Citation Impact
Citing Papers
Protein characterization of Saccharomyces cerevisiae RNA polymerase II after in vivo cross-linking
2007 StandoutNobel
β-Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2
2009 StandoutNobel
Role of Rpn11 Metalloprotease in Deubiquitination and Degradation by the 26 S Proteasome
2002 Science
Parkinson-like syndrome induced by continuous MPTP infusion: Convergent roles of the ubiquitin-proteasome system and α-synuclein
2005 StandoutNobel
Ferroptosis regulation by the NGLY1/NFE2L1 pathway
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Multiubiquitin Chain Binding and Protein Degradation Are Mediated by Distinct Domains within the 26 S Proteasome Subunit Mcb1
1998
Mapping Subunit Contacts in the Regulatory Complex of the 26 S Proteasome
2000
PCI proteins eIF3e and eIF3m define distinct translation initiation factor 3 complexes
2005
Interaction of hHR23 with S5a
1999
Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin–proteasome degradation
2001
The 26S-proteasome: regulation and substrate recognition
1997
An Integrated Mass Spectrometry-based Proteomic Approach
2005
The Structure of the 26S Proteasome Subunit Rpn2 Reveals Its PC Repeat Domain as a Closed Toroid of Two Concentric α-Helical Rings
2012
Quaternary Structure of the ATPase Complex of Human 26S Proteasomes Determined by Chemical Cross-Linking
2001
Protein Translocation Channels in the Proteasome and Other Proteases
1997
Proteasomal Inhibition by α-Synuclein Filaments and Oligomers
2004
Huntingtin Is Ubiquitinated and Interacts with a Specific Ubiquitin-conjugating Enzyme
1996
Regulatory Subunits of Energy-Dependent Proteases
1997
The ubiquitin‐proteasome pathway
2004
A Proteasome Howdunit
2000
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
2002 StandoutNatureNobel
Specific Interactions between ATPase Subunits of the 26 S Protease
1997
Getting in and out of the proteasome
2000
Ubiquitin in chains
2000
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
The COP9/signalosome complex is conserved in fission yeast and has a role in S phase
1999
Protein stability: The COP9 signalosome gets in on the act
2001
Yeast chromatin structure and regulation of GAL gene expression
2000
Investigating the importance of proteasome-interaction for Rad23 function
2002
The 26S proteasome: assembly and function of a destructive machine
2010
The fission yeast COP9/signalosome is involved in cullin modification by ubiquitin-related Ned8p
2001
Evidence for an Interaction between Ubiquitin-Conjugating Enzymes and the 26S Proteasome
2000
The Proteasome, a Novel Protease Regulated by Multiple Mechanisms
1999
The base of the proteasome regulatory particle exhibits chaperone-like activity
1999
Human umbilical cord plasma proteins revitalize hippocampal function in aged mice
2017 Nature
The N-end rule pathway controls the import of peptides through degradation of a transcriptional repressor
1998
Subunit interaction maps for the regulatory particle of the 26S proteasome and the COP9 signalosome
2001
SUG1, a Component of the 26 S Proteasome, Is an ATPase Stimulated by Specific RNAs
1997
SUG1, a Putative Transcriptional Mediator and Subunit of the PA700 Proteasome Regulatory Complex, Is a DNA Helicase
1997
The ubiquitin-proteasome proteolytic pathway
1994 StandoutNobel
Rapid Isolation and Characterization of the Yeast Proteasome Regulatory Complex
2000
Structural Organization of the 19S Proteasome Lid: Insights from MS of Intact Complexes
2006
Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate
2003
Uch2/Uch37 is the Major Deubiquitinating Enzyme Associated with the 26 S Proteasome in Fission Yeast
2004
Electron microscopy and subunit-subunit interaction studies reveal a first architecture of COP9 signalosome11Edited by M. F. Moody
2000
Purification of tetrahymena telomerase and cloning of genes encoding the two protein components of the enzyme
1995 StandoutNobel
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants
2009 StandoutNatureNobel
Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3
2017 StandoutNatureNobel
Identification of ubiquitin-like protein-binding subunits of the 26S proteasome
2002
Cyclin-dependent kinase and Cks/Suc1 interact with the proteasome in yeast to control proteolysis of M-phase targets
1999
Global unfolding of a substrate protein by the Hsp100 chaperone ClpA
1999 Nature
An Archaebacterial ATPase, Homologous to ATPases in the Eukaryotic 26 S Proteasome, Activates Protein Breakdown by 20 S Proteasomes
1999
Nob1p, a new essential protein, associates with the 26S proteasome of growing Saccharomyces cerevisiae cells
2000
Symmetrical Modularity of the COP9 Signalosome Complex Suggests its Multifunctionality
2009
The DUG gene of Drosophila melanogaster encodes a structural and functional homolog of the S. cerevisiae SUG1 predicted ATPase associated with the 26S proteasome
1998
p38 Binds to the Intracellular Precursor of the Lutropin/Choriogonadotropin Receptor and Promotes Its Degradation
2000
A protein conjugation system essential for autophagy
1998 StandoutNatureNobel
Cloning and characterization of Pros45, the Drosophila SUG1 proteasome subunit homolog
1998
Rational design of α-helical tandem repeat proteins with closed architectures
2015 StandoutNatureNobel
Homologues of 26S proteasome subunits are regulators of transcription and translation
1998
The Proteasome: Paradigm of a Self-Compartmentalizing Protease
1998
Transcription Factor Nrf1 Mediates the Proteasome Recovery Pathway after Proteasome Inhibition in Mammalian Cells
2010
The XPB subunit of repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative transcription factor
1997
cDNA Cloning and Characterization of a Human Proteasomal Modulator Subunit, p27 (PSMD9)
1998
Antigen processing by the proteasome
2001
Subcellular Localization, Stoichiometry, and Protein Levels of 26 S Proteasome Subunits in Yeast
1999
Quantitative dynamics and binding studies of the 20S proteasome by NMR
2007 Nature
Complete subunit architecture of the proteasome regulatory particle
2012 Nature
cDNA cloning of p42, a shared subunit of two proteasome regulatory proteins, reveals a novel member of the AAA protein family
1996
Structure of mammalian eIF3 in the context of the 43S preinitiation complex
2015 StandoutNatureNobel
Themes and variations on ubiquitylation
2001
Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1
1999 Nature
Active site mutants in the six regulatory particle ATPases reveal multiple roles for ATP in the proteasome
1998
Reconstitution of the 26S proteasome reveals functional asymmetries in its AAA+ unfoldase
2013
Rpn4p acts as a transcription factor by binding to PACE, a nonamer box found upstream of 26S proteasomal and other genes in yeast
1999
The Ubiquitin System and the N-End Rule Pathway
2000
Multiubiquitin Chain Receptors Define a Layer of Substrate Selectivity in the Ubiquitin-Proteasome System
2004
Degradation of Ornithine Decarboxylase by the 26S Proteasome
2000
The COP9 signalosome is essential for development of Drosophila melanogaster
1999
Formation of an Intricate Helical Bundle Dictates the Assembly of the 26S Proteasome Lid
2013
A Novel Ubiquitination Factor, E4, Is Involved in Multiubiquitin Chain Assembly
1999
The Human 26 S and 20 S Proteasomes Generate Overlapping but Different Sets of Peptide Fragments from a Model Protein Substrate
2000
PCI complexes: pretty complex interactions in diverse signaling pathways
2001
The 19S complex of the proteasome regulates nucleotide excision repair in yeast
2001
The protein translocation channel binds proteasomes to the endoplasmic reticulum membrane
2005
Multiple Associated Proteins Regulate Proteasome Structure and Function
2002
Structural Insights into the COP9 Signalosome and Its Common Architecture with the 26S Proteasome Lid and eIF3
2010
cDNA cloning and functional analysis of p44.5 and p55, two regulatory subunits of the 26S proteasome
1997
Ubiquitin Lys63 is involved in ubiquitination of a yeast plasma membrane protein
1997
The Logic of the 26S Proteasome
2017
Resistance to Diverse Drugs and Ultraviolet Light Conferred by Overexpression of a Novel Human 26 S Proteasome Subunit
1997
cDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome
1998
Loss of autophagy in the central nervous system causes neurodegeneration in mice
2006 StandoutNature
Proteasome: from structure to function
1996
Isolation and Characterization of SUG2
1996
Rad23 and Rpn10: perennial wallflowers join the m�l�e
2004
A Function for Monoubiquitination in the Internalization of a G Protein–Coupled Receptor
1998
Regulation of proteasome assembly and activity in health and disease
2018
Mammalian COP9 signalosome
2009
Environmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice
2005 Standout
The general transcription factors of RNA polymerase II.
1996
Rad23 links DNA repair to the ubiquitin/proteasome pathway
1998 Nature
Recognition of the polyubiquitin proteolytic signal
2000
Molecular cloning and testicular expression of the gene transcripts encoding the murine multiubiquitin-chain-binding protein (Mcb1)
1998
Proteasome Activators
2011
The pad1 + Gene Encodes a Subunit of the 26 S Proteasome in Fission Yeast
1998
Regulatory subunit interactions of the 26S proteasome, a complex problem
2000
Hybrid Proteasomes
2000
Structural and Functional Characterization of Interaction between Hepatitis B Virus X Protein and the Proteasome Complex
2000
Proteasome subunit Rpn1 binds ubiquitin-like protein domains
2002
Cic1, an adaptor protein specifically linking the 26S proteasome to its substrate, the SCF component Cdc4
2001
Structural basis for the activation of 20S proteasomes by 11S regulators
2000 Nature
A surprising simplicity to protein folding
2000 StandoutNatureNobel
Self-compartmentalizing proteases
1997
A gated channel into the proteasome core particle.
2000
COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system
2001
Activation of a UBC4-Dependent Pathway of Ubiquitin Conjugation during Postnatal Development of the Rat Testis
1999
The DNA repair protein Rad23 is a negative regulator of multi-ubiquitin chain assembly
2000
The 19S Regulatory Complex of the Proteasome Functions Independently of Proteolysis in Nucleotide Excision Repair
1999
Global quantification of mammalian gene expression control
2011 StandoutNature
Specificity of the Ubiquitin Isopeptidase in the PA700 Regulatory Complex of 26 S Proteasomes
1997
The ubiquitin system
1997
Recognition of Misfolding Proteins by PA700, the Regulatory Subcomplex of the 26 S Proteasome
2000
NF-κB p105 Processing via the Ubiquitin-Proteasome Pathway
1998
Son1p is a component of the 26S proteasome of the yeast Saccharomyces cerevisiae
1998
Proteins containing the UBA domain are able to bind to multi-ubiquitin chains
2001
Biochemical and immunological characterization of rice homologues of the human immunodeficiency virus-1 Tat binding protein and subunit 4 of human 26S proteasome subunits
1998
26 S Proteasome-mediated Production of an Authentic Major Histocompatibility Class I-restricted Epitope from an Intact Protein Substrate
1999
A ubiquitin-like system mediates protein lipidation
2000 StandoutNatureNobel
AAA+ superfamily ATPases: common structure–diverse function
2001
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
The ubiquitin-mediated proteolytic pathway: Mode of action and clinical implications
2000 StandoutNobel
JAB1 Interacts with Both the Progesterone Receptor and SRC-1
2000
Mapping the ubiquitin‐binding domains in the p54 regulatory complex subunit of the Drosophila 26S protease
1997
A cryptic protease couples deubiquitination and degradation by the proteasome
2002 Nature
Histone and histone gene compilation and alignment update
1991
Characterization of Two Polyubiquitin Binding Sites in the 26 S Protease Subunit 5a
1998
COP9 signalosome revisited: a novel mediator of protein degradation
2001
Modes of regulation of ubiquitin-mediated protein degradation
2000 StandoutNobel
Identification of a 26S Proteasome-Associated UCH in Fission Yeast
2000
Caspase Activation Inhibits Proteasome Function during Apoptosis
2004 StandoutNobel
Structure of the Mammalian Ribosomal 43S Preinitiation Complex Bound to the Scanning Factor DHX29
2013 StandoutNobel
COP9 Signalosome-directed c-Jun Activation/Stabilization Is Independent of JNK
1999
A proteasomal ATPase subunit recognizes the polyubiquitin degradation signal
2002 Nature
Mts4, a Non-ATPase Subunit of the 26 S Protease in Fission Yeast Is Essential for Mitosis and Interacts Directly with the ATPase Subunit Mts2
1997
Ubiquitin‐associated (UBA) domains in Rad23 bind ubiquitin and promote inhibition of multi‐ubiquitin chain assembly
2001
JAB1/CSN5 and the COP9 signalosome
2001
A protein–protein interaction map of the Caenorhabditis elegans 26S proteasome
2001
The proteasome activator 11 S REG (PA28) and Class I antigen presentation
1999
The Regulatory Complex of Drosophila melanogaster 26s Proteasomes
2000
Posttranslational Quality Control: Folding, Refolding, and Degrading Proteins
1999 Science
Two-hybrid analysis of theSaccharomyces cerevisiae26S proteasome
2001
The mouse and human genes encoding the recognition component of the N-end rule pathway
1998 StandoutNobel
Pleiotropic Defects Caused by Loss of the Proteasome-Interacting Factors Rad23 and Rpn10 of Saccharomyces cerevisiae
1999
Architecture of an RNA Polymerase II Transcription Pre-Initiation Complex
2013 StandoutScienceNobel
Degradation of Proteins with Acetylated Amino Termini by the Ubiquitin System
1989 StandoutScienceNobel
Interactions of the COP9 Signalosome with the E3 Ubiquitin Ligase SCF TIR1 in Mediating Auxin Response
2001 Science
Multiubiquitin Chain Binding Subunit MCB1 (RPN10) of the 26S Proteasome Is Essential for Developmental Progression in Physcomitrella patens
1999
RPN4 is a ligand, substrate, and transcriptional regulator of the 26S proteasome: A negative feedback circuit
2001
Ligand-dependent interactions of coactivators steroid receptor coactivator-1 and peroxisome proliferator-activated receptor binding protein with nuclear hormone receptors can be imaged in live cells and are required for transcription
2000 StandoutNobel
The Regulatory Particle of the Saccharomyces cerevisiae Proteasome
1998
Proteasome regulation of activation-induced T cell death
1997 StandoutNobel
The 26S Proteasome: A Molecular Machine Designed for Controlled Proteolysis
1999 Standout
Rad23 Promotes the Targeting of Proteolytic Substrates to the Proteasome
2002
Regulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-Arrestin
2001 StandoutScienceNobel
Arabidopsis cop8 and fus4 Mutations Define the Same Gene That Encodes Subunit 4 of the COP9 Signalosome
1999
McsB Is a Protein Arginine Kinase That Phosphorylates and Inhibits the Heat-Shock Regulator CtsR
2009 StandoutScienceNobel
Inhibition of proteasomal degradation by the Gly-Ala repeat of Epstein–Barr virus is influenced by the length of the repeat and the strength of the degradation signal
2000
Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach
2012
The DNA of ciliated protozoa
1994
The coregulator exchange in transcriptional functions of nuclear receptors
2000 Standout
ATG Systems from the Protein Structural Point of View
2009 StandoutNobel
Purification and Characterization of Proteasomes from Saccharomyces cerevisiae
2001
Promotion of NEDD8-CUL1 Conjugate Cleavage by COP9 Signalosome
2001 Science
Biochemical and Physical Properties of theMethanococcus jannaschii20S Proteasome and PAN, a Homolog of the ATPase (Rpt) Subunits of the Eucaryal 26S Proteasome
2000
Hepatitis B Virus X Protein Is both a Substrate and a Potential Inhibitor of the Proteasome Complex
1999
The histone fold: evolutionary questions.
1995 StandoutNobel
Yeast counterparts of subunits S5a and p58 (S3) of the human 26S proteasome are encoded by two multicopy suppressors of nin1-1.
1997
Rational design of a split-Cas9 enzyme complex
2015 StandoutNobel
Identification of a phylogenetically conserved Sug1 CAD family member that is differentially expressed in the mouse nervous system
1997
Accurate protein structure modeling using sparse NMR data and homologous structure information
2012 StandoutNobel
Proteasomes in the archaea: from structure to function
2000
Inhibition of the 26 S Proteasome by Polyubiquitin Chains Synthesized to Have Defined Lengths
1997
Mechanisms Underlying Ubiquitination
2001 Standout
Ubiquitin-mediated proteolysis: biological regulation via destruction
2000 StandoutNobel
Characterization of two subunits of Arabidopsis 19S proteasome regulatory complex and its possible interaction with the COP9 complex
1999
Assembly of the 26S Proteasome Is Regulated by Phosphorylation of the p45/Rpt6 ATPase Subunit
2000
Simultaneous binding of PA28 and PA700 activators to 20 S proteasomes
1998
AAA-ATPase p97/Cdc48p, a Cytosolic Chaperone Required for Endoplasmic Reticulum-Associated Protein Degradation
2002
Proteasomes play an essential role in thymocyte apoptosis.
1996
The ubiquitin-proteasome pathway: on protein death and cell life
1998 StandoutNobel
Nuclear Receptor Coregulators: Cellular and Molecular Biology*
1999 Standout
DEGRADATION OF CELL PROTEINS AND THE GENERATION OF MHC CLASS I-PRESENTED PEPTIDES
1999
The Ubiquitin-Proteasome Pathway and Its Role in Cancer
2005
The Doa4 Deubiquitinating Enzyme Is Functionally Linked to the Vacuolar Protein-sorting and Endocytic Pathways
2000
Dis-assembly lines: the proteasome and related ATPase-assisted proteases
2000
A Proteasome Cap Subunit Required for Spindle Pole Body Duplication in Yeast
1997
THE PROTEASOME
1999 Nobel
Analysis of a Gene Encoding Rpn10 of the Fission Yeast Proteasome Reveals That the Polyubiquitin-binding Site of This Subunit Is Essential When Rpn12/Mts3 Activity Is Compromised
2000
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
2003 StandoutNobel
Near-atomic resolution structural model of the yeast 26S proteasome
2012
Chaperone rings in protein folding and degradation
1999
At the crossroads of cell biology and immunology: DRiPs and other sources of peptide ligands for MHC class I molecules
2001
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3)
2011 StandoutNobel
Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3
2008 StandoutNobel
Mammalian Sug1 and c-Fos in the nuclear 26S proteasome.
1996 Nobel
Proteasomal dysfunction activates the transcription factor SKN-1 and produces a selective oxidative-stress response in Caenorhabditis elegans
2007
Physical association of ubiquitin ligases and the 26S proteasome
2000
Pathways of ubiquitin conjugation
1997
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Altered ubiquitination and stability of aquaporin-1 in hypertonic stress
2001 StandoutNobel
Yeast Cycloheximide-resistantcrlMutants Are Proteasome Mutants Defective in Protein Degradation
1997
Multiple Click-Selective tRNA Synthetases Expand Mammalian Cell-Specific Proteomics
2018 StandoutNobel
Scanning the human proteome for calmodulin-binding proteins
2005 StandoutNobel
Unique double-ring structure of the peroxisomal Pex1/Pex6 ATPase complex revealed by cryo-electron microscopy
2015 StandoutNobel
ER Degradation of a Misfolded Luminal Protein by the Cytosolic Ubiquitin-Proteasome Pathway
1996 Science
The Axial Channel of the Proteasome Core Particle Is Gated by the Rpt2 ATPase and Controls Both Substrate Entry and Product Release
2001
Protein Translocation Across Biological Membranes
2005 StandoutScienceNobel
Targeting of substrates to the 26S proteasome
1997
Association of the Mediator complex with enhancers of active genes
2003 StandoutNobel
Rpn9 Is Required for Efficient Assembly of the Yeast 26S Proteasome
1999
Proteasomal Proteomics: Identification of Nucleotide-sensitive Proteasome-interacting Proteins by Mass Spectrometric Analysis of Affinity-purified Proteasomes
2000
Mutation of the E6-AP Ubiquitin Ligase Reduces Nuclear Inclusion Frequency While Accelerating Polyglutamine-Induced Pathology in SCA1 Mice
1999 StandoutNobel
Works of Inge Wefes being referenced
Functional analysis of the proteasome regulatory particle
1999
ATPase and ubiquitin-binding proteins of the yeast proteasome
1997
Identification of the gal4 suppressor Sug1 as a subunit of the yeast 26S proteasome
1996 Nature
Characterization of a cDNA clone encoding E2-20K, a murine ubiquitin-conjugating enzyme
1995
The two macronuclear histone H4 genes of the hypotrichous ciliate Stylonychi lemnae
1990
A Subcomplex of the Proteasome Regulatory Particle Required for Ubiquitin-Conjugate Degradation and Related to the COP9-Signalosome and eIF3
1998
Environmental enrichment improves cognition in aged Alzheimer's transgenic mice despite stable β-amyloid deposition
2004
Induction of ubiquitin-conjugating enzymes during terminal erythroid differentiation.
1995
The Multiubiquitin-Chain-Binding Protein Mcb1 Is a Component of the 26S Proteasome in Saccharomyces cerevisiae and Plays a Nonessential, Substrate-Specific Role in Protein Turnover
1996
GM-CSF Upregulated in Rheumatoid Arthritis Reverses Cognitive Impairment and Amyloidosis in Alzheimer Mice
2010