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Nonalcoholic Fatty Liver Disease
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Drug-Induced Hepatotoxicity
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Uric Acid and Cardiovascular Risk
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Chronic pain and distress in older people: A cluster analysis
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Pharmacogenomics of proton pump inhibitors
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Subtle Acquired Renal Injury as a Mechanism of Salt-Sensitive Hypertension
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Molecular Regulation of Hepatic Fibrosis, an Integrated Cellular Response to Tissue Injury
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Developmental Changes in Human Liver CYP2D6 Expression
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Free radicals and antioxidants in normal physiological functions and human disease
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Limitations of the Sense of Coherence Scale in a Swedish Pentecostal Population
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2010
Identification of the Missing Component in the Mitochondrial Benzamidoxime Prodrug-converting System as a Novel Molybdenum Enzyme
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Sense of coherence and illness appraisal in older women's quality of life
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Reverse transcriptase-PCR quantification of mRNA levels from cytochrome (CYP)1, CYP2 and CYP3 families in 22 different human tissues
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Significance of the Minor Cytochrome P450 3A Isoforms
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Coping potential and disability--sense of coherence in adults with cerebral palsy
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Functional characterization of eight human cytochrome P450 1A2 gene variants by recombinant protein expression
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The AmpliChip CYP450 test: cytochrome P450 2D6 genotype assessment and phenotype prediction
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Intergenic mRNA Molecules Resulting fromtrans-Splicing
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The ChEMBL database in 2017
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On the Mechanism of Action of Cytochrome P450: Evaluation of Hydrogen Abstraction in Oxygen-Dependent Alcohol Oxidation
1994
A novel polymorphism in the 17β-hydroxysteroid dehydrogenase type 5 (aldo-keto reductase 1C3) gene is associated with lower serum testosterone levels in caucasian men
2006
Molecular epidemiology of human cancer risk: gene-environment interactions andp53 mutation spectrum in human lung cancer
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Genetic Polymorphism of Cytochrome P450s, CYP2C19, and CYP2C9 in a Japanese Population
1998
The Ligands of Estrogen Receptor α Regulate Cytochrome P4502C9 (CYP2C9) Expression
2011
Oxygen and Xenobiotic Reductase Activities of Cytochrome P450
1995
Oxidative stress and antioxidant defenses in ethanol-induced cell injury
2004
Search for an association between the human CYP1A2 genotype and CYP1A2 metabolic phenotype
2006
CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis
2000
Polymorphic Cytochrome P450 2D6: Humanized Mouse Model and Endogenous Substrates
2004
Population genetic structure of variable drug response
2001
A functional C–G polymorphism in the CYP7B1 promoter region and its different distribution in Orientals and Caucasians
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The genetic determinants of the CYP3A5 polymorphism
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CYP3A7 protein expression is high in a fraction of adult human livers and partially associated with the CYP3A7*1C allele
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Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugs
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ABCB1 and Cytochrome P450 Polymorphisms
2009
p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling
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Non-specific low back pain
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Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation
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Pathway-Targeted Pharmacogenomics of CYP1A2 in Human Liver
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The P450 Superfamily: Update on New Sequences, Gene Mapping, and Recommended Nomenclature
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Evaluation of probe drugs and pharmacokinetic metrics for CYP2D6 phenotyping
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Use of human hepatocyte-like cells derived from induced pluripotent stem cells as a model for hepatocytes in hepatitis C virus infection
2011
Molecular Mechanisms of Polymorphic CYP3A7 Expression in Adult Human Liver and Intestine
2002
Novel CYP2C9 Promoter Variants and Assessment of Their Impact on Gene Expression
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Scanning chimeragenesis: the approach used to change the substrate selectivity of fatty acid monooxygenase CYP102A1 to that of terpene ω-hydroxylase CYP4C7
2009
Influence of CYP2C9 genetic variants on gastrointestinal bleeding associated with nonsteroidal anti-inflammatory drugs
2011
Allele-specific expression and gene methylation in the control of CYP1A2 mRNA level in human livers
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Sequence diversity and haplotype structure at the human CYP3A cluster
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CYP2D6 genotyping strategy based on gene copy number determination by TaqMan real-rime PCR
2003
Clinical relevance of genetic polymorphisms in the human CYP2C subfamily
2001
The role of O2.− in the production of HO.: in vitro and in vivo
1994
Developmental Expression of CYP2E1 in the Human Liver
1996
Models and mechanisms of O‐O bond activation by cytochrome P450
2004
The P450 Superfamily: Update on New Sequences, Gene Mapping, Accession Numbers, Early Trivial Names of Enzymes, and Nomenclature
1993 Standout
Pharmacogenetics of antiarrhythmic therapy
2006
Xenobiotic metabolizing enzymes in the central nervous system: Contribution of cytochrome P450 enzymes in normal and pathological human brain
2007
A critical appraisal of human genotyping for pain therapy
2010
Pharmacogenetics of antimalarial drugs: effect on metabolism and transport
2009
The role of iron in the initiation of lipid peroxidation
1987
Mammalian Cytochrome P450 Enzymes Catalyze the Phenol-coupling Step in Endogenous Morphine Biosynthesis
2009
N-Nitrosodiethylamine mechanistic data and risk assessment: Bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation
1996
DNA Microarray Technology in the Clinical Environment:The AmpliChip CYP450 Test for CYP2D6 and CYP2C19 Genotyping
2009
New Insights into the Regulation of CYP2C9 Gene Expression: The Role of the Transcription Factor GATA-4
2009
Developmental Pharmacology — Drug Disposition, Action, and Therapy in Infants and Children
2003 Standout
Cytochrome P450: Structure, function, and generation of reactive oxygen species
1995
Pharmacogenetics of Neonatal Opioid Toxicity Following Maternal Use of Codeine During Breastfeeding: A Case–Control Study
2008
Association between CYP2E1 genetic polymorphisms and lung cancer risk: A meta-analysis
2009
[47] Superoxide production
1984
Relationship between cytochrome P450 catalytic cycling and stability: fast degradation of ethanol-inducible cytochrome P450 2E1 (CYP2E1) in hepatoma cells is abolished by inactivation of its electron donor NADPH–cytochrome P450 reductase
1999
The Fourth Molybdenum Containing Enzyme mARC: Cloning and Involvement in the Activation ofN-Hydroxylated Prodrugs
2008
Significant Effect of Polymorphisms inCYP2D6andABCC2on Clinical Outcomes of Adjuvant Tamoxifen Therapy for Breast Cancer Patients
2010
Effect of a New FunctionalCYP3A4Polymorphism on Calcineurin Inhibitors‘ Dose Requirements and Trough Blood Levels in Stable Renal Transplant Patients
2011
Organic Photoredox Catalysis
2016 Standout
Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine.
1993
Fine-scale structural variation of the human genome
2005
Efficient Differentiation of Functional Hepatocytes from Human Embryonic Stem Cells
2008
Cytochrome P4502C9 genotype in Southeast Anatolia and possible relation with some serum tumour markers and cytokines.
2001
The Free Radical Theory of Aging Matures
1998 Standout
Genetic Structure of Human Populations
2002 StandoutScience
Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences.
1997
Pharmacogenomics of Tamoxifen Therapy
2009
Deficiencies in Mouse Myh and Ogg1 Result in Tumor Predisposition and G to T Mutations in Codon 12 of the K-Ras Oncogene in Lung Tumors
2004 StandoutNobel
MOLECULAR MECHANISMS OF GENETIC POLYMORPHISMS OF DRUG METABOLISM
1997
Multiplex Assay for Comprehensive Genotyping of Genes Involved in Drug Metabolism, Excretion, and Transport
2007
Association of CYP1A1 Polymorphisms with Differential Metabolic Activation of 17β-Estradiol and Estrone
2005
Induction of cytochrome P-4502E1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger RNA
1993
Catalytic Dehydrogenative Cross-Coupling: Forming Carbon−Carbon Bonds by Oxidizing Two Carbon−Hydrogen Bonds
2011 Standout
On the stoichiometry of the oxidase and monooxygenase reactions catalyzed by liver microsomal cytochrome P-450. Products of oxygen reduction.
1984
Electrochemiluminescence (ECL)
2004 Standout
Evaluation of the prognostic value of the health assessment form among patients clinically ready for discharge
1994
Cytochrome P450-mediated metabolism in the human gut wall
2009
Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells
2012 StandoutNobel
Oxidation of benzene by the OH radical. A product and pulse radiolysis study in oxygenated aqueous solution
1993
The Mitochondrial Amidoxime Reducing Component (mARC) Is Involved in Detoxification of N-Hydroxylated Base Analogues
2012
Identification of Variants of CYP3A4 and Characterization of Their Abilities to Metabolize Testosterone and Chlorpyrifos
2001
CYP2E1 – Biochemical and Toxicological Aspects and Role in Alcohol-Induced Liver Injury
2008
Superoxide Ion: Generation and Chemical Implications
2016 Standout
Hydroxyl-radical-induced oxidation of cyclohexa-1,4-diene by O2 in aqueous solution. A pulse radiolysis and product study
1993
Reductive beta-scission of the hydroperoxides of fatty acids and xenobiotics: role of alcohol-inducible cytochrome P-450.
1990
Cytochrome P450 3A4 and P‐glycoprotein Expression in Human Small Intestinal Enterocytes and Hepatocytes: A Comparative Analysis in Paired Tissue Specimens
2004
The Mononuclear Molybdenum Enzymes
2014 Standout
Oxidative Stress, Toxicology, and Pharmacology of CYP2E1
2004
Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study.
2004
Heme-Containing Oxygenases
1996 Standout
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Comprehensive analysis of the genetic factors determining expression and function of hepatic CYP2D6
2001
Pharmacogenomics: Translating Functional Genomics into Rational Therapeutics
1999 StandoutScience
Mechanism of Oxidation Reactions Catalyzed by Cytochrome P450 Enzymes
2004 Standout
The Search for Endogenous Activators of the Aryl Hydrocarbon Receptor
2007
Oxidative and reductive metabolism by cytochrome P450 2E1
1992
Enzyme-Controlled Nitrogen-Atom Transfer Enables Regiodivergent C–H Amination
2014 StandoutNobel
CLINICAL AND TOXICOLOGICAL RELEVANCE OF CYP2C9: Drug-Drug Interactions and Pharmacogenetics
2005
Cytochrome P450 and Chemical Toxicology
2007
A New Functional CYP3A4 Intron 6 Polymorphism Significantly Affects Tacrolimus Pharmacokinetics in Kidney Transplant Recipients
2011
The Induction of Cytochrome P450 3A5 (CYP3A5) in the Human Liver and Intestine Is Mediated by the Xenobiotic Sensors Pregnane X Receptor (PXR) and Constitutively Activated Receptor (CAR)
2004
Structure and Chemistry of Cytochrome P450
2005 Standout
Works of Inger Johansson being referenced
Amidoxime Reductase System Containing Cytochrome b5 Type B (CYB5B) and MOSC2 Is of Importance for Lipid Synthesis in Adipocyte Mitochondria
2011
Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis.
1995
The impact of CYP2E1 on the development of alcoholic liver disease as studied in a transgenic mouse model
2008
Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation.
1994
Analysis of the CYP2D6 gene in relation to debrisoquin and desipramine hydroxylation in a Swedish population
1992
CNVs of human genes and their implication in pharmacogenetics
2008
Ethanol-inducible cytochrome P4502E1: Genetic polymorphism, regulation, and possible role in the etiology of alcohol-induced liver disease
1993
CHARACTERIZATION AND PARTIAL PURIFICATION OF THE RAT AND HUMAN ENZYME SYSTEMS ACTIVE IN THE REDUCTION OF N-HYDROXYMELAGATRAN AND BENZAMIDOXIME
2005
Zonation of cytochrome P450 isozyme expression and induction in rat liver
1992
Cloning and Tissue Distribution of a Novel Human Cytochrome P450 of the CYP3A Subfamily, CYP3A43
2001
Validation of Methods for CYP2C9 Genotyping: Frequencies of Mutant Alleles in a Swedish Population
1999
Expression of drug metabolizing enzymes in hepatocyte-like cells derived from human embryonic stem cells
2007
Debrisoquine and S-mephenytoin hydroxylation phenotypes and genotypes in a Korean population
1996
The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine
1997
Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1
2006
Phenotype and genotype analysis of debrisoquine hydroxylase (CYP2D6) in a black Zimbabwean population
1996
Acetone‐regulated synthesis and degradation of cytochrome P4502E2 and cytochrome P4502B1 in rat liver
1991
Transcriptional control of CYP2E1 in the perivenous liver region and during starvation
1990
Colorectal Cancer-Specific Cytochrome P450 2W1: Intracellular Localization, Glycosylation, and Catalytic Activity
2010
PCR-based genotyping for duplicated and deleted CYP2D6 genes
1996
Characterization and tissue distribution of a novel human cytochrome P450—CYP2U1
2004
CYP2D6 genotype and antipsychotic-induced extrapyramidal side effects in schizophrenic patients
2000
Genetic mechanisms for duplication and multiduplication of the human CYP2D6 gene and methods for detection of duplicated CYP2D6 genes
1999
Signal Transduction-mediated Activation of the Aryl Hydrocarbon Receptor in Rat Hepatoma H4IIE Cells
1997
Hepatotoxicity induced by iron overload and alcohol
1996
Genetic polymorphism of cytochrome P450 CYP2D6 in Zimbabwean population
1993
Centrilobular expression of ethanol-inducible cytochrome P-450 (IIE1) in rat liver
1988
Genetic analysis of the CYP2D locus in relation to debrisoquine hydroxylation capacity in Korean, Japanese and Chinese subjects
1995
A Combination of Mutations in the CYP2D6*17(CYP2D6Z) Allele Causes Alterations in Enzyme Function
1997
Ethanol-, fasting-, and aceton-inducible cytochromes P-450 in rat liver: regulation and characteristics of enzymes belonging to the IIB and IIE gene subfamilies
1988
COMPARATIVE ANALYSIS OF CYP3A EXPRESSION IN HUMAN LIVER SUGGESTS ONLY A MINOR ROLE FOR CYP3A5 IN DRUG METABOLISM
2003
Phenotyping and genotyping of S-mephenytoin hydroxylase (cytochrome P450 2C19) in a Shona population of Zimbabwe*
1995
Time-dependent pharmacokinetics and drug metabolism of atovaquone plus proguanil (Malarone) when taken as chemoprophylaxis
2002
Ligand-dependent maintenance of ethanol-inducible cytochrome P-450 in primary rat hepatocyte cell cultures
1988
Characterization of the CYP2D6*29 allele commonly present in a black Tanzanian population causing reduced catalytic activity
2001
Genetic analysis of the interethnic difference between Chinese and Caucasians in the polymorphic metabolism of debrisoquine and codeine
1991
THE IMPACT OF CYP2C9 GENETICS AND ORAL CONTRACEPTIVES ON CYTOCHROME P450 2C9 PHENOTYPE
2004
Genetic Polymorphism and Toxicology—With Emphasis on Cytochrome P450
2010
Genetic polymorphism of xenobiotic metabolizing enzymes among Chinese lung cancer patients
1999
Hydroxylation of acetone by ethanol‐ and acetone‐inducible cytochrome P‐450 in liver microsomes and reconstituted membranes
1986
In VitroKinetics of Two HumanCYP1A1Variant Enzymes Suggested to Be Associated with Interindividual Differences in Cancer Susceptibility
1997
Carbon tetrachloride‐induced lipid peroxidation dependent on an ethanol‐inducible form of rabbit liver microsomal cytochrome P‐450
1985
Sense of coherence among elderly somatic patients: predictive power regarding future needs of care
1995
Decreased capacity for debrisoquine metabolism among black Tanzanians: analyses of the CYP2D6 genotype and phenotype.
1999
Hydroxyl radical-mediated, cytochrome P-450-dependent metabolic activation of benzene in microsomes and reconstituted enzyme systems from rabbit liver.
1983
Mechanisms of hydroxyl radical formation and ethanol oxidation by ethanol-inducible and other forms of rabbit liver microsomal cytochromes P-450.
1984
Catalytic properties of purified forms of rabbit liver microsomal cytochrome P-450 in reconstituted phospholipid vesicles
1980
Cytochrome b5 as electron donor to rabbit liver cytochrome P-450LM2 in reconstituted phospholipid vesicles
1980
The mechanism of cytochrome P-450-dependent oxidation of ethanol in reconstituted membrane vesicles.
1981
Substrate-, hormone-, and cAMP-regulated cytochrome P450 degradation.
1990
Benzene metabolism by ethanol-, acetone-, and benzene-inducible cytochrome P-450 (IIE1) in rat and rabbit liver microsomes.
1988
Frequent distribution of ultrarapid metabolizers of debrisoquine in an ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles.
1996
Perindopril Treatment Affects Both Preglomerular Renal Vascular Lumen Dimensions and In Vivo Responsiveness to Vasoconstrictors in Spontaneously Hypertensive Rats
1998
Ultrarapid metabolism of sparteine
1998
Decreased capacity for debrisoquine metabolism among black Tanzanians
1999
Ten percent of North Spanish individuals carry duplicated or triplicated CYP2D6 genes associated with ultrarapid metabolism of debrisoquine
1999