti Expression Is Sex‐Specific but Not Depot‐Specific
2002
Conformation of the Core Sequence in Melanocortin Peptides Directs Selectivity for the Melanocortin MC3 and MC4 Receptors
1999
Minireview: Human Obesity—Lessons from Monogenic Disorders
2003
Evidence That the Caudal Brainstem Is a Target for the Inhibitory Effect of Leptin on Food Intake
2002
The 1,4-Benzodiazepine-2,5-dione Small Molecule Template Results in Melanocortin Receptor Agonists with Nanomolar Potencies
2008
Hypothalamic Agouti-Related Protein Messenger Ribonucleic Acid Is Inhibited by Leptin and Stimulated by Fasting*
1999
Identification of Tetrapeptides from a Mixture Based Positional Scanning Library That Can Restore nM Full Agonist Function of the L106P, I69T, I102S, A219V, C271Y, and C271R Human Melanocortin-4 Polymorphic Receptors (hMC4Rs)
2014
Minireview: The Melanocortin 2 Receptor Accessory Proteins
2009
Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance
1998
Structure−Activity Relationships of the Melanocortin Tetrapeptide Ac-His-DPhe-Arg-Trp-NH2 at the Mouse Melanocortin Receptors. 1. Modifications at the His Position
2002
GH-Releasing Peptide-2 Increases Fat Mass in Mice Lacking NPY: Indication for a Crucial Mediating Role of Hypothalamic Agouti-Related Protein
2002
Molecular cloning, tissue distribution, and expression of a 14-kDa bile acid-binding protein from rat ileal cytosol.
1994
Signals That Regulate Food Intake and Energy Homeostasis
1998 Science
Systematic Backbone Conformational Constraints on a Cyclic Melanotropin Ligand Leads to Highly Selective Ligands for Multiple Melanocortin Receptors
2015
Engineered Biosynthesis of β‐Alkyl Tryptophan Analogues
2018 StandoutNobel
Independent β-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2
2003 StandoutNobel
The Effect of Mutations in the DRY Motif on the Constitutive Activity and Structural Instability of the Histamine H2 Receptor
2000
Characterization of Melanocortin NDP-MSH Agonist Peptide Fragments at the Mouse Central and Peripheral Melanocortin Receptors
2001
The Central Melanocortin System and Energy Homeostasis
1999
Regulation of C. elegans Life-Span by Insulinlike Signaling in the Nervous System
2000 StandoutScienceNobel
Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain.
1994
Selectivity of Cyclic [d-Nal7] and [d-Phe7] Substituted MSH Analogues for the Melanocortin Receptor Subtypes
1997
Postembryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype
2005
Synthetic Analogues of Glycosylphosphatidylinositol-Anchored Proteins and Their Behavior in Supported Lipid Bilayers
2007 StandoutNobel
Leptin Signaling in the Central Nervous System and the Periphery
2004
Obesity-Induced Inflammation in White Adipose Tissue Is Attenuated by Loss of Melanocortin-3 Receptor Signaling
2007
Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
2018 Standout
The mouse ileal lipid-binding protein gene: a model for studying axial patterning during gut morphogenesis.
1994
Genetics of obesity
2006
60 YEARS OF POMC: Melanocortin receptors: evolution of ligand selectivity for melanocortin peptides
2016
Peptide-Labeled Quantum Dots for Imaging GPCRs in Whole Cells and as Single Molecules
2007
Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur.
1995
Inflamed phenotype of the mesenteric microcirculation of melanocortin type 3 receptor‐null mice after ischemia‐reperfusion
2008
Agonist-induced conformational changes in the G-protein-coupling domain of the β 2 adrenergic receptor
2001 StandoutNobel
Synthesis of Native Proteins by Chemical Ligation
2000
Selective, High Affinity Peptide Antagonists of α-Melanotropin Action at Human Melanocortin Receptor 4: Their Synthesis and Biological Evaluation in Vitro
2001
Uncovering Molecular Mechanisms Involved in Activation of G Protein-Coupled Receptors
2000
Structure−Activity Studies of the Melanocortin Peptides: Discovery of Potent and Selective Affinity Antagonists for thehMC3 andhMC4 Receptors
2002
Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects.
1996 StandoutNobel
A Macrocyclic Agouti-Related Protein/[Nle4,DPhe7]α-Melanocyte Stimulating Hormone Chimeric Scaffold Produces Subnanomolar Melanocortin Receptor Ligands
2017
Semisynthesis and Folding of the Potassium Channel KcsA
2002 StandoutNobel
The family of G‐protein‐coupled receptors
1995
Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans
2004
Design of cyclized selective melanotropins
2016
The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice
1998
Computational Modeling Approaches to Structure−Function Analysis of G Protein-Coupled Receptors
2005
Click-Chemistry-Mediated Synthesis of Selective Melanocortin Receptor 4 Agonists
2017 StandoutNobel
Orexigenic Action of Peripheral Ghrelin Is Mediated by Neuropeptide Y and Agouti-Related Protein
2004
Melanocortin Antagonists Define Two Distinct Pathways of Cardiovascular Control by α- and γ-Melanocyte-Stimulating Hormones
1996
Synthesis of β-Branched Tryptophan Analogues Using an Engineered Subunit of Tryptophan Synthase
2016 StandoutNobel
The Melanocortin-4 Receptor: Physiology, Pharmacology, and Pathophysiology
2010
Obesity, diabetes, and neoplasia in yellow A vy /‐ mice: ectopic expression of the agouti gene
1994
Melanocortin receptors: their functions and regulation by physiological agonists and antagonists
2001
Compounds That Activate the Mouse Melanocortin-1 Receptor Identified by Screening a Small Molecule Library Based upon the β-Turn
1999
Structure−Activity Relationships of the Melanocortin Tetrapeptide Ac-His-d -Phe-Arg-Trp-NH2 at the Mouse Melanocortin Receptors. 4. Modifications at the Trp Position
2002
Synthesis of (2S,3S)-β-methyltryptophan
2001
The Function of Leptin in Nutrition, Weight, and Physiology
2002
The Role of the Dorsal Vagal Complex and the Vagus Nerve in Feeding Effects of Melanocortin-3/4 Receptor Stimulation*
2000
Structure–Activity Relationships of Peptides Incorporating a Bioactive Reverse-Turn Heterocycle at the Melanocortin Receptors: Identification of a 5800-fold Mouse Melanocortin-3 Receptor (mMC3R) Selective Antagonist/Partial Agonist versus the Mouse Melanocortin-4 Receptor (mMC4R)
2013
Synthesis and Pharmacology of α/β3-Peptides Based on the Melanocortin Agonist Ac-His-d Phe-Arg-Trp-NH2 Sequence
2015
An Engineered Tryptophan Synthase Opens New Enzymatic Pathways to β‐Methyltryptophan and Derivatives
2016
Synthesis, Biophysical, and Pharmacological Evaluation of the Melanocortin Agonist AST3-88: Modifications of Peptide Backbone at Trp 7 Position Lead to a Potent, Selective, and Stable Ligand of the Melanocortin 4 Receptor (MC4R)
2014
Design, Synthesis, and Evaluation of Proline and Pyrrolidine Based Melanocortin Receptor Agonists. A Conformationally Restricted Dipeptide Mimic Approach
2006
Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons
1998
Tissue-specific contributions of Tmem79 to atopic dermatitis and mast cell-mediated histaminergic itch
2018 StandoutNobel
The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity
1998 Standout
Update 1 of: Computational Modeling Approaches to Structure–Function Analysis of G Protein-Coupled Receptors
2011
Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands
2009 StandoutNobel
Characterization of the Neuroanatomical Distribution of Agouti-Related Protein Immunoreactivity in the Rhesus Monkey and the Rat*
1999
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue
2016 StandoutNobel
1,4-Disubstituted-[1,2,3]triazolyl-Containing Analogues of MT-II: Design, Synthesis, Conformational Analysis, and Biological Activity
2014
Compact Biocompatible Quantum Dots Functionalized for Cellular Imaging
2008 StandoutNobel
Selective deletion of leptin receptor in neurons leads to obesity
2001
A Solid-Phase Approach to Mouse Melanocortin Receptor Agonists Derived from a Novel Thioether Cyclized Peptidomimetic Scaffold
2002 StandoutNobel
Structure−Activity Relationships of the Melanocortin Tetrapeptide Ac-His-DPhe-Arg-Trp-NH2 at the Mouse Melanocortin Receptors: Part 2 Modifications at the Phe Position
2002
Neither Agouti-Related Protein nor Neuropeptide Y Is Critically Required for the Regulation of Energy Homeostasis in Mice
2002
Structure activity studies of the melanocortin antagonist SHU9119 modified at the 6, 7, 8, and 9 positions☆
2000
Interactions of Human Melanocortin 4 Receptor with Nonpeptide and Peptide Agonists,
2005
Synthesis of Lipidated Green Fluorescent Protein and Its Incorporation in Supported Lipid Bilayers
2005 StandoutNobel
A Novel Selective Melanocortin-4 Receptor Agonist Reduces Food Intake in Rats and Mice without Producing Aversive Consequences
2000
Identification of a Nuclear Receptor for Bile Acids
1999 StandoutScience
Structure Activity Studies of the Melanocortin-4 Receptor by in Vitro Mutagenesis: Identification of Agouti-Related Protein (AGRP), Melanocortin Agonist and Synthetic Peptide Antagonist Interaction Determinants
2001
Role of Signal Transducer and Activator of Transcription 3 in Regulation of Hypothalamic Proopiomelanocortin Gene Expression by Leptin
2003
Synthesis and Structure–Activity Relationships of Substituted Urea Derivatives on Mouse Melanocortin Receptors
2015
Expression of Leptin Receptor Isoforms in Rat Brain Microvessels
1998
The Central Melanocortin System Can Directly Regulate Serum Insulin Levels*
2000
γ-MSH, sodium metabolism, and salt-sensitive hypertension
2004
A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors
2000
Works of Ira Gantz being referenced
Chimeras of the agouti-related protein: Insights into agonist and antagonist selectivity of melanocortin receptors
2005
Structures of the Agouti Signaling Protein
2005
Binding and cAMP Studies of Melanotropin Peptides with the Cloned Human Peripheral Melanocortin Receptor, hMC1R
1994
Cloning and Chromosomal Localization of a Gene (GPR18) Encoding a Novel Seven Transmembrane Receptor Highly Expressed in Spleen and Testis
1997
Molecular Determination of Agouti-Related Protein Binding to Human Melanocortin-4 Receptor
2003
Molecular Cloning, Expression, and Characterization of a Fifth Melanocortin Receptor
1994
Topographical modification of melanotropin peptide analogs with .beta.-methyltryptophan isomers at position 9 leads to differential potencies and prolonged biological activities
1995
Naturally Occurring Mutations in the Melanocortin Receptor 3 Gene Are Not Associated with Type 2 Diabetes Mellitus in French Caucasians1
2001
NMR structure of a minimized human agouti related protein prepared by total chemical synthesis
1999
Contribution of Melanocortin Receptor Exoloops to Agouti-related Protein Binding
1999
Molecular Basis for the Interaction of [Nle4,d-Phe7]Melanocyte Stimulating Hormone with the Human Melanocortin-1 Receptor (Melanocyte α-MSH Receptor)
1997
Molecular cloning of the human histamine H2 receptor
1991
Inverse agonist activity of agouti and agouti-related protein
2003
Molecular Determinants of Human Melanocortin-4 Receptor Responsible for Antagonist SHU9119 Selective Activity
2002
Neuroendocrine Regulation by the Agouti/Agrp-Melanocortin System
2000
Agouti-Related Protein-Like Immunoreactivity: Characterization of Release from Hypothalamic Tissue and Presence in Serum1
2000
Characterization of Agouti-Related Protein Binding to Melanocortin Receptors
1999
Structural determinants of the melanocortin peptides required for activation of melanocortin-3 and melanocortin-4 receptors.
1995
Design, Pharmacology, and NMR Structure of a Minimized Cystine Knot with Agouti-Related Protein Activity
2002
Discovery of Prototype Peptidomimetic Agonists at the Human Melanocortin Receptors MC1R and MC4R
1997
Anatomy of an Endogenous Antagonist: Relationship between Agouti-Related Protein and Proopiomelanocortin in Brain
1999
Molecular basis for the interaction of histamine with the histamine H2 receptor.
1992
Characterizations of the Unusual Dissociation Properties of Melanotropin Peptides from the Melanocortin Receptor, hMC1R
1996
Physiological and Anatomical Circuitry between Agouti-Related Protein and Leptin Signaling*
1999
Biological and Conformational Examination of Stereochemical Modifications Using the Template Melanotropin Peptide, Ac-Nle-c[Asp-His-Phe-Arg-Trp- Ala-Lys]-NH2, on Human Melanocortin Receptors
1997
A randomized clinical trial evaluating the safety and efficacy of sitagliptin added to the combination of sulfonylurea and metformin in patients with type 2 diabetes mellitus and inadequate glycemic control
2015
Interaction of dual intracellular signaling pathways activated by the melanocortin-3 receptor.
1994
Three-dimensional molecular models of the hMC1R melanocortin receptor: complexes with melanotropin peptide agonists.
1996
Molecular cloning, expression, and gene localization of a fourth melanocortin receptor
1993
Molecular cloning of a novel melanocortin receptor.
1993
Effects of Recombinant Agouti-Signaling Protein on Melanocortin Action
1997
Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein
1997 StandoutScience
Molecular Determinants of Ligand Binding to the Human Melanocortin-4 Receptor
2000
Gastrotropin: not an enterooxyntin but a member of a family of cytoplasmic hydrophobic ligand binding proteins
1989
The melanocortin system
2003
Receptor−Antagonist Interactions in the Complexes of Agouti and Agouti-Related Protein with Human Melanocortin 1 and 4 Receptors,
2005
Inhibition of Adipogenesis by Ghrelin
2004
α-MSH and its receptors in regulation of tumor necrosis factor-α production by human monocyte/macrophages
1999
Histamine H2 receptor activates adenylate cyclase and PLC via separate GTP-dependent pathways
1996