Standout Papers
Citation Impact
Citing Papers
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
2008 Standout
A selective PIKfyve inhibitor blocks PtdIns(3,5)P 2 production and disrupts endomembrane transport and retroviral budding
2008
ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation
2009 StandoutScience
Platelet activation and platelet-monocyte aggregate formation trigger tissue factor expression in patients with severe COVID-19
2020 Standout
Vulnerabilities of PTEN – TP53 -Deficient Prostate Cancers to Compound PARP–PI3K Inhibition
2014
TOR Signaling in Growth and Metabolism
2006 Standout
Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation
2016
A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension
2019 StandoutNobel
TSC1 Activates TGF-β-Smad2/3 Signaling in Growth Arrest and Epithelial-to-Mesenchymal Transition
2015
PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity
2017 StandoutNature
Hallmarks of Cancer: The Next Generation
2011 Standout
β-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation
2009 StandoutNobel
Inositol Pyrophosphates Inhibit Akt Signaling, Thereby Regulating Insulin Sensitivity and Weight Gain
2010
Molecular mechanisms of GLUT4 regulation in adipocytes
2014
Chapter 2 PI3K/PTEN Signaling in Angiogenesis and Tumorigenesis
2009
Mechanisms of Thrombus Formation
2008 Standout
mTOR Signaling in Growth Control and Disease
2012 Standout
mTOR·RICTOR Is the Ser473 Kinase for Akt/Protein Kinase B in 3T3-L1 Adipocytes
2005
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
2006 Standout
Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
2012 Standout
Paullones are potent inhibitors of glycogen synthase kinase‐3β and cyclin‐dependent kinase 5/p25
2000
AKT/PKB Signaling: Navigating Downstream
2007 Standout
Dynamic control of neuroexocytosis by phosphoinositides in health and disease
2010
Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy
2011
3-Anilino-4-arylmaleimides: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3)
2001
Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer
2016
Mammalian phosphoinositide kinases and phosphatases
2009 StandoutNobel
The role of pathway-selective insulin resistance and responsiveness in diabetic dyslipoproteinemia
2012
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
2014 StandoutNature
Cancer Cell Metabolism: Warburg and Beyond
2008 Standout
Hallmarks of aging: An expanding universe
2023 Standout
The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation
2012
Protease‐activated receptor‐induced Akt activation – regulation and possible function
2007
The ground state of embryonic stem cell self-renewal
2008 StandoutNature
Akt-dependent transformation: there is more to growth than just surviving
2005
Acetyl Coenzyme A: A Central Metabolite and Second Messenger
2015
Phosphatidylinositol 3,5-bisphosphate: metabolism and cellular functions
2005
The Role of Phosphoinositide 3-Kinase C2α in Insulin Signaling
2007
mTOR Signaling in Growth, Metabolism, and Disease
2017 Standout
Cloning and subcellular localization of a human phosphatidylinositol 3-phosphate 5-kinase, PIKfyve/Fab1
2006
Membrane protein sequestering by ionic protein–lipid interactions
2011 StandoutNatureNobel
ATP citrate lyase is an important component of cell growth and transformation
2005
The ATP-gated P2X1 Receptor Plays a Pivotal Role in Activation of Aspirin-treated Platelets by Thrombin and Epinephrine
2008 StandoutNobel
Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen
2001
Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
2010 Standout
PI(3,4,5)P 3 Engagement Restricts Akt Activity to Cellular Membranes
2017
Identification of a Proline-rich Akt Substrate as a 14-3-3 Binding Partner
2003
Signalling by insulin and IGF receptors: supporting acts and new players
2011
Inhibition of voltage‐dependent sodium channels by Ro 31‐8220, a ‘specific’ protein kinase C inhibitor
2000
The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid β-oxidation
2005
The GLUT4 Glucose Transporter
2007
Beginnings of a signal-transduction pathway for bioenergetic control of cell survival
2004
Rapid Ca2+-mediated activation of Rap1 in human platelets
1997
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
2016 Standout
A novel PtdIns3P and PtdIns(3,5)P2 phosphatase with an inactivating variant in centronuclear myopathy
2006
Glycogen synthase kinase 3 (GSK‐3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation
2002
Non-ATP competitive protein kinase inhibitors as anti-tumor therapeutics
2009
ArPIKfyve–PIKfyve interaction and role in insulin-regulated GLUT4 translocation and glucose transport in 3T3-L1 adipocytes
2007
SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth
2008
The Emerging Hallmarks of Cancer Metabolism
2016 Standout
A Role for 14-3-3 in Insulin-stimulated GLUT4 Translocation through Its Interaction with the RabGAP AS160
2006
PI3K/Akt: getting it right matters
2008
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Phosphoinositides in cell regulation and membrane dynamics
2006 StandoutNature
AKT/PKB Signaling: Navigating the Network
2017 Standout
Missing Links in GSK3 Regulation
2001
Specificity and mechanism of action of some commonly used protein kinase inhibitors
2000 Standout
ATP citrate lyase inhibition can suppress tumor cell growth
2005
The tumour suppressor RASSF1A is a novel substrate of PKC
2008
TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth
2006 Standout
The PI3K Pathway in Human Disease
2017 Standout
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans
2009 StandoutNobel
Endogenous Gαq-Coupled Neuromodulator Receptors Activate Protein Kinase A
2017
Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation
2006
PIKfyve: Partners, significance, debates and paradoxes
2008
Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
2007 Standout
The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na + channels
2004 StandoutNobel
PTEN
2014
Lithium-related genetics of bipolar disorder
2001
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
Cyclic Nucleotide Phosphodiesterase 3 Signaling Complexes
2012
ATP Citrate Lyase: Activation and Therapeutic Implications in Non–Small Cell Lung Cancer
2008
Insulin Receptor Isoforms in Physiology and Disease: An Updated View
2017
A Family of cAMP-Binding Proteins That Directly Activate Rap1
1998 StandoutScience
A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action
2010
Akt/PKB: one kinase, many modifications
2015
Physiological roles of PKB/Akt isoforms in development and disease
2007
Activation of the Small GTPase Ral in Platelets
1998
Iterative in Situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for Akt1
2011 StandoutNobel
Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
1998 StandoutNature
Phosphatidylinositol 3-Phosphate [PtdIns(3)P] Is Generated at thePlasma Membrane by an Inositol Polyphosphate 5-Phosphatase: Endogenous PtdIns(3)P Can Promote GLUT4 Translocation to the Plasma Membrane
2006
Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment
2018 StandoutNobel
A circadian gene expression atlas in mammals: Implications for biology and medicine
2014 Standout
Spermidine in health and disease
2018 StandoutScience
Inositol Polyphosphate Multikinase Inhibits Angiogenesis via Inositol Pentakisphosphate-Induced HIF-1α Degradation
2017 StandoutNobel
Metabolic reprogramming and cancer progression
2020 StandoutScience
Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum
2011 StandoutScience
GSK-3: tricks of the trade for a multi-tasking kinase
2003 Standout
Tyrosine kinase inhibitor–induced platelet dysfunction in patients with chronic myeloid leukemia
2009
CD4 Ligation on Human Blood Monocytes Triggers Macrophage Differentiation and Enhances HIV Infection
2014
Exogenous spermine inhibits hypoxia/ischemia-induced myocardial apoptosis via regulation of mitochondrial permeability transition pore and associated pathways
2016
Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal
2014 Standout
First Non-ATP Competitive Glycogen Synthase Kinase 3 β (GSK-3β) Inhibitors: Thiadiazolidinones (TDZD) as Potential Drugs for the Treatment of Alzheimer's Disease
2002
NOX4 Pathway as a Source of Selective Insulin Resistance and Responsiveness
2012
Inflammation and metabolism in tissue repair and regeneration
2017 StandoutScience
Convergence of Multiple Signaling Cascades at Glycogen Synthase Kinase 3: Edg Receptor-Mediated Phosphorylation and Inactivation by Lysophosphatidic Acid through a Protein Kinase C-Dependent Intracellular Pathway
2002
Cytokine Stimulation Promotes Glucose Uptake via Phosphatidylinositol-3 Kinase/Akt Regulation of Glut1 Activity and Trafficking
2007
Turning Signals On and Off: GLUT4 Traffic in the Insulin-Signaling Highway
2005
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
Works of Ingeborg Hers being referenced
Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles
2004
Protein Kinase C-mediated Phosphorylation and Activation of PDE3A Regulate cAMP Levels in Human Platelets
2009
The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31‐8220) are potent inhibitors of glycogen synthase kinase‐3 activity
1999
The Identification of ATP-citrate Lyase as a Protein Kinase B (Akt) Substrate in Primary Adipocytes
2002
Evidence against a direct role of the integrin α2β1 in collagen‐induced tyrosine phosphorylation in human platelets
2000
Insulin/IGF‐1 hybrid receptor expression on human platelets: consequences for the effect of insulin on platelet function
2009
Targeting Non-Small Cell Lung Cancer Cells by Dual Inhibition of the Insulin Receptor and the Insulin-Like Growth Factor-1 Receptor
2013
Regulation of small GTP-binding proteins by insulin
2006
Akt signalling in health and disease
2011 Standout
Regulation of small GTP-binding proteins by insulin
2006
Integrin αIIbβ3 outside-in signaling
2017
Exposure of ligand-binding sites on platelet integrin alpha IIB/beta 3 by phosphorylation of the beta 3 subunit.
1996
Exposure of ligand-binding sites on platelet integrin αIIB/β3 by phosphorylation of the β3 subunit
1996
Role of protein kinase B in insulin-regulated glucose uptake
2005
Fyn and Lyn phosphorylate the Fc receptor γ chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway
2000