Citation Impact
Citing Papers
High-throughput characterization of protein–protein interactions by reprogramming yeast mating
2017 StandoutNobel
Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic
2005
mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt
2006 Standout
Pten Loss Causes Hypertrophy and Increased Proliferation of Astrocytes In vivo
2004
mTOR Kinase Inhibition Causes Feedback-Dependent Biphasic Regulation of AKT Signaling
2011
The Structure of a Human p110α/p85α Complex Elucidates the Effects of Oncogenic PI3Kα Mutations
2007 Science
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Transferrin receptor targeting by de novo sheet extension
2021 StandoutNobel
Recurrent Fusion of TMPRSS2 and ETS Transcription Factor Genes in Prostate Cancer
2005 StandoutScience
EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
2004 StandoutScience
Akt1 Ablation Inhibits, whereas Akt2 Ablation Accelerates, the Development of Mammary Adenocarcinomas in Mouse Mammary Tumor Virus (MMTV)-ErbB2/Neu and MMTV-Polyoma Middle T Transgenic Mice
2007
MK-2206, an Allosteric Akt Inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular Targeted Drugs In vitro and In vivo
2010 Standout
The oncogenic properties of mutant p110α and p110β phosphatidylinositol 3-kinases in human mammary epithelial cells
2005
A Dual Phosphoinositide-3-Kinase α/mTOR Inhibitor Cooperates with Blockade of Epidermal Growth Factor Receptor in PTEN -Mutant Glioma
2007
High Frequency of Mutations of the PIK3CA Gene in Human Cancers
2004 StandoutScience
The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation
2009 Science
TOR Signaling in Growth and Metabolism
2006 Standout
The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas
2007 Standout
Comprehensive molecular portraits of human breast tumours
2012 StandoutNature
Activation of Akt-1 (PKB-α) Can Accelerate ErbB-2-Mediated Mammary Tumorigenesis but Suppresses Tumor Invasion
2004
Mutations of PIK3CAin gastric adenocarcinoma
2005
De novo design of modular and tunable protein biosensors
2021 StandoutNatureNobel
AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity
2011
Somatic mutation and gain of copy number of PIK3CA in human breast cancer
2005
Hallmarks of Cancer: The Next Generation
2011 Standout
A Phase II Study of Trastuzumab Emtansine in Patients With Human Epidermal Growth Factor Receptor 2–Positive Metastatic Breast Cancer Who Were Previously Treated With Trastuzumab, Lapatinib, an Anthracycline, a Taxane, and Capecitabine
2012
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
2008 StandoutNature
Opportunities and challenges in the development of kinase inhibitor therapy for cancer
2003
Cancer Chemoprevention and Nutri-Epigenetics: State of the Art and Future Challenges
2012
Chapter 2 PI3K/PTEN Signaling in Angiogenesis and Tumorigenesis
2009
Mechanisms of type-I- and type-II-interferon-mediated signalling
2005 Standout
Genetic Alterations of Phosphoinositide 3‐kinase Subunit Genes in Human Glioblastomas
2004
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
2020 Standout
Analysis of the genome to personalize therapy for melanoma
2010
Will mTOR inhibitors make it as cancer drugs?
2003
The tor pathway: a target for cancer therapy
2004 Standout
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
2006 Standout
Insulin-like Growth Factor-I Inhibits Transcriptional Responses of Transforming Growth Factor-β by Phosphatidylinositol 3-Kinase/Akt-dependent Suppression of the Activation of Smad3 but Not Smad2
2003
Regulation of Phosphorylation of Thr-308 of Akt, Cell Proliferation, and Survival by the B55α Regulatory Subunit Targeting of the Protein Phosphatase 2A Holoenzyme to Akt
2007
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Signal integration by JNK and p38 MAPK pathways in cancer development
2009 Standout
Targeting the PI3K-Akt pathway in human cancer
2003
Targeting the ERK signaling pathway in cancer therapy
2006
Functional inhibition of PI3K by the βGBP molecule suppresses Ras–MAPK signalling to block cell proliferation
2007
Activation of the p70 S6 Kinase and Phosphorylation of the 4E-BP1 Repressor of mRNA Translation by Type I Interferons
2003
PHLPP and a Second Isoform, PHLPP2, Differentially Attenuate the Amplitude of Akt Signaling by Regulating Distinct Akt Isoforms
2007
Mutant PIK3CA promotes cell growth and invasion of human cancer cells
2005
Malignant astrocytic glioma: genetics, biology, and paths to treatment
2007 Standout
Tenets of PTEN Tumor Suppression
2008
PI3K pathway alterations in cancer: variations on a theme
2008
Current development of mTOR inhibitors as anticancer agents
2006
Genetic Alterations and Aberrant Expression of Genes Related to the Phosphatidyl‐lnositol‐3′‐Kinase/Protein Kinase B (Akt) Signal Transduction Pathway in Glioblastomas
2003
Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways
2005 StandoutNobel
Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer
2003 Standout
Evidence that Inositol Polyphosphate 4-Phosphatase Type II Is a Tumor Suppressor that Inhibits PI3K Signaling
2009
Oncogenic PI3K and its role in cancer
2005
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
Molecularly targeted therapy for malignant glioma
2007
Apoptotic mechanisms in the control of erythropoiesis
2004
Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery
2005 Standout
Integration of Smad and Forkhead Pathways in the Control of Neuroepithelial and Glioblastoma Cell Proliferation
2004
Comprehensive analysis of oncogenic effects of PIK3CA mutations in human mammary epithelial cells
2007
Upstream and downstream of mTOR
2004 Standout
Molecular Analysis of Glioblastoma: Pathway Profiling and Its Implications for Patient Therapy
2003
A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation
2015 StandoutNobel
Targeted Molecular Therapy of GBM
2003
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
2012 StandoutNobel
Intrinsic tumour suppression
2004 Nature
Targeting AKT1-E17K and the PI3K/AKT Pathway with an Allosteric AKT Inhibitor, ARQ 092
2015
Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis
2019 StandoutNobel
De novo design of bioactive protein switches
2019 StandoutNatureNobel
An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior
2005 StandoutNobel
Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells
2005
The IGF-1/PI3K/Akt Pathway Prevents Expression of Muscle Atrophy-Induced Ubiquitin Ligases by Inhibiting FOXO Transcription Factors
2004 Standout
Differential effects of AKT1(p.E17K) expression on human mammary luminal epithelial and myoepithelial cells
2012
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
2011 StandoutNobel
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Mutations in a signalling pathway
2005 Nature
Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy
2004 Nature
The STATs of cancer — new molecular targets come of age
2004 Standout
Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
2008 Standout
AKT/PKB Signaling: Navigating the Network
2017 Standout
The prevalence of PIK3CA mutations in gastric and colon cancer
2005
PHLPP: A Phosphatase that Directly Dephosphorylates Akt, Promotes Apoptosis, and Suppresses Tumor Growth
2005
The functions and regulation of the PTEN tumour suppressor
2012 Standout
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
2012 Nature
AKT1 E17K mutation profiling in breast cancer: prevalence, concurrent oncogenic alterations, and blood-based detection
2016
Cancer-related inflammation
2008 StandoutNature
Control of apoptosis by p53
2003
Pervasive Adaptive Evolution in Primate Seminal Proteins
2005
PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas
2004
A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma
2006
Human cancer, PTEN and the PI-3 kinase pathway
2004
mTOR Promotes Survival and Astrocytic Characteristics Induced by Pten/Akt Signaling in Glioblastoma
2005
Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
2004 Standout
Pten Dose Dictates Cancer Progression in the Prostate
2003
Oncogenic PI3K deregulates transcription and translation
2005
Lost in translation
2004
Proteolytic Activation of Influenza Viruses by Serine Proteases TMPRSS2 and HAT from Human Airway Epithelium
2006
Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production
2003 StandoutNobel
CX3CR1-Fractalkine Expression Regulates Cellular Mechanisms Involved in Adhesion, Migration, and Survival of Human Prostate Cancer Cells
2004
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
2011 StandoutNobel
SPAS-1 (stimulator of prostatic adenocarcinoma-specific T cells)/SH3GLB2: A prostate tumor antigen identified by CTLA-4 blockade
2008 StandoutNobel
eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation
2016 StandoutNatureNobel
Combinatorial efficacy achieved through two-point blockade within a signaling pathway-a chemical genetic approach.
2003
Apoptosis: A Review of Programmed Cell Death
2007 Standout
AKT-Independent Signaling Downstream of Oncogenic PIK3CA Mutations in Human Cancer
2009
Caveolin-1 Maintains Activated Akt in Prostate CancerCells through Scaffolding Domain Binding Site Interactions with andInhibition of Serine/Threonine Protein Phosphatases PP1 andPP2A
2003
Akt Stimulates Aerobic Glycolysis in Cancer Cells
2004
Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer
2016 StandoutNobel
Genes and pathways downstream of telomerase in melanoma metastasis
2006 StandoutNobel
Mutation of the PIK3CA Gene in Ovarian and Breast Cancer
2004
Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma
2007
Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release
2014 Standout
Frequent Mutation of the PIK3CA Gene in Ovarian and Breast Cancers
2005
Iterative in Situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for Akt1
2011 StandoutNobel
Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor
2013 StandoutNobel
Phenotypic Analysis of Mice Lacking the Tmprss2-Encoded Protease
2006
Role of β-arrestin 1 in the metastatic progression of colorectal cancer
2006
Dose- and Schedule-Dependent Inhibition of the Mammalian Target of Rapamycin Pathway With Everolimus: A Phase I Tumor Pharmacodynamic Study in Patients With Advanced Solid Tumors
2008
A Transmembrane Serine Protease Is Linked to the Severe Acute Respiratory Syndrome Coronavirus Receptor and Activates Virus Entry
2010
Murine six-transmembrane epithelial antigen of the prostate, prostate stem cell antigen, and prostate-specific membrane antigen: prostate-specific cell-surface antigens highly expressed in prostate cancer of transgenic adenocarcinoma mouse prostate mice.
2001
Migrating glioma cells activate the PI3-K pathway and display decreased susceptibility to apoptosis
2003
A Pictet-Spengler ligation for protein chemical modification
2012 StandoutNobel
Targeting Signal Transduction Pathways in Colorectal Cancer—More Than Skin Deep
2005
The Steap proteins are metalloreductases
2006
Cancer Genome Landscapes
2013 StandoutScience
Epidermal growth factor receptor exposed to cigarette smoke is aberrantly activated and undergoes perinuclear trafficking
2007
Inhibitors of the mammalian target of rapamycin
2005
Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline
2010 StandoutNobel
Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth
2014 StandoutNobel
Phosphoinositide 3-Kinase : Diverse Roles in Immune Cell Activation
2004
Recurrent AKT mutations in human cancers: functional consequences and effects on drug sensitivity
2015
Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors
2005
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
2008 StandoutNobel
Inhibitors of mTOR reverse doxorubicin resistance conferred by PTEN status in prostate cancer cells.
2002
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten
2004 StandoutNobel
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
Works of Igor Vivanco being referenced
Mammalian Target of Rapamycin Inhibition Promotes Response to Epidermal Growth Factor Receptor Kinase Inhibitors in PTEN-Deficient and PTEN-Intact Glioblastoma Cells
2006
The phosphatidylinositol 3-Kinase–AKT pathway in human cancer
2002 Standout
Identification of the JNK Signaling Pathway as a Functional Target of the Tumor Suppressor PTEN
2007
Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death
2012
Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia.
2001
A kinase-independent function of AKT promotes cancer cell survival
2014
STEAP: A prostate-specific cell-surface antigen highly expressed in human prostate tumors
1999