Standout Papers
Citation Impact
Citing Papers
Twist Transcriptionally Up-regulates AKT2 in Breast Cancer Cells Leading to Increased Migration, Invasion, and Resistance to Paclitaxel
2007
Twist1-Mediated Adriamycin-Induced Epithelial-Mesenchymal Transition Relates to Multidrug Resistance and Invasive Potential in Breast Cancer Cells
2009
Loss of E-Cadherin Promotes Metastasis via Multiple Downstream Transcriptional Pathways
2008
A Novel Lung Metastasis Signature Links Wnt Signaling with Cancer Cell Self-Renewal and Epithelial-Mesenchymal Transition in Basal-like Breast Cancer
2009
Visualizing extravasation dynamics of metastatic tumor cells
2010
SNAI1 Is Required for Tumor Growth and Lymph Node Metastasis of Human Breast Carcinoma MDA-MB-231 Cells
2007
N-cadherin Gene Expression in Prostate Carcinoma Is Modulated by Integrin-Dependent Nuclear Translocation of Twist1
2006
HMGA2 Is a Driver of Tumor Metastasis
2013
Genetic Profiling of Epithelial Cells Expressing E-Cadherin Repressors Reveals a Distinct Role for Snail, Slug, and E47 Factors in Epithelial-Mesenchymal Transition
2006
Brachyury, a Driver of the Epithelial–Mesenchymal Transition, Is Overexpressed in Human Lung Tumors: An Opportunity for Novel Interventions against Lung Cancer
2012
Circulating Tumor Cells from Patients with Advanced Prostate and Breast Cancer Display Both Epithelial and Mesenchymal Markers
2011
Epithelial to Mesenchymal Transition Contributes to Drug Resistance in Pancreatic Cancer
2009
Protein Kinase D1 Suppresses Epithelial-to-Mesenchymal Transition through Phosphorylation of Snail
2010
The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins
2019 StandoutNobel
Snail and Slug Play Distinct Roles during Breast Carcinoma Progression
2006
Epithelial-Mesenchymal Transition in Cervical Cancer: Correlation with Tumor Progression, Epidermal Growth Factor Receptor Overexpression, and Snail Up-Regulation
2008
Kruppel-Like Factor 8 Induces Epithelial to Mesenchymal Transition and Epithelial Cell Invasion
2007
Epithelial-Mesenchymal Transition in Breast Cancer Relates to the Basal-like Phenotype
2008
Reassessing Epithelial to Mesenchymal Transition as a Prerequisite for Carcinoma Invasion and Metastasis
2006
Expression of L1-CAM and ADAM10 in Human Colon Cancer Cells Induces Metastasis
2007
Up-Regulation of TWIST in Prostate Cancer and Its Implication as a Therapeutic Target
2005
EMT and Stem Cell–Like Properties Associated with miR-205 and miR-200 Epigenetic Silencing Are Early Manifestations during Carcinogen-Induced Transformation of Human Lung Epithelial Cells
2011
Twist Overexpression Induces In vivo Angiogenesis and Correlates with Chromosomal Instability in Breast Cancer
2005
The Transcriptional Repressor ZEB1 Promotes Metastasis and Loss of Cell Polarity in Cancer
2008
Snail2 is an Essential Mediator of Twist1-Induced Epithelial Mesenchymal Transition and Metastasis
2011
Radiation-Induced CXCL16 Release by Breast Cancer Cells Attracts Effector T Cells
2008
An emerging role for class I bHLH E2-2 proteins in EMT regulation and tumor progression
2010
HMGA2 and Smads Co-regulate SNAIL1 Expression during Induction of Epithelial-to-Mesenchymal Transition
2008
Comprehensive genomic characterization of head and neck squamous cell carcinomas
2015 StandoutNature
Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis
2014 StandoutNobel
Snail regulates p21WAF/CIP1 expression in cooperation with E2A and Twist
2004
Mesenchyme Forkhead 1 ( FOXC2 ) plays a key role in metastasis and is associated with aggressive basal-like breast cancers
2007
Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity
2016
The transcriptional repressor Snail promotes mammary tumor recurrence
2005
Epithelial-Mesenchymal Transition in Cancer: Parallels Between Normal Development and Tumor Progression
2010
Hallmarks of Cancer: The Next Generation
2011 Standout
The class I bHLH factors E2-2A and E2-2B regulate EMT
2009
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA
2016 StandoutNobel
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Biology of hypoxia-inducible factor-2α in development and disease
2008
Mesenchymal Transition of High-Grade Breast Carcinomas Depends on Extracellular Matrix Control of Myeloid Suppressor Cell Activity
2016
The Hypoxia-controlled FBXL14 Ubiquitin Ligase Targets SNAIL1 for Proteasome Degradation
2009
Twist1-Induced Invadopodia Formation Promotes Tumor Metastasis
2011
Slug is overexpressed in gastric carcinomas and may act synergistically with SIP1 and Snail in the down‐regulation of E‐cadherin
2007
twist is a potential oncogene that inhibits apoptosis
1999
Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
2011 Standout
Unraveling signalling cascades for the Snail family of transcription factors
2004
Involvement of Members of the Cadherin Superfamily in Cancer
2009
A Signaling Pathway Involving TGF-β2 and Snail in Hair Follicle Morphogenesis
2004
Stabilization of Snail by NF-κB Is Required for Inflammation-Induced Cell Migration and Invasion
2009
Snail Represses the Splicing Regulator Epithelial Splicing Regulatory Protein 1 to Promote Epithelial-Mesenchymal Transition
2012
Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening
2009 Standout
The miR-200 Family Inhibits Epithelial-Mesenchymal Transition and Cancer Cell Migration by Direct Targeting of E-cadherin Transcriptional Repressors ZEB1 and ZEB2
2008
Development and Characterization of Gemcitabine-Resistant Pancreatic Tumor Cells
2007
Snail silencing effectively suppresses tumour growth and invasiveness
2006
Cancer Stem Cells: Impact, Heterogeneity, and Uncertainty
2012 Standout
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
2008 Standout
Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis
2008 Standout
SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell-cell junctions
2005
Metastasis: a question of life or death
2006
Cancer Metastasis: Building a Framework
2006 Standout
Key signalling nodes in mammary gland development and cancer. The Snail1-Twist1 conspiracy in malignant breast cancer progression
2010
New potential therapeutic targets to combat epithelial tumor invasion
2006
Imaging in the era of molecular oncology
2008 StandoutNature
Embryonic transcription factors in human breast cancer
2006
Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer
2015 StandoutNature
E-cadherin transcriptional downregulation by promoter methylation but not mutation is related to epithelial-to-mesenchymal transition in breast cancer cell lines
2006
Upregulation of Twist in oesophageal squamous cell carcinoma is associated with neoplastic transformation and distant metastasis
2006
The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it
2005
Proliferation, cell cycle and apoptosis in cancer
2001 StandoutNature
Epithelial-Mesenchymal Transitions
2004 Standout
Role of the epithelial-mesenchymal transition regulator Slug in primary human cancers
2009
P68 RNA Helicase Mediates PDGF-Induced Epithelial Mesenchymal Transition by Displacing Axin from β-Catenin
2006
A Transient, EMT-Linked Loss of Basement Membranes Indicates Metastasis and Poor Survival in Colorectal Cancer
2006
Identification of an mRNP Complex Regulating Tumorigenesis at the Translational Elongation Step
2011
New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer
2018 Standout
NF-κB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2
2006
Twist is an essential regulator of the skeletogenic gene regulatory network in the sea urchin embryo
2008
Complex networks orchestrate epithelial–mesenchymal transitions
2006 Standout
Snail in the frame of malignant tumor recurrence
2006
Isolation of rare circulating tumour cells in cancer patients by microchip technology
2007 StandoutNature
TGF-β and epithelial-to-mesenchymal transitions
2005
Bypassing cellular EGF receptor dependence through epithelial-to-mesenchymal-like transitions
2008
Up-regulation of gastric cancer cell invasion by Twist is accompanied by N-cadherin and fibronectin expression
2007
ESRP1 and ESRP2 Are Epithelial Cell-Type-Specific Regulators of FGFR2 Splicing
2009
Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis
2006
BRCA1-IRIS inactivation sensitizes ovarian tumors to cisplatin
2014
Inflammation Mediated Metastasis: Immune Induced Epithelial-To-Mesenchymal Transition in Inflammatory Breast Cancer Cells
2015
Induction of EMT by Twist Proteins as a Collateral Effect of Tumor-Promoting Inactivation of Premature Senescence
2008
High Twist expression is involved in infiltrative endometrial cancer and affects patient survival
2006
EMT Inducers Catalyze Malignant Transformation of Mammary Epithelial Cells and Drive Tumorigenesis towards Claudin-Low Tumors in Transgenic Mice
2012
Notch3 is important for TGF-β-induced epithelial–mesenchymal transition in non-small cell lung cancer bone metastasis by regulating ZEB-1
2014
E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer
2009
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
2007 StandoutNature
Expression of the Transcription Factors Snail, Slug, and Twist and Their Clinical Significance in Human Breast Cancer
2005
A twist for survival and cancer progression
2005
Intrinsic Immunity Shapes Viral Resistance of Stem Cells
2017 StandoutNobel
New Insights into the Regulation of Epithelial–Mesenchymal Transition and Tissue Fibrosis
2012
Activation of NF-κB by Akt upregulates Snail expression and induces epithelium mesenchyme transition
2007
Tissue repair and stem cell renewal in carcinogenesis
2004 Nature
Prognostic Role of Twist, Slug, and Foxc2 Expression in Stage I Non–Small-Cell Lung Cancer After Curative Resection
2011
The mighty mouse: genetically engineered mouse models in cancer drug development
2006
Targeting the Epithelial-to-Mesenchymal Transition: The Case for Differentiation-Based Therapy
2016
Immunity, Inflammation, and Cancer
2010 Standout
The emerging role of miR-200 family of MicroRNAs in epithelial-mesenchymal transition and cancer metastasis
2008
Direct regulation of TWIST by HIF-1α promotes metastasis
2008
The epigenetic progenitor origin of human cancer
2005
The epigenetics of epithelial-mesenchymal plasticity in cancer
2013
Pc2-mediated Sumoylation of Smad-interacting Protein 1 Attenuates Transcriptional Repression of E-cadherin
2005
Molecular requirements for epithelial–mesenchymal transition during tumor progression
2005 Standout
Tumour heterogeneity and cancer cell plasticity
2013 StandoutNature
Migrating cancer stem cells — an integrated concept of malignant tumour progression
2005
Defining the E-Cadherin Repressor Interactome in Epithelial-Mesenchymal Transition: The PMC42 Model as a Case Study
2010
Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
2007 Standout
Calreticulin Represses E-cadherin Gene Expression in Madin-Darby Canine Kidney Cells via Slug
2006
Ajuba LIM Proteins Are Snail/Slug Corepressors Required for Neural Crest Development in Xenopus
2008
Current and emerging concepts in tumour metastasis
2010
The T-box transcription factor Brachyury promotes epithelial-mesenchymal transition in human tumor cells
2010
Elf5 inhibits the epithelial–mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2
2012
Snail1, Snail2, and E47 promote mammary epithelial branching morphogenesis
2011
Hypoxic gene expression and metastasis
2004
CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer
2015
Decreased TIP30 promotes Snail-mediated epithelial–mesenchymal transition and tumor-initiating properties in hepatocellular carcinoma
2014
Epithelial-Mesenchymal Transitions in development and disease: old views and new perspectives
2009
Paracrine and Autocrine Signals Induce and Maintain Mesenchymal and Stem Cell States in the Breast
2011
ILEI: A cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells
2006
Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State
2012
Upholding a role for EMT in breast cancer metastasis
2017 Nature
MicroRNAs and Cancer: Short RNAs Go a Long Way
2009
Braveheart, a Long Noncoding RNA Required for Cardiovascular Lineage Commitment
2013
Smad3 is key to TGF-β-mediated epithelial-to-mesenchymal transition, fibrosis, tumor suppression and metastasis
2005
G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer
2012
TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP
2011
Molecular Basis of Metastasis
2008
EMT-activating transcription factors in cancer: beyond EMT and tumor invasiveness
2012
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
2002 StandoutNature
Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization
2011
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
1999 StandoutNature
KLF17 is a negative regulator of epithelial–mesenchymal transition and metastasis in breast cancer
2009
Epithelial-Mesenchymal Transition
2009
Collagen type I-induced Smad-interacting protein 1 expression downregulates E-cadherin in pancreatic cancer
2006
The basics of epithelial-mesenchymal transition
2009 Standout
The role of twist during palate development
2008
Clonal evolution in cancer
2012 StandoutNature
Interaction with Suv39H1 is critical for Snail-mediated E-cadherin repression in breast cancer
2012
Snail Regulates Cell-Matrix Adhesion by Regulation of the Expression of Integrins and Basement Membrane Proteins
2008
New Insights into Epithelial-Mesenchymal Transition in Kidney Fibrosis
2009
Ingression of primary mesenchyme cells of the sea urchin embryo: A precisely timed epithelial mesenchymal transition
2007
Molecular mechanisms of metastasis in breast cancer—clinical applications
2010
Biomarkers for epithelial-mesenchymal transitions
2009 Standout
Systemic Spread Is an Early Step in Breast Cancer
2008
Comparative Oncogenomics Identifies NEDD9 as a Melanoma Metastasis Gene
2006
A coding-independent function of gene and pseudogene mRNAs regulates tumour biology
2010 StandoutNature
A Twist in fate: evolutionary comparison of Twist structure and function
2002
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
Mechanisms of metastasis: Epithelial‐to‐mesenchymal transition and contribution of tumor microenvironment
2007
A molecular role for lysyl oxidase‐like 2 enzyme in Snail regulation and tumor progression
2005
The epithelial–mesenchymal transition under control: Global programs to regulate epithelial plasticity
2012
Genes that mediate breast cancer metastasis to lung
2005 StandoutNature
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
2010 StandoutNature
Snail controls differentiation of hepatocytes by repressing HNF4α expression
2006
TGF-β-induced epithelial to mesenchymal transition
2009 Standout
Mechanisms of Disease: fibroblasts—a new look at an old problem
2006
A proximal activator of transcription in epithelial-mesenchymal transition
2007
Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1
2012
Regulatory networks defining EMT during cancer initiation and progression
2013 Standout
CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
2011 StandoutNature
Role of YAP/TAZ in mechanotransduction
2011 StandoutNature
Spatiotemporal Regulation of Epithelial-Mesenchymal Transition Is Essential for Squamous Cell Carcinoma Metastasis
2012
MicroRNA control of epithelial–mesenchymal transition and metastasis
2012
Heterogeneous expression of Wnt/β‐catenin target genes within colorectal cancer
2007
Gene-Regulatory Interactions in Neural Crest Evolution and Development
2004
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
2008 Standout
Bmi1 is essential in Twist1-induced epithelial–mesenchymal transition
2010
Life with Oxygen
2007 StandoutScienceNobel
Vascular Endothelial Growth Factor Receptor-1 Activation Mediates Epithelial to Mesenchymal Transition in Human Pancreatic Carcinoma Cells
2006
Exploring a New Twist on Tumor Metastasis
2006
Epithelial-mesenchymal transition
2005
Twist Overexpression Correlates with Hepatocellular Carcinoma Metastasis through Induction of Epithelial-Mesenchymal Transition
2006
Signaling mechanisms of the epithelial-mesenchymal transition
2014
The Fallacy of Epithelial Mesenchymal Transition in Neoplasia
2005
Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis
2015 StandoutNobel
A Perspective on Cancer Cell Metastasis
2011 StandoutScience
Role of Hypoxia-Inducible Factors in Breast Cancer Metastasis
2013 StandoutNobel
Identification and Prognostic Significance of an Epithelial-Mesenchymal Transition Expression Profile in Human Bladder Tumors
2007
EMT, CSCs, and drug resistance: the mechanistic link and clinical implications
2017 Standout
Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment
2018 StandoutNobel
Signalling interactions during facial development
1998
Cooperation between Snail and LEF-1 Transcription Factors Is Essential for TGF-β1-induced Epithelial-Mesenchymal Transition
2006
Constitutively Active Type I Insulin-Like Growth Factor Receptor Causes Transformation and Xenograft Growth of Immortalized Mammary Epithelial Cells and Is Accompanied by an Epithelial-to-Mesenchymal Transition Mediated by NF-κB and Snail
2007
Molecular correlates of gefitinib responsiveness in human bladder cancer cells
2007
Epithelial-Mesenchymal Transformation during Craniofacial Development
2005
Engineering Orthogonal Polypeptide GalNAc-Transferase and UDP-Sugar Pairs
2019 StandoutNobel
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
Transforming growth factor-β employs HMGA2 to elicit epithelial–mesenchymal transition
2006
Hepatocyte-Derived Snail1 Propagates Liver Fibrosis Progression
2011
Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers
2008
AACR Centennial Series: The Biology of Cancer Metastasis: Historical Perspective
2010
The protein tyrosine phosphatase Pez regulates TGFβ, epithelial–mesenchymal transition, and organ development
2007
HOXB7, a Homeodomain Protein, Is Overexpressed in Breast Cancer and Confers Epithelial-Mesenchymal Transition
2006
Identification of a pharmacologically tractable Fra-1/ADORA2B axis promoting breast cancer metastasis
2013
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
2018 StandoutNobel
The F-box protein Ppa is a common regulator of core EMT factors Twist, Snail, Slug, and Sip1
2011
Dual roles of myocardin-related transcription factors in epithelial–mesenchymal transition via slug induction and actin remodeling
2007
Snail and Slug Promote Epithelial-Mesenchymal Transition through β-Catenin–T-Cell Factor-4-dependent Expression of Transforming Growth Factor-β3
2008
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
A reciprocal repression between ZEB1 and members of the miR‐200 family promotes EMT and invasion in cancer cells
2008
TRANSCRIPTIONAL CONTROL OF MUSCLE DEVELOPMENT BY MYOCYTE ENHANCER FACTOR-2 (MEF2) PROTEINS
1998
Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes
2010
A bulky glycocalyx fosters metastasis formation by promoting G1 cell cycle progression
2017 StandoutNobel
Resolved
2010
Epidermal Growth Factor Receptor Cooperates with Signal Transducer and Activator of Transcription 3 to Induce Epithelial-Mesenchymal Transition in Cancer Cells via Up-regulation of TWIST Gene Expression
2007
Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment
2014 StandoutNobel
Epithelial to Mesenchymal Transition Is a Determinant of Sensitivity of Non–Small-Cell Lung Carcinoma Cell Lines and Xenografts to Epidermal Growth Factor Receptor Inhibition
2005
Caenorhabditis elegansTwist plays an essential role in non-striated muscle development
2000 StandoutNobel
Breast Cancer‐Derived Exosomes Reflect the Cell‐of‐Origin Phenotype
2019
The Spemann organizer gene, Goosecoid , promotes tumor metastasis
2006
Epithelial to Mesenchymal Transition: Expression of the Regulators Snail, Slug, and Twist in Pancreatic Cancer
2007
The epithelial–mesenchymal transition: new insights in signaling, development, and disease
2006 Standout
EGF induces epithelial-mesenchymal transition through phospho-Smad2/3-Snail signaling pathway in breast cancer cells
2016
Slug stability is dynamically regulated during neural crest development by the F-box protein Ppa
2006
Works of Inna Gitelman being referenced
Twist Protein in Mouse Embryogenesis
1997
Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis
2004 Standout
Twist Relates to Tubular Epithelial-Mesenchymal Transition and Interstitial Fibrogenesis in the Obstructed Kidney
2007
A Twist-Snail Axis Critical for TrkB-Induced Epithelial-Mesenchymal Transition-Like Transformation, Anoikis Resistance, and Metastasis
2009
Msx2andTwistcooperatively control the development of the neural crest-derived skeletogenic mesenchyme of the murine skull vault
2003