Standout Papers
Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
Computational Design of Self-Assembling Protein Nanomaterials with Atomic Level Accuracy
2012 StandoutScienceNobel
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
2001 StandoutScienceNobel
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
2001 StandoutScienceNobel
A Sulfilimine Bond Identified in Collagen IV
2009 StandoutScienceNobel
Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants
2019 StandoutScienceNobel
The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency
2008 StandoutScienceNobel
Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate
2005
The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases
2001
Functional Analysis of Conserved Histidine Residues in Cephalosporium acremonium Isopenicillin N Synthase by Site-directed Mutagenesis
1996
HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O2 levels
2003 StandoutNobel
Computational design of soluble and functional membrane protein analogues
2024 StandoutNatureNobel
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
The 2‐His‐1‐Carboxylate Facial Triad — An Emerging Structural Motif in Mononuclear Non‐Heme Iron(II) Enzymes
1997
Structure of a Voltage-Dependent K+ Channel β Subunit
1999 StandoutNobel
Automated protein model building combined with iterative structure refinement.
1999 Standout
Ta6Br122+, a tool for phase determination of large biological assemblies by X-ray crystallography
1997 Nobel
Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases
2003 StandoutNobel
C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation
2001 StandoutNobel
A 9 Å Resolution X-Ray Crystallographic Map of the Large Ribosomal Subunit
1998 StandoutNobel
Destabilization of the complete protein secondary structure on binding to the chaperone GroEL
1994 StandoutNatureNobel
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
2002 StandoutNatureNobel
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
2002 Standout
Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases
2010
Isolation and Biochemical Characterization of Hypophosphite/ 2-Oxoglutarate Dioxygenase
2002
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Alteration of the Co-substrate Selectivity of Deacetoxycephalosporin C Synthase
2001
Site-directed Mutagenesis of 2,4-Dichlorophenoxyacetic Acid/α-Ketoglutarate Dioxygenase
2000
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
2012 StandoutNatureNobel
Structure of isopenicillinN synthase complexed with substrate and the mechanism ofpenicillin formation
1997 Nature
Oxygen sensing by HIF hydroxylases
2004 StandoutNobel
Principles for designing ideal protein structures
2012 StandoutNatureNobel
HIF-1, O2, and the 3 PHDs
2001 StandoutNobel
The Active Site of an Algal Prolyl 4-Hydroxylase Has a Large Structural Plasticity
2007
Structure of an aromatic-ring-hydroxylating dioxygenase – naphthalene 1,2-dioxygenase
1998
The Geometry of the Ribosomal Polypeptide Exit Tunnel
2006 StandoutNobel
Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes
1999
Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage
2002 StandoutNatureNobel
High-resolution structure prediction and the crystallographic phase problem
2007 StandoutNatureNobel
Crystal structure of a clavaminate synthase–Fe(II)–2‐oxoglutarate–substrate–NO complex: evidence for metal centred rearrangements
2002
THE CRYSTAL STRUCTURE OF THE ALDOSE REDUCTASE NADPH BINARY COMPLEX
1992
Atomic structures at last: the ribosome in 2000
2001 StandoutNobel
Structure and Mechanism of Anthocyanidin Synthase from Arabidopsis thaliana
2002
Structural and energetic basis of folded-protein transport by the FimD usher
2013 StandoutNatureNobel
Characterization of the iron- and 2-oxoglutarate-binding sites of human prolyl 4-hydroxylase
1997
Alternative oxidation by isopenicillin N synthase observed by X-ray diffraction
2001
Assessment of protein models with three-dimensional profiles
1992 StandoutNature
Organization, Structure, and Assembly of α-Carboxysomes Determined by Electron Cryotomography of Intact Cells
2009
Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA
2003 Nature
The use of dioxygen by HIF prolyl hydroxylase (PHD1)
2002 StandoutNobel
Anaerobic Crystallisation of an Isopenicillin N Synthase · Fe(II) · Substrate Complex Demonstrated by X‐Ray Studies
1996
The Structure of Isolated Synechococcus Strain WH8102 Carboxysomes as Revealed by Electron Cryotomography
2007
Identification of Strictly Conserved Histidine and Arginine Residues as Part of the Active Site in Petunia hybrida Flavanone 3β‐Hydroxylase
1997
Mechanistic studies of 1-aminocyclopropane-1-carboxylic acid oxidase: single turnover reaction
2004
Structure of proline 3‐hydroxylase
2001
Prolyl 4-hydroxylases and their protein disulfide isomerase subunit
1998
Localization of insulin-like growth factor-1 mRNA in murine central nervous system during postnatal development
1991
The iron(II) and 2-oxoacid-dependent dioxygenases and their role in metabolism (1967 to 1999)
2000
Discoveries in Rubisco (Ribulose 1,5-bisphosphate carboxylase/oxygenase): a historical perspective
2007
RF3 Induces Ribosomal Conformational Changes Responsible for Dissociation of Class I Release Factors
2007 StandoutNobel
Crystal Structure of Carbapenem Synthase (CarC)
2003
A protein-folding reaction under kinetic control
1992 StandoutNatureNobel
Structure of Human FIH-1 Reveals a Unique Active Site Pocket and Interaction Sites for HIF-1 and von Hippel-Lindau
2003
Alternative Reactivity of an α-Ketoglutarate-Dependent Iron(II) Oxygenase: Enzyme Self-Hydroxylation
2001
Crystal structure of the 30 S ribosomal subunit from Thermus thermophilus: purification, crystallization and structure determination
2001 StandoutNobel
Characterization of α-Ketoglutarate-dependent Taurine Dioxygenase from Escherichia coli
1997
HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
2007 StandoutNobel
Kinetic and crystallographic studies on deacetoxycephalosporin C synthase (DAOCS)
2001
Rubisco activase – Rubisco's catalytic chaperone
2003
Selection of tRNA by the Ribosome Requires a Transition from an Open to a Closed Form
2002 StandoutNobel
Crystal Structures of the Ribosome in Complex with Release Factors RF1 and RF2 Bound to a Cognate Stop Codon
2005 StandoutNobel
The transition between the open and closed states of rubisco is triggered by the inter-phosphate distance of the bound bisphosphate
2000
Activity-Dependent IGF-1 Exocytosis Is Controlled by the Ca2+-Sensor Synaptotagmin-10
2011 StandoutNobel
Crystal structure of human homogentisate dioxygenase.
2000
The Retinoblastoma Binding Protein RBP2 Is an H3K4 Demethylase
2007 StandoutNobel
Ribosome Structure and the Mechanism of Translation
2002 StandoutNobel
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
2011 StandoutNobel
Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase.
2000
Structural studies on human 2-oxoglutarate dependent oxygenases
2010
Collagen Hydroxylases and the Protein Disulfide Isomerase Subunit of Prolyl 4‐Hydroxylases
1998
Reconstitution of active dimeric ribulose bisphosphate carboxylase from an unfolded state depends on two chaperonin proteins and Mg-ATP
1989 Nature
One motif--many different reactions.
2000
Life with Oxygen
2007 StandoutScienceNobel
Geometric and Electronic Structure/Function Correlations in Non-Heme Iron Enzymes
1999 Standout
Herbicide-Degrading α-Keto Acid-Dependent Enzyme TfdA: Metal Coordination Environment and Mechanistic Insights
1999
X-ray Structure of the FimC-FimH Chaperone-Adhesin Complex from Uropathogenic Escherichia coli
1999 Science
Mobilization of Rubisco and Stroma-Localized Fluorescent Proteins of Chloroplasts to the Vacuole by anATGGene-Dependent Autophagic Process
2008 StandoutNobel
Structural basis of the oxidative activation of the carboxysomal γ-carbonic anhydrase, CcmM
2010
Oxygen Activation and Arene Hydroxylation by Functional Mimics of α-Keto Acid-Dependent Iron(II) Dioxygenases
1999
Structural and Functional Aspects of Metal Sites in Biology
1996 Standout
Catalysis for the Valorization of Exhaust Carbon: from CO2to Chemicals, Materials, and Fuels. Technological Use of CO2
2013 Standout
The crystal structure of the aldose reductase.NADPH binary complex.
1992
‘Chemical co-substrate rescue’ of phytanoyl-CoA 2-hydroxylase mutants causing Refsum’s Disease
2001
A Mechanistic Study of Isopenicillin N Formation Using Density Functional Theory
2000
MonoanionicN,N,O-Scorpionate Ligands and their Iron(II) and Zinc(II) Complexes: Models for Mononuclear Active Sites of Non-Heme Iron Oxidases and Zinc Enzymes
2001
Synthesis and Characterization of the Benzoylformato Ferrous Complexes with the Hindered Tris(pyrazolyl)borate Ligand as a Structural Model for Mononuclear Non-Heme Iron Enzymes
1997
Synthetic Analogues of Glycosylphosphatidylinositol-Anchored Proteins and Their Behavior in Supported Lipid Bilayers
2007 StandoutNobel
Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway
2002 Nobel
Covalent organic frameworks comprising cobalt porphyrins for catalytic CO 2 reduction in water
2015 StandoutScienceNobel
Ethylene biosynthesis: The role of 1‐aminocyclopropane‐1‐carboxylate (ACC) oxidase, and its possible evolutionary origin
1997
Pterin-Dependent Amino Acid Hydroxylases
1996
Circular Dichroism and Magnetic Circular Dichroism Spectroscopic Studies of the Non-Heme Ferrous Active Site in Clavaminate Synthase and Its Interaction with α-Ketoglutarate Cosubstrate
1998
Crystal Structure of Soybean Lipoxygenase L-1 at 1.4 Å Resolution,
1996
Dioxygen Activation at Mononuclear Nonheme Iron Active Sites: Enzymes, Models, and Intermediates
2004 Standout
Nitric Oxide Impairs Normoxic Degradation of HIF-1α by Inhibition of Prolyl Hydroxylases
2003
Spectroscopic Studies of Substrate Interactions with Clavaminate Synthase 2, a Multifunctional α-KG-Dependent Non-Heme Iron Enzyme: Correlation with Mechanisms and Reactivities
2001
Interconversion of two oxidized forms of taurine/α-ketoglutarate dioxygenase, a non-heme iron hydroxylase: Evidence for bicarbonate binding
2003
Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling
2002 StandoutScienceNobel
Minireview
1997
Bis(pyrazol-1-yl)acetates as Tripodal Heteroscorpionate Ligands in Iron Chemistry: Syntheses and Structures of Iron(II) and Iron(III) Complexes with bpza, bdmpza, and bdtbpza Ligands
2003
Frontiers, Opportunities, and Challenges in Biochemical and Chemical Catalysis of CO2 Fixation
2013 Standout
Mechanism of Rubisco: The Carbamate as General Base
1998
Engineering Rubisco to change its catalytic properties
1995
Tertiary Structure of Plant RuBisCO: Domains and Their Contacts
1988 Science
Role of the nonheme Fe(II) center in the biosynthesis of the plant hormone ethylene
1999
Resonance Raman Studies of the Iron(II)−α-Keto Acid Chromophore in Model and Enzyme Complexes
2001
Reversal of DNA alkylation damage by two human dioxygenases
2002 StandoutNobel
Oxygen Activation by Nonheme Iron(II) Complexes: α-Keto Carboxylate versus Carboxylate
2003
Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth
2014 StandoutNobel
Catalytic Versatility, Stability, and Evolution of the (βα)8-Barrel Enzyme Fold
2005
Between objectivity and subjectivity
1990 Nature
Models for Amide Ligation in Nonheme Iron Enzymes
1997
Molecular Biology of Prion Diseases
1991 StandoutScienceNobel
O2- and α-Ketoglutarate-Dependent Tyrosyl Radical Formation in TauD, an α-Keto Acid-Dependent Non-Heme Iron Dioxygenase
2003
Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity
2004 StandoutNobel
Spectroscopic Studies of 1-Aminocyclopropane-1-carboxylic Acid Oxidase: Molecular Mechanism and CO2 Activation in the Biosynthesis of Ethylene
2002
Product-substrate engineering by bacteria: Studies on clavaminate synthase, a trifunctional dioxygenase
1999
Dioxygen Activation by Enzymes with Mononuclear Non-Heme Iron Active Sites
1996
Works of Inger Andersson being referenced
The structure of the complex between rubisco and its natural substrate ribulose 1,5-bisphosphate
1997
Structural transitions during activation and ligand binding in hexadecameric Rubisco inferred from the crystal structure of the activated unliganded spinach enzyme
1996
Structure and function of Rubisco
2008
Catalysis and regulation in Rubisco
2007
Studies on the active site of deacetoxycephalosporin C synthase
1999
Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes
1995 Nature
A Common Structural Basis for the Inhibition of Ribulose 1,5-Bisphosphate Carboxylase by 4-Carboxyarabinitol 1,5-Bisphosphate and Xylulose 1,5-Bisphosphate
1996
Crystal structure of activated tobacco rubisco complexed with the reaction‐intermediate analogue 2‐carboxy‐arabinitol 1, 5‐bisphosphate
1993
Structural framework for catalysis and regulation in ribulose-1,5-bisphosphate carboxylase/oxygenase
2003
Large Structures at High Resolution: The 1.6 Å Crystal Structure of Spinach Ribulose-1,5- Bisphosphate Carboxylase/Oxygenase Complexed with 2-Carboxyarabinitol Bisphosphate
1996
Structure of a cephalosporin synthase
1998 Nature
Crystallographic analysis of ribulose 1,5-bisphosphate carboxylase from spinach at 2·4 Å resolution
1990
Differing expression of insulin‐like growth factor I in the developing and in the adult rat cerebellum
1988
Comparison of the crystal structures of L2 and L8S8 Rubisco suggests a functional role for the small subunit.
1990
Crystal structure of the active site of ribulose-bisphosphate carboxylase
1989 Nature
Formation of the active site of ribulose-1,5-bisphosphate carboxylase/oxygenase by a disorder-order transition from the unactivated to the activated form.
1993
Crystallization and preliminary x-ray studies of spinach ribulose 1,5-bisphosphate carboxylase/oxygenase complexed with activator and a transition state analogue.
1983
Chimeric Small Subunits Influence Catalysis without Causing Global Conformational Changes in the Crystal Structure of Ribulose-1,5-bisphosphate Carboxylase/Oxygenase,
2005
Structure of a Product Complex of Spinach Ribulose-1,5-bisphosphate Carboxylase/Oxygenase,
1997
Reexamination of the Three-Dimensional Structure of the Small Subunit of RuBisCo from Higher Plants
1989 Science