Standout Papers
- Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans (1993)
- Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing (2001)
- A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation. (1996)
Citation Impact
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2002
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2004
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2002
Using RNA interference to identify genes required for RNA interference
2002
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2006
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2005
An Extensive Class of Small RNAs in Caenorhabditis elegans
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2003 Standout
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2002
The Bearded box, a novel 3′ UTR sequence motif, mediates negative post-transcriptional regulation of Bearded and Enhancer of split Complex gene expression
1997
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2006
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2008 StandoutNobel
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2002
Molecular architecture of a miRNA-regulated 3′ UTR
2008
Both Natural and Designed Micro RNAs Can Inhibit the Expression of Cognate mRNAs When Expressed in Human Cells
2002
Identification of Tissue-Specific MicroRNAs from Mouse
2002 Standout
Heterochronic Genes and the Nature of Developmental Time
2007
The Role of Human TFIIB in Transcription Start Site Selection in Vitro and in Vivo
1999
MicroRNAs
2004 Standout
Evidence That Transcription Factor IIB Is Required for a Post-assembly Step in Transcription Initiation
1999
The nuclear RNase III Drosha initiates microRNA processing
2003 StandoutNature
Human Argonaute2 Mediates RNA Cleavage Targeted by miRNAs and siRNAs
2004 Standout
A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast
1993
DNA topoisomerase I is involved in both repression and activation of transcription
1993 Nature
Regulatory Mutations of mir-48, a C. elegans let-7 Family MicroRNA, Cause Developmental Timing Defects
2005
Control of leaf morphogenesis by microRNAs
2003 Nature
Two classes of short interfering RNA in RNA silencing
2002
MicroRNAs: Hidden in the Genome
2002
Concordant Regulation of Translation and mRNA Abundance for Hundreds of Targets of a Human microRNA
2009
Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs
2003 Standout
Computational identification of microRNA targets
2004
Solution structure of the c-terminal core domain of human TFIIB: Similarity to cyclin A and interaction with TATA-binding protein
1995
Genetic and Functional Diversification of Small RNA Pathways in Plants
2004 Standout
Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate
2001
Systematic Identification of C. elegans miRISC Proteins, miRNAs, and mRNA Targets by Their Interactions with GW182 Proteins AIN-1 and AIN-2
2007
Animal MicroRNAs Confer Robustness to Gene Expression and Have a Significant Impact on 3′UTR Evolution
2005
Recycling of the general transcription factors during RNA polymerase II transcription.
1995
nhl-2 Modulates MicroRNA Activity in Caenorhabditis elegans
2009 StandoutNobel
Small RNAs with Imperfect Match to Endogenous mRNA Repress Translation
2003
The lin-4 Regulatory RNA Controls Developmental Timing in Caenorhabditis elegans by Blocking LIN-14 Protein Synthesis after the Initiation of Translation
1999 StandoutNobel
Patterns of flanking sequence conservation and a characteristic upstream motif for microRNA gene identification
2004
Binding of TFIIB to RNA Polymerase II
2003
GERp95 Belongs to a Family of Signal-transducing Proteins and Requires Hsp90 Activity for Stability and Golgi Localization
2001
MicroRNAs act sequentially and asymmetrically to control chemosensory laterality in the nematode
2004 Nature
Family of proteins that interact with TFIID and regulate promoter activity
1991
miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs
2002
The Cold Shock Domain Protein LIN-28 Controls Developmental Timing in C. elegans and Is Regulated by the lin-4 RNA
1997 StandoutNobel
Interaction of thyroid-hormone receptor with a conserved transcriptional mediator
1995 Nature
Interacting endogenous and exogenous RNAi pathways in Caenorhabditis elegans
2006 StandoutNobel
Potent effect of target structure on microRNA function
2007 StandoutNobel
The Timing oflin-4RNA Accumulation Controls the Timing of Postembryonic Developmental Events inCaenorhabditis elegans
1999 StandoutNobel
CTD kinase associated with yeast RNA polymerase II initiation factor b
1991
A microRNA Mediates EGF Receptor Signaling and Promotes Photoreceptor Differentiation in the Drosophila Eye
2005
Human let-7 stem-loop precursors harbor features of RNase III cleavage products
2003
Embryonic Stem Cell-Specific MicroRNAs
2003
A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II
1992 Nature
Pervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-box-class microRNAs
2005
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
2005 StandoutNature
New core promoter element in RNA polymerase II-dependent transcription: sequence-specific DNA binding by transcription factor IIB
1998
Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA
2000 StandoutNatureNobel
Mammalian microRNAs predominantly act to decrease target mRNA levels
2010 StandoutNature
MicroRNAs: Target Recognition and Regulatory Functions
2009 Standout
Short-Interfering-RNA-Mediated Gene Silencing in Mammalian Cells Requires Dicer and eIF2C Translation Initiation Factors
2003
Asymmetry in the Assembly of the RNAi Enzyme Complex
2003 Standout
A micrococcal nuclease homologue in RNAi effector complexes
2003 Nature
The microRNAs of Caenorhabditis elegans
2003
Residues in the TATA-binding protein required to mediate a transcriptional response to retinoic acid in EC cells
1993 Nature
A Whole-Genome RNAi Screen for C. elegans miRNA Pathway Genes
2007 StandoutNobel
An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo
2003
Functional dissection of TFIIB domains required for TFIIB–TFIID–promoter complex formation and basal transcription activity
1993 Nature
Functional siRNAs and miRNAs Exhibit Strand Bias
2003 Standout
RAS Is Regulated by the let-7 MicroRNA Family
2005 Standout
Two Genetic Circuits Repress the Caenorhabditis elegans Heterochronic Gene lin-28 after Translation Initiation
2002
P1/HC-Pro, a Viral Suppressor of RNA Silencing, Interferes with Arabidopsis Development and miRNA Function
2003
Model for binding of transcription factor TFIIB to the TBP-DNA complex
1995 Nature
Identification of Drosophila MicroRNA Targets
2003
lin-28 Controls the Succession of Cell Fate Choices via Two Distinct Activities
2012
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
1993 StandoutNobel
The yeast SUA7 gene encodes a homolog of human transcription factor TFIIB and is required for normal start site selection in vivo
1992
Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs
2004
microRNAs: Runts of the Genome Assert Themselves
2003
Prediction of Plant MicroRNA Targets
2002 Standout
The MicroRNA mir-71 Inhibits Calcium Signaling by Targeting the TIR-1/Sarm1 Adaptor Protein to Control Stochastic L/R Neuronal Asymmetry in C. elegans
2012
Determinants of targeting by endogenous and exogenous microRNAs and siRNAs
2007
Regulation by let-7 and lin-4 miRNAs Results in Target mRNA Degradation
2005
Analysis of the C. elegans Argonaute Family Reveals that Distinct Argonautes Act Sequentially during RNAi
2006 StandoutNobel
Chromatin and RNAi factors protect the C. elegans germline against repetitive sequences
2005
The Role of Transcription Factor B in Transcription Initiation and Promoter Clearance in the Archaeon Sulfolobus acidocaldarius
2000
Metazoan MicroRNAs
2018 Standout
Distinct Roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA Silencing Pathways
2004
Thirty-Three Years Later, a Glimpse at the Ribonuclease III Active Site
2001
Ribonuclease activity and RNA binding of recombinant human Dicer
2002
Sequence-Specific Inhibition of Small RNA Function
2004 StandoutNobel
Substrate requirements for let-7 function in the developing zebrafish embryo
2016
Computational and Experimental Identification of C. elegans microRNAs
2003 StandoutNobel
Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP
2002
Conservation of the heterochronic regulator Lin-28, its developmental expression and microRNA complementary sites
2003
Trans -splicing and polyadenylation of let-7 microRNA primary transcripts
2004
An elegant miRror: microRNAs in stem cells, developmental timing and cancer
2009
RNAi Related Mechanisms Affect Both Transcriptional and Posttranscriptional Transgene Silencing in Drosophila
2002
Killing the messenger: short RNAs that silence gene expression
2003
MicroRNAs in plants
2002 Standout
Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis
2003 StandoutNobel
Argonaute proteins: key players in RNA silencing
2007
Control of developmental timing in Caenorhabditis elegans
2000 StandoutNobel
A transcriptional co-repressor that interacts with nuclear hormone receptors
1995 StandoutNature
Wnt signaling controls temporal identities of seam cells in Caenorhabditis elegans
2010
Involvement of small RNAs and role of the qde genes in the gene silencing pathway in Neurospora
2002
Structure and functional properties of human general transcription factor IIE
1991 Nature
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2007
MiR-150 Controls B Cell Differentiation by Targeting the Transcription Factor c-Myb
2007
Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis
2005 Nature
Novel small RNA-encoding genes in the intergenic regions of Escherichia coli
2001
Mutations in Conserved Residues of the C. elegans microRNA Argonaute ALG-1 Identify Separable Functions in ALG-1 miRISC Loading and Target Repression
2014 StandoutNobel
Deadenylation is a widespread effect of miRNA regulation
2008
Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
1995 StandoutNature
RNAi is activated during Drosophila oocyte maturation in a manner dependent on aubergine and spindle-E
2002
Assembly and function of RNA silencing complexes
2005
TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing
2005 StandoutNature
Non–coding RNA genes and the modern RNA world
2001
A pancreatic islet-specific microRNA regulates insulin secretion
2004 StandoutNature
The C. elegans hunchback Homolog, hbl-1, Controls Temporal Patterning and Is a Probable MicroRNA Target
2003
Specificity of microRNA target selection in translational repression
2004
The microRNA-argonaute complex: A platform for mRNA modulation
2008
A Member of the Polymerase β Nucleotidyltransferase Superfamily Is Required for RNA Interference in C. elegans
2005 StandoutNobel
A Genome-Wide Map of Conserved MicroRNA Targets in C. elegans
2006
PPW-1, a PAZ/PIWI Protein Required for Efficient Germline RNAi, Is Defective in a Natural Isolate of C. elegans
2002
DICER-LIKE1: blind men and elephants in Arabidopsis development
2002
Processing of primary microRNAs by the Microprocessor complex
2004 StandoutNature
MicroRNAs and Other Tiny Endogenous RNAs in C. elegans
2003 StandoutNobel
Crystallographic and Modeling Studies of RNase III Suggest a Mechanism for Double-Stranded RNA Cleavage
2001
The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3′UTR
2004
Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans
2001 Standout
MicroRNA Targeting Specificity in Mammals: Determinants beyond Seed Pairing
2007 Standout
DAF-12 Regulates a Connected Network of Genes to Ensure Robust Developmental Decisions
2011
MicroRNA silencing through RISC recruitment of eIF6
2007 Nature
Sequence requirements for micro RNA processing and function in human cells
2003
The dsRNA Binding Protein RDE-4 Interacts with RDE-1, DCR-1, and a DExH-Box Helicase to Direct RNAi in C. elegans
2002 StandoutNobel
News on initiation and elongation of transcription by RNA polymerase II
1995
Fragile X-related protein and VIG associate with the RNA interference machinery
2002
Multiple mechanisms are involved in regulating the expression of the developmental timing regulator lin‐28 in Caenorhabditis elegans
2006
New microRNAs from mouse and human
2003
Real-time quantification of microRNAs by stem-loop RT-PCR
2005 Standout
Noncoding RNA genes
1999
bantam Encodes a Developmentally Regulated microRNA that Controls Cell Proliferation and Regulates the Proapoptotic Gene hid in Drosophila
2003 Standout
Evidence that siRNAs Function as Guides, Not Primers, in the Drosophila and Human RNAi Pathways
2002
Crystal structure of a TFIIB–TBP–TATA-element ternary complex
1995 Nature
A microRNA array reveals extensive regulation of microRNAs during brain development
2003
A combined computational-experimental approach predicts human microRNA targets
2004
Principles of MicroRNA–Target Recognition
2005 Standout
RNA interference
2002 StandoutNature
Prediction of Mammalian MicroRNA Targets
2003 Standout
The Caenorhabditis elegans hunchback-like Gene lin-57/hbl-1 Controls Developmental Time and Is Regulated by MicroRNAs
2003
Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II
1994 StandoutNatureNobel
The Arabidopsis Heterochronic Gene ZIPPY Is an ARGONAUTE Family Member
2003
The lin-41 RBCC Gene Acts in the C. elegans Heterochronic Pathway between the let-7 Regulatory RNA and the LIN-29 Transcription Factor
2000 StandoutNobel
The Drosophila SDE3 Homolog armitage Is Required for oskar mRNA Silencing and Embryonic Axis Specification
2004
A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II
1994 StandoutNobel
Structure of a (Cys3His) zinc ribbon, a ubiquitous motif in archaeal and eucaryal transcription
2000
Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs
2007
Structure and conserved RNA binding of the PAZ domain
2003 Nature
Revealing the world of RNA interference
2004 StandoutNatureNobel
siRNAs can function as miRNAs
2003
The Developmental Timing Regulator AIN-1 Interacts with miRISCs and May Target the Argonaute Protein ALG-1 to Cytoplasmic P Bodies in C. elegans
2005
Micro RNAs are complementary to 3′ UTR sequence motifs that mediate negative post-transcriptional regulation
2002
Negative Feedback Regulation of Dicer-Like1 in Arabidopsis by microRNA-Guided mRNA Degradation
2003
Temporal regulation of microRNA expression in Drosophila melanogaster mediated by hormonal signals and Broad-Complex gene activity
2003 StandoutNobel
Functional Proteomics Reveals the Biochemical Niche of C. elegans DCR-1 in Multiple Small-RNA-Mediated Pathways
2006 StandoutNobel
Control of developmental timing in animals
2001
Human general transcription factor IIH phosphorylates the C-terminal domain of RNA polymerase II
1992 Nature
Dicer is essential for mouse development
2003 Standout
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
2000 StandoutNatureNobel
The Role of RNA Editing by ADARs in RNAi
2002
MicroRNA maturation: stepwise processing and subcellular localization
2002 Standout
Computational identification of DrosophilamicroRNA genes
2003
The slicing activity of miRNA-specific Argonautes is essential for the miRNA pathway in C. elegans
2012
MicroRNAs: deviants no longer
2002
Two-Dimensional Crystallography of TFIIB– and IIE–RNA Polymerase II Complexes: Implications for Start Site Selection and Initiation Complex Formation
1996 StandoutNobel
Ligand Modulates the Interaction of Thyroid Hormone Receptor β with the Basal Transcription Machinery
1995
siRNA-directed inhibition of HIV-1 infection
2002
A role for the P-body component GW182 in microRNA function
2005
CARPEL FACTORY, a Dicer Homolog, and HEN1, a Novel Protein, Act in microRNA Metabolism in Arabidopsis thaliana
2002
A biochemical framework for RNA silencing in plants
2003
Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells
2002
Most Caenorhabditis elegans microRNAs Are Individually Not Essential for Development or Viability
2007 StandoutNobel
The Functions of MicroRNAs: mRNA Decay and Translational Repression
2015
Mechanisms of gene silencing by double-stranded RNA
2004 StandoutNature
Characterization of cDNA for the large subunit of the transcription initiation factor TFIIF
1992 Nature
The time of appearance of the C. elegans let-7 microRNA is transcriptionally controlled utilizing a temporal regulatory element in its promoter
2003
The microRNA Registry
2003 Standout
Heterochronic genes and the temporal control of C. elegans development
1994 StandoutNobel
Non-coding RNAs: Lightning strikes twice
2000
Reciprocal expression of lin‐41 and the microRNAs let‐7 and mir‐125 during mouse embryogenesis
2005
Large-Scale Sequencing Reveals 21U-RNAs and Additional MicroRNAs and Endogenous siRNAs in C. elegans
2006
The Drosha-DGCR8 complex in primary microRNA processing
2004 Standout
microRNAs
2001 StandoutNobel
MicroRNA control of PHABULOSA in leaf development: importance of pairing to the microRNA 5′ region
2004
The functions of animal microRNAs
2004 StandoutNatureNobel
Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways
2004
The Small RNA Profile during Drosophila melanogaster Development
2003
Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing
2004
ATP Requirements and Small Interfering RNA Structure in the RNA Interference Pathway
2001
Caenorhabditis elegans as a model for stem cell biology
2010
The let-7 MicroRNA Family Members mir-48, mir-84, and mir-241 Function Together to Regulate Developmental Timing in Caenorhabditis elegans
2005 StandoutNobel
Transcriptional silencing of a transgene by RNAi in the soma of C. elegans
2005
The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis
2002
Modeling neurodevelopmental disorder-associated humanAGO1mutations inCaenorhabditis elegansArgonautealg-1
2024 StandoutNobel
Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer
2004
MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms
2003
Identification of the gene (SSU71/TFG1) encoding the largest subunit of transcription factor TFIIF as a suppressor of a TFIIB mutation in Saccharomyces cerevisiae.
1995
Distinct TPR motifs of Cyc8 are involved in recruiting the Cyc8-Tup1 corepressor complex to differentially regulated promoters.
1995
Mapping and mutagenesis of the amino-terminal transcriptional repression domain of the Drosophila Krüppel protein.
1994
Delineation of two functional regions of transcription factor TFIIB.
1993
DNA Repair Helicase: a Component of BTF2 (TFIIH) Basic Transcription Factor
1993 Science
Purification and characterization of yeast RNA polymerase II transcription factor b.
1991 StandoutNobel
Mechanisms for synergistic activation of thyroid hormone receptor and retinoid X receptor on different response elements.
1994
Potential RNA polymerase II-induced interactions of transcription factor TFIIB.
1993
The Genetics of RNA Silencing
2002
Factors involved in specific transcription by mammalian RNA polymerase II. Identification and characterization of factor IIH.
1992
Initiation of eukaryotic messenger RNA synthesis.
1991
Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor.
1995
RNA Polymerase II Initiation Factor Interactions and Transcription Start Site Selection
1994 StandoutScienceNobel
Transcription from a TATA-less promoter requires a multisubunit TFIID complex.
1991
Transcription initiated by RNA polymerase II and transcription factors from liver. Structure and action of transcription factors epsilon and tau.
1991
The sua8 suppressors of Saccharomyces cerevisiae encode replacements of conserved residues within the largest subunit of RNA polymerase II and affect transcription start site selection similarly to sua7 (TFIIB) mutations.
1994
Cloning of the 62-Kilodalton Component of Basic Transcription Factor BTF2
1992 Science
Argonaute2, a Link Between Genetic and Biochemical Analyses of RNAi
2001 Science
Fractionation of the general RNA polymerase II transcription factors from Drosophila embryos.
1990
Ribo-gnome: The Big World of Small RNAs
2005 Science
The nonphosphorylated form of RNA polymerase II preferentially associates with the preinitiation complex.
1991
Purification and characterization of yeast RNA polymerase II general initiation factor g
1992 StandoutNobel
Purification and properties of Saccharomyces cerevisiae RNA polymerase II general initiation factor a
1992 StandoutNobel
Transcription Factor TFIIB Sites Important for Interaction with Promoter-Bound TFIID
1993 Science
Specific interference with gene expression induced by long, double-stranded RNA in mouse embryonal teratocarcinoma cell lines
2001
The Temporal Patterning MicroRNA let-7 Regulates Several Transcription Factors at the Larval to Adult Transition in C. elegans
2005
Germ Line Transcripts Are Processed by a Dicer-Like Protein That Is Essential for Developmentally Programmed Genome Rearrangements of Tetrahymena thermophila
2005
Core Promoter-Dependent TFIIB Conformation and a Role for TFIIB Conformation in Transcription Start Site Selection
2002
Purification and interaction properties of the human RNA polymerase B(II) general transcription factor BTF2.
1991
Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein.
1993
Functional Evidence for Ligand-Dependent Dissociation of Thyroid Hormone and Retinoic Acid Receptors from an Inhibitory Cellular Factor
1994
Transcription factor IIE binds preferentially to RNA polymerase IIa and recruits TFIIH: a model for promoter clearance.
1994
Coactivators for a proline-rich activator purified from the multisubunit human TFIID complex.
1991
The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18.
1995
Dicer is required for chromosome segregation and gene silencing in fission yeast cells
2002 Nobel
Structural basis for microRNA targeting
2014 Science
RNA polymerase II-associated proteins are required for a DNA conformation change in the transcription initiation complex.
1991
Distance constraints between microRNA target sites dictate efficacy and cooperativity
2007
Unliganded thyroid hormone receptor inhibits formation of a functional preinitiation complex: implications for active repression.
1993
Control of Developmental Timing by MicroRNAs and Their Targets
2002 StandoutNobel
A Parsimonious Model for Gene Regulation by miRNAs
2011 Science
Control of stem cell self-renewal and differentiation by the heterochronic genes and the cellular asymmetry machinery in Caenorhabditis elegans
2015 StandoutNobel
MicroRNAs AND THEIR REGULATORY ROLES IN PLANTS
2006 Standout
Holo-TFIID supports transcriptional stimulation by diverse activators and from a TATA-less promoter.
1992
Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II).
1992
Dissection of transcription factor TFIIF functional domains required for initiation and elongation.
1995
Fertile Hypomorphic ARGONAUTE (ago1) Mutants Impaired in Post-Transcriptional Gene Silencing and Virus Resistance
2002
The mammalian TFIID protein is present in two functionally distinct complexes.
1991
RNA interference machinery regulates chromosome dynamics during mitosis and meiosis in fission yeast
2002
Identification of Heterochronic Mutants in Caenorhabditis elegans: Temporal Misexpression of a Collagen::Green Fluorescent Protein Fusion Gene
1998
Transcription factor TFIIB and the vitamin D receptor cooperatively activate ligand-dependent transcription.
1995
A highly conserved domain of RNA polymerase II shares a functional element with acidic activation domains of upstream transcription factors.
1994
The N-terminal Region of Yeast TFIIB Contains Two Adjacent Functional Domains Involved in Stable RNA Polymerase II Binding and Transcription Start Site Selection
1998
Mutational Analysis of the D1/E1 Core Helices and the Conserved N-Terminal Region of Yeast Transcription Factor IIB (TFIIB): Identification of an N-terminal Mutant That Stabilizes TATA-Binding Protein-TFIIB-DNA Complexes
1997
A Highly Conserved Domain of RNA Polymerase II Shares a Functional Element with Acidic Activation Domains of Upstream Transcription Factors
1994
The Ligand-Binding Domains of the Thyroid Hormone/Retinoid Receptor Gene Subfamily Function in Vivo To Mediate Heterodimerization, Gene Silencing, and Transactivation
1995
An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans
2001 StandoutScience
Yeast RNA polymerase II initiation factor e: isolation and identification as the functional counterpart of human transcription factor IIB.
1992 StandoutNobel
A carboxyl-terminal-domain kinase associated with RNA polymerase II transcription factor delta from rat liver.
1992
Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily
1995 StandoutScience
The General Transcription Factor RAP30 Binds to RNA Polymerase II and Prevents It from Binding Nonspecifically to DNA
1992
Factors Involved in Specific Transcription by Mammalian RNA Polymerase II: Purification and Analysis of Transcription Factor ILA and Identification of Transcription Factor IIJ
1992
Factors involved in specific transcription by mammalian RNA polymerase II: purification and characterization of general transcription factor TFIIE.
1990
Inhibition of E2F-1 Transactivation by Direct Binding of the Retinoblastoma Protein
1993
Interaction of proteins with transcriptionally active estrogen receptors.
1994
Characterization of sua7 mutations defines a domain of TFIIB involved in transcription start site selection in yeast.
1994
Structural Basis of Transcription: An RNA Polymerase II-TFIIB Cocrystal at 4.5 Angstroms
2004 StandoutScienceNobel
The t4 Activation Domain of the Thyroid Hormone Receptor Is Required for Release of a Putative Corepressor(s) Necessary for Transcriptional Silencing
1995
Similarity of the C. elegans Developmental Timing Protein LIN-42 to Circadian Rhythm Proteins
1999 Science
Structural Basis for Double-Stranded RNA Processing by Dicer
2006 StandoutScienceNobel
The lin-4 MicroRNA Targets the LIN-14 Transcription Factor to Inhibit Netrin-Mediated Axon Attraction
2012
Micro-RNA Regulation of the Mammalian lin-28 Gene during Neuronal Differentiation of Embryonal Carcinoma Cells
2005
Enhancement of human estrogen receptor activity by SPT6: a potential coactivator.
1995
Cell shape and Wnt signaling redundantly control the division axis ofC. elegansepithelial stem cells
2011
Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
2003 StandoutNobel
The yeast general transcription factor TFIIA is composed of two polypeptide subunits.
1991
Multiple sets of basal factors initiate transcription by RNA polymerase II
1994
Potent and Specific Inhibition of Human Immunodeficiency Virus Type 1 Replication by RNA Interference
2002
Disrupting the Pairing Between let-7 and Hmga2 Enhances Oncogenic Transformation
2007 Science
A Role for the RNase III Enzyme DCR-1 in RNA Interference and Germ Line Development in Caenorhabditis elegans
2001 Science
Transcription Factor IID Mutants Defective for Interaction with Transcription Factor IIA
1992 Science
A biochemical approach to identifying microRNA targets
2007
Reconstitution of transcription with five purified initiation factors and RNA polymerase II from Saccharomyces cerevisiae
1992 StandoutNobel
Distinct roles for RDE-1 and RDE-4 during RNA interference in Caenorhabditis elegans.
2001 StandoutNobel
Caenorhabditis elegans microRNAs of the let-7 family act in innate immune response circuits and confer robust developmental timing against pathogen stress
2015 StandoutNobel
Functional domains of transcription factor TFIIB.
1993
Stage-specific accumulation of the terminal differentiation factor LIN-29 during Caenorhabditis elegans development
1996
TEMPORAL PATTERN FORMATION BY HETEROCHRONIC GENES
1997 StandoutNobel
Works of Ilho Ha being referenced
Multiple functional domains of human transcription factor IIB: distinct interactions with two general transcription factors and RNA polymerase II.
1993
Cloning of a human gene encoding the general transcription initiation factor IIB
1991 Nature
Binding of general transcription factor TFIIB to an acidic activating region
1991 Nature
A TATA-like sequence located downstream of the transcription initiation site is required for expression of an RNA polymerase II transcribed gene.
1990
Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing
2001 StandoutNobel
Interaction between an acidic activator and transcription factor TFIIB is required for transcriptional activation
1993 Nature
Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
1993 StandoutNobel
Factors involved in specific transcription by mammalian RNA polymerase II: role of transcription factors IIA, IID, and IIB during formation of a transcription-competent complex.
1990
Factors involved in specific transcription by mammalian RNA polymerase II. Purification and subunit composition of transcription factor IIF.
1990
Interaction of human thyroid hormone receptor beta with transcription factor TFIIB may mediate target gene derepression and activation by thyroid hormone.
1993
A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation.
1996 StandoutNobel
Factors Involved in Specific Transcription by Mammalian RNA Polymerase II: Role of Transcription Factors IIA, IID, and IIB during Formation of a Transcription-Competent Complex
1990
Dr1, a TATA-binding protein-associated phosphoprotein and inhibitor of class II gene transcription
1992