Standout Papers
Citation Impact
Citing Papers
Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality
2020 StandoutNobel
Proteomics of HCV virions reveals an essential role for the nucleoporin Nup98 in virus morphogenesis
2016 StandoutNobel
Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses
2013 Science
PARP inhibitors: Synthetic lethality in the clinic
2017 StandoutScience
Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis
2023 StandoutNobel
Host cell transcriptional profiling during malaria liver stage infection reveals a coordinated and sequential set of biological events
2009
Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA
2021 StandoutNobel
Nucleoside-modified VEGFC mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema
2021 StandoutNobel
The Ig Domain Protein CD9P-1 Down-regulates CD81 Ability to Support Plasmodium yoelii Infection
2009
Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge
2017 StandoutNobel
UV Light Potentiates STING (Stimulator of Interferon Genes)-dependent Innate Immune Signaling through Deregulation of ULK1 (Unc51-like Kinase 1)
2015 StandoutNobel
Lipid-like materials for low-dose, in vivo gene silencing
2010
Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2′,3′ cGAMP Signaling
2015 StandoutNobel
Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA
2013
Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing
2016 Standout
Cyclic Dinucleotides and the Innate Immune Response
2013
Lipid nanoparticles for mRNA delivery
2021 Standout
Ionizable Amphiphilic Dendrimer‐Based Nanomaterials with Alkyl‐Chain‐Substituted Amines for Tunable siRNA Delivery to the Liver Endothelium In Vivo
2014
mRNA-based therapeutics — developing a new class of drugs
2014 StandoutNobel
Structural mechanism of cytosolic DNA sensing by cGAS
2013 Nature
Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity
2015 Standout
Lipid-based vectors for siRNA delivery
2012
Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity
2014 StandoutNobel
Identification and characterization of phosphodiesterases that specifically degrade 3′3′-cyclic GMP-AMP
2015
Crosstalk between the cGAS DNA Sensor and Beclin-1 Autophagy Protein Shapes Innate Antimicrobial Immune Responses
2014
Malaria: Biology and Disease
2016
An ionizable lipid toolbox for RNA delivery
2021 StandoutNobel
Structural Biochemistry of a Vibrio cholerae Dinucleotide Cyclase Reveals Cyclase Activity Regulation by Folates
2014
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
mRNA vaccines for infectious diseases: principles, delivery and clinical translation
2021 StandoutNobel
Colorectal cancer
2019 Standout
Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STING
2014
Non-viral vectors for gene-based therapy
2014 Standout
Immunotherapy in colorectal cancer: rationale, challenges and potential
2019
Targeting the hypnozoite reservoir of Plasmodium vivax: the hidden obstacle to malaria elimination
2010
Inhibition of the OAS/RNase L pathway by viruses
2015
DNA‐Based Asymmetric Catalysis
2005 StandoutNobel
RNAi-based therapeutic strategies for metabolic disease
2011
Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs
2014
Interferons and viruses: an evolutionary arms race of molecular interactions
2015 StandoutNobel
Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy
2017 Standout
Lipid‐based nanotherapeutics for siRNA delivery
2009
Structural Basis for the Catalytic Mechanism of DncV, Bacterial Homolog of Cyclic GMP-AMP Synthase
2015
Communication by Extracellular Vesicles: Where We Are and Where We Need to Go
2016 Standout
Cyclic GMP–AMP signalling protects bacteria against viral infection
2019 Nature
Lipid nanoparticles for nucleic acid delivery: Current perspectives
2020
Cyclic Dinucleotides Trigger ULK1 (ATG1) Phosphorylation of STING to Prevent Sustained Innate Immune Signaling
2013
Binding-Pocket and Lid-Region Substitutions Render Human STING Sensitive to the Species-Specific Drug DMXAA
2014
Chemistry of Class 1 CRISPR-Cas effectors: Binding, editing, and regulation
2020 StandoutNobel
A Microscale Human Liver Platform that Supports the Hepatic Stages of Plasmodium falciparum and vivax
2013
OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids
2014
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
2016 Standout
Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens
2015 StandoutNobel
Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy
2015
Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies
2018 StandoutNobel
Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer
2016
Overlapping Patterns of Rapid Evolution in the Nucleic Acid Sensors cGAS and OAS1 Suggest a Common Mechanism of Pathogen Antagonism and Escape
2015
TMEM41B Is a Pan-flavivirus Host Factor
2020 StandoutNobel
The Unexpected Importance of the Primary Structure of the Hydrophobic Part of One-Component Ionizable Amphiphilic Janus Dendrimers in Targeted mRNA Delivery Activity
2022 StandoutNobel
Ionizable Lipid Nanoparticles for In Vivo mRNA Delivery to the Placenta during Pregnancy
2023 StandoutNobel
Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer
2018 Standout
Optimization-by-design of hepatotropic lipid nanoparticles targeting the sodium-taurocholate cotransporting polypeptide
2019
Covalent Schiff Base Catalysis and Turnover by a DNAzyme: A M2+-Independent AP-Endonuclease Mimic
2004
Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs
2015
Targeted and Equally Distributed Delivery of mRNA to Organs with Pentaerythritol-Based One-Component Ionizable Amphiphilic Janus Dendrimers
2023 StandoutNobel
eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation
2016 StandoutNatureNobel
Nucleic Acid Delivery: The Missing Pieces of the Puzzle?
2012
Lipid Nanoparticle Formulations for Enhanced Co-delivery of siRNA and mRNA
2018
The Hitchhiker’s Guide to Flow Chemistry
2017 Standout
One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA
2021 StandoutNobel
Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids
2014
Lipid Nanoparticle Technology for Clinical Translation of siRNA Therapeutics
2019
Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems
2014 StandoutNobel
Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo**
2012
Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals
2022 StandoutNobel
Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release
2016 Standout
A bacterial Argonaute with noncanonical guide RNA specificity
2016 StandoutNobel
Nanotechnology for Multimodal Synergistic Cancer Therapy
2017 Standout
Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo**
2012
Interferon-Stimulated Genes: A Complex Web of Host Defenses
2014 StandoutNobel
Layer-by-Layer Nanoparticles for Systemic Codelivery of an Anticancer Drug and siRNA for Potential Triple-Negative Breast Cancer Treatment
2013
Specific hepatic delivery of procollagen α1(I) small interfering RNA in lipid‐like nanoparticles resolves liver fibrosis
2015
Viruses transfer the antiviral second messenger cGAMP between cells
2015 Science
Lipids and Lipid Derivatives for RNA Delivery
2021
Multistage nanoparticle delivery system for deep penetration into tumor tissue
2011 StandoutNobel
Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune adaptor protein STING
2015
STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade
2015
Lipid Delivery Systems for Nucleic-Acid-Based-Drugs: From Production to Clinical Applications
2019
Genomic Screening with RNAi: Results and Challenges
2010
Targeted Delivery of mRNA with One-Component Ionizable Amphiphilic Janus Dendrimers
2021 StandoutNobel
In vivo hematopoietic stem cell modification by mRNA delivery
2023 StandoutScienceNobel
Rapid Discovery of Potent siRNA-Containing Lipid Nanoparticles Enabled by Controlled Microfluidic Formulation
2012
Scalable mRNA and siRNA Lipid Nanoparticle Production Using a Parallelized Microfluidic Device
2021 StandoutNobel
Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment
2022 StandoutNobel
Throughput-scalable manufacturing of SARS-CoV-2 mRNA lipid nanoparticle vaccines
2023 StandoutNobel
Transmission of innate immune signaling by packaging of cGAMP in viral particles
2015 Science
Design of Chitosan-Based Nanoformulations for Efficient Intracellular Release of Active Compounds
2014
Treatment of erythropoietin deficiency in mice with systemically administered siRNA
2012 StandoutNobel
N‐Carboxyanhydride Polymerization of Glycopolypeptides That Activate Antigen‐Presenting Cells through Dectin‐1 and Dectin‐2
2018 StandoutNobel
Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects
2013 Science
Promising Targets for Cancer Immunotherapy: TLRs, RLRs, and STING-Mediated Innate Immune Pathways
2017
Works of Ingo Röhl being referenced
Kinome-Wide RNAi Screen Implicates at Least 5 Host Hepatocyte Kinases in Plasmodium Sporozoite Infection
2008
Defined Folate-PEG-siRNA Conjugates for Receptor-specific Gene Silencing
2012
cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
2013 StandoutNature
Modified Nucleoside Triphosphates: Synthesis and Applications for RNA In Vitro Selection
2003
Development of Lipidoid–siRNA Formulations for Systemic Delivery to the Liver
2009
Host Scavenger Receptor SR-BI Plays a Dual Role in the Establishment of Malaria Parasite Liver Infection
2008